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All Journal Majalah Kedokteran Bandung International Journal of Public Health Excellence (IJPHE) Media Dermato-Venereologica Indonesiana
Indah, Astrina Rosaria
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Health Professions Medicine & Pharmacology Nursing Public Health

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CRANIAL CHARACTERISTICS, MAXILLOFACIAL, AND SKULL BASE STRUCTURE OF NON-HUMAN PRIMATE (ADULT MACACA FASCICULARIS): A PRELIMINARY STUDY FOR CRANIAL CRANIOTOMY MODEL Bolly, Hendrikus Masang Ban; Indah, Astrina Rosaria; Faried, Ahmad; Noverina, Rachmawati; Arifin, Muhammad Zafrullah; Wirakusumah, Firman Fuad
Majalah Kedokteran Bandung Vol 51, No 2 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v51n2.1650

Abstract

The use of non-human primate (NHP) animal models, which anatomical and physiological similarities to human, is important for the sake of learning the anatomical properties. This study aimed to characterize the cranial, maxillofacial, and skull base structures of non-human primates as a potential model suitable for a cranial craniotomy model. Adult Macaca fascicularis (MF) skulls classified asspecificpathogen-free for TB, SIV, SV40, Polio, Foamy virus and Herpes B virus from PT Bio Farma (Persero) Animal Lab. Library were used to represent the anatomical model.The open access database from Mammalian Crania Photographic Archive 2nd Edition (MCPA2) was used for cranial characterization analysis. This study was performed at the Department of Neurosurgery, Dr. Hasan Sadikin General Hospital and the Animal Laboratory of PT. Biofarma (Persero) from November 2018 to January 2019. The skull base structures were assessed for its analogies with its human counterpart. Comparison by t-student analysis between male and female skulls shows the mean male cranial length (CL) is greater than in female (116.68 vs 102.50 mm), with p=0.000; the mean male bizygomatic width (BZB) is greater than in female (79.30 vs 69.70 mm) with p=0.001; the mean male posterior cranial breadth (CBN) is greater than in female (63.40 vs 58.79 mm) with p=0.019; and the mean male cranial base length (CBL) is greater than in female (63.32 vs 57.55 mm), with p=0.001. The skull of MF is suitable for Neurosurgery and Neuroscience study since the MF cranial characterization and structure are similar to that of human. Its structure is ideal for performing craniotomy since it has several characteristics such as cranial vault, maxillofacial structure with huge temporal muscle, and skull base structure.  Karakteristik Kranium, Maksilofasial, dan Struktur Dasar Tengkorak Non-human Primate Macaca fascicularis dewasa: Studi Pendahuluan untuk Model Craiotomi Kranium Penggunaan hewan model berasal dari primata bukan-manusia (NHP), dimana secara anatomis dan fisiologis mirip dengan manusia, sangat penting untuk dapat mempelajari struktur anatominya. Penelitian ini bertujuan untuk karakterisasi struktur kranium, maksilofasial dan dasar tengkorak primata (Non-human Primate) yang berpotensi sebagai model penelitian kraniotomi. Tengkorak dewasa Macaca fascicularis (MF) dari  Laboratorium Hewan PT Biofarma (Persero), bebas infeksi TBC, SIV, SV40, Polio, Foamy Virus,  dan Herpes B digunakan sebagai model anatomi. Basis data terbuka Mammalian Cranial Photographic Archive 2nd Edition (MCPA2) digunakan untuk analisis kranium. Penelitian dilakukan di Departmen Bedah Saraf RSHS dan Laboratorium Hewan  PT. Biofarma  pada November 2018?Januari 2019. Struktur tengkorak MF dipelajari analogi seperti pada struktur tengkorak manusia. Analisis uji-t tengkorak jantan dan betina menunjukan rerata panjang kranial (Cranial length, CL) jantan lebih panjang dibanding betina (116.68 vs 102.50 mm, p=0.000); rerata bizygomatic width (BZB) jantan lebih panjang dibanding betina (79.30 vs 69.70 mm, p=0.001); rerata posterior cranial breadth (CBN) jantan lebih panjang dibanding betina (63.40 vs 58.79 mm, p=0.019);dan rerata cranial base length (CBL) jantan lebih panjang dibanding betina (63.32 vs57.55 mm, p=0.001). Tengkorak MF sesuai untuk berbagai penelitian bidang bedah saraf dan neurosains. Karakterisasi kranial dan strukturnya sama dengan yang dimiliki manusia. Struktur kranium MF merupakan model ideal untuk kraniotomi berdasar karakteristik tulang tengkorak, otot temporal besar pada maksilofasial, dan struktur dasar tengkorak.
COMPARISON OF HISTOLOGICAL CHARACTERISTICS OF DRIED AND FRESH AMNION MEMBRANES AND DURA MATER IN NON-HUMAN PRIMATE (MACACA FASCICULARIS) Indah, Astrina Rosaria; Bolly, Hendrikus Masang B.; Faried, Ahmad; Arifin, Muhammad Zafrullah; Achadiyani, Achadiyani; Wirakusumah, Firman Fuad
Majalah Kedokteran Bandung Vol 51, No 1 (2019)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.785 KB) | DOI: 10.15395/mkb.v51n1.1651

