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All Journal CRJIM (Clinical and Research Journal in Internal Medicine) Caring : Jurnal Pengabdian Masyarakat Jurnal Penyakit Dalam Indonesia Indonesian Journal of Biomedicine and Clinical Sciences
Fachrureza, Mochamad
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Lean Non-Alcoholic Fatty Liver Disease (NAFLD) Fachrureza, Mochamad; Pratomo, Bogi
Clinical and Research Journal in Internal Medicine Vol 1, No 1 (2020): New: The First Volume of Clinical and Research Journal in Internal Medicine
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2020.001.01.6

Abstract

Non-Alcoholic Fatty Liver Disease (NAFLD) is a condition that can develop into advanced liver disease. The NAFLD spectrum includes simple steatosis, non-alcoholic steatohepatitis (NASH), liver fibrosis, and liver cirrhosis to hepatocellular carcinoma. One of the underlying pathophysiologies is insulin resistance found in metabolic syndrome. People with metabolic syndrome are not always obese, and NAFLD can also be found in this group, known as lean NAFLD, which has different metabolic characteristics. Metabolic characteristics of lean NAFLD include high levels of transaminases and insulin, low insulin sensitivity, low fasting glucose, low necroinflammatory activity, and liver fibrosis. Some related factors are methionine and choline deficiency, excessive acyl-coA expression, and PNPLA3 gene polymorphism. Lean NAFLD is an interesting topic to discuss because practitioners' awareness of lean NAFLD is lower compared to obese patients. NAFLD is a risk factor for chronic diseases such as cardiovascular disease, kidney disease, colorectal, atrial fibrillation, and hypothyroidism, so it is essential to be recognized by clinicians. To date, there are no guidelines or recommendations that discuss specific treatments in this lean NAFLD population.  
The Additive Effect of Rosmarinic Acid for The Reduction of Glomerular NF-kB Expression in Diabetes Rat that was given Telmisartan Fachrureza, Mochamad; Samsu, Nur; Rudijanto, Achmad
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 3
Publisher : UI Scholars Hub

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Abstract

Introduction. Diabetic nephropathy is one of the common complications of diabetes, which one of its causes is the increase of free radicals through the activation of NF-kβ and Angiotensin II. Rosmarinic acid has the activity as the anti-oxidant and anti-inflammatory, and the telmisartan is the partial PPAR-γ agonist that has the anti-fibrotic effect. This study aimed to identify the effect of rosmarinic acid and telmisartan in the reduction of subunit p65 NF-kB expression on the glomerular diabetes rat. Methods. An experimental study with a post-test only controlled group was conducted in a group of rats (Rattus norvegicus). Rats were randomly divided into five groups (n=3-4 per group): three treatment groups (group 1: rosmarinic acid 75 mg/kg/ day; group 2: telmisartan 1 mg/kg/day, group 3: combination of rosmarinic acid 75 mg/kg/day and telmisartan 1mg/kg/ day per day), and two control groups (negative and positive control group). After eight weeks, rats were dissected. Blood sugar more than 270 mg/dl confirmed that the rats in diabetes state. The measurement of albuminuria was done using ELISA and the expression of subunit p65 NF-kβ using the immunofluorescence method. Results. The expression of subunit p65 NF-kβ in negative control group was 519.70 (SD 158.12), 702.19 (SD 189.69) in positive control group, 631.19 (SD 119.21) in the rosmarinic acid group, 355.68 (SD 44.71) in the telmisartan group, and 572.37 (SD 98.09) in the combination group (p<0.001). The post hoc test showed that the mean value of subunit p65 NF-kβ expression was significantly different between the positive control group and the telmisartan group (p<0.001). But, there was no significant mean difference of subunit p65 NF-kβ expression between the positive control group and the rosmarinic acid group (p=1.000), as well as between the combination rosmarinic acid and telmisartan group. Conclusion. The addition of telmisartan can reduce expression of the subunit p65 NF-kB. However, adding the rosmarinic acid in diabetes rats given telmisartan did not reduce the expression of subunit p65 NF-kB in the same level with the negative control group.
INCREASING PUBLIC AWARENESS OF HEPATITIS B DISEASE IN GONDANGLEGI, MALANG REGENCY Supriono, Supriono; Wibowo, Bogi Pratomo; Mustika, Syifa; Fachrureza, Mochamad
Caring: Jurnal Pengabdian Masyarakat Vol 3, No 3 (2023): CARING Jurnal Pengabdian Masyarakat (Desember 2023)
Publisher : Caring: Jurnal Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.caringjpm.2023.003.03.2

