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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Science and Technology Indonesia Majalah Kesehatan FKUB Ina Kidney JIMEK : Jurnal Ilmiah Mahasiswa Ekonomi Heart Science Journal CRJIM (Clinical and Research Journal in Internal Medicine) Jurnal Jeumpa Narra J Jurnal Klinik dan Riset Kesehatan Jurnal Penyakit Dalam Indonesia Jurnal Kesehatan Deka in Medicine
Nur Samsu
Brawijaya University, Dr. Saiful Anwar Hospital, Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Profil Kejadian Bakteriuria Asimtomatik serta Faktor-Faktor yang Terkait dengan Kejadian Bakteriuria Asimtomatik pada Ibu Hamil di Puskesmas Janti Kota Malang Zahroh, Fatimatuz; Roebijoso, Jack; Samsu, Nur
Majalah Kesehatan FKUB Vol 1, No 4 (2014)
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (245.991 KB)

Abstract

Infeksi saluran kemih (ISK) adalah infeksi yang paling umum dijumpai selama kehamilan. Bakteriuria asimtomatik didefinisikan sebagai bakteriuria yang terdiri dari ≥ 105 colony forming unit per milliliter (cfu/mL) dengan satu jenis bakteri pada urin pancaran tengah serta tidak terdapat tanda dan gejala infeksi simptomatik. Sebanyak 25 % dari bakteriuria asimtomatik yang tidak diobati dapat menyebabkan infeksi simptomatik akut selama kehamilan. Tujuan penelitian  ini untuk mengetahui profil ibu hamil yang menderita bakteriuria asimtomatik serta faktor-faktor sosial ekonomi yang terkait dengannya. Desain penelitian menggunakan cross sectional. Penelitian ini dilakukan di Puskesmas Janti, Malang. Subjek adalah 43 orang ibu hamil dengan 13 orang  menderita bakteriuria asimtomatik. Hasil penelitian ini menunjukkan bahwa prevalensi bakteriuria asimtomatik pada ibu hamil adalah 30,2 %. Proporsi bakteriuria asimtomatik relatif tinggi pada ibu hamil berusia 20-29 tahun (69,2 %), nullipara (76,9 %), trimester II (61,5 %),  ibu hamil dengan pendapatan rendah sebesar (61,5 %), serta aktivitas seksual tinggi sebesar (61,5 %). Hasil analisis bivariat menunjukkan adanya  hubungan yang bermakna antara nullipara (rasio prevalensi = 3,833, Cl 95 % = 1,223-12,017; p = 0,008) dan aktivitas seksual tinggi (rasio prevalensi = 3,314, Cl 95 % 1,324-8,295; p = 0,008) dengan terjadinya bakteriuria asimtomatik pada ibu hamil. Berdasarkan hasil penelitian, petugas kesehatan disarankan untuk melakukan penyaringan mengenai paritas dan aktivitas seksual ibu hamil saat kunjungan pertama pemeriksaan antenatal care (ANC). Kata kunci : Aktivitas seksual, Bakteriuria asimtomatik, Ibu hamil, Nullipara.
ANALISIS COMMON-SIZE UNTUK MENILAI KINERJA KEUANGAN PERUSAHAAN PADA PT INDOSAT TBK. DAN PT TELKOMUNIKASI TBK. (Tahun 2014-2016) Zuhri, Mohammad harisudin; Satriyono, Gandung; Samsu, Nur
JIMEK : Jurnal Ilmiah Mahasiswa Ekonomi Vol 1, No 2 (2018): Desember 2018
Publisher : Fakultas Ekonomi Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.651 KB) | DOI: 10.30737/jimek.v1i2.313

