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All Journal Jurnal Ilmu Dasar AL KAUNIYAH Cropsaver : Journal of Plant Protection Humanika JURNAL MEDIA KESEHATAN Indonesia Natural Research Pharmaceutical Journal (INRPJ) Journal of Agriculture and Applied Biology Journal of Agriculture and Applied Biology ( JAAB) Jurnal Kefarmasian Indonesia

Sogandi, Sogandi

Unknown Affiliation

Author-ID : 1149809

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Control & Systems Engineering Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Social Sciences

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UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 96% DAUN RAMBAI (Sonneratia caseolaris, (L.) Engl) TERHADAP PERTUMBUHAN BAKTERI Escherichia coli Sogandi, Sogandi
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 2, No 1 (2017)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

ABSTRAK Kebanyakan masyarakat Indonesia telah mengenal obat-obatan tradisional dan lebih suka menggunakan obat-obatan tradisional untuk mengobati berbagai penyakit. Di Kalimantan Tengah buah rambai dapat dimakan demikian pula daunnya digunakan untuk mengobati penyakit cacar, obat diare dan mengobati luka memar dikulit, daun rambai mengandung tanin, flavonoid dan saponin. Tujuan penelitin ini untuk mengetahui efektivitas ekstrak daun rambai (Sonneratia caseolaris (L.) Engl) dalam menghambat pertumbuhan bakteri Escherichia coli (ATCC 25922). Metode yang digunakan adalah metode difusi cakram tujuannya untuk mengetahui aktivitas antibakteri ekstrak etanol 96% daun rambaiÂ (Sonneratia caseolaris (L.) Engl). Kotrimoxazol 25Î¼g digunakan sebagai pembanding aktivitas antibakteri. Ekstrak etanol 96% daun rambai (Sonneratia caseolaris (L.) Engl) menunjukkan adanya aktivitas antibakteri terhadap bakteri Escherichia coli. Aktivitas antibakeri yang paling tinggi adalah pada konsentrasi 100% dengan rerata diameter adalah 22,48 mm. Kata Kunci: Sonneratia caseolaris L. Engl, antibakteri, difusi cakram ABSTRACT Most Indonesian people have known traditional medicine and prefer to use traditional medicine to treat various diseases. In Central Kalimantan,rambai fruit is edibleas well as its leaves are used to treat smallpox, diarrhea and skin bruises. Rambai leaves contain tannins, flavonoids and saponins. The purpose of this study is to determine the effectiveness of the extract of Rambai leaf (Sonneratia caseolaris (L.) Engl) in inhibiting the growth of Escherichia coli bacterium (ATCC 25922). The method used is disc diffusion method to determine the antibacterial activity of 96% ethanol extract of the Rambai leaf (Sonneratia caseolaris (L.) Engl). Cotrimoxazole 25Î¼g is used as a comparison of antibacterial activity. 96% ethanol extract of Rambai leaf (Sonneratia caseolaris (L.) Engl) shows antibacterial activity against Escherichia coli. The highestantibacterial activity is at a concentration of 100% with a mean diameter of 22.48 mm. Keywords: Sonneratia caseolaris, L. Engl, antibacterial, disc difussion

IDENTIFIKASI SENYAWA AKTIF EKSTRAK DAUN CENGKEH (Syzygium aromaticum) SEBAGAI INHIBITOR Streptococcus mutans Suhendar, Usep; Sogandi, Sogandi
Al-Kauniyah: Jurnal Biologi Vol 12, No 2 (2019): Al-Kauniyah Jurnal Biologi
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