Abstract

This study aimed to characterize the histological properties of dry-lyophilized amniotic membrane, fresh amniotic membrane (AM), and duramater membrane in search for a biologically-derived material suitable for meninges surface reconstruction. This descriptive study was conducted at the Unit-3 Laboratory of Animal Test of PT. Bio Farma (Persero), Bandung and Cell Biology Laboratory of the Faculty of Medicine, Universitas Padjadjaran Bandung. This study was conducted from 2018-2019. Fresh Macacafascicularis placenta from healthy donors,classified as specific pathogen-free for TB, SIV, SV40, Polio type 1,2,3, Foamy virus and Herpes B virus, were obtained from selected caesarean sections.The harvested dried and fresh AM and duramater membrane were stained with hematoxylin-eosin and prepared for characterization. Histological examination of dry-lyophilized and fresh AM showed similar results. Histologically, AM is represented by a single layer of metabolically-active cuboidal to columnar epithelium with microvilli firmly attached to a basement membrane and an avascular and relatively sparsely populated stroma. Meninges layers consists of 3 layers: duramater, arachnoid membrane, and piamater. Most of these cells have the same characteristics as fibroblasts, including long organelles and nuclei with various levels of fibril formation. The histological study of amniotic membrane and duramater membrane shows comparable results. The AM is a biologically-derived material suitable for meninges surface reconstruction since its histological structure is somewhat similar to that of the duramater. Its structure is ideal for replacing duramater since it has several characteristics, such as having hygroscopic properties, good biocompatibility, relatively easy to apply, and inexpensive. Key words: Dried and fresh amnion membranes, duramater membranes, non-human primate Karakteristik Histologis Membran Amnion Jenis Kering dan Segar dengan Membran Duramater pada Primata Non-Human Macaca fascicularisPenelitian ini bertujuan mengetahui karakteristik histologis membran amnion kering yang diliofilisasi, membran amnion segar, dan duramater, dalam rangka mencari bahan biologis yang cocok untuk rekonstruksi permukaan meninges. Penelitian deskriptif dilakukan di Laboratorium Hewan Uji PT. Bio Farma dan Laboratorium Biologi Sel FK Universitas Padjadjaran periode 2018-2019. Plasenta Primata non-human Macaca fascicularis segar dari donor sehat, yang bebas dari pathogen spesifik TB, SIV, SV40, Polio tipe 1, 2, 3, virus Foamy dan virus Herpes B, diperoleh dari seksio sesarea. Kemudian, dilakukan pewarnaan dengan hematoxylin-eosin untuk membran amnion kering dan segar, serta membran duramater untuk mengetahui karakterisasi histologisnya. Pemeriksaan histologis membran amnion kering-yang aktif bermetabolisme hingga kolumnar dengan mikrovili; melekat kuat pada membran basal dan stroma yang avaskular dan relatif jarang. Lapisan Meninges terdiri dari 3 lapisan: duramater, arachnoid dan piamater. Sebagian besar sel-sel ini memiliki karakteristik yang sama dengan fibroblas. Studi histologis membran amnion dan membran duramater memiliki struktur yang relatif serupa. Membran amnion adalah material yang secara biologis cocok untuk rekonstruksi permukaan meningen, karena struktur histologinya agak mirip dengan duramater. Oleh karena itu secara struktur, membran amnion ideal untuk menggantikan duramater karena memiliki beberapa karakteristik seperti sifat higroskopis, biokompatibilitas baik, mudah diterapkan, dan murah.Kata kunci: Membran amnion segar dan kering, membran duramater, primate non-human
THE DIAGNOSTIC TESTING OF YAWS USING THE RAPID DIAGNOSTIC TEST (RDT) METHOD IN THE BORDER AREA OF PAPUA NEW GUINEA AND PAPUA-JAYAPURA Sumolang, Inneke Viviane; Indah, Astrina Rosaria; Reba, Timothy Verellino; Nelson, Jefferson
Media Dermato-Venereologica Indonesiana Vol 52 No 2 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i2.556

