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All Journal Majalah Kesehatan FKUB Caring : Jurnal Pengabdian Masyarakat The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Indonesian Journal of Biomedicine and Clinical Sciences
Wibowo, Bogi Pratomo
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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PERBANDINGAN POTENSI TELBIVUDIN DAN TENOFOVIR DALAM MENURUNKAN SKOR ASPARTATE TRANSAMINASE TO PLATELET RATIO INDEX (APRI) PADA PASIEN HEPATITIS B Wibowo, Bogi Pratomo; Susanto, Edy; Supriono, Supriono; Mustika, Syifa
Majalah Kesehatan FKUB Vol 7, No 1 (2020): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (571.155 KB) | DOI: 10.21776/ub.majalahkesehatan.2020.007.01.5

Abstract

Telbivudin dan tenofovir merupakan analog nukleosida untuk terapi hepatitis B dengan efektivitas tinggi meskipun telbivudin memiliki resistensi yang lebih tinggi daripada tenofovir. Telbivudin memiliki resistensi 2,3-5% pasien pada terapi tahun pertama dan 21,6% pasien pada terapi tahun kedua, sedangkan tenofovir dapat digunakan selama 3 tahun tanpa memunculkan resistensi. Hal ini menyebabkan tenofovir direkomendasikan sebagai terapi lini pertama oleh beberapa panduan. Namun demikian, bila terjadi resistensi tenofovir, sampai saat ini belum ada obat pengganti yang bisa digunakan. Tujuan pengobatan hepatitis B disamping menekan HBV DNA juga memperbaiki histologi jaringan hati. Oleh karena itu, perlu dilakukan penelitian untuk membandingkan potensi telbivudin dan tenofovir sebagai pilihan terapi hepatitis B kronis dengan melihat penurunan HBV DNA dan skor Aspartate Transaminasi to Platelet ratio Index (APRI). Penelitian analitik ini menggunakan pendekatan cross sectional. Data rekam medik dari pasien dengan terapi telbivudin dan tenofovir meliputi parameter skor APRI, yaitu kadar AST dan jumlah platelet, serta HBV DNA bulan 0 dan bulan 12. Data skor APRI dibandingkan menggunakan uji t independen dan dependen dengan nilai P < 0,05.Dari 145 pasien, 103 pasien mendapat terapi telbivudin, dan 42 pasien diterapi dengan tenofovir. Rerata penurunan skor APRI pada kelompok telbivudin adalah 1,17±0,17, sedangkan pada kelompok tenofovir 0,75±0,42. Pada kedua kelompok terjadi penurunan skor APRI sebelum dan sesudah terapi yang signifikan (p=0,00). Namun tidak didapatkan perbedaan yang bermakna antara kedua kelompok (p=0,28).Tidak terdapat perbedaan yang signifikan dalam potensi terapi antivirus antara telbivudin dan tenofovir dalam menurunkan skor APRI pasien hepatitis B kronis
INCREASING PUBLIC AWARENESS OF HEPATITIS B DISEASE IN GONDANGLEGI, MALANG REGENCY Supriono, Supriono; Wibowo, Bogi Pratomo; Mustika, Syifa; Fachrureza, Mochamad
Caring: Jurnal Pengabdian Masyarakat Vol 3, No 3 (2023): CARING Jurnal Pengabdian Masyarakat (Desember 2023)
Publisher : Caring: Jurnal Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.caringjpm.2023.003.03.2

Abstract

AbstractHepatitis B is an illness resulting from the hepatitis B virus, which can spread through both horizontal and vertical transmission. According to the World Health Organization (WHO) in 2019, approximately 296 million individuals across the globe were afflicted with hepatitis B, with an anticipated annual increase of 1.5 million cases. Various approaches and solutions have been implemented to prevent and address the impact of this disease, including hepatitis B immunization policies from birth. According to the Regulation of the Minister of Health No. 25 of 2015, other approaches are also being pursued through health promotion using various media. This study aims to determine the effectiveness and factors related to public knowledge about hepatitis B through interactive educational media for the community in Gondanglegi Village, Malang Regency. A total of 176 respondents completed the questionnaire, with 75% being female and 24% male. The majority of respondents fell within the age range of 51-60 years (34.7%). The Wilcoxon test results show a significant difference between pre-test and post-test scores (p=0.000). The Spearman test, which relates age and the last level of education to pre-test and post-test scores, reveals a significant relationship between pre-test scores and age (p=0.000, r=-0.458) as well as the last level of education (p=0.000, r=0.472). The correlation analysis results indicate that older age is associated with lower pre-test scores, while higher levels of education are associated with higher pre-test scores. A similar pattern is observed in the correlation test between post-test scores and age (p=0.082, r=-0.204) and the last level of education (p=0.013, r=0.013). These results indicate that the community engagement program to increase awareness of hepatitis B has successfully improved participants' knowledge, as reflected in the difference between pre-test and post-test scores." 
The curative effect of ethanolic extract of Moringa oleifera leaf in an animal model of liver fibrosis Supriono; Putri, Dinda Amalia Eka; Priyanto, Tia Rahmi; Sholihah, Al Imroatus; Larasati, Putu Anissa; Nabila, Salsala Sifa; Hartaya, Arsy Hanandya; Budiarto, Andika Agus; Fachrureza, Mochamad; Wibowo, Bogi Pratomo; Mustika, Syifa
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 2 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i2.13416

