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All Journal Jurnal Kedokteran Brawijaya Majalah Kesehatan FKUB CRJIM (Clinical and Research Journal in Internal Medicine) Jurnal Penyakit Dalam Indonesia
Bogi Pratomo
Division of Gastroentero-hepatology, Department of Internal Medicine, Faculty of Medicine, University of Brawijaya/Dr. Saiful Anwar General Hospital, Malang
Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Insiden dan Gambaran Klinis Hepatitis Akibat Obat Anti Tuberkulosis di Rumah Sakit Umum Daerah Dr. Saiful Anwar Malang Rifai, Achmad; Herlianto, Budi; Mustika, Syifa; Pratomo, Bogi; Supriono, Supriono
Jurnal Kedokteran Brawijaya Vol 28, No 3 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1078.681 KB) | DOI: 10.21776/ub.jkb.2015.028.03.14

Abstract

 Hepatitis akibat obat anti tuberkulosis (OAT) merupakan ancaman yang serius terhadap pengendalian penyakit tuberkulosis. Namun belum ada data yang representatif mengenai hal tersebut dalam suatu populasi. Penelitian ini bertujuan untuk memahami gambaran klinis dan mengevaluasi efek dari terapi obat anti tuberkulosis di Rumah Sakit Umum Daerah Dr. Saiful Anwar Malang pada tahun 2013. Penelitian ini merupakan penelitian deskriptif potong-lintang (cross sectional) yang melibatkan sebanyak 460 pasien tuberkulosis (TB) yang menerima directly observed treatment strategy (DOTS). Dari hasil penelitian diperoleh 25 pasien yang mengalami hepatitis akibat OAT dengan nilai insiden sebesar 5,4%. Gejala-gejala yang paling sering timbul adalah rasa mual dan muntah (48%). Terjadi hepatitis ringan (20%), sedang (48%), berat (4%), dan sengat berat (4%). Sebanyak 60% tanpa penyakit penyerta. Efek Hepatitis yang menyebabkan pemberhentian OAT sementara sebesar 56% kasus dan yang tetap meneruskan OAT sebesar 44% kasus,  rata-rata durasi terapi hepatitis akibat Obat Anti Tuberkulosis adalah 18 hari. Hepatitis akibat OAT dapat mempengaruhi angka keberhasilan (outcome) terapi. Adanya insiden hepatitis akibat OAT dan besarnya populasi Hepatitis tersebut di Rumah Sakit Saiful Anwar menunjukkan bahwa mendeteksi efek negatif dari terapi OAT sangatlah penting.Kata Kunci: Anti-tuberculosis drug induced liver injury (ATLI), Obat Anti Tuberkulosis (OAT), tuberkulosis paru
Hubungan Pola Penggunaan OAINS dengan Gejala Klinis Gastropati pada Pasien Reumatik Waranugraha, Yoga; Suryana, BP Putra; Pratomo, Bogi
Jurnal Kedokteran Brawijaya Vol 26, No 2 (2010)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (551.018 KB) | DOI: 10.21776/ub.jkb.2010.026.02.8

Abstract

ABSTRAKKata Kunci : Obat Anti Inflamasi Non Steroid (OAINS) merupakan obat pilihan utama untuk osteoartritis. Penggunaan OAINS yang kurang  tepat  dapat  menyebabkan  gastropati.  Penelitian  ini  bertujuan  untuk  mengetahui  hubungan  pola  penggunaan OAINS dengan gejala klinis gastropati pada pasien reumatik Penelitian dilakukan dengan desain cross sectional pada 40 orang  pasien  dipilih  dengan  metode  consecutive  sampling.  Penelitian  ini  menilai  pola  pengguaan  OAINS  (jenis,  lama penggunaan,  cara  penggunaan,    pemakaian  obat  sitoproteksi  )  dan  gejala  klinis  gastropati  yang  timbul.  55%  pasien mengalami gejala klinis gastropati berupa sindrom dispepsia. Uji Kruskal Wallis gejala klinis gastropati antara penggunaan Na diclofenac, meloxicam, dengan ibuprofen menunjukkan p = 0,732. Uji regresi logistik lama penggunaan dengan gejala klinis  gastropati  menunjukkan  p  =  0,047.  Uji  Mann  Whitney  gejala  klinis  gastropati  pada  penggunaan  OAINS  secara periodik dengan berkelanjutan menunjukkan p > 0,05. Uji Mann Whitney gejala klinis gastropati pada penggunaan OAINS bersama  obat  sitoproteksi  dengan  penggunaan  OAINS  tanpa  obat  sitoproteksi  menunjukkan  p  =  0,000.  Penelitian  ini membuktikan  bahwa  jenis  OAINS  tidak  memberikan  perbedaan  gejala  klinis  gastropati,  demikian  juga  penggunaan periodik dan berkelanjutan. Dibuktikan juga bahwa lama penggunaan OAINS berhubungan dengan gejala klinis gastropati dan penggunaan obat sitoproteksi bersama dengan OAINS mengurangi gejala klinis gastropati.Gastropati, OAINS, reumatik
Lean Non-Alcoholic Fatty Liver Disease (NAFLD) Fachrureza, Mochamad; Pratomo, Bogi
Clinical and Research Journal in Internal Medicine Vol 1, No 1 (2020): New: The First Volume of Clinical and Research Journal in Internal Medicine
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2020.001.01.6

