Article Per Year (5 Year)
p-Index From 2021 - 2026
1.881
P-Index
This Author published in this journals
All Journal Pharmaciana: Jurnal Kefarmasian Research Journal of Life Science Journal of Mathematical and Fundamental Sciences JURNAL PHARMASCIENCE Farmasains : Jurnal Ilmiah Ilmu Kefarmasian PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASI GALENIKA Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Indonesian Journal of Global Health research BERNAS: Jurnal Pengabdian Kepada Masyarakat Mattawang: Jurnal Pengabdian Masyarakat MAHESA : Malahayati Health Student Journal Media Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Lontara Journal Of Health Science And Technology Jurnal Kefarmasian Indonesia Jurnal Sains dan Kesehatan Journal of Pharmascience
Asmiyenti Djaliasrin Djalil
Universitas Muhammadiyah Purwokerto
Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

Published : 25 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 25 Documents
Search

 1   2   3 
Hubungan Kuantitatif Struktur-Aktifitas dan Doking Molekular Senyawa Meso-Tetraphenylporphyrin dan Meso-Tetraphenylchlorin sebagai Fotosensitizer untuk Terapi Fotodinamik Djalil, Asmiyenti Djaliasrin; Saputri, Nurul Fadhilah Deni; Suparman, Suparman; Hamad, Alwani
JURNAL PHARMASCIENCE Vol 3, No 1 (2016): JURNAL PHARMASCIENCE
Publisher : JURNAL PHARMASCIENCE

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Terapi fotodinamik (Photodynamic Therapy/PDT) merupakan metode alternatif pengobatan kanker yang selektif. Terapi ini memerlukan fotosensitizer yang diberi penyinaran dalam lingkungan oksigen sehingga dihasilkan oksigen singlet yang mampu menghancurkan sel kanker dan merusak jaringan. Meso-tetraphenylchlorin (MTPP) dan meso-tetraphenylporphyrin (MTPC) adalah fotosensitizer yang memiliki struktur molekul yang mirip, hanya berbeda kejenuhan pada satu cincin pirolnya. MTPP adalah tetrapirol makrosiklik dengan cincin pirol tidak tereduksi sedangkan struktur MTPC tereduksi pada salah satu cincin pirolnya. Penelitian ini bertujuan untuk memprediksi hubungan antara struktur tetrapirol makrosiklik terhadap aktivitasnya secara in silico. Analisis hubungan kuantitatif-struktur aktifitas (HKSA) menggunakan serangkaian senyawa turunan porfirin dilakukan untuk memperoleh persamaan yang secara statistik memiliki kemampuan korelatif dan prediktif. Perangkat lunak Molecular Operating Environment (MOE) digunakan untuk melakukan analisis HKSA. Doking molekul dilakukan terhadap human serum albumine (HSA) dan  peripheral benzodiazepine receptor (PBR) untuk memperoleh energi doking yang berhubungan dengan energi afinitas antara ligan dan reseptor. Simulasi doking dilakukan dengan menggunakan perangkat lunak AutoDock. Hasil menunjukkan bahwa MTPC memiliki energi doking terhadap HSA dan PBR yang paling baik. Analisis HKSA yang diperoleh  menunjukkan bahwa MTPC lebih potensial sebagai fotosensitizer yang ditunjukkan dengan nilai IC50 yang lebih kecil.  Kata kunci: doking molekular, fotosensitizer, HKSA, MTPC, MTPP, PDT
Isolation, identification, phytochemical screening, and antibacterial activity of Aspergillus sp. MFD-01, an endophytic fungus derived from Mesua ferrea Hartanti, Dwi; Andestia Sinaga, Risda Yunita; Djalil, Asmiyenti Djaliasrin; Wahyuningrum, Retno
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.676 KB) | DOI: 10.12928/pharmaciana.v8i2.10009

