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All Journal JFIOnline Jurnal Farmasi Higea Pharmaceutical And Biomedical Sciences Journal (PBSJ) Journal of Philology and Historical Review
Aldrat, Hendri
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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UJI SITOTOKSISITAS BUAH MERAH, MAHKOTA DEWA DAN TEMU PUTIH TERHADAP SEL KANKER SERVIKS Radji, Maksum; Aldrat, Hendri; Harahap, Yahdiana; Irawan, Cosphiadi
Jurnal Farmasi Indonesia Vol 5, No 1 (2010)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i1.36

Abstract

The cytotoxic effect of herbal medicines has been examined using HeLa cells line (cervical cancer cell culture). The result showed that the LC50 value of buah merah [Pandanus conoideus Lam.], mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.] and temu putih [Curcuma zedoaria (Berg.) Roscoe] extracts were  421 µg/ml, 835µg/ml and 58,9 µg/ml after 24 hour incubation, whereas the LC50 of each extract were 276.79 µg/ml, 415,9 µg/ml and 29.19 µg/ml after 48 hour incubation respectively. The cytotoxic activity of temu putih [Curcuma zedoaria (Berg.)] extract to HeLa cells was stronger than buah merah [Pandanus conoideus Lam.] and mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.] extracts.   ABSTRAK Telah dilakukan penelitian efek sitotoksisitas ekstrak buah merah [Pandanus conoideus Lam.], mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.] and temu putih [Curcuma zedoaria (Berg.) Roscoe] terhadap sel HeLa (kultur sel kanker serviks). Hasil penelitian menunjukkan bahwa nilai LC50 dari ketiga ekstrak tersebut masing-masing adalah 421 µg/ml, 835µg/ml and 58,9 µg/ml, setelah waktu inkubasi selama 24 jam, sedangkan LC50 setelah diinkubasi selama 48 jam adalah  276.79 µg/ml, 415,9 µg/ml and 29.19 µg/ml. Aktivitas sitotoksik  temu putih [Curcuma zedoaria (Berg.)] terhadap sel HeLa  lebih kuat dibandingkan dengan buah merah [Pandanus conoideus Lam.] dan mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.]
Co-Authors Asmara, Adhiko E Az Zahra, Alfiyah Cosphiadi Irawan Defiza, Defiza Khoerunnisa Khudri, Khudri Kurnia, Sultan Maksum Radji Mita Restinia Musdja, M. Yanis Musir, Ahmad Ningsih, Handaryni Ratna Pangestuti, Alia Dening Permana, Zera Soares, Ghio V. D Supandi Suparmi Suparmi Wandani, Karina Wulandari, Winda Trya Yahdiana Harahap