Abstract

   Pendahuluan: Frambusia merupakan penyakit endemis treponematosis non-venereal yang disebabkan oleh infeksi bakteri Treponema pertenue. Penyakit ini adalah penyakit terabaikan dengan beban kesehatan kepada pasien dan masyarakat baik fisik, psikologik, dan ekonomi. Di Indonesia, lebih banyak ditemukan di Provinsi Nusa Tenggara Timur, Maluku, Sulawesi Tenggara, dan Papua. Tujuan dari penelitian ini adalah untuk mendapatkan gambaran diagnostik frambusia dengan metode rapid diagnostic test (RDT) di perbatasan Papua Nugini dan Papua-Jayapura tahun 2021-2022. Metode: Desain penelitian deskriptif dengan pemeriksaan darah kapiler serum pasien frambusia menggunakan rapid diagnostic test. Hasil: Pemeriksaan serologis terhadap 31 orang anak yang didiagnosis secara klinis sebagai frambusia memberikan hasil RDT positif sebesar 74,2% (26 anak). Gambaran karakteristik anak dengan RDT positif adalah 47% berusia 6-11 tahun, 65% berjenis kelamin laki-laki, dan sebanyak 73% lesi berlokasi di tungkai. Kesimpulan: Gambaran penelitian ini menjadi informasi penting untuk diagnostik cepat dan penanganan frambusia di daerah terpencil dengan keterbatasan akses ke fasilitas laboratorium. 
Profile of Leprosy Among Children in Jayapura City Sumolang, Inneke V.; Indah, Astrina Rosaria; Reba, Timothy V. P
International Journal of Public Health Excellence (IJPHE) Vol. 2 No. 2 (2023): January-May
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v2i2.1474

Abstract

Leprosy is a chronic infectious disease caused by Mycobacterium leprae with highly variable clinical presentations. Leprosy remains a health problem in Indonesia. Leprosy cases in children are an epidemiological index to determine disease transmission as an indicator of the success of the national leprosy eradication program. Objective: To analyze the picture of leprosy in children in Jayapura City. A retrospective study method was used to examine all new leprosy cases in children (0-14 years) in all community health centers in Jayapura City who came to the Community Health Center Outpatient Unit from January 2019 to December 2022. The results of this study revealed that of the 967 new leprosy cases, 811 (83.87%) were adults and 156 (16.13%) were children aged 0-14. The most common age group was 10-14 years with 96 people (61.54%). Male gender was 82 people (52.56%) and female gender was 74 people (47.44%). In general, there were 103 Papuans (66.03%), while 53 non-Papuans (33.97%) had multibacillary leprosy. 128 (82.05%) had paucibacillary leprosy, and 28 (17.95%) had paucibacillary leprosy. Twenty-three (14.75%) of the children with leprosy dropped out. The leprosy rate among children in Jayapura City remains very high, at around 16.13%.
Co-Authors Achadiyani Ahmad Faried Firman Fuad Wirakusumah Hendrikus Masang Ban Bolly Inneke V. Sumolang Muhammad Zafrullah Arifin Nelson, Jefferson Noverina, Rachmawati Reba, Timothy V. P Reba, Timothy Verellino Sumolang, Inneke Viviane