Abstract

We have successfully isolated and identified endophytic fungi from medicinal plant Mesua ferrea L. grown at Banyumas were for the first time. One of those fungi was MFD-01. In this study, we report the isolation, identification, antibacterial activity, and phytochemical screening of Aspergillus sp. MFD-01. The endophytic fungus was isolated from the leaves of M. ferrea by subsequent inoculation on potato dextrose agar (PDA). The identification was based on its morphology and ITS-DNA sequence. The antibacterial activity was determined by dilution method. The identification of compounds in ethyl acetate extract of it was conducted according to the standart phytochemical screening method. MFD-01 was identified as Aspergillus sp. MFD-01. The ethyl acetate extract of Aspergillus sp. MFD-01 inhibited the growth of both Staphylococcus aureus, and Escherichia coli. At concentration of 1000 ppm, its diameter of inhibitory zone against those bacteria was 10.53 and 11.84, respectively. The extract contained flavonoids, alkaloids, saponins, terpenoids, and tannins, which might responsible for its antibacterial activity against both tested bacteria.
Formulasi Krim Antibakteri Ekstrak Teripang Pasir (Holothuria scabra Jaeger) Djalil, Asmiyenti Djaliasrin; Ivani, Adhika Rifki; Genatrika, Erza
JURNAL FARMASI GALENIKA Vol 4 No 3 (2017): Jurnal Farmasi Galenika Volume 4 No. 3, 2017
Publisher : Sekolah Tinggi Farmasi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.639 KB)

Abstract

Penelitian ini bertujuan untuk membuat formulasi dan mengevaluasi krim antiacne yang mengandung ekstrak metanol teripang pasir (Holothuria scabra Jaeger, 1833).  Aktivitas antiacne ekstrak dan krim pada berbagai konsentrasi ekstrak diteliti terhadap bakteri Staphylococcus aureus dan Propionibacterium acnes menggunakan metode difusi agar dengan kertas cakram.  Krim antiacne disiapkan dengan mencampurkan bahan-bahan dengan jumlah tertentu dengan ekstrak pada berbagai konsentrasi (0,05%; 0,1%; 0,2%). Krim yang dibuat dievaluasi sifat fisik dan reologi. Selanjutnya efikasi krim antiacne dibandingkan dengan produk komersial. Hasil penelitian menunjukkan bahwa ekstrak memiliki aktivitas antiacne yang baik, aktivitas semakin meningkat dengan meningkatnya konsentrasi ekstrak. Aktifitas antiacne tetap dimiliki pada saat ekstrak dibuat krim. Semua formula krim menunjukkan viskositas, daya sebar, pH, dan daya lekat yang baik. Krim juga menunjukkan kestabilan yang baik selama 1 bulan penyimpanan. Krim yang mengandung ekstrak teripang pasir berpotensi untuk dikembangkan sebagai krim antiacne untuk infeksi kulit yang disebabkan oleh Staphylococcus aureus and Propionibacterium acnes.
PENETAPAN KADAR AMIODARON HIDROKLORIDA DALAM TABLET MENGGUNAKAN METODE RP HPLC-UV Djalil, Asmiyenti Djaliasrin; Kumala, Rosa; Subagio, Resita
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol 5 No 2 (2018)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (567.304 KB) | DOI: 10.22236/farmasains.v5i2.2388