Abstract

Non-Alcoholic Fatty Liver Disease (NAFLD) is a condition that can develop into advanced liver disease. The NAFLD spectrum includes simple steatosis, non-alcoholic steatohepatitis (NASH), liver fibrosis, and liver cirrhosis to hepatocellular carcinoma. One of the underlying pathophysiologies is insulin resistance found in metabolic syndrome. People with metabolic syndrome are not always obese, and NAFLD can also be found in this group, known as lean NAFLD, which has different metabolic characteristics. Metabolic characteristics of lean NAFLD include high levels of transaminases and insulin, low insulin sensitivity, low fasting glucose, low necroinflammatory activity, and liver fibrosis. Some related factors are methionine and choline deficiency, excessive acyl-coA expression, and PNPLA3 gene polymorphism. Lean NAFLD is an interesting topic to discuss because practitioners' awareness of lean NAFLD is lower compared to obese patients. NAFLD is a risk factor for chronic diseases such as cardiovascular disease, kidney disease, colorectal, atrial fibrillation, and hypothyroidism, so it is essential to be recognized by clinicians. To date, there are no guidelines or recommendations that discuss specific treatments in this lean NAFLD population.  
Comparison of Mortality between Intravenous Albumin and No Intravenous Albumin in Sepsis Patients with Hypoalbuminemia Conditions and Factors that Influence the Mortality of Sepsis Patients Marzuki, Mochammad Jalalul; Supriono, Supriono; Pratomo, Bogi; Mustika, Syifa
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 4
Publisher : UI Scholars Hub

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Abstract

Introduction. Hypoalbuminemia is a strong predictor of mortality in nonoperative and operative patients. Albumin plays a role in maintaining oncotic pressure in critical conditions such as sepsis. The administration of exogenous Human Serum Albumin (HSA) in sepsis with hypoalbuminemia conditions is still controversial with varying outcomes.This study aimed to know the mortality ratio between intravenous albumin administration and no intravenous albumin administration in sepsis patients with hypoalbuminemia conditions and also to know the factors that influence the mortality of sepsis patients. Methods. An observational study with a prospective approach involving 75 research subjects aged >18 years with sepsis accompanied by hypoalbuminemia (<2.5 g/dL) treated in the high care unit of RSUD dr. Saiful Anwar Malang during the period 1 September 2018-31 August 2019. Subjects were divided into two groups namely albumin and nonalbumin groups. Both groups were followed during hospitalization until they discharged or died. Differences in mortality between the two groups were analyzed by chi square bivariate test. The most influential factors on mortality were analyzed by multivariate binary logistic regression tests. Results. There were 39 people (52%) from the albumin group and 36 people (48%) from the non-albumin group. Difference in mortality between albumin and nonalbumin groups {25 (64.1%) vs 16 (44.4%) with OR 2, p=0.138} means there was no statistically significant difference. Factors that influence mortality included: SOFA score (OR 34.27, p <0.001), MAP value (OR 8, p<0.001), septic shock (OR 4.31, p=0.03), diabetes mellitus (OR 0.28, p=0.009), respiratory failure (OR 8.02, p <0.001), decreased of consciousness (OR 64.75, p <0.001), cardiovascular failure (OR 6, p <0.001), hematological failure (OR 3.05, p=0.027). The most dominant factor affecting mortality in sepsis patients is decreased of consciousness (OR 2.67, p=0.001). Conclusion. The administration of albumin transfusion did not make a significant difference in the incidence of mortality in sepsis patients with hypoalbuminemia. The most influential factor on mortality of sepsis patients is decreased of consciousness.
Arthritis in Chronic Hepatitis C Infection: Is It Rheumatoid Like Arthritis or True Rheumatoid Arthritis? Susanto, Jefri P.; Mustika, Syifa; Pratomo, Bogi
Jurnal Penyakit Dalam Indonesia Vol. 7, No. 1
Publisher : UI Scholars Hub

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Abstract

The Effects of Curcumin on NF-κB Level and Degree of Liver Fibrosis in Rat Liver Fibrosis Supriono, Supriono; Pratomo, Bogi; Praja, Dedy Indra
Jurnal Penyakit Dalam Indonesia Vol. 5, No. 4
Publisher : UI Scholars Hub