Abstract

AbstractHepatitis B is an illness resulting from the hepatitis B virus, which can spread through both horizontal and vertical transmission. According to the World Health Organization (WHO) in 2019, approximately 296 million individuals across the globe were afflicted with hepatitis B, with an anticipated annual increase of 1.5 million cases. Various approaches and solutions have been implemented to prevent and address the impact of this disease, including hepatitis B immunization policies from birth. According to the Regulation of the Minister of Health No. 25 of 2015, other approaches are also being pursued through health promotion using various media. This study aims to determine the effectiveness and factors related to public knowledge about hepatitis B through interactive educational media for the community in Gondanglegi Village, Malang Regency. A total of 176 respondents completed the questionnaire, with 75% being female and 24% male. The majority of respondents fell within the age range of 51-60 years (34.7%). The Wilcoxon test results show a significant difference between pre-test and post-test scores (p=0.000). The Spearman test, which relates age and the last level of education to pre-test and post-test scores, reveals a significant relationship between pre-test scores and age (p=0.000, r=-0.458) as well as the last level of education (p=0.000, r=0.472). The correlation analysis results indicate that older age is associated with lower pre-test scores, while higher levels of education are associated with higher pre-test scores. A similar pattern is observed in the correlation test between post-test scores and age (p=0.082, r=-0.204) and the last level of education (p=0.013, r=0.013). These results indicate that the community engagement program to increase awareness of hepatitis B has successfully improved participants' knowledge, as reflected in the difference between pre-test and post-test scores." 
The curative effect of ethanolic extract of Moringa oleifera leaf in an animal model of liver fibrosis Supriono; Putri, Dinda Amalia Eka; Priyanto, Tia Rahmi; Sholihah, Al Imroatus; Larasati, Putu Anissa; Nabila, Salsala Sifa; Hartaya, Arsy Hanandya; Budiarto, Andika Agus; Fachrureza, Mochamad; Wibowo, Bogi Pratomo; Mustika, Syifa
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 2 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i2.13416

Abstract

Studies about the prevention effect of Moringa oleifera on liver fibrosis has been reported. However, its curative effect has not been reported, yet. This study was conducted to evaluate the curative effect of M. oleifera leaf extract on liver fibrosis. It was a laboratory experimental study with a post-test-only control group design. Rats were divided into 5 groups i.e. normal control which received intraperitoneally injections of 1 mL/kg BW of 0.9% NaCl solution twice a wk for 11 wk. Liver fibrosis control which received intraperitoneally injections of 1 mL/kg BW of 10% CCl4 solution twice a wk for 11 wk. Three M. oleifera treatment group which received intraperitoneally injections of 1 mL/kg BW of 10% CCl4 solution twice a wk for 11 wk continued by M. oleifera leaf ethanolic extract at dose of 600 mg/kg BW daily for 3 (MO3), 6 (MO6), and 10 (MO10) wk, respectively. The liver fibrosis level was assessed based on the METAVIR score. Histopathological analysis of liver tissues demonstrated that the 11-week CCl4 induction successfully resulted in liver fibrosis in rats (F3 and F4). The administration of M. oleifera leaf ethanolic extract decreased METAVIR scores ranged from F3 to F1. The optimal reduction of the METAVIR scores (F1) was observed in MO3 group after 6 wk administration (p<0.05). It was indicated that M. oleifera leaf ethanolic extract ameliorated liver fibrosis. In conclusion, M. oleifera leaf ethanolic extract has a curative effect against liver fibrosis.
COMPARING LECTURE AND INTERACTIVE DISCUSSION METHODS TO ENHANCE HEPATITIS B KNOWLEDGE IN PREGNANT WOMEN AND COUPLES IN GONDANGLEGI Supriono, Supriono; Wibowo, Bogi Pratomo; Mustika, Syifa; Fachrureza, Mochamad; Imroatussholihah, Al; Prayitno, Tia Rahmi; Amalia, Dinda; Nugroho, Rama Tiar
Caring: Jurnal Pengabdian Masyarakat Vol 5, No 2 (2025): CARING Jurnal Pengabdian Masyarakat (Agustus 2025)
Publisher : Caring: Jurnal Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.caringjpm.2025.005.02.1

Abstract

Hepatitis B is a global health issue that has a significant impact on society, especially in terms of the risk of transmission from mother to child during childbirth. Health education is an important effort to prevent the spread of infection, particularly among pregnant women. This community service activity aims to increase knowledge about hepatitis B among pregnant women and reproductive-age couples in Gondanglegi, Malang, through two educational methods: lectures and interactive discussions. The lecture was conducted using a conventional approach, where information about hepatitis B was delivered directly to participants with the aid of visual PowerPoint materials to clarify the content. Meanwhile, the interactive discussion involved several speakers discussing the topic of hepatitis B, allowing participants to engage in discussions, share experiences, and ask questions to the speakers. Both methods were effective in increasing participants' knowledge, with the lecture method providing a more significant improvement. This activity is expected to strengthen public understanding of hepatitis B, while also supporting efforts to prevent the transmission from pregnant women to their babies.
Co-Authors Achmad Rudijanto Amalia, Dinda Bogi Pratomo Budiarto, Andika Agus Hartaya, Arsy Hanandya Imroatussholihah, Al Larasati, Putu Anissa Nabila, Salsala Sifa Nugroho, Rama Tiar Nur Samsu Prayitno, Tia Rahmi Priyanto, Tia Rahmi Putri, Dinda Amalia Eka Sholihah, Al Imroatus Supriono Supriono Supriono Syifa Mustika Wibowo, Bogi Pratomo