Abstract

Penelitian ini bertujuan untuk mengetahui kinerja keuangan dengan menggunakan common size pada perusahaan PT Indosat, Tbk. dan PT Telekomunikasi, Tbk. yang terdaftar di Bursa Efek Indonesia selama tahun 2014-2016 ditinjau dari neraca dan laporan laba rugi. Penelitian ini merupakan penelitian deskriptif kuantitatif. Data dikumpulkan dengan metode dokumentasi dan analisis data yang digunakan yaitu analisis persentase per komponen atau common size. Hasil penelitian menunjukkan bahwa common size ditinjau dari neraca, PT Indosat, Tbk. yang mengalokasikan dana untuk aktiva sebagian besar dari utang PT Telekomunikasi, Tbk. mengalokasikan dana untuk aktiva dari modal sendiri sehingga meningkatkan margin of safety bagi kreditur dan menguatkan posisi keuangan perusahaan. Common size ditinjau dari laporan laba rugi, PT Indosat, Tbk. dan PT Telekomunikasi, Tbk.mengalami peningkatan pada laba bersihnya pada tahun 2016 sehingga kinerja keuangan perusahaan semakin baik dan tahun 2014-2015 kinerja keuangan kurang baik karena mengalami penurunan pada laba bersihnya. Kata kunci: common size, kinerja keuangan, laporan laba rugi, neraca.
Pengaruh Word Of Mouth (WOM) Dan Brand Image Terhadap Keputusan Penggunaan Jasa Foto Pada Studio Foto 4 Warna Photography Kota Kediri Kusuma, Yeziga Enggar; Satriyono, Gandung; Samsu, Nur
JIMEK : Jurnal Ilmiah Mahasiswa Ekonomi Vol 2, No 1 (2019)
Publisher : Fakultas Ekonomi Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (98.425 KB) | DOI: 10.30737/jimek.v2i1.425

Abstract

The research aims to analyze and determine the effect of Word of Mouth and Brand Image on the decision to use photo services on 4 colors of Kediri City Photography. This research uses quantitative methods. The type of research used is the correlation with sampling techniques. The research sample was 60 respondents in number. The multiple linear regression analysis techniques is tested for validity and reliability first. The conclusion of this study is (1) Word of Mouth has a significant effect on the decision to use photo services on 4 colors of photography. (2) Brand image has a significant effect on the Decision of Using Photo Services on 4 Colors of Photography. (3) Simultaneously or together with two independent variables consisting of word of mouth, brand image has a significant effect on service use decisions. Penelitian bertujuan menganalisis dan mengetahui pengaruh Word Of Mouth dan Brand Image terhadap Keputusan Penggunaan Jasa foto pada 4 Warna Photography Kota Kediri. Penelitian ini menggunakan metode kuantitatif. Jenis penelitian yang digunakan penelitian adalah korelasi dengan teknik pengambilan sampel. Sampel penelitian 60 responden jumlahnya. Teknik analisis regresi linier berganda dengan terlebih dahulu di uji validitas dan reliabilitas.Kesimpulan penelitian ini adalah (1) Word Of Mouth berpengaruh signifikan terhadap Keputusan Penggunaan Jasa Foto pada 4 Warna Photography. (2) Brand image berpengaruh signifikan terhadap Keputusan Penggunaan Jasa Foto pada 4 Warna Photography. (3) Secara simultan atau bersama – sama dua variabel bebas yang terdiri dari word of mouth, brand image berpengaruh signifikan terhadap keputusan penggunaan jasa.
Role of Antibody Anti-AGE in the Expression of Nephrin and RAGE on Primary Glomerulus Cell Exposed with AGE Salam, Rudy; Lyrawati, Diana; Samsu, Nur
Journal of Tropical Life Science Vol 7, No 2 (2017)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.07.02.03

