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All Journal JFIOnline Jurnal Farmasi Higea Pharmaceutical And Biomedical Sciences Journal (PBSJ) Journal of Philology and Historical Review
Aldrat, Hendri
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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UJI SITOTOKSISITAS BUAH MERAH, MAHKOTA DEWA DAN TEMU PUTIH TERHADAP SEL KANKER SERVIKS Radji, Maksum; Aldrat, Hendri; Harahap, Yahdiana; Irawan, Cosphiadi
Jurnal Farmasi Indonesia Vol 5, No 1 (2010)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v5i1.36

Abstract

The cytotoxic effect of herbal medicines has been examined using HeLa cells line (cervical cancer cell culture). The result showed that the LC50 value of buah merah [Pandanus conoideus Lam.], mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.] and temu putih [Curcuma zedoaria (Berg.) Roscoe] extracts were  421 µg/ml, 835µg/ml and 58,9 µg/ml after 24 hour incubation, whereas the LC50 of each extract were 276.79 µg/ml, 415,9 µg/ml and 29.19 µg/ml after 48 hour incubation respectively. The cytotoxic activity of temu putih [Curcuma zedoaria (Berg.)] extract to HeLa cells was stronger than buah merah [Pandanus conoideus Lam.] and mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.] extracts.   ABSTRAK Telah dilakukan penelitian efek sitotoksisitas ekstrak buah merah [Pandanus conoideus Lam.], mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.] and temu putih [Curcuma zedoaria (Berg.) Roscoe] terhadap sel HeLa (kultur sel kanker serviks). Hasil penelitian menunjukkan bahwa nilai LC50 dari ketiga ekstrak tersebut masing-masing adalah 421 µg/ml, 835µg/ml and 58,9 µg/ml, setelah waktu inkubasi selama 24 jam, sedangkan LC50 setelah diinkubasi selama 48 jam adalah  276.79 µg/ml, 415,9 µg/ml and 29.19 µg/ml. Aktivitas sitotoksik  temu putih [Curcuma zedoaria (Berg.)] terhadap sel HeLa  lebih kuat dibandingkan dengan buah merah [Pandanus conoideus Lam.] dan mahkota dewa [Phaleria macrocarpa (Scheff.) Boerl.]
Pengaruh Pretreatment Microwave Terhadap Rendemen dan Profil Kimiawi Minyak Gaharu Aquilaria Sp. Defiza, Defiza; Az Zahra, Alfiyah; Supandi, Supandi; Aldrat, Hendri
Jurnal Farmasi Higea Vol 15, No 2 (2023)
Publisher : STIFARM Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52689/higea.v15i2.555

Abstract

Minyak gaharu salah satu produk hasil penyulingan dari resin gaharu yang selain aromanya yang unik dan memiliki aktivitas biologis. Oleh karena tingginya minat  serta kelangkaan sumber-sumbernya secara alamiah, peneliti berusaha menemukan cara agar proses penyulingannya lebih efisien tanpa mengorbankan kualitas. Pada penelitian ini serbuk resin gaharu diberikan pretreatmen sebelum disuling dengan menggunakan microwave dengan daya 180 Watt selama 3 x 3 menit. Selanjutnya serbuk resin tersebut direndam masing-masing 1, 2, 3, dan 4 minggu sebelum dilakukan hidrodistilasi selama 15 jam. Minyak atsiri yang dihasilkan selanjutnya dianalisa menggunakan GCMS, sedangkan aromanya diuji hedonis untuk mengetahui perlakuan mana yang paling disukai responden. Hasil penelitian menunjukkan bahwa terjadi peningkatan rendemen minyak atsiri setelah pretreatment. Ada senyawa yang konsisten muncul pada semua perlakuan termasuk kontrol seperti benzylacetone, β-selinene, alloaromadendrene, n-hexadecanoic acid, β-guaiene, dan agarospirol, sedangkan senyawa yang muncul setelah diberikan perlakuan microwave di antaranya adalah di antaranya adalah γ-gurjunene, valerenol, valencene, dibenzylacetone, α-selinene, α-guaiene, beta elemene, γ-muurolene, isocaryophyllene, ocimene, valerenal, cadinene dan dimetil octatriene. Adapun di antara senyawa di atas, yang baru muncul setelah mengalami perendaman adalah valerenal, dibenzylacetone, isocaryophyllene, ocimene, α-guaiene, β-elemene, dan γ-muurolene. Praperlakuan dengan menggunakan microwave dengan daya 180W dan perendaman sampai 2 minggu dapat meningkatkan jumlah rendemen dan keanekaragaman komponen minyak gaharu atsiri. Uji hedonik menunjukkan responden aroma minyak atsiri setelah pretreatment tidak merusak kualitas minyak gaharu.
Pengaruh Beberapa Jenis Praperlakuan Terhadap Peningkatan Rendemen Minyak Gaharu Hasil Hidrodistilasi Aldrat, Hendri; Supandi, Supandi; Musdja, M. Yanis
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.46701