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Abstract

Gastroesophageal Reflux Risk Factor Analysis at Saiful Anwar Hospital in Malang Tarigan, Ricky C; Pratomo, Bogi
Jurnal Penyakit Dalam Indonesia Vol. 6, No. 2
Publisher : UI Scholars Hub

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Abstract

Introduction. Gastroesophageal reflux disease (GERD) is a pathological condition as a result of reflux of stomach contents into the esophagus with various symptoms that arise due to the involvement of the esophagus, larynx, and airways. The prevalence of GERD has increased lately. In Indonesia, 22.8% cases of esophagitis were reported. Analysis of the risk factors for GERD is very important in reducing the prevalence of GERD. This study aimed to identify the most influential risk factors for GERD patients so that it could become a reference to reduce the prevalence of GERD in the following year. Methods. This study was a cross-sectional study where data was taken based on data from medical records of patients undergoing the endoscopic procedure in the division of Hepatology Gastroenterology at Saiful Anwar Hospital Malang during 2016. The diagnosis was obtained from history, physical examination, and GERD diagnostic criteria from endoscopy according to the Los Angeles criteria. Results. Among 57 patients, there were 20 female (32.5%) and 37 male (67.5%), 63.16% of them are >40 years old. This study found that 28 patients (49.12%) consumed herbs, 31 patients (54.38%) found smoking, and those who consumed alcohol were 18 patients (31.48%). The analysis showed that factors related to the incidence of GERD were herbal consumption (p=0.007; OR 4.586 (95% CI: 95%: 1.386-15.177)) and alcohol consumption (p 0.027; OR 4.846 (95% CI: 1.024-22.929)). Conclusion. Consumption of herbal and alcohol appear to be risk factors of the incidence of GERD in this study.
HUBUNGAN AKTIVITAS PRODUKSI SHORT CHAIN FATTY ACID (SCFA) PADA SINDROM METABOLIK DAN DERAJAT FIBROSIS HATI PADA PASIEN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) Mustika, Syifa; Pratomo, Bogi; Faridah, Amirah
Majalah Kesehatan Vol. 11 No. 4 (2024): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2024.011.04.2

Abstract

Saluran pencernaan dan hati memiliki interaksi anatomis dan fungsional yang kuat, yang disebut dengan gut-liver axis (GLA). GLA terdiri dari komponen-komponen yang kompleks, apabila terjadi perubahan pada salah satu komponen seperti disbiosis mikrobiota usus, maka dapat berpengaruh terhadap fungsi hati. Disbiosis mikrobiota usus dapat dinilai dari perubahan hasil fermentasi mikrobiota usus yaitu asam lemak rantai pendek (short chain fatty acid/SCFA) yang terdiri dari asetat, propionat, dan butirat. Penelitian ini bertujuan untuk mengidentifikasi hubungan aktivitas produksi SCFA dengan sindrom metabolik dan derajat fibrosis hati, serta membandingkan aktivitas produksi SCFA pasien non-alcoholic fatty liver disease (NAFLD) dengan subjek kontrol. Studi cross-sectional terhadap 27 pasien NAFLD dan 10 subjek kontrol dengan sampel penelitian berupa feses. Derajat fibrosis hati diukur menggunakan transient elastography dan kadar SCFA diukur menggunakan teknik pemeriksaan gas chromatography. Analisis data dengan uji Chi-square, independent t-test dan uji korelasi Spearman. Hasil menunjukkan terdapat hubungan antara kadar SCFA dengan sindrom metabolik dengan korelasi negatif (r = -0,381, p = 0,020), terdapat hubungan antara kadar SCFA dengan derajat fibrosis hati pasien NAFLD dengan korelasi negatif (r = -0,665, p = 0,001), dan didapatkan penurunan signifikan kadar SCFA pada pasien NAFLD dibandingkan subjek kontrol (total SCFA p = 0,001, asam asetat p < 0,001, asam propionat p = 0,005, asam butirat p < 0,001). Kesimpulan, terdapat penurunan signifikan kadar SCFA pada pasien NAFLD dibandingkan subjek kontrol. Semakin rendah kadar SCFA berhubungan dengan semakin tinggi risiko terjadinya sindrom metabolik dan semakin tinggi derajat fibrosis hati pada pasien NAFLD.
Co-Authors A.A. Ketut Agung Cahyawan W BP Putra Suryana Budi Herlianto Fachrureza, Mochamad Faridah, Amirah Hani Susianti Harijono Achmad Helena Helena, Helena Irawati, Ekamaya Sofa Komala, Anton Kriestian, Muhammad Marzuki, Mochammad Jalalul Nugraha Setiawan Nugraha, Bayu Eka Praja, Dedy Indra Praja, Dedy Indra Sasmithae, Lia Supriono Supriono Supriono Supriono Susanto, Jefri P. Syifa Mustika Tarigan, Ricky C Yoga Waranugraha