Abstract

Upregulation of nephrin expression occurs at the early stage of nephropathy and decrease in the period 6 months on hyperglycaemic condition. Nephrin is associated with the initial stage of the loss of the permeability barrier in diabetic nephropathy. Interaction AGE-RAGE increases angiotensin II on Renin Angiotensin-Aldosterone System (RAAS) and activation of protein kinase c (PKC) which induce alterations in nephrin mRNA expression. Alterations of nephrin expression induces transformation of slit membrane structure and the permeability changes at the glomerular filtration barrier. Anti-AGE vaccination once may cause the changes of nephrin and RAGE expression and can prevent progression of diabetic nephropathy. This study used primary glomerulus cell culture obtained from renal of Wistar mice aged 3 months, weighting 200-300 grams that consist of negative control group that exposed to BSA 100 µg/ml, positive control group that exposed to AGE-BSA 100 µg/ml, treatment group 1 that exposed to polyclonal anti-AGE 5 µg/ml and AGE-BSA 100 µg/ml and treatment group 2 that exposed to monoclonal antibody anti-CML 5 µg/ml and AGE-BSA 100 µg/ml. Paired t-test with a 0.05 level of confidence results showed that there were significant differences in level of RAGE expression among experimental groups with control groups. Administration of polyclonal antibody decreased RAGE expression among negative control (p=0.188). but not in positive control (p=0.000). In contrast to monoclonal anti-AGE antibody, RAGE expression did not differ significantly compared to negative control but significant than positive control. Administration of monoclonal anti-AGE antibody inhibited increasing of nephrin expression compared to negative and positive control (p=0.73; 0.125). In conclusion, this study suggested that administration of polyclonal and monoclonal anti-AGE antibody could inhibit increasing of RAGE and nephrin expression in glomerulus primary culture that exposed to AGE which is expected to prevent the progression of diabetic nephropaty.
Renal Artery Stenosis: Diagnostic and Management Problems Samsu, Nur; Waafi, Affa Kiysa
Clinical and Research Journal in Internal Medicine Vol 1, No 2 (2020): New: The Second Issue is Coming!
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2020.001.02.6

Abstract

Renal artery stenosis is one common clinical problem. It has wide spectrum of pathophysiology with 3 most common clinical syndromes, ischemic nephropathy, hypertension, and cardiac destabilization syndrome. Aim: To date there was not any specific diagnostic criteria for renal artery stenosis. Method: Clinicians only used some clinical syndromes to guide the diagnostic possibility of renal artery stenosis. RADUS as one sensitive and specific diagnostic method, still had some disadvantages. Results: it gives false negative results in 10-20% of patients due to confounding factors such as operator capability, obesity, or abdominal gas distribution. CTA and MRA was excellent, but possessed some risks for the patient. Therefore, CTA was mostly recommended in patient with the planning of revascularization. Management of renal artery stenosis was still debated between optimal medical management and revascularization because the complexities of mechanisms underlying the renal artery stenosis. Because of the complicated pathophysiology of renal artery stenosis, revascularization could not entirely improve renovascular hypertension and nephropathy. Revascularization offered best results in fibromuscular dysplasia, although procedure related complication was still high. Revascularization, even though it might have high success rate in atherosclerotic renal artery stenosis, but the incidence of re-stenosis was also fairly high. Conclusion: Overall, revascularization was recommended in FMD, but should only be preserved for atherosclerotic renal artery stenosis after the failure of optimal medical management.
Challenges in Diagnostic and Management of Nephritic Syndrome in Diabetic Nephropathy Patient: a Case Report Novitasari, Adinda Dian; Samsu, Nur
Clinical and Research Journal in Internal Medicine Vol 2, No 1 (2021): First Issue of 2021
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2021.002.01.7

Abstract

The clinical presentation of patients with acute glomerulonephritis (GN) varies widely, from asymptomatic to clinical presentations of acute kidney injury (AKI), edema, and hypertension. Diagnosis of GN in patients with diabetic nephropathy (DN) is a challenge due to pre-existing edema, hypertension, and decreased renal function. Likewise in terms of management of steroid immunosuppressants related to blood sugar regulation. It has been reported that 35-year-old male patients with diabetes mellitus (DM) with DN whose kidney function deteriorated rapidly. The patient complained of cola-red urine and decreased urine volume the day before admission. Physical examination showed blood pressure of 160/95 mmHg, bilateral leg edema, active chronic ulcer in the left lower leg, hemoglobin level was 8.7 g / dl, leukocytes 17.400 / ul, serum urea level 96 mg / dl, serum creatinine level 7.01 mg / dl, ASTO titer + 800 IU / ml, macroscopic hematuria, and albuminuria +4 on urinalysis. Ultrasonography revealed enlarged kidney size and signs of acute renal inflammation. Based on these data the patient was diagnosed clinically as rapidly progressive GN due to post-infectious GN. The patient received 3 days of pulse methyl prednisolone therapy continued orally, blood sugar regulation with insulin, RAS blockers, intravenous antibiotics and ulcer debridement. After 1 week of therapy, clinical and laboratory improvements were found and at the next follow-up renal function returned to baseline about 2 weeks later.
Differences in Carotid Intima-Media Thickness (CIMT) In Patients With Newly Diagnosed Hypertension, and Chronic Hypertensive Patients Treated by Calcium Channel Blockers (CCB) or Angiotensin Converting Enzyme (ACE)-Inhibitors Tantri, Ni Luh; Rudijanto, Achmad; Samsu, Nur; Wursito, Wursito
Clinical and Research Journal in Internal Medicine Vol 1, No 1 (2020): New: The First Volume of Clinical and Research Journal in Internal Medicine
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2020.001.01.2

