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All Journal Majalah Obat Tradisional Pharmascience Kesmas Indonesia: Jurnal Ilmiah Kesehatan Masyarakat Acta Pharmaciae Indonesia : Acta Pharm Indo Syntax Literate: Jurnal Ilmiah Indonesia PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JURNAL FARMASI GALENIKA Jurnal Ilmiah Medicamento Jurnal Buana Farma Jurnal Pengabdian dan Pengembangan Masyarakat Indonesia Journal of Global Pharma Technology Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Kefarmasian Indonesia Journal of Pharmacopoeia
Genatrika, Erza
Fakultas Farmasi, Universitas Muhammadiyah Purwokerto
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Journal of Global Pharma Technology

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Physical Stability of Commonly Used Medication Administered by Parenteral Nutrition Admixtures in Hospital: A Systematic Review Erza Genatrika
Journal of Global Pharma Technology Volume 12 Issue 06 (2020) June 2020
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Inpatients requiring parenteral nutrition (PN) often need to receive intravenous medication, but physical instability can occur between medications and PN. This review aimed to bring together the available literature on the physical stability of medication with PN used in hospitals. Methods: We conducted a systematic electronic literature search of PubMed, Science Direct, and SpringerLink during the period 2009-2019 for all English language research publications evaluating the physical stability of commonly used medication administered by PN in hospital. Results: Out of 88 studies, 7 studies selected for this review. From all studies conducted in this review found 14 combinations of drugs that are not compatible with PN admixtures, including levetiracetam, albumin, amoxicillin, cefepime, esomeprazole, fluorouracil, pantoprazole, tropics, trace elements, vitamins, and vancomycin. For adding medications directly to the PN solution, specific criteria should be considered, such as physicochemical properties of the ingredients and drug concentration. Conclusion: The stability of IV medications and PN is an important concern in delivering safe and effective medication and nutritional therapy. The role of healthcare professionals is needed to avoid this incident so that patient safety can be guaranteed. Keywords: Parenteral nutrition, Drug, Medication, Stability, Physical.
Co-Authors Aditya Singgih Raharjo Aisali, Ledyta Asa Andi Nurul Annisa Anjar Mahardian Kusuma Annisa, Andi Nurul Annissya, Widia Primi Arif Budiman Asmiyenti Djaliasrin Djalil Bayu Satria Nugroho Putra Biky, Muhammad Amir Djoko Wahyono Dwi Hartanti Ferliati, Rosi Eka Fitri, Adriana Eka Hasyyati, Uqie Shabrina Ika Yuni Astuti Indri Hapsari Indri Hapsari Irma Nur Pahalawati Irmas Miranti Isna Nurkhikmah Ivani, Adhika Rifki Julyanti, Ai Rian Mayang Ika Oktaviana Nofita Fitri Kurniasih Pratama, Okta Nurandi Pratika Azzahra Puteri Khazizah Isnaini Rossy Faizah Nur Utami Setyaningrum, Nenden Setyaningsih, Ike Budi Siti Musyarofah Sundhani, Elza Susanti, Susanti Tika Ambarwati Trisna Rohmiyati Wahyu Utaminingrum Widyowati, Ulfi Wijayanto, Yayat Yola Anggraeni Zainur Rahman Hakim