Abstract

Metode Kromatografi Cair Kinerja Tinggi Fase Balik ? Ultra Violet (KCKT FB ? UV) telah dikembangkan untuk menentukan kadar amiodaron hidroklorida dalam tablet. Metode kromatografi cair ini menggunakan kolom Shim-pack CLC-ODS column (C18) untuk pemisahan dengan detektor UV pada panjang gelombang 242 nm. Elusi isokratik dilakukan menggunakan fase gerak campuran methanol : asetonitril : buffer (25 mM KH2PO4 + 3 mM H2SO4 + 3,6 mM trietilamina)  (63:12:25, v/v/v) dengan laju alir 0,8 mL/menit.  Metode analisis divalidasi dengan parameter meliputi limit deteksi, limit kuantitasi, kisaran konsentrasi analisis, presisi, dan akurasi. Hasil validasi menunjukan linearitas yang baik pada kisaran konsentrasi amiodaron hidroklorida 2-10 ?g mL-1. Perolehan kembali yang tinggi dan standar deviasi pengukuran yang rendah menunjukkan bahwa metode ini sesuai untuk analisis rutin amiodaron hidroklorida dalam tablet.
Isolation, identification, phytochemical screening, and antibacterial activity of Aspergillus sp. MFD-01, an endophytic fungus derived from Mesua ferrea Dwi Hartanti; Risda Yunita Andestia Sinaga; Asmiyenti Djaliasrin Djalil; Retno Wahyuningrum
Pharmaciana Vol 8, No 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (215.676 KB) | DOI: 10.12928/pharmaciana.v8i2.10009

Abstract

We have successfully isolated and identified endophytic fungi from medicinal plant Mesua ferrea L. grown at Banyumas were for the first time. One of those fungi was MFD-01. In this study, we report the isolation, identification, antibacterial activity, and phytochemical screening of Aspergillus sp. MFD-01. The endophytic fungus was isolated from the leaves of M. ferrea by subsequent inoculation on potato dextrose agar (PDA). The identification was based on its morphology and ITS-DNA sequence. The antibacterial activity was determined by dilution method. The identification of compounds in ethyl acetate extract of it was conducted according to the standart phytochemical screening method. MFD-01 was identified as Aspergillus sp. MFD-01. The ethyl acetate extract of Aspergillus sp. MFD-01 inhibited the growth of both Staphylococcus aureus, and Escherichia coli. At concentration of 1000 ppm, its diameter of inhibitory zone against those bacteria was 10.53 and 11.84, respectively. The extract contained flavonoids, alkaloids, saponins, terpenoids, and tannins, which might responsible for its antibacterial activity against both tested bacteria.
Phytochemical analysis, FTIR fingerprint and bioactivity of crude extract and fractions of Mesua ferrea L. Dwi Hartanti; Zainur Rahman Hakim; Anna Nurlativah; Arinda Nur Cahyani; Fadhilah Zahra Nadia; Asmiyenti Djaliasrin Djalil
Research Journal of Life Science Vol 6, No 1 (2019)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.rjls.2019.006.01.7

Abstract

Mesua ferrea L. (Ceylon ironwood, Calophyllaceae) is a popular medicinal plant with a long history in South and Southeast Asia folk medicines. In this study, we report the phytochemical analysis, FTIR fingerprint, as well as antimicrobial and antioxidant activities of the crude extract of leaves of M. ferrea and its fractions. The dried leaves of M. ferrea were extracted with ethanol by the re-maceration method. The crude extract was further partitioned in ethanol-water and ethyl acetate to obtain ethanol and ethyl acetate fractions, respectively. The identification of compounds in the extract and fractions was conducted according to the standard phytochemical screening method. Fourier-transform infrared spectroscopy (FTIR) was utilized to record their metabolites fingerprint. The antimicrobial activity was evaluated with the disk diffusion method against Escherichia coli, Bacillus subtilis, Candida albicans, and Saccharomyces cerevisiae. The antioxidant activity assay was conducted with 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. The crude extract of M. ferrea leaves and it fractions contained saponins, phenolic compounds, flavonoids, and terpenoids. The FTIR data supported the presence of terpenoids and glycosides in those samples as well. The extract and fractions demonstrated considerable antimicrobial activity against all tested bacteria and fungi, with MIC values ranged 3.9-31.3 μg/ml.  The ethyl acetate fraction of M. ferrea leaves showed a moderate antioxidant activity with an IC50 value of 49.19 μg/ml. 
Molecular modeling on the identification of potential Janus Kinase 3 (JAK3) inhibitor based on the Indonesian Medicinal Plant Database Muhammad Arba; Sanang Nur Safitri; Andry Nur Hidayat; Arry Yanuar; Muhammad Sulaiman Zubair; Asmiyenti Djaliasrin Djalil; Daryono Hadi Tjahjono
Journal of Mathematical and Fundamental Sciences Vol. 52 No. 3 (2020)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2020.52.3.2