Abstract

Minyak gaharu memiliki potensi untuk dikembangkan sebagai aromaterapi namun ketersediaannya di alam yang terbatas sehingga diperlukan upaya yang efektif untuk mendapatkan rendemen yang optimal. Berbagai pretreatment ekstraksi diketahui dapat meningkatkan rendemen minyak gaharu. Penelitian ini bertujuan untuk membandingkan rendemen dan profil senyawa minyak gaharu yang diperoleh dari pretreatment maserasi, microwave, ultrasonik, dan fermentasi. Penelitian dilakukan dengan melakukan pretreatment ekstraksi, distilasi serbuk kayu gaharu, identifikasi senyawa minyak atsiri melalui Gas Chromatography Mass Spectrometry (GCMS), serta uji hedonik. Hasil distilasi menunjukkan bahwa pretreatment fermentasi ragi tapai memiliki persentase rendemen minyak gaharu tertinggi sebesar 0,050% diikuti fermentasi Fusarium sp. (0,036%), ultrasonik (0,034%), microwave (0,030%), maserasi (0,024%) dan kontrol (0,018%). Ada sejumlah 6 senyawa yang konsisten dijumpai pada setiap sampel seperti α-agarofuran dan dihydrocolumellarin, dan asam heksadekanoat. Senyawa sesquiterpen terbanyak diperoleh dari pretreatment menggunakan ragi tempe. Berdasarkan hasil penelitian diketahui bahwa pretreatment maserasi, microwave, ultrasonik dan fermentasi dapat meningkatkan rendemen dan mempengaruhi profil senyawa minyak gaharu.
Penggunaan Obat Herbal pada Responden COVID-19 yang Menjalani Isolasi Mandiri Restinia, Mita; Aldrat, Hendri; Pangestuti, Alia Dening; Musir, Ahmad
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32294

Abstract

COVID-19 is an infectious disease caused by spreading the coronavirus worldwide. In Indonesia, COVID-19 patients with mild symptoms can undergo independent isolation at home. The public widely uses herbal medicines in the treatment of COVID-19. A non-experimental cross-sectional study was performed to identify the profile of the use of herbal medicines by COVID-19 respondents during independent isolation in South Tangerang. The sampling technique conducted purposive sampling on 96 respondents who met the inclusion criteria. The instrument used is a questionnaire with close-formatted and open-ended questions. Questionnaires were distributed online from March to May 2022. The most used herbal medicines were honey (85.4%), ginger (52.1%), propolis (35.4%), turmeric (32.3%) and garlic (26%). The reason respondents used herbs because they were made from natural ingredients (84.4%), the method of use was boiled or brewed (58.3%), information on the use of herbal medicines was obtained from the family (63.5%), the source of obtaining herbal medicines was sent by relatives/family/friends (69.8%), the duration of using herbal medicines is 1-7 days (39.6%), the time to use herbal medicines was generally in the morning (49%), and the cost of herbal medicines is IDR 100,000 - 500,000 (44.8%). Through this research, it can be concluded that South Tangerang City's people still use herbal medicines as an alternative treatment while infected with COVID-19. Therefore, further education on the safety and maximum use of herbal medicines is required.
Penggunaan Tumbuhan Obat Sebagai Penunjang Kesehatan pada Masyarakat Betawi Aldrat, Hendri; Wulandari, Winda Trya; Restinia, Mita
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 1 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i1.32588

Abstract

Changes in land use from rice fields and plantations to residential areas, offices, and trading complexes will certainly result in changes in the biodiversity of the environment of the inhabitants of the capital city of Jakarta, including the Betawi community. The scarcity of certain species due to land conversion also affects people’s ethnobotanical knowledge. This study aimed to explore how the Betawi people, with the rapid flow of urbanization, use medicinal plants around them. A total of 25 respondents of the selected Betawi ethnicity were interviewed about the use of medicinal plants. Purposive sampling and snowball sampling were used. The data obtained from the respondents were collected and compared using triangulation techniques with previously published ethnobotanical reports. The results showed that as many as 61 species from 36 families were used by the Betawi people to support their health. Ginger, lemongrass, and jatropha are the most widely used plants. The most widely used species belong to the Zingiberaceae family. The most commonly used part is the leaves (55%), the most common processing method is boiling (48%), the most common way to administer the medicine is by drinking (49%), and as much as 61% of medicinal plants are used in the home. In conclusion, the Betawi people still maintain the tradition of using herbal medicine amidst the high rate of urbanization in the capital city of Jakarta. Furthermore, it is necessary to conduct further experiments in the laboratory to validate the safety, efficacy, and identification of the active ingredients in these plants. 
Pengaruh Praperlakuan Fermentasi Fusarium terhadap Rendemen dan Profil Kimia Hidrodistilasi Minyak Gaharu Defiza, Defiza; Ningsih, Handaryni Ratna; Supandi, Supandi; Aldrat, Hendri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 6 No. 2 (2024)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v6i2.42108