AbstrakKaries gigi adalah penyakit yang umum dialami oleh masyarakat yang terjadi karena buruknya kebersihan mulut. Kebiasaan masyarakat yang kurang menjaga kebersihan mulut mengakibatkan terbentuknya plak. Plak pada gigi terbentuk karena aktivitas dari berbagai macam mikroorganisme di mulut. Mikroorganisme yang diketahui terlibat dalam pembentukan karies gigi adalah Streptococcus mutans. Salah satu bahan alternatif sebagai antibakteri adalah daun cengkeh. Penelitian ini bertujuan untuk mengidentifikasi senyawa bioaktif daun cengkeh dan mengetahui mekanisme aksinya dalam menghambat pertumbuhan Streptococcus mutans. Daun cengkeh (Syzygium aromaticum) yang digunakan dalam penelitian ini dimaserasi menggunakan metanol 96%. Pengujian aktivitas antibakteri dilakukan dengan metode difusi agar, senyawa bioaktif diidentifikasi menggunakan gas chromatography mass spectrometry dan perubahan membran sel bakteri diamati dengan scanning electron microscopy. Hasil penelitian menunjukkan ekstrak metanol daun cengkeh memiliki aktivitas penghambatan terhadap pertumbuhan bakteri Streptococcus mutans dengan zona hambat sebesar Â±32 mm serta nilai konsentrasi hambat minimum (KHM) 20% ekstrak. Mekanisme aksi penghambatan ekstrak daun cengkeh terhadap pertumbuhan bakteri diduga dengan membuat lubang pada membran sel bakteri. Hasil penelitian ini juga menunjukkan bahwa daun cengkeh memiliki kandungan senyawa bioaktif 3-allyl-6-methoxyphenol-eugenol, caryophyllene 1,4,7,-cycloundecatriene, 1,5,9,9-tetramethyl, phenol, 2-methoxy-4-(2-propenyl), dan eugenol acetate yang dapat menjadi kandidat penghasil senyawa aktif untuk mengatasi karies gigi.Abstract Dental caries is a common disease experienced by people who do not maintain oral hygiene. Habits of not maintain oral hygiene result in the formation of plaque. The microorganism known to be involved in the formation of dental caries is Streptococcus mutans. Plants that have antibacterial properties, such as clove (Syzygium aromaticum) leaf, can be an alternative for carrying this problem. This study aims to identify the bioactive compounds of clove leaves and to determine the mechanism of its action in inhibiting the growth of Streptococcus mutans. Clove leaves were macerated using 96% methanol for the extraction. Antibacterial activity was examined by agar diffusion method, bioactive compounds were identified using gas chromatography mass spectrometry, and bacterial cell membrane changes were observed by an image captured using scanning electron microscopy. The results showed that the methanol extract of clove leaf had inhibitory activity on Streptococcus mutans growth, with inhibitory zones of Â±32 mm and the minimum inhibitory concentration (MIC) of 20% extract. It was suspected that the mechanism of inhibitory action is by making pores in the bacterial cell membrane. The results also showed that the clove leaves contain bioactive compounds of 3-allyl-6-methoxyphenol-eugenol, caryophyllene, 1,4,7, -cycloundecatriene, 1,5,9,9-tetramethyl, phenol, 2 -methoxy-4- (2-propenyl), and eugenol acetate which can be candidates for producing active compounds to overcome dental caries.

BAKTERI ENDOFIT SUMBER PENGHASIL SENYAWA ANTIOKSIDAN Sogandi, Sogandi
Jurnal Ilmiah Humanika 2020: DUNIA BUKU PERSADA
Publisher : CV. Pena Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (982.754 KB)

Puji syukur kami panjatkan kehadirat Tuhan Yang Maha Esa karena berkat dan rahmat-Nyalah kami bisa menyelesaikan Bahan Ajar ini tepat pada waktu yang kami rencanakan. Bahan Ajar ini dibuat sebagai salah satu alat bantu mahasiswa farmasi yang menempuh mata kuliah Kimia Bahan Alam dalam mempelajari, dan memahami materi tentang senyawa antioksidan dari sumber alami. Bahan Ajar ini dapat terselesaikan karena bantuan dari teman-teman sejawat di Fakultas Farmasi, Universitas 17 Agustus 1945 Jakarta, maka dari itu kami mengucapkan banyak-banyak terima kasih.

BIOLOGI MOLEKULER IDENTIFIKASI BAKTERI SECARA MOLEKULER Sogandi, Sogandi
Jurnal Ilmiah Humanika 2020: DUNIA BUKU PERSADA
Publisher : CV. Pena Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (575.977 KB)

Panduan ini berisi teori dasar teknik PCR, prosedur, tahapan dan uraian analisis data genetika hasil sequencing untuk keperluan identifikasi bakteri secara molekuler. Program pengolahan data genetik dalam panduan ini adalah: Sequence Scanner 2.0, ChromasPro, DNA MAN 9.0 dan MEGA X. Tujuan dari penulisan buku ini adalah memberikan panduan lengkap mulai dari tahapan paling dasar untuk mengolah data hasil sequencing mulai dari proses editing, sequence assembly, pensejajaran sekuen, analisis Blast, dan cara membuat pohon phylogenetic. Program analisis data genetik lainnya juga tersedia namun tidak dijelaskan dalam panduan ini. Pembaca bebas mengembangkan dan mencoba berbagai program lain untuk menambah keahlian

TINGKAT KEPATUHAN PENGGUNAAN MASKER DAN HAND SANITIZER MAHASISWA UNIVERSITAS 17 AGUSTUS 1945 JAKARTA SELAMA PANDEMI COVID-19 Kining, Ekajayanti; Ginting, Dina Marsella Br.; Sogandi, Sogandi
JURNAL MEDIA KESEHATAN Vol 14 No 1 (2021): Jurnal Media Kesehatan Poltekkes Kemenkes Bengkulu Volume 14 No 1 Juni 2021
Publisher : Politeknik Kesehatan Kemenkes Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33088/jmk.v14i1.621

