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All Journal Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal Folia Medica Indonesiana
Winarni, Dwi Retno Adi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Therapy selection for tinea corporis and cruris with commorbidity: 3 case series Yefta, Yefta; Winarni, Dwi Retno Adi; Siswati, Agnes Sri
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Dermatophytosis is a superficial (skin, hair and nails) fungal infection caused by dermatophyte group fungi (Trichophyton, Epidermophyton and Microsporum). Immunocompromised conditions cause fungal infections to become more widespread and require consideration of therapy. Case Illustration: This case series represented three cases of tinea corporis and tinea cruris in patients with comorbidities. The first case was tinea corporis and tinea cruris in a patient with congestive heart failure with oral terbinafine therapy. The second case was tinea corporis and tinea cruris in a patient with bilateral fourth degree hydronephrosis with oral griseofulvin therapy. The third case was tinea corporis in a patient with autoimmune hemolytic anemia with oral itraconazole therapy. A two-week post-systemic antifungal evaluation gave good results in all of the patients. Discussion: Selection of antifungals in dermatophytosis cases considering the patient's condition (contraindications and side effects that can be caused) provides a good outcome in patients with comorbidities. Conclusion: Dermatophytosis (tinea corporis and tinea cruris) is common in immunocompromised patients. This is due to decreased immunity causing dermatophytes to develop easily on the skin. Selection of the right therapy, considering comorbid conditions is important in order to get the best results for the patients.
The effectiveness of ceramide moisturizing cream in pruritic papular eruption treatment of HIV/AIDS patients Sayekti, Ayu Wikan; Putri, Ann Kautsarina; Pudjiati, Satiti Retno; Winarni, Dwi Retno Adi
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 7, Issue 1 (January 2024)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/balidervenaesthj.v7i1.96

Abstract

Background: Pruritic papular eruption (PPE) is one of the most common skin manifestations in HIV/AIDS patients. Pruritic papular eruptions are due to immune dysregulation, causing dominance of interleukin-4, which causes a decrease in ceramide synthesis (CER) and impaired skin barrier function. This study aimed to investigate the effectiveness of CER over non-CER moisturizing cream in HIV/AIDS patients with PPE. Methods: Double-blind experimental design. The research subjects are PPE patients at Dr. Sardjito General Hospital. CER and non-CER moisturizing cream are applied for three weeks, respectively. Analysis of the trans-epidermal water loss (TEWL), skin hydration, and itching were analyzed using an unpaired T-test or the Mann-Whitney test with a significance of p<0.05. Results: Ceramide synthesis moisturizing cream decreased the TEWL value by 3.56 ± 2.38 g/m2/hour; increased the value of skin hydration by 16.39±7.19 a.u.; decreased skin lesions by 0.79 ± 4.95; reduced itching by 1.54 ± 0.78 and without causing side effects. Non-CER moisturizing cream decreased the TEWL value by 1.57 ± 2.00 g/m2/hour; increased the value of skin hydration by 12.03 ± 6.88 a.u.; decreased skin lesions by 1.42 ± 3.00; reduced itching by 1.17 ± 0.70 and also without causing side effects. Conclusion: Ceramide cream is more effective than non-CER moisturizing cream in reducing TEWL and increasing skin hydration. Ceramide and non-CER moisturizing creams have the same effectiveness in reducing the number of lesions and reducing itching. Ceramide and non-CER moisturizing creams do not cause side effects.
KOMBINASI FRACTIONAL CO2 DAN PLATELET-RICH FIBRIN SEBAGAI TERAPI SKAR AKNE ATROFI: LAPORAN KASUS Diovani, Sonia; Winarni, Dwi Retno Adi; Febriana, Sri Awalia; Khalidah, Miya; Anggatama, Marcella
Media Dermato-Venereologica Indonesiana Vol 52 No 2 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i2.530

Abstract

   Pendahuluan: Skar akne adalah komplikasi kronis yang sering muncul setelah episode akne inflamasi, yang dapat memberikan dampak psikososial negatif dan sulit diobati. Skar terbentuk akibat kerusakan pada folikel pilosebasea yang disebabkan oleh inflamasi, diikuti dengan penyembuhan jaringan yang tidak sempurna. Oleh karena itu, penting untuk menentukan terapi yang efektif bagi skar akne atrofi. Tujuan laporan kasus ini adalah untuk memberikan gambaran modalitas terapi untuk skar akne atrofi. Kasus: Wanita berusia 32 tahun, mengalami bekas jerawat di wajah, yang mengganggu penampilannya. Pasien ini memiliki riwayat jerawat sejak usia 17 tahun, dengan pemeriksaan dermatologis yang menunjukkan pada wajah tampak skar atrofi tipe ice pick, rolling, dan boxcar, multipel, tanpa akne aktif. Pasien ini diterapi dengan laser fraksional CO2 sebanyak tiga kali dan penggunaan topikal platelet-rich fibrin (PRF) pada malam hari. Hasil terapi menunjukkan perbaikan skar dari derajat sedang menjadi ringan dengan grading Goodman and Baron. Diskusi: Skar atrofi adalah penipisan kulit akibat kurangnya kolagen dan elastin pasca penyembuhan luka, sering terlihat cekung dan umum terjadi setelah jerawat dengan tiga jenis utama: icepick, boxcar, dan rolling. Penanganannya harus disesuaikan dengan jenis skar, seperti penggunaan laser fraksional CO2 yang efektif untuk tipe boxcar dan rolling karena kemampuannya merangsang remodeling kolagen. Kombinasi dengan Platelet-Rich Fibrin (PRF), yang kaya faktor pertumbuhan, dapat mempercepat regenerasi jaringan dan meningkatkan produksi kolagen untuk hasil yang optimal. Kesimpulan: Penanganan skar akne perlu disesuaikan dengan jenis skar dan harapan pasien. Terapi kombinasi dengan laser fraksional CO2 dan PRF memberikan hasil yang memuaskan pada skar akne atrofi derajat sedang.
Expressions of Interleukin-4 and Interleukin-5 in Nodular Prurigo and Pruritic Papular Lesions Sayekti, Ayu Wikan; Putri, Ann Kautsaria; Winarni, Dwi Retno Adi; Pudjiati, Satiti Retno
Folia Medica Indonesiana Vol. 60, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. An examination of IL-4 and IL-5 expressions in nodular prurigo and pruritic papular eruption is crucial for enhancing the effectiveness of biological agent therapy, specifically for HIV/AIDS patients. 2. The findings offer evidence suggesting the possibility of IL-4 as a treatment target for individuals diagnosed with nodular prurigo, as well as IL-4 and IL-5 for those diagnosed with pruritic papular eruption. Abstract Pruritic papular eruption is a dermatosis characterized by pruritic symptoms in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Similarly, nodular prurigo is an itchy dermatosis with lesions and histopathological features that resemble those of pruritic papular eruption. Both conditions share a common etiopathogenesis, which involves the cytokines produced by T helper 2 (Th2) cells. Nodular prurigo and pruritic papular eruption are chronic and frequently recalcitrant, thus posing challenges in treatment. The use of biological agents represents a treatment development for chronic and recalcitrant dermatoses. This study aimed to determine the difference in the mean percentage of interleukin-4 (IL-4) and interleukin-5 (IL-5) expressions between nodular prurigo and pruritic papular eruption lesions, which may establish a basis for further biological agent therapy. A cross-sectional study was conducted using paraffin block preparations of the skin lesions of patients diagnosed with nodular prurigo (n=16) and pruritic papular eruption (n=16). Each paraffin block preparation involved immunohistochemical staining using IL-4 and IL-5 monoclonal antibodies. The expressions of IL-4 and IL-5 were assessed through ImageJ for Windows, version 1.53 (National Institutes of Health and the Laboratory for Optical and Computational Instrumentation, University of Wisconsin, USA) by pathologists. The data were analyzed using an unpaired t-test with a significance level of p<0.05. The analytical results indicated that data on the average age of the two groups, disease duration, and storage sample duration followed a normal distribution (p>0.05). The mean percentage of IL-4 expression was significantly different between the nodular prurigo and pruritic papular eruption groups (p=0.000). However, the mean percentage of IL-5 expression was not significantly different between the two groups (p=0.060). In conclusion, the expression of IL-4 was higher in the nodular prurigo group in comparison to the pruritic papular eruption group. Nonetheless, the expression of IL-5 was comparably high in both the nodular prurigo and pruritic papular eruption groups.
Co-Authors Agnes Sri Siswati Anggatama, Marcella Diovani, Sonia Febriana, Sri Awalia Khalidah, Miya Putri, Ann Kautsaria Putri, Ann Kautsarina Satiti Retno Pudjiati Satiti Retno Pudjiati Sayekti, Ayu Wikan Yefta, Yefta