Abstract

 Hypertension is a significant risk factor for cardiovascular diseases. It closely related to the inflammatory process and resulting in chronic inflammation, which had a critical role in the progression of atherosclerosis. Carotid Intima-Media Thickness (CIMT) was known as a surrogate marker of atherosclerosis. Anti-hypertensive drugs are expected to affect CIMT. Aim: to examine the difference CIMT between newly diagnosed hypertension and chronic hypertensive treated by ACE-I or CCB. Method: this cross-sectional study was conducted on 12 newly diagnosed hypertensive patients (control or group 1), 9 hypertensive patients treated by CCB (group 2), and 9 hypertensive patients treated by ACE-I (group 3). Their hypertensive condition was controlled at least for 6 months. We compared CIMT of patients and Tumour Necrosis Factor Alfa (TNF-α) also Interleukin-6 (IL-6) among the groups. Result: there was a significant difference in CIMT between the group 1 and 2 (0.86 vs 0.70; p = 0.027), group 1 and 3 (0.86 vs 0.69; p = 0.018). There was no significant difference between group 2 and 3 (0.70 vs 0.69; p = 0.88). There was no association between CIMT and TNF-α, IL-6, Low-Density Lipoprotein (LDL), triglycerides (TGs) levels, and body mass index (BMI), systolic blood pressure. Conclusion: we found that the CIMT of the control group was thicker than those of the treatment groups. Moreover, differences in the thickness of CIMT of the three groups were not associsted with level of TNF-α, IL-6, TG, and LDL, also BMI, and systolic blood pressure.
Carotid Intima-Media Thickness (CIMT), Hypertension, and CVD Event Samsu, Nur
Clinical and Research Journal in Internal Medicine Vol 1, No 1 (2020): New: The First Volume of Clinical and Research Journal in Internal Medicine
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2020.001.01.1

Abstract

Advanced Glycation End Products (AGEs) Antibody Protects Against AGEs-induced Apoptosis and NF-ĸB p65 Subunit Overexpression in Rat Glomerular Culture Adianingsih, Oktavia Rahayu; Lyrawati, Diana; Samsu, Nur
Journal of Tropical Life Science Vol 6, No 3 (2016)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.06.03.08

Abstract

Advanced glycation end products (AGEs) have been thought to be a major cause of diabetic nephropathy (DN). The mechanisms underlying the involvement of AGEs antibody in diabetic nephropathy are not fully understood. The present study was designed to investigate the protective effect of AGEs antibody on AGEs-induced glomerular damage. Isolated glomeruli were pre-incubated either with 10 µg/mL polyclonal anti-AGEs antibody (AGE-pAb) or monoclonal anti-Nɜ -carboxymethyl-lysine antibody (CML-mAb) as a model of AGEs antibody to block interaction of AGEs with receptor for AGEs (RAGE) and incubated afterwards either with 100 µg/mL bovine serum albumin (BSA) or AGE-modified bovine serum albumin (AGE-BSA) for 48 h. Annexin V/nephrin doublestaining was performed to determine apoptosis. Using immunofluorescence, we found that administration of AGE-BSA not only significantly increased glomerular cells apoptosis and nuclear factor kappa B (NF-ĸB) p65 expression, but also reduced expression of nephrin, an important structural and signal molecule of podocytes slit diaphragm. Blocking the interaction of AGE-RAGE with AGEs antibody significantly protected glomerular cells from AGEs-induced apoptosis and NF-ĸB p65 overexpression. We found that AGE-pAb conferred superior protective effect compared with CmL-mAb for the same reduction in apoptosis and NF-ĸB p65 expression. In sharp contrast, CmL-mAb led to preserve expression of podocytes nephrin better than AGE-pAb. These results demonstrate that the antibody against AGEs may be beneficial for preventing the glomerular damage in DN.
The Additive Effect of Rosmarinic Acid for The Reduction of Glomerular NF-kB Expression in Diabetes Rat that was given Telmisartan Fachrureza, Mochamad; Samsu, Nur; Rudijanto, Achmad
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 3
Publisher : UI Scholars Hub