Wearing mask and hand hygiene were the main choices in an effort to reduce the transmission of Covid-19 when doing outdoor activity. Various efforts have been made by the government in disseminating this recommendation to all levels of society including college students. College students as a layer with a high level of education were expected to obey the appeal given, including students of the University of 17 August 1945 Jakarta. This study aimed to determine the compliance college students at the University of 17 August 1945 of wearing mask and hand sanitizer during the Covid-19 pandemic. The method was used descriptive quantitative with a cross-sectional study design. Data collection used an online questionnaire containing closed questions. A total of 309 people participated in this survey and answered the use of masks and hand sanitizers. College students used masks and hand sanitizers during the Covid-19 pandemic. The compliance rate for the use of masks was 68.6% and hand sanitizer 78.3% during the Covid-19 pandemic. Men werw more obedient to using mask 73.6% and hand sanitizer 84.3% compared to women using mask 64.5% and hand sanitizer 73.4%.

Antibacterial Potency from Ethanol Extract Leaves of Kluwih (Artocarpus camansi Blanco) against Shigella dysenteriae and Bacillus subtilis Sogandi, Sogandi; Amelia, Amelia
Jurnal ILMU DASAR Vol 21 No 2 (2020)
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jid.v21i2.11568

Gastrointestinal infection is a common infection in Indonesia. Many bacteria could cause gastrointestinal disorder, including Shigella dysenteriae and Bacillus subtilis. Currently, they are treated using chemical and traditional drugs. One of the common pants in Indonesia is Kluwih (Artocarpus camansi). The objective our study to determine antibacterial activity and inhibitory mechanism of Kluwih leaf extract against pathogenic bacteria which cause gastrointestinal infection, i.e. Shigella dysenteriae and Bacillus subtilis. The extraction process used maceration technique using 96% ethanol solvent and the antibacterial activity was studied using agar diffusion method. The research result showed that Kluwih leaf extract had inhibitory power with KHM (minimum inhibitory concentration) value of 25% against S. dysenteriae and 6.25% against B. subtilis. The present study also revealed that Kluwih leaf was suspected to have inhibitory activity against bacteria by making holes in the membrane of bacterial cell, leading to the release of nucleic acid and protein and cell death.Keywords: antibacterial, Artocarpus camansi, kluwih, Shigella dysenteriae, Bacillus subtilis.

Identifikasi Senyawa Aktif Ekstrak Buah Mengkudu (Morinda citrifolia L.) dan Potensinya sebagai Inhibitor Karies Gigi Sogandi, Sogandi; Nilasari, Putu
Jurnal Kefarmasian Indonesia VOLUME 9, NOMOR 2, AGUSTUS 2019
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v9i2.1289

Dental caries is a disease that many people experience, which is formed by the buildup of plaque on the teeth and the presence of bacteria. The bacteria known to be involved in the formation of dental caries is Streptococcus mutans. Dental caries used to be treated using antibiotics. However, it is known that many antibiotics are no longer effective against this bacteria hence it is necessary to look for another alternative. One alternative choice as an antibacterial is Noni fruit. This study aims to identify the bioactive compounds of noni fruit (Morinda citrifolia L) and to know the mechanism of action in inhibiting the growth of Streptococcus mutans. Noni fruit was macerated using 96% ethanol, then fractionated using n-hexane and ethyl acetate. Antibacterial activity test was done using agar difusion method, and identification of bioactive compounds was conducted using GCMS. The results showed that ethyl acetate fraction has the highest inhibitory activity on the growth of Streptococcus mutans with inhibition zone of ±17 mm and MIC (minimum inhibitor concentration) value of 10%. The inhibition mechanism is asumed to be done by making holes in cell membranes, which can be seen from the high concentration of proteins and nucleic acids coming out of cells after treatment that in turn means that cell leakage has occurred. The results of this study indicate that noni fruit (Morinda citrifolia L) contain bioactive quinolone compounds that can be a new source for treating dental caries

Filtrate Culture of Trichoderma, Gliocladium, Penicilium and Aspergillus flavus as Inhibitor on Downy Mildew on Maize Ilmi, Nur; Sogandi, Sogandi; Hikmahwati, Hikmahwati
CROPSAVER Vol 7, No 2 (2024)
Publisher : Departemen Hama dan Penyakit Tumbuhan Fakultas Pertanian Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cropsaver.v7i2.57771

