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All Journal Indonesian Journal of Urology Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Buletin Farmatera JURNAL ILMIAH SIMANTEK Jurnal Pandu Husada Medicina Biomedica Journal
Rizaldi, Aril
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THE EFFECT OF CHRONIC EXPOSURE OF NICOTINE INHALATION TO THE COUNT OF SPERMATOGONIA, SERTOLI CELLS AND LEYDIG CELLS OF YOUNG WHITE RAT WISTAR STRAIN Rizaldi, Aril; Soebadi, Doddy M; Soetojo, Soetojo
Indonesian Journal of Urology Vol 26 No 2 (2019)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v26i2.512

Abstract

Objective: To analyze the difference in the number of spermatogonia, leydig cells and sertoli cells in young age of  white mice Wistar strain after inhalation of chronic nicotine exposure. Material & Method: Laboratory experimental study with post test only control group design, measurement of spermatogonium, leydig cell, sertoli cell in 5 groups of young male Wistar strain, negative control group and treatment group given nicotine exposure 0.5 mg, 1 mg, 2 mg, and 4 mg/kg body weight/day for 30 days. Results: A significant reduction in spermatogonium was found in the group given nicotine 0.5 mg/kgBW/day (p=0.048), 1 mg/kgBW/day (p=0.002), 2 mg/kgBW/day (p=0.002) and 4 mg/kgBW/day (p=0.000) when compared to the control group. Significant decreases were also seen in the group receiving 4 mg of nicotine exposure compared with 0.5 mg (p=0.018). Significant decrease in sertoli cell count was seen only in the nicotine group of 4 mg/kgBW/day compared with the control group (p=0.047). A significant decrease in leydig cell count was found in the nicotine 2 mg/kgBW/day (p=0.037) and nicotine group 4 mg/kgBW/day (p=0.023) when compared with the control group. Significant decreases were also found in the 4 mg/kgBW/day group compared to the 0.5 mg/kgBW/day group (p=0.004). In this study there were also a decrease in the number of spermatogonia, sertoli cells, and leydig cells in the increased dose of nicotine given although not statistically significant. Conclusion: Chronic exposure of nicotine per inhalation may decrease the number of spermatogonia, sertoli cells, and leydig cells. The higher the dose of nicotine given the greater the decrease in the number of spermatogonium cells, sertoli cells, and leydig cells that occur. This proves that nicotine is one of the causes of infertility in men.
HUBUNGAN VOLUME PROSTAT DENGAN SKOR IPSS PADA PENDERITA BENIGN PROSTATIC HYPERPLASIA (BPH) DI RSU HAJI MEDAN MAGHFIRA, JIHAN; FATHURRAHMAN, HASRONI; RIZALDI, ARIL
JURNAL ILMIAH SIMANTEK Vol 7 No 4 (2023): JURNAL ILMIAH SIMANTEK
Publisher : LP2MTBM MAKARIOZ

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Benign prostatic hyperplasia (BPH) is a benign neoplasm in which the periurethral state of the prostate experiences hyperplasia. Benign prostatic hyperplasia (BPH) can cause complaints that interfere with daily activities, although it is rarely life-threatening. These complaints can be in the form of lower urinary tract symptoms (LUTS). The IPSS questionnaire is used as a measure of the severity of lower urinary tract symptoms (LUTS). Prostate volume is important as a reference for the severity of the progression of benign prostatic hyperplasia (BPH) or the outcome of this disease in the form of acute urinary retention (AUR), as well as the response to treatment. This study aims to determine the relationship between prostate volume and IPSS score in patients with Benign prostatic hyperplasia (BPH) at RSU Haji Medan. This study used a retrospective analytic observational study design with a cross-sectional design approach that met the inclusion and exclusion criteria and was carried out in the urology department of RSU Haji Medan. Based on the results of a study conducted from September to December at the Haji Medan General Hospital, 93 samples were obtained. The highest incidence of BPH was in the age range of 61–70 years, with 40 people (43.0%). The highest volume was in classification 1 (20-39cc), with as many as 53 people (57.0%), and the most frequent degree was the degree of severity, with as many as 39 people (41.9%). The results of the Spearman correlation test showed that there was a significant relationship between volume and the IPSS score in patients with benign prostatic hyperplasia (BPH), p<0,001 with a correlation coefficient (r = 0.853), indicating a very strong correlation, where the value of the correlation coefficient is positive, which means that the relationship between the two variables is unidirectional. Prostate volume and IPSS score have a significant relationship in patients with benign prostatic hyperplasia (BPH).
Retensi Urine Akut Pada Pasien Benign Prostatic Hyperplasia (BPH) Tidak Berhubungan Dengan Usia dan Volume Prostat Rizki, Muhammad Devin Fauzan; Rizaldi, Aril
JURNAL PANDU HUSADA Vol 5, No 2 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jph.v5i2.19854

Abstract

Abstrak: (BPH) Benign Prostatic Hyperplasia dapat  menyebabkan retensi urine dan kondisi ini juga menyebabkan penyempitan lumen uretra prostatika dan dapat menyebabkan terjadinya hambatnya aliran urine yang mana  kondisi ini sering dikaitkan dengan usia dan volume prostat pasien. Penelitian ini bertujuan untuk mengetahui adanya hubungan retensi urine akut pada pasien BPH dengan usia dan volume prostat. Penelitian ini menggunakan desain penelitian studi observasional analitik secara retrospektif dengan pendekatan rancangan cross-sectional. Hasil uji Chi Square, didapatkan nilai. asymp sig (2-sided) yaitu 0,962 (P0.05) yang bermakna bahwa tidak terdapat hubungan yang signifikan antara usia dengan kejadian retensi urine akut pada pasien BPH. Didapatkan nilai asymp sig (2-sided) yaitu 0,72 (P0.05) yang bermakna bahwa tidak terdapat hubungan yang signifikan antara volume prostat dengan kejadian retensi urine akut pada pasien BPH. Usia dan volume prostat tidak memiliki hubungan yang signifikan antara kejadian retensi urine akut pada pasien BPH.
Differences in Sleep Quality of Schizophrenia Patients Based on Gender at Madani Hospital Medan, North Sumatra Zulhilmi, Zulhilmi; Nuralita, Nanda Sari; Rizaldi, Aril; Asfur, Robitah
Buletin Farmatera Vol 9, No 2 (2024)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v9i2.16340

Abstract

Abstract: Schizophrenia is a severe mental disorder, this disorder is characterized by delusions, hallucinations, thought disorder, restlessness, strange or hostile behaviour, feeling (affect) dull or flat, interest away from social interactions, little emotional contact (quiet, difficult to talk to), passive, apathetic or indifferent, difficult to think abstractly and lose of motivation. Sleep disturbances have been assessed in various studies in patients with schizophrenia, using subjective (ie daily interviews, sleep diaries) and objective (ie, polysomnography and actigraphy) parameters. Compared with healthy controls, patients with schizophrenia exhibit longer sleep onset latency, decreased sleep efficiency, more nighttime awakenings, increased daytime dysfunction due to sleep deprivation, poorer overall sleep quality, and a higher proportion of sleep disturbances. Previous studies have suggested that poor sleep quality is associated with female gender in schizophrenic patients. This study aims to determine the difference in sleep quality of schizophrenia patients based on gender at Madani Hospital Medan, North Sumatra. This study is an analytical descriptive with a cross-sectional study approach, sampling method using a purposive sampling technique. The data of this study were obtained from primary data using questionnaire instruments and patient medical records. Data analysis using Chi-Square test. The results showed that the sleep quality of male research respondents with disturbed sleep quality was found in 18 people (51.4%), and undisturbed sleep quality was found in 17 people (48.6%). Of female research respondents, 22 people (62.9%) had disturbed sleep quality and 13 people (37.1%). The p-value was found to be 0.334 (p0.05), which means that there was no significant difference in the sleep quality of schizophrenic patients based on gender at Madani Hospital Medan, North Sumatra. There was no significant difference in the sleep quality of schizophrenic patients based on gender at Madani Hospital Medan, North Sumatra.
Usia Dan Lama Menderita Diabetes Melitus Tipe 2 Berhubungan Dengan Kejadian Disfungsi Ereksi Berdasarkan Skor Iief-5 Di Poliklinik Endokrin RSU Haji Medan Joelya, Miracle Suci; Rizaldi, Aril; Andila, Yossi
JURNAL PANDU HUSADA Vol 6, No 1 (2025)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jph.v6i1.21581

Abstract

Abstrak: Diabetes melitus merupakan gangguan metabolik yang meningkat setiap tahun nya disertai dengan komplikasi. Disfungsi ereksi merupakan ketidakmampuan dalam mempertahankan atau mencapai ereksi penis yang cukup memuaskan ketika berhubungan seksual. Pada pria dengan diabetes, disfungsi ereksi disebabkan oleh kegagalan nitric oxide (NO) yang menyebabkan relaksasi otot polos karena keduanya disfungsi endotel. Penelitian ini bertujuan untuk mengetahui hubungan antara lama menderita diabetes melitus tipe 2 dengan terjadinya disfungsi ereksi berdasarkan skor Iief-5 di Poliklinik Endokrin RSU Haji Medan. Penelitian ini merupakan penelitian observasional analitik, dengan menggunakan metode korelasional dengan desain cross-sectional. Pengambilan sampel menggunakan accidental sampling. Hasil dianalisis menggunakan uji Spearman. Hasil penelitian didapatkan yaitu 0,001 (P-value 0,05) yang bermakna terdapat hubungan yang signifikan antara usia pasien diabetes melitus, dan hasil 0,001 (P-value 0,05) yang bermakna terdapat hubungan yang signifikan antara lama menderita diabetes melitus dengan kejadian disfungsi ereksi. Terdapat hubungan antara usia dan lama menderita diabetes melitus tipe 2 dengan kejadian disfungsi ereksi.
A Giant Urethral Stone With Urethrocutaneous Fistula: A Case Report Ikhwan, Haznur; Rizaldi, Aril
ANATOMICA MEDICAL JOURNAL | AMJ Vol 6, No 2 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/amj.v6i2.14663

Abstract

Urethral stones are commonly associated with urinary tract calculi and underlying   diverticulum   or   stricture urethra. Urethral calculus represent less then 1%  of all urinary stones diseases. Giant urethral calculi frequently may occur in male and rarely in female. This purpose of reporting this case is to describe a way to diagnose urethral stone cases and so that patients can be treated by urologists. CASE PRESENTATION: A 48-year-old man patient with a giant urethral stone with urethrocutaneous fistula for the past 1 year and a diventral penile meatotomy was performed. With physical examination found on the penis palpable stone +/- 4cm anterior to the penis, the tip of the stone can be seen from Eksternum Urethra Orifice. There was also a urethrocutaneous fistula on the ventral penis, about a stone, measuring +/- 0.1 cm so a diventral penis meatotomy was performed, a stone measuring 4x1 cm was found, with unhealthy tissue in the urethra along the stone. DISCUSSION: The incidence of penile urethral stones is increasing which may due to various factors especially climate change and genetic factors. The gradual formation of this long penile urethral stone could take approximately around 5-10 years which indicates the patient’s persistent ignorance of pain and discomfort in the urinary tract. In our case, 3 months after the first operation, urethrocutaneous fistula repair was performed. Evaluation after 2 months after fistula repair, Urination is smooth, no pain, good wound, no fistula, was performed in our report. CONCLUSION: From our experience some predisposing factors of urethral stone with a Urethrocutaneous fistula. The complications seriously affect the quality of life and even cause more serious consequences, so physicians and patients should be aware.Keywords: giant urethral stone, urethrocutaneous fistula, meatotomi ventral penis
CLINICAL AND LABORATORY CHARACTERISTICS OF PERIRENAL ABSCESS CASES AND THEIR MANAGEMENT Rizaldi, Aril; Soetojo, Soetojo
Medicina Biomedica Journal Vol 2, No 1 (2023)
Publisher : Medicina Biomedica Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/mbj.v1i1.9158

Abstract

BACKGROUND: Perirenal abscess is a rare disease, often leading to morbidity and mortality due to delay in diagnosis and inadequate treatment. Cases of perirenal abscess in RSUD Soetomo often have been going on for a long time and are severe.AIM: The purpose of this study was to determine the characteristics of patients with perirenal abscess and their management.MATERIAL AND METHODS: This research is a descriptive retrospective study. Characteristics of patients with perirenal abscess both clinical, laboratory, and management obtained from medical records at RSUD dr. Soetomo Surabaya during the period 2011-2016 and analyzed using SPSS 20.0.RESULTS: There were 38 patients with perirenal abscess with the mean age was 46.21 11.74 years. Most of the abscesses were mixed (peri-pararenal) namely 21 patients (55.2%), 15 patients (39.5%) perirenal abscess and 2 patients (5.3%) pararenal abscess. The most risk factors for perirenal abscess were 17 patients (44.7%) with kidney/ureter stones and 15 patients (39.5%) with diabetes. The most frequent clinical symptoms were low back/abdominal pain in 38 patients (100%), mass in the waist/lower abdomen in 36 patients (94.7%) and fever in 28 patients (73.7%), CVA tenderness in 28 patients (73, 7%), and nausea/vomiting in 12 patients (31.6%). From the laboratory, 29 patients (76.3%) were anemic, 28 patients (73.7%) had hypoalbuminemia, and 32 patients (84.2%) had leukocytosis. Management in the form of abscess drainage, namely 35 patients (92.1%) underwent open drainage surgery, 3 patients (7.9%) underwent open drainage surgery and nephrectomy.CONCLUSION: Perirenal abscess has non-specific clinical signs and symptoms is sometimes difficult to make a diagnosis. Patients with low back/abdominal pain with a lump in the waist and fever lasting more than 5 days may suggest a perirenal abscess and need further diagnostics. Abscess drainage is the best option for the treatment of perirenal abscesses.
Co-Authors Andila, Yossi Doddy M Soebadi Fathurrahman, Hasroni Ikhwan, Haznur Joelya, Miracle Suci MAGHFIRA, JIHAN Nuralita, Nanda Sari Rizki, Muhammad Devin Fauzan Robitah Asfur Soetojo Soetojo Zulhilmi, Zulhilmi