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Abstract

Introduction. Diabetic nephropathy is one of the common complications of diabetes, which one of its causes is the increase of free radicals through the activation of NF-kβ and Angiotensin II. Rosmarinic acid has the activity as the anti-oxidant and anti-inflammatory, and the telmisartan is the partial PPAR-γ agonist that has the anti-fibrotic effect. This study aimed to identify the effect of rosmarinic acid and telmisartan in the reduction of subunit p65 NF-kB expression on the glomerular diabetes rat. Methods. An experimental study with a post-test only controlled group was conducted in a group of rats (Rattus norvegicus). Rats were randomly divided into five groups (n=3-4 per group): three treatment groups (group 1: rosmarinic acid 75 mg/kg/ day; group 2: telmisartan 1 mg/kg/day, group 3: combination of rosmarinic acid 75 mg/kg/day and telmisartan 1mg/kg/ day per day), and two control groups (negative and positive control group). After eight weeks, rats were dissected. Blood sugar more than 270 mg/dl confirmed that the rats in diabetes state. The measurement of albuminuria was done using ELISA and the expression of subunit p65 NF-kβ using the immunofluorescence method. Results. The expression of subunit p65 NF-kβ in negative control group was 519.70 (SD 158.12), 702.19 (SD 189.69) in positive control group, 631.19 (SD 119.21) in the rosmarinic acid group, 355.68 (SD 44.71) in the telmisartan group, and 572.37 (SD 98.09) in the combination group (p<0.001). The post hoc test showed that the mean value of subunit p65 NF-kβ expression was significantly different between the positive control group and the telmisartan group (p<0.001). But, there was no significant mean difference of subunit p65 NF-kβ expression between the positive control group and the rosmarinic acid group (p=1.000), as well as between the combination rosmarinic acid and telmisartan group. Conclusion. The addition of telmisartan can reduce expression of the subunit p65 NF-kB. However, adding the rosmarinic acid in diabetes rats given telmisartan did not reduce the expression of subunit p65 NF-kB in the same level with the negative control group.
Co-Authors ACHMAD RIFAI Achmad Rudijanto Akhmad Sabarudin Albaar, Thoha M. Arie Srihardyastutie asihanti rosita ferdiana Atma Gunawan Aulanni’am Aulya, Justika Usmadhani Baridwan, Fakhri Camoya Gersom Dela, Jamaludin A. Dewi, Ratih TK. Diana Lyrawati Didi Candradikusuma Dwinata, Michael Fachrureza, Mochamad Fahmi, Ahmad Luthfi Fajar, Jonny Karunia Farahdina, Farahdina Fatimatuz Zahroh, Fatimatuz Fiddaroini, Saidun Fredo Tamara, Fredo Friatna, Yudha Gandung Satriyono, Gandung Hani Susanti, Hani Heri Sutanto Huda, Fariz N. Ida Wahyuni Indiastari, Dewi Jack Roebijoso Jonny K. Fajar Kosasih, Angelia Kusuma, Yeziga Enggar Matondang, Asri Rizqi Mutia, Tari Ni Luh Tantri Niniek Budiarti B Novitasari, Adinda Dian Nurike S Mudjari, Nurike S Oktavia Rahayu Adianingsih Pratama, Satya Putra, Riyantono Putri, Irawati E. Rifa'i, Achmad Rizaliansyah, Ferdian Roja’i, Abdul Munir Rudy Salam, Rudy Salsabila, Isadora Evani Saraswati, Dara Sari, Fitria R. Susanto, Agung Suseno, Aryo Sutrisno, Muhammad A. Tidel, Caesar Tupamahu, Alvira R. Waafi, Affa Kiysa Wicaksono, Ramadi S. Wicaksono, Ramadi Satryo Winoto, Eden Wursito, Wursito Zuhri, Mohammad harisudin