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All Journal Jurnal Kedokteran Diponegoro Jurnal Health Sains COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Alfarizi, Rizki
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Humanities Dentistry Economics, Econometrics & Finance Education Health Professions Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Correlation between TGF-β Levels and Degree of Wound Healing in Leprosy Ulcer Patients: An Observational Study at dr. Rehatta Regional Hospital Jepara Alfarizi, Rizki; Yuniati, Renni; Mundhofir, Farmaditya Eka Putra; Wijayahadi, Noor; Nindita, Yora
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 3 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i3.44999

Abstract

Background: Ulcers are one form of chronic wounds as one form of complication experienced by leprosy sufferers. In the process of healing wounds such as ulcers, TGF-β has a broad role. Several studies have stated that in chronic wound conditions there is a decrease in TGF-β levels so that the wound is increasingly difficult to heal. This study aims to determine the relationship between TGF-β serum levels and the degree of ulcer wound healing. Methods: This study is an observational analysis study with a cross-sectional design and involved 33 leprosy ulcer patients undergoing treatment at the dr. Rehatta Jepara Hospital in the period March-April 2024. Serum TGF-β levels were measured using the Enzyme-linked immunosorbent assay (ELISA) method while the degree of wound healing was assessed by scoring the Pressure Ulcer Scale for Healing (PUSH). Bivariate analysis using the Spearman Correlation Rank Test. Results: The correlation test between serum TGF-β levels and the degree of wound healing (p = 0.807) and duration of leprosy as covariate (p = 0.96) showed insignificant results. Conclusion: There is no relationship between serum TGF-β levels and the degree of wound healing and duration of leprosy. 
Vitamin D Levels and its Influence on Maternal Blood Glucose, Blood Pressure, and Fetal Weight Reza, Hanif; Soraya, Yulice; Makarim, Fadhli Rizal; Alfarizi, Rizki
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 5 No. 2 (2025): COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v5i2.3230

Abstract

Vitamin D is essential for various physiological functions. Vitamin D deficiency is a global concern, including vitamin D deficiency during pregnancy. Maternal vitamin D deficiency is associated with an increased risk of adverse gestational outcomes. The objective of this cross-sectional study is to examine the impact of maternal Vitamin D levels on blood sugar, blood weight, and fetal weight. The study used quantitative method. Twenty-six women with gestational age 12-16 weeks as participants of this study were recruited from two Primary health care in Semarang, Indonesia between September - October 2023 were analyzed for serum 25-hydroxy Vit. D (25(OH)D). The samples then were evaluated for blood glucose, blood pressure and fetal weight using ultrasonography. The results of the Pearson's correlation rank test for Vitamin D with estimated fetal weight, blood glucose, systolic blood pressure, and gestational ages as covariate showed P>0.05, It implies that there is no relationship between Vit. D and other variables. Our study showed level of Vitamin D has no influence on of blood glucose level, incidence of hypertension, and low fetal weight.
Vitamin D Levels and its Influence on Maternal Blood Glucose, Blood Pressure, and Fetal Weight Reza, Hanif; Soraya, Yulice; Makarim, Fadhli Rizal; Alfarizi, Rizki
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 5 No. 2 (2025): COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v5i2.3230

Abstract

Vitamin D is essential for various physiological functions. Vitamin D deficiency is a global concern, including vitamin D deficiency during pregnancy. Maternal vitamin D deficiency is associated with an increased risk of adverse gestational outcomes. The objective of this cross-sectional study is to examine the impact of maternal Vitamin D levels on blood sugar, blood weight, and fetal weight. The study used quantitative method. Twenty-six women with gestational age 12-16 weeks as participants of this study were recruited from two Primary health care in Semarang, Indonesia between September - October 2023 were analyzed for serum 25-hydroxy Vit. D (25(OH)D). The samples then were evaluated for blood glucose, blood pressure and fetal weight using ultrasonography. The results of the Pearson's correlation rank test for Vitamin D with estimated fetal weight, blood glucose, systolic blood pressure, and gestational ages as covariate showed P>0.05, It implies that there is no relationship between Vit. D and other variables. Our study showed level of Vitamin D has no influence on of blood glucose level, incidence of hypertension, and low fetal weight.
Adjuvant Therapy Effect of Curcuma Longa Rhizome Extract On TGF-β Serum Levels in Leprosy Ulcer Patients Alfarizi, Rizki; Yuniati, Renni; Mundhofir, Farmaditya Eka Putra; Wijayahadi, Noor; Nindita, Yora
Jurnal Health Sains Vol. 5 No. 6 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i6.1300

Abstract

Leprosy ulcer is one of the worsening manifestations of leprosy that often causes disability if not appropriately handled. Healing of ulcers requires a long enough duration so that a good immunological response is needed to encourage the wound healing process, one of which is transforming growth factor-  (TGF-), which is necessary of the plants that plays a role in the expression of TGF-  to spur wound healing is Curcuma longa rhizome or turmeric rhizome. This study is expected to prove that administering Curcuma longa rhizome extract can increase serum TGF-β levels in leprosy ulcer patients. This study is an experimental study with a pre and post-randomised single-blind controlled trial design involving 22 subjects with leprosy ulcers. The control group obtained standard therapy for leprosy ulcers, and the treatment group received standard therapy and adjuvant Curcuma longa rhizome extract at a dose of 1 g per day for 30 days. TGF-β levels were measured by the ELISA method. Data analysis used the Wilcoxon test and the Mann-Whitney test. The results showed no significant difference in TGF-β levels after and before the intervention in the control group (p=0.79) and the treatment group (p=0.14). However, there was a significant difference in TGF-β levels after the intervention in the control group and treatment (p=0.01). Curcuma longa rhizome extract did not show an important role in changes in serum TGF-β levels in leprosy ulcer patients. This study showed that administering Curcuma longa rhizome extract for 1 month did not show a potential role as an adjuvant therapy. Leprosy ulcer is one of the worsening manifestations of leprosy that often causes disability if not appropriately handled. Healing of ulcers requires a long enough duration so that a good immunological response is needed to encourage the wound healing process, one of which is transforming growth factor-  (TGF-), which is necessary of the plants that plays a role in the expression of TGF-  to spur wound healing is Curcuma longa rhizome or turmeric rhizome. This study is expected to prove that administering Curcuma longa rhizome extract can increase serum TGF-β levels in leprosy ulcer patients. This study is an experimental study with a pre and post-randomised single-blind controlled trial design involving 22 subjects with leprosy ulcers. The control group obtained standard therapy for leprosy ulcers, and the treatment group received standard therapy and adjuvant Curcuma longa rhizome extract at a dose of 1 g per day for 30 days. TGF-β levels were measured by the ELISA method. Data analysis used the Wilcoxon test and the Mann-Whitney test. The results showed no significant difference in TGF-β levels after and before the intervention in the control group (p=0.79) and the treatment group (p=0.14). However, there was a significant difference in TGF-β levels after the intervention in the control group and treatment (p=0.01). Curcuma longa rhizome extract did not show an important role in changes in serum TGF-β levels in leprosy ulcer patients. This study showed that administering Curcuma longa rhizome extract for 1 month did not show a potential role as an adjuvant therapy.
Co-Authors Makarim, Fadhli Rizal Mundhofir, Farmaditya Eka Putra Noor Wijayahadi Renni Yuniati Reza, Hanif Soraya, Yulice Yora Nindita