Abstract

Studies about the prevention effect of Moringa oleifera on liver fibrosis has been reported. However, its curative effect has not been reported, yet. This study was conducted to evaluate the curative effect of M. oleifera leaf extract on liver fibrosis. It was a laboratory experimental study with a post-test-only control group design. Rats were divided into 5 groups i.e. normal control which received intraperitoneally injections of 1 mL/kg BW of 0.9% NaCl solution twice a wk for 11 wk. Liver fibrosis control which received intraperitoneally injections of 1 mL/kg BW of 10% CCl4 solution twice a wk for 11 wk. Three M. oleifera treatment group which received intraperitoneally injections of 1 mL/kg BW of 10% CCl4 solution twice a wk for 11 wk continued by M. oleifera leaf ethanolic extract at dose of 600 mg/kg BW daily for 3 (MO3), 6 (MO6), and 10 (MO10) wk, respectively. The liver fibrosis level was assessed based on the METAVIR score. Histopathological analysis of liver tissues demonstrated that the 11-week CCl4 induction successfully resulted in liver fibrosis in rats (F3 and F4). The administration of M. oleifera leaf ethanolic extract decreased METAVIR scores ranged from F3 to F1. The optimal reduction of the METAVIR scores (F1) was observed in MO3 group after 6 wk administration (p<0.05). It was indicated that M. oleifera leaf ethanolic extract ameliorated liver fibrosis. In conclusion, M. oleifera leaf ethanolic extract has a curative effect against liver fibrosis.
Correlation of Short Chain Fatty Acid Levels in Patients Non-Alcoholic Fatty Liver Disease with Obesity Mustika, Syifa; Safira, Zahra; Rosandi, Rulli; ., Supriono; Wibowo, Bogi Pratomo; Muthiah, Mark
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202528-35

Abstract

Background: NAFLD has the potential to develop into severe diseases like NASH and cirrhosis and is often linked to obesity, although it can also occur in non-obese individuals, complicating diagnosis. SCFAs, produced by intestinal bacteria through the fermentation of dietary fibers, are essential for metabolic health and may influence liver fat and weight regulation. The purpose of this study was to explore the connection between SCFA levels and the severity of NAFLD, including liver fibrosis, in individuals both with and without obesity.Methods: A cross-sectional investigation of 16 NAFLD patients with obesity and 11 without, with stool samples analyzed for SCFA via gas chromatography. Obesity was defined by abdominal circumference. Data were analyzed using Spearman’s correlation, Eta’s correlation, and Pearson’s test.Results: Levels of SCFAs, including butyrate, propionate, and acetate, were significantly correlated in both obese and non-obese individuals diagnosed with NAFLD (r=0.618, p=0.001; p=0.019; p=0.037; p=0.012). Obesity was found to be positively associated with the severity of NAFLD (r=0.582, p=0.001). However, obesity did not exhibit a statistically significant connection with liver fibrosis (p = 0.351).Conclusion: Obese NAFLD patients exhibited decreased SCFA levels compared to non-obese individuals. Central obesity was linked to NAFLD severity but not fibrosis progression. SCFAs and obesity are crucial in the pathogenesis of NAFLD.Keywords: Central obesity, gut microbiota, NAFLD, SCFA
COMPARING LECTURE AND INTERACTIVE DISCUSSION METHODS TO ENHANCE HEPATITIS B KNOWLEDGE IN PREGNANT WOMEN AND COUPLES IN GONDANGLEGI Supriono, Supriono; Wibowo, Bogi Pratomo; Mustika, Syifa; Fachrureza, Mochamad; Imroatussholihah, Al; Prayitno, Tia Rahmi; Amalia, Dinda; Nugroho, Rama Tiar
Caring: Jurnal Pengabdian Masyarakat Vol 5, No 2 (2025): CARING Jurnal Pengabdian Masyarakat (Agustus 2025)
Publisher : Caring: Jurnal Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.caringjpm.2025.005.02.1

Abstract

Hepatitis B is a global health issue that has a significant impact on society, especially in terms of the risk of transmission from mother to child during childbirth. Health education is an important effort to prevent the spread of infection, particularly among pregnant women. This community service activity aims to increase knowledge about hepatitis B among pregnant women and reproductive-age couples in Gondanglegi, Malang, through two educational methods: lectures and interactive discussions. The lecture was conducted using a conventional approach, where information about hepatitis B was delivered directly to participants with the aid of visual PowerPoint materials to clarify the content. Meanwhile, the interactive discussion involved several speakers discussing the topic of hepatitis B, allowing participants to engage in discussions, share experiences, and ask questions to the speakers. Both methods were effective in increasing participants' knowledge, with the lecture method providing a more significant improvement. This activity is expected to strengthen public understanding of hepatitis B, while also supporting efforts to prevent the transmission from pregnant women to their babies.
Co-Authors Amalia, Dinda Budiarto, Andika Agus edy susanto Fachrureza, Mochamad Hartaya, Arsy Hanandya Imroatussholihah, Al Larasati, Putu Anissa Muthiah, Mark Nabila, Salsala Sifa Nugroho, Rama Tiar Prayitno, Tia Rahmi Priyanto, Tia Rahmi Putri, Dinda Amalia Eka Rulli Rosandi Safira, Zahra Sholihah, Al Imroatus Supriono Supriono ., Supriono Supriono Supriono Supriono Supriono Syifa Mustika