Abstract

Gaharu dari Aquilaria sp. telah menjadi wewangian resin alami yang berharga selama ribuan tahun, dihargai karena keunikan dan aromanya. Namun, kelangkaannya di alam liar telah mendorong strategi inovatif untuk meningkatkan produksi, mulai dari membangun perkebunan berkelanjutan hingga mengoptimalkan metode penyulingan. Penelitian ini menyajikan pendekatan untuk meningkatkan hasil gaharu melalui pretreatment fermentasi menggunakan Fusarium sp. untuk jangka waktu 1 hingga 4 minggu. Setelah itu, hidrodistilasi dan analisis komponen minyak gaharu dilakukan menggunakan GC-MS (Gas Chromatography-Mass Spectrometry). Hasil menunjukkan peningkatan rendemen gaharu, bersama dengan profil kimia yang diperkaya, yang menunjukkan efektivitas praperlakuan Fusarium sp. sebelum hidrodistilasi. Penelitian ini tidak hanya membuka jalan bagi produksi gaharu yang berkelanjutan, tetapi juga menyoroti potensi besar pemanfaatan metode alami untuk meningkatkan aroma dari produk bernilai ekonomis tinggi ini.
Genealogy of the Raja Alam Pagaruyung Dynasty in Kitab Salasilah Rajo-Rajo di Minangkabau (1336-1825) Kurnia, Sultan; Permana, Zera; Soares, Ghio V. D; Suparmi, Suparmi; Aldrat, Hendri; Khudri, Khudri; Asmara, Adhiko E
Journal of Philology and Historical Review Vol. 1 No. 2 (2023)
Publisher : Regalia Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61540/jphr.v1i2.65

Abstract

Studies on the history and genealogy of the Raja Alam Pagaruyung are still limited, one of the reasons is the lack of written sources. Previous studies have only revealed several kings in Pagaruyung, such as Adityawarman (14th century AD), Sultan Ahmadsyah, and Gagar Alam (17th - 18th century AD). Therefore, this study aimed to explain the history and genealogy of the Raja Alam Pagaruyung from the 14th century to the 19th century AD. This study used historical research methods: heuristics, source criticism, interpretation, and historical writing. The two main sources are a photocopy and the translation book of Kitab Salasilah Rajo-Rajo di Minangkabau manuscript. The results of this study showed that the Raja Alam Pagaruyung Dynasty was the descendant of previous king dynasties, namely the dynasty of kings in Bukit Siguntang (Palembang), Sumpur Sireno Puro, Malayu Tapi Air Jambi, and Ranah Tiga Laras (Dharmasraya). The existence of Raja Alam is related to Dewang Palakama Raja Indra Dewawana (Adityawarman) as Raja Undang in the Rajo Tigo Selo concept (1336-1376). Later, the term Raja Undang was changed to Raja Alam by Dewang Pandan Putowano as the fourth king (1420 – 1457). The first 12 Kings of Alam Pagaruyung reigned at Balai Gudam, but since the Yamtuan Bakilap Alam period (1543), they moved to Balai Janggo.
Pengaruh Beberapa Jenis Praperlakuan Terhadap Peningkatan Rendemen Hidrodistilasi Minyak Atsiri Gaharu Aldrat, Hendri; Khoerunnisa; Wandani, Karina; Supandi; Musdja, M. Yanis
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.49005

Abstract

Agarwood essential oil (minyak atsiri gaharu or minyak gaharu) has the potential to be developed as aromatherapy to help reduce stress, but its availability in nature is not abundant, so effective efforts are needed to get optimal results. Although various pretreatments before hydrodistillation are known to enhance the yield of agarwood oil, no comparative study using the same sample has been reported to date. This research aims to compare the yield and profile of agarwood oil compounds obtained from maceration, microwave, ultrasonic and fermentation using ragi tapai and ragi tempe pretreatments. The research was carried out by pretreatment extraction, distillation of agarwood powder, identification of essential oil compounds via Gas Chromatography Mass Spectrometry (GC-MS), and hedonic tests. The distillation results showed that pretreatment yeast tapai fermentation had the highest percentage yield of agarwood oil at 0.050% followed by Fusarium sp fermentation. (0.036%), ultrasonic (0.034%), microwave (0.030%), maceration (0.024%), control (0.018%) and ragi tempe (0.002%). Six compounds were consistently found in each sample, such as α-agarofuran, neoisolongifolene, α-santalol, δ-guaiene, dihydrocolumellarin, and hexadecanoic acid. The most sesquiterpene compounds were obtained from pretreatment using tempeh yeast. Based on the research results, it is known that maceration, microwave, ultrasonic and fermentation pretreatments can increase the yield and influence the compound profile of agarwood oil.
Co-Authors Asmara, Adhiko E Az Zahra, Alfiyah Cosphiadi Irawan Defiza, Defiza Khoerunnisa Khudri, Khudri Kurnia, Sultan Maksum Radji Mita Restinia Musdja, M. Yanis Musir, Ahmad Ningsih, Handaryni Ratna Pangestuti, Alia Dening Permana, Zera Soares, Ghio V. D Supandi Suparmi Suparmi Wandani, Karina Wulandari, Winda Trya Yahdiana Harahap