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All Journal Jurnal Kedokteran Diponegoro Jurnal Health Sains Journal of Social Research Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan
Mundhofir, Farmaditya Eka Putra
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Humanities Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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The Effect of Moringa Leaf Extract (moringa oleifera) on the Microscopic Structure of the Lungs of Male Wistar Rats Given Inhalation of E-cigarette Liquid Vapor Bialangi, Alif Akbar; Ismail, Akhmad; Purnawati, Ratna Damma; Mundhofir, Farmaditya Eka Putra
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 6 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i6.39824

Abstract

Background: Moringa leaf extract is proven to have high antioxidant bioactive compounds and acts as an anti-inflammatory and prevents cell damage due to exposure to free radicals or oxidative. In the respiratory system exposed to Electronic Delivery Nicotine System liquid vapor, an inflammatory response and oxidative stress occur. Objective: This study aimed to determine the effect of Moringa leaf extract (Moringa oleifera) on the microscopic structure of the lungs of male Wistar rats given inhalation of e-cigarette liquid vapor. Methods: This research is an experimental laboratory with Post Test Only Control Group Design. Rats were divided into 4 groups containing 6 rats in each group, determined based on simple random sampling with the following divisions: Aquadest 3 mL (K1), gave inhalation of liquid vapours of electric cigarettes (K2), gave inhalation of liquid vapours of electric cigarettes + Moringa leaf extract with the dekoxy method dose of 500 mg/kgBW (P1), administration of vapor inhalation of e-cigarette liquid + Moringa leaf extract with the dekoxy method at a dose of 500 mg/kgBW (P2). Termination of the experimental animals was carried out on the 15th day and the rat pulmonary organs were taken to assess the microscopic structure of the rat lung. Results: The results of the Kruskal-Wallis test and continued with the Mann-Whitney test showed a significant difference (p < 0.05), however, there was no significant difference in the degree of pulmonary damage in the P1 to P2 groups. Conclusion: There is an effect of Moringa leaf extract (Moringa oleifera) on the microscopic structure of the lungs of male Wistar rats given inhalation of liquid vapor of electric cigarettes. 
Efficacy of Adjuvant Therapy Curcuma Longa Rhizome Extract and Moringa Oleifera Leaf Extract to Wound Healing in Leprosy Ulcer Patients Yuniati, Renni; Mundhofir, Farmaditya Eka Putra; Sugianto, Sylvia Christiana
Journal of Social Research Vol. 4 No. 6 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i6.2565

Abstract

Leprosy (Morbus Hansen) is a chronic infectious disease caused by Mycobacterium leprae, primarily affecting the peripheral nerves and leading to sensory loss and the formation of chronic ulcers. This study investigates the efficacy of Curcuma longa rhizome and Moringa oleifera leaf extracts, known for their antibacterial and anti-inflammatory properties, in promoting wound healing in leprosy-related ulcers. Utilizing a pre-post, randomized, single-blinded controlled trial design, the study was conducted at Kelet Regional Hospital, Jepara, from January to April 2024. Participants included leprosy ulcer patients with a mean disease duration of 101.5 months, predominantly male (63.6%), and largely in the 51–60 age group (39.4%). Results indicated significant improvements in PUSH (Pressure Ulcer Scale for Healing) scores from pre-test to post-test within both the intervention and control groups (p<0.001). However, intergroup analysis showed no statistically significant difference in PUSH scores between groups (pre-test p=0.669; post-test p=0.198). These findings suggest that while C. longa and M. oleifera extracts have promising therapeutic potential in enhancing ulcer healing, their clinical efficacy may be limited by factors such as oral bioavailability. This research contributes to the limited literature on the use of plant-based adjunctive therapies in leprosy ulcer management and underscores the need for further studies with larger samples and improved delivery mechanisms to optimize clinical outcomes.
Effect of Vitamin D Supplementation on Aorta Diameter of Pregnant Wistar Rats (Rattus norvegicus) Haryono, Az Zahra Khaiirunnisa; Cahyanti, Ratnasari Dwi; Mundhofir, Farmaditya Eka Putra; Pramono, M.Besari Adi
DINAMIKA KESEHATAN: JURNAL KEBIDANAN DAN KEPERAWATAN Vol 16, No 1 (2025): Dinamika Kesehatan: Jurnal Kebidanan dan Keperawatan
Publisher : Universitas Sari Mulia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33859/dksm.v16i1.1019

Abstract

Background: Hypertension is one of the clinical signs of preeclampsia or eclampsia, which is estimated to be seven times higher in developing countries than in developed countries. It can be caused by the differences in nutritional status and nutritional intake, one of which is vitamin D. Vitamin D deficiency (VDD) has a negative impact on pregnancy. It increases the risk of preeclampsia, long-term hypertension, miscarriage, and vascular disorder. Vasoconstriction as the beginning of preeclampsia can be related to the diameter of the aorta which is the largest blood vessel in the human body.Purpose: Determine the effect of vitamin D intake on the aorta diameter of pregnant Wistar rats (Rattus norvegicus).Method: True experimental with post-test only control group design. Research on pregnant Wistar rats (Rattus norvegicus) was divided into control and treatment groups. The treatment group of pregnant Wistar rats was given a standard diet during pregnancy and given a dose of 1000 IU/day (human doses) or 18 IU/day (rat doses) of vitamin D on days 1 to 17. On the 18th day, surgery was performed to take the aorta, and its diameter was measured.Results: The mean aorta diameter of the control group was 1742,04 µm and the treatment group was 1889,30 µm.Conclusion: There is a clinical inclination that the mean aorta diameter of pregnant Wistar rats (Rattus norvegicus) in the treatment group given 18 IU vitamin D is greater than the control group.
Adjuvant Therapy Effect of Curcuma Longa Rhizome Extract On TGF-β Serum Levels in Leprosy Ulcer Patients Alfarizi, Rizki; Yuniati, Renni; Mundhofir, Farmaditya Eka Putra; Wijayahadi, Noor; Nindita, Yora
Jurnal Health Sains Vol. 5 No. 6 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i6.1300