Abstract

The Janus tyrosine kinases (JAKs) have shown great promise as therapeutic protein targets in the treatment of cancer and inflammation diseases. This study used pharmacophore modeling to identify potential inhibitors of Janus kinase 3 (JAK3). A pharmacophore model was developed based on a known JAK3 inhibitor (1NX) and was employed to search for potential JAK3 inhibitors against Indonesian herbal compounds. Among 28 hit molecules that were identified and subjected to a molecular docking protocol against JAK3, the three compounds that had the highest affinities toward JAK3 were camelliaside B, 3-O-galloylepicatechin-(4beta-6)-epicatechin-3-O-gallate, and mesuaferrone B. These were then each subjected to a 50-ns molecular dynamics (MD) simulation. Analysis of RMSD and RMSF values indicated that the three compounds reached stability during the MD simulation. Interestingly, all three compounds had lower binding energies than 1NX against JAK3, as predicted by the MM-PBSA binding energy calculation.
Preservation Potential of Galangal Water Extract on Tofu Alwani Hamad; Asmiyenti Djaliasrin Djalil; Tina Syah Putri; Dwi Hartanti
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 18 No. 02 Desember 2021
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v18i2.13630

Abstract

Galangal (Alpinia galanga (L.) Willd.) has been long used for medicinal purposes. It showed promising effects on the food-spoilage microorganisms and is commonly used as spices in various cuisines. This study aimed to evaluate the microbial growth inhibitory activity and the preservation potential of galangal water extracts on tofu. The water extracts were prepared by infundation method in the concentrations of 5, 10, and 20%w/v. The phytochemical compounds in the extracts were screened as per standard methods. The tofu was preserved by immersion method for eight days under room temperature with an evaluation time point of two days. The microbial growth inhibitory activity was evaluated by indirect optical density (OD)-based enumeration, and the OD reduction by the extracts was calculated accordingly. The preservation potential was calculated from the changes of the physical characters on tofu evaluated by sensorial analysis. Galangal water extracts contained tannins and terpenoids. It concentration- dependently inhibited microbial growth on tofu, and the extract showed the best OD reduction at a concentration of 20%. It changed the color of tofu but maintained its texture. It also masked the odor of fresh tofu with the aromatic galangal scent. All three tested concentrations showed an equal preservation potential of 2 days. Our data suggested galangal water extract in the optimum concentration of 20% inhibited the microbial growth on tofu and potentially preserved it for two days. This moderate preservation effect might be attributable to its tannins and terpenoids content.
PENETAPAN KADAR IBUPROFEN DALAM TABLET SERTA APLIKASINYA PADA PLASMA TIKUS JANTAN WISTAR SECARA IN VITRO DENGAN METODE KCKT Susanti Susanti; Aditya Hanif Evridianto; Ika Diandana Yulia Asmara; Asmiyenti Djaliasrin Djalil
Molekul Vol 9, No 2 (2014)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.822 KB) | DOI: 10.20884/1.jm.2014.9.2.165

Abstract

Telah dilakukan penelitian mengenai pengembangan metode KCKT dalam penetapan kadar tablet ibuprofen dalam plasma darah tikus jantan wistar secara in vitro. Metode  divalidasi berdasarkan parameter linearitas, akurasi, dan presisi. Kondisi KCKT yang digunakan adalah fase terbalik dengan kolom shim pack CLC ODS dan fase gerak asetonitril:bufer fosfat (35:65 v/v), laju alir 0,8 mL/min. Hasil uji linearitas menunjukan nilai r = 0,993 pada kisaran konsentrasi 0,5-5 μg/mL, presisi 0,93 (%RSD), dan perolehan kembali 92,9%. Penentuan ibuprofen dalam tablet generik dan merek pada matriks  plasