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One pot two-step borylation/fluorination reaction of dysobinin from Chisocheton macrophyllus and its cytotoxicity against cancer cell Huda, Muhammad Badrul; Nurlelasari; Safriansyah, Wahyu; Fajar, Mohamad; Widiyowati, Iis Intan; Supratman, Unang; Permana, Yessi; Budiman, Yudha P.
Communications in Science and Technology Vol 9 No 2 (2024)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.9.2.2024.1514

Abstract

Dysobinin is a naturally occurred limonoid, which is a specific form of triterpenoid, mostly found in certain plants, particularly the Meliaceae family. Overall, it has been found that limonoids have a wide range of biological functions. Typically, the compound comprises anticancer, antimicrobial, and anti-inflammatory properties. Even though dysobinin has shown some effectiveness, its potential in pharmacology, so far, is found limited. This study, therefore, aims to enhance the pharmacological properties of dysobinin through the addition of fluorine. To do this, a one-pot, two-step reaction comprising C-H borylation and selectfluor was used to turn dysobinin into two new compounds: 1,2-dihydro-6?-acetoxyazadirone (5) and 1?-fluorodysobinin (6). After the transformation, various spectroscopic methods, including UV (Ultraviolet), IR (infrared), MS (mass spectra), as well as NMR (1D and 2D) were applied to figure out the structures of the new compounds. Accordingly, of the derived compounds, 1?-fluorodysobinin showed significantly higher cytotoxicity against A549 lung cancer cells when compared to dysobinin.
Prevention of disaster triggered by crowd surge: comparative insights in selected countries and Indonesia Fajar, Mohamad
Sustainable Urban Development and Environmental Impact Journal Vol. 1 No. 1: (Februari) 2024
Publisher : Institute for Advanced Science, Social, and Sustainable Future

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61511/sudeij.v1i1.2024.633

Abstract

Introduction: Hazards, whether caused by natural or human activities, can potentially lead to disaster. In 2015, the United Nations (UN) at its conference in Sendai, Japan established a framework related to disaster risk reduction to be guided until 2030. However, disaster management related to human-induced hazards has received less attention. The Covid-19 pandemic that has been overcome has made restrictions on human movement begin to loosen. With the increase in travel between regions, countries, and continents, people began to form crowds at events related to religion, entertainment, sports, and other activities. A poorly managed crowd develops into an uncontrolled crowd or riot, and disaster ensues. This paper aims to develop alternative prevention efforts so that similar disasters do not occur in the future. Methods: The method of this paper is a literature review and systematic content analysis of previous scientific articles and research. First, the paper describes disasters at planned events such as music concerts in Texas, United States, and less planned ones such as the Halloween festival in Seoul, South Korea. Then the countermeasures of the two events were compared with the incident in Malang, Indonesia. Finding: The result is that strong cooperation between related parties is needed in organizing events to maintain community safety. The use of technology and tightening regulations can be factors supporting the prevention of this disaster. Increasing the capacity of communities to deal with similar disaster risks is still not widely discussed, so further research is needed. Conclusion: Islamic science is a comprehensive paradigm, similar to Western science, that can serve as a framework for scientists from various fields of knowledge. The Islamic paradigm attempts to critique the concept of universality, which has been one of the values embraced by the Western scientific paradigm. This concept has been one of the reasons why scientific revolutions have occurred slowly.
Disaster Prevention Strategy at Gelora Bung Karno Main Stadium from the Perspective of the Police Role Fajar, Mohamad; Warno Utomo, Suyud; Achjani Zulfa, Eva
Jurnal Ilmu Kepolisian Vol 19 No 3 (2025): Jurnal Ilmu Kepolisian Volume 19 Nomor 3 Tahun 2025
Publisher : Sekolah Tinggi Ilmu Kepolisian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35879/jik.v19i3.698

Abstract

Disaster risk is formed by the interaction of hazards with a vulnerable community. Risks arising from intentional hazards are generally more predictable than those from natural and technological causes. Therefore, when a hazard is predictable, a disaster can be prevented. On October 1, 2022, a major disaster occurred at Kanjuruhan Stadium, Malang Regency, East Java, Indonesia, following a Liga 1 Indonesia professional football match between Arema FC and Persebaya, resulting in 712 casualties, including 132 fatalities, 96 serious injuries, and 484 minor injuries. Strengthening the police’s role in disaster prevention at stadiums is essential to minimize the likelihood of similar incidents in the future. This study aims to formulate a disaster prevention strategy from the police role perspective from the case study of the 2024-2025 Liga 1 football match between Persija Jakarta and Dewa United at the Gelora Bung Karno Main Stadium (SUGBK) on September 16, 2024. A qualitative approach was applied through interviews and literature review, analyzed using qualitative SWOT analysis and descriptive analysis. The findings show that Polda Metro Jaya conducted a risk assessment in accordance with existing regulations. The study concludes that the risk assessment performed by the Directorate of Vital Object Protection of Polda Metro Jaya for SUGBK was rated good, ensuring the match could proceed safely. Furthermore, the police play an important role in the disaster prevention strategy at SUGBK. However, current regulation only provides guidelines for risk assessment in sports competitions, and do not yet comprehensively address other mass gatherings such as entertainment or religious events.