Abstract

Leprosy ulcer is one of the worsening manifestations of leprosy that often causes disability if not appropriately handled. Healing of ulcers requires a long enough duration so that a good immunological response is needed to encourage the wound healing process, one of which is transforming growth factor-  (TGF-), which is necessary of the plants that plays a role in the expression of TGF-  to spur wound healing is Curcuma longa rhizome or turmeric rhizome. This study is expected to prove that administering Curcuma longa rhizome extract can increase serum TGF-β levels in leprosy ulcer patients. This study is an experimental study with a pre and post-randomised single-blind controlled trial design involving 22 subjects with leprosy ulcers. The control group obtained standard therapy for leprosy ulcers, and the treatment group received standard therapy and adjuvant Curcuma longa rhizome extract at a dose of 1 g per day for 30 days. TGF-β levels were measured by the ELISA method. Data analysis used the Wilcoxon test and the Mann-Whitney test. The results showed no significant difference in TGF-β levels after and before the intervention in the control group (p=0.79) and the treatment group (p=0.14). However, there was a significant difference in TGF-β levels after the intervention in the control group and treatment (p=0.01). Curcuma longa rhizome extract did not show an important role in changes in serum TGF-β levels in leprosy ulcer patients. This study showed that administering Curcuma longa rhizome extract for 1 month did not show a potential role as an adjuvant therapy. Leprosy ulcer is one of the worsening manifestations of leprosy that often causes disability if not appropriately handled. Healing of ulcers requires a long enough duration so that a good immunological response is needed to encourage the wound healing process, one of which is transforming growth factor-  (TGF-), which is necessary of the plants that plays a role in the expression of TGF-  to spur wound healing is Curcuma longa rhizome or turmeric rhizome. This study is expected to prove that administering Curcuma longa rhizome extract can increase serum TGF-β levels in leprosy ulcer patients. This study is an experimental study with a pre and post-randomised single-blind controlled trial design involving 22 subjects with leprosy ulcers. The control group obtained standard therapy for leprosy ulcers, and the treatment group received standard therapy and adjuvant Curcuma longa rhizome extract at a dose of 1 g per day for 30 days. TGF-β levels were measured by the ELISA method. Data analysis used the Wilcoxon test and the Mann-Whitney test. The results showed no significant difference in TGF-β levels after and before the intervention in the control group (p=0.79) and the treatment group (p=0.14). However, there was a significant difference in TGF-β levels after the intervention in the control group and treatment (p=0.01). Curcuma longa rhizome extract did not show an important role in changes in serum TGF-β levels in leprosy ulcer patients. This study showed that administering Curcuma longa rhizome extract for 1 month did not show a potential role as an adjuvant therapy.
Effect of Curcuma longa Extract as Adjuvant Therapy on IL-6 Serum Levels in Leprosy Type 1 Reaction Patients Putri, Syifa Nurisma; Mundhofir, Farmaditya Eka Putra; Yuniati, Renni; Wijayahadi, Noor; Nindita, Yora
Jurnal Health Sains Vol. 5 No. 6 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i6.1301

Abstract

Type 1 leprosy reaction / Reversal reaction (RR) is an inflammatory episode in existing leprosy lesions and aggravates the pain rate. Long-term therapy with steroids causes a variety of side effects, so an adjuvant therapy alternative is needed to alleviate steroid use. Curcuma longa rhizome extract has become an anti-inflammatory therapy choice in various previous inflammatory diseases. This study aims to determine the anti-inflammatory effect of Curcuma longa rhizome extract as an adjuvant therapy for reversal reaction patients by analyzing serum levels of IL-6 as a marker of inflammation. The pre and post-test randomized single-blinded controlled trial was conducted on two groups, namely control (RR patients with steroid therapy & placebo) and treatment (steroid therapy & Curcuma longa rhizome extract 1 gram/day). IL-6 serum levels were analyzed from sampling before and after the intervention for one month. The serum levels of IL-6 post-test in the control group were significantly higher than those of the pre-test. The treatment group showed lower serum levels of IL-6 post-test compared to pre-test, although there was no significant difference. Curcuma longa rhizome extract 1 gram/day for one month as adjuvant therapy for patients with type 1 leprosy reaction did not significantly reduce serum IL-6 levels.
Co-Authors Akhmad Ismail Alfarizi, Rizki Bialangi, Alif Akbar Haryono, Az Zahra Khaiirunnisa Noor Wijayahadi Pramono, M.Besari Adi Putri, Syifa Nurisma Ratna Damma Purnawati Ratnasari Dwi Cahyanti, Ratnasari Dwi Renni Yuniati Sugianto, Sylvia Christiana Yora Nindita