Controlling downy mildew caused by Perenosclerospora philipinensis in maize plants is currently dependent on the use of synthetic pesticides; therefore, it is necessary to develop biocontrol agents as a sustainable alternative control. Filtrate cultures of biocontrol agent fungi consist of antibiotics, enzymes, and secondary metabolites that are antimicrobial in nature. We conducted the research from July to August 2024 at the Plant Disease Laboratory of the Department of Protection, Faculty of Agriculture, and the Biochemistry Laboratory of the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University. This study had four parts: (1) identifying the morphology of biocontrol agent isolates and pathogenic fungi; (2) measuring growth diameter of antagonist fungi;(3) testing filtrate cultures for their ability to inhibit pathogens; and (4) testing filtrate cultures for their ability in vigor of sprouting on corn seeds. Based on morphological identification, the four biocontrol agent isolates are Trichoderma, Gliocladium, Penicillium, and Aspergillus flavus, with the best growth diameter on the Trichoderma, which is 8.5 cm on seven days. The filtrate cultures performed the best in the inhibition test on P. philipinensis, exhibiting spore damage percentages of 70-74%. The vigor test performed best on Trichoderma and Aspergillus flavus, with growth potential (GP) of 100% and 63%, respectively. Filtrate culture with biological agents has good potential for P. philipinensis spore inhibition and corn seed germination.

Antioxidant Activity of Endophytic Bacterial Extract Isolated from Clove Leaf (Syzygium aromaticum L.) Sogandi, Sogandi; Triandriani, Widya; Saputri, Dina; Suhendar, Usep
Journal of Agriculture and Applied Biology Vol 1 No 1 (2020): Journal of Agriculture and Applied Biology
Publisher : Future Science

Clove (Syzygium aromaticum L.) is one type of spice plant that has high antioxidant content because of the high eugenol compounds. However, iso-lating these bioactive compounds require a significant amount of biomass. A known alternative solution to overcome the problems is through the utiliza-tion of endophytic bacteria in clove leaves. Endophytic cloves leaf bacteria can be a good antioxidant resource. Endophytic bacteria are bacteria that grow in plant tissues that is not pathogenic, which can replace these plants. The aim of this study is isolating endophytic bacterial from clove leaves, screening endophytic bacteria, determining potential endophytic bacteria as producer antioxidant compounds, and identifying potential isolate using 16S rRNA. This study used endophytic bacteria isolated from clove leaves (Syzygium aromaticum L.). Antioxidant activity determined using DPPH method. It was founded 7 isolates of endophytic bacteria namely WDY1, WDY2, WDY3, WDY4, WDY5, WDY6, and WDY7. The isolate WDY6 shows the highest antioxidant activity. WDY6 isolate is identical to Staphylococcus sp. with a 100% similarity. Staphylococcus sp. has the highest antioxidant activ-ity in the stationary phase. The content of chemical compounds from WDY6 isolates is pyrazine that belongs to alkaloids.

Investigating the anti-acne potential of endophytic bacterial extracts isolated from Mangifera casturi in indigenous South Borneo, Indonesia Sogandi, Sogandi; Riyanto, Julius
Journal of Agriculture and Applied Biology Vol 1 No 2 (2020): Journal of Agriculture and Applied Biology
Publisher : Future Science

Endophytic bacteria are beneficial microorganisms living in the tis-sues system of various parts of a plant, including fruits, leaves, twigs, and roots. The bacteria are stated as forming colonies without caus-ing any damage to the plant. Thus, this study aimed at isolating endo-phytic bacterial from the leaves, barks, and fruits of Kasturi plant (Mangifera casturi), screening its endophytic bacteria, determining the potential of those endophytic bacteria, identifying 16S rRNA and analyzing potential growth of the bacteria. The isolated endophytic bacteria appeared to show potential activity against pathogenic bac-teria Propionibacterium acnes with disc-diffusion methods. Besides, the observations on bacterial activities showed isolate L2, S2 and F4 isolated from leaves, bark and fruits, respectively, as the most potent producers of antibacterial compounds. Technically, those activities were indicated by the formation of clear zones. Molecular identifica-tion was investigated by applying PCR amplification on 16S rRNA gene. Furthermore, the isolate L2 was identified as Enterobacter clo-acae with 99% sequence similarities; however, isolates S2 and F4 were identified as Escherichia coli. Therefore, these findings sug-gested that the identified strains would contribute to any further searches for new sources of anti-acne substances.

Co-Authors Amelia Amelia Ekajayanti Kining Ginting, Dina Marsella Br. Nilasari, Putu Nur Ilmi Nurul Mukhlisah, Nurul Riyanto, Julius Saputri, Dina Triandriani, Widya usep suhendar

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