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All Journal Majalah Obat Tradisional Journal of Food and Pharmaceutical Sciences Jurnal Medika: Medika
Indah Indah
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Universitas Sriwijaya, Indralaya, Sumatera Selatan, 30662
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Manajemen Obat dalam Penyimpanan dan Pemusnahan Untuk Mencegah Keracunan Obat pada Masyarakat di Desa Pulau Semambu Ogan Ilir Viva Starlista; Alinda Tania; Indah Indah; Cindy Marseli; Adinda Putri Maharani; Nabilah Fildzah Shabrina; Rafisya Deta Paralika Putri; Novalista Salsabila; Tiara Rafifa Salsabila
Jurnal Medika: Medika Vol. 4 No. 4 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/p05s1m77

Abstract

Penggunaan obat secara mandiri merupakan kegiatan yang umum terjadi di masyarakat, termasuk di wilayah pedesaan. Masyarakat melakukan pengobatan secara mandiri dengan membeli obat melalui apotek, warung tanpa konsultasi dengan dokter, atau dengan meminum jamu (Sari, Maulana, & Arnida, 2022). Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan masyarakat Desa Pulau Semambu, Kabupaten Ogan Ilir, mengenai manajemen obat dalam penyimpanan dan pemusnahan sebagai upaya pencegahan keracunan obat di rumah tangga. Permasalahan yang dihadapi masyarakat adalah kurangnya pemahaman terhadap cara penyimpanan obat yang tepat serta pemusnahan obat kedaluwarsa yang aman. Kegiatan dilaksanakan oleh dosen dan mahasiswa Jurusan Farmasi Universitas Sriwijaya melalui penyuluhan, demonstrasi, dan praktik langsung yang diikuti oleh 28 peserta. Hasil evaluasi menunjukkan adanya peningkatan pengetahuan masyarakat yang signifikan, dengan rata-rata nilai pretest sebesar 59,84% meningkat menjadi 92,50% pada posttest. Masyarakat mampu menerapkan cara penyimpanan dan pemusnahan obat sesuai prinsip DAGUSIBU, serta menunjukkan peningkatan kesadaran terhadap pentingnya pengelolaan obat yang aman dan bertanggung jawab.
Analysis of Antioxidant Activity of Ethanol Extracts of Cocoa Fruit Peel (Theobroma cacao L.) and Arabica Coffee Fruit Peel (Coffee arabica L.) with Maceration and Reflux Extraction Method Indah Indah; Dina Lestari; Shintia Puja Lasenda; Rina S E Sitindaon
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.20800

Abstract

Cocoa and coffee are well-known commodities in the world, including Indonesia. The seeds of cocoa and coffee are often utilized. Cocoa beans are usually processed into chocolate products, while coffee becomes a beverage product. Utilization of cocoa and coffee beans, and fruits produces waste, namely the skin. The more cocoa and coffee production, the more fruit skin waste. One of the efforts to utilize fruit skin waste is by extracting the antioxidant content from it. The choice of extraction method is important to produce extracts with the maximum amount of extract. Therefore, a study was conducted on the comparison of maceration and reflux extraction methods in determining the highest level of antioxidant activity. Cocoa and coffee fruit peels were extracted using ethanol, and the extracts were tested for antioxidant activity using DPPH with ascorbic acid as a positive control using UV-Vis spectrophotometry. The results of the antioxidant activity test conducted with the DPPH method showed that the IC50 value of macerated cocoa fruit peel extract was 5.440 ppm, and coffee was 62.99 ppm the reflux extract of cocoa fruit peel was 4.999 ppm, and coffee was 61.68 ppm. This shows that the maceration and reflux methods of cocoa can be categorized as very strong antioxidants and strong arabica coffee. from the two extraction methods of this study, it is concluded that there is no significant difference between maceration and reflux.
Antioxidant Activity and Network Pharmacology of Ruellia tuberosa L. Leaf Extract Targeting TNF-PPARγ in Diabetes Mellitus Muhammad Andry; Shaum Shiyan; Cindy Marseli; Tiara Ramadaini; Indah Indah; Muhammad Amin Nasution; Muhammad Fauzan Lubis
Majalah Obat Tradisional Vol 31, No 2 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.111845

Abstract

Diabetes mellitus (DM) is conditionally defined by chronic high blood sugar, oxidative stress, and inflammation, with tumor necrosis factor (TNF) and peroxisome proliferator-activated receptor gamma (PPARγ) acting as critical therapeutic targets. This research investigated the phytochemical profile, antioxidant potential, and molecular pathways of Ruellia tuberosa L. leaf extract in relation to diabetes using a dual experimental and computational framework. The total phenolic content (TPC) and total flavonoid content (TFC) were quantified using Folin-Ciocalteu and aluminum chloride colorimetry assays, respectively, while antioxidant efficacy was assessed using the DPPH radical scavenging assay. Furthermore, a Network pharmacology approach incorporating target prediction, protein-protein interaction (PPI) analysis, and molecular docking was used to uncover multi-target interactions. Results showed a TPC of 34.14 mg GAE/g and a TFC of 4.949 ± 0.089 mg QE/g, with the extract demonstrating strong antioxidant activity (IC₅₀ = 83.96 ppm). Key bioactive compounds identified included β-sitosterol, stigmasterol, betulinic acid, apigenin, and luteolin. Computational docking revealed high binding affinity of β-sitosterol and stigmasterol toward TNF (-8.7 and -8.5 kcal/mol) and PPARγ (-10.2 and -9.8 kcal/mol). Network modeling identified 87 protein targets with TNF (0.79) and PPARγ (0.77) showing the highest centrality, emphasizing their significance in the extract's antidiabetic effects.  This study provides molecular insights into the multi-target therapeutic potential of R. tuberosa L. leaf extract for diabetes treatment, addressing both inflammation and metabolic dysregulation.
Co-Authors Adinda Putri Maharani Alinda Tania Dina Lestari Marseli, Cindy Muhammad Amin Nasution Muhammad Andry Muhammad Fauzan Lubis Nabilah Fildzah Shabrina Novalista Salsabila Rafisya Deta Paralika Putri Rina Swita Esther Sitindaon Shaum Shiyan Shintia Puja Lasenda Tiara Rafifa Salsabila Tiara Ramadaini Viva Starlista