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All Journal Communications in Science and Technology Jurnal Penelitian Hasil Hutan
Nurlelasari
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Agriculture, Biological Sciences & Forestry Decision Sciences, Operations Research & Management Engineering Materials Science & Nanotechnology

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One pot two-step borylation/fluorination reaction of dysobinin from Chisocheton macrophyllus and its cytotoxicity against cancer cell Huda, Muhammad Badrul; Nurlelasari; Safriansyah, Wahyu; Fajar, Mohamad; Widiyowati, Iis Intan; Supratman, Unang; Permana, Yessi; Budiman, Yudha P.
Communications in Science and Technology Vol 9 No 2 (2024)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.9.2.2024.1514

Abstract

Dysobinin is a naturally occurred limonoid, which is a specific form of triterpenoid, mostly found in certain plants, particularly the Meliaceae family. Overall, it has been found that limonoids have a wide range of biological functions. Typically, the compound comprises anticancer, antimicrobial, and anti-inflammatory properties. Even though dysobinin has shown some effectiveness, its potential in pharmacology, so far, is found limited. This study, therefore, aims to enhance the pharmacological properties of dysobinin through the addition of fluorine. To do this, a one-pot, two-step reaction comprising C-H borylation and selectfluor was used to turn dysobinin into two new compounds: 1,2-dihydro-6?-acetoxyazadirone (5) and 1?-fluorodysobinin (6). After the transformation, various spectroscopic methods, including UV (Ultraviolet), IR (infrared), MS (mass spectra), as well as NMR (1D and 2D) were applied to figure out the structures of the new compounds. Accordingly, of the derived compounds, 1?-fluorodysobinin showed significantly higher cytotoxicity against A549 lung cancer cells when compared to dysobinin.
ISOLASI SENYAWA STEROID DARI AKAR TUMBUHAN ASAM KANDIS (Garcinia cowa Roxb. ex DC) SEBAGAI OBAT PENURUN DEMAM Darwati; Nurlelasari; Tri Mayanti
Jurnal Penelitian Hasil Hutan Vol. 37 No. 1 (2019): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2019.37.1.51-57

Abstract

Garcinia cowa is belong to the Guttiferae family. In Indonesia this plant is locally named asam kandis. Traditionally, the stem bark of Garcinia cowa are used as antipyretic dan antimicroba, the fruits and leaves used as expectorat, and laxative, and the roots is used for fever medicine. The variaty use are Garcinia cowa as traditional medicine is based it chemical compounds. In our continuing phytochemical investigation to found the secondary metabolite compounds of Garcinia plants found in Indonesia, The objective of this research was to find the steroid compound from the roots of Garcinia cowa. Isolation was conducted by extraction and chromatography methods. The structure of this compound was determined based on spectroscopic data from NMR and comparison with the reported data.
STUDI EKSTRAK n-HEKSANA DARI KULIT BATANG KANDIS HUTAN (Garcinia cymosa) Darwati; Nurlelasari; Tri Mayanti; Unang Supratman
Jurnal Penelitian Hasil Hutan Vol. 39 No. 3 (2021): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2021.39.3.148-154

Abstract

Plants of Garcinia genera (Fam: Guttiferae) that grows in Indonesia's tropical forests are potential of triterpenoidcompounds contents. Garcinia cymosa has been reported as the main source of triterpenoid compounds whichprovided useful biological activity such as anti-inflammatory, antibacterial, antifungal, antioxidant, cytotoxic, andanti-HIV. Currently, data and information of triterpenoid compounds in the G. cymosa is relatively low. Thispaper studies triterpenoid compound of G. cymosa. This compound was obtained from macerated G. cymosa stembark using n-hexane solvent. G. cymosa bark was macerated using n-hexsana solution, which was them separatedand purified by chromatography method, to produce pure isolate in the form of white needle crystals (10.8 mg). Thechemical structure was then determmined by using spectroscopy methods of IR, 1D-NMR, 2D-NMR, and massspectroscopy compared with published structure. Result show friedelin compound was succesfully isolated from extractedn-heksana of G. cymosa bark.
Co-Authors Budiman, Yudha P. Darwati Fajar, Mohamad Huda, Muhammad Badrul Iis Intan Widiyowati Safriansyah, Wahyu Tri Mayanti Unang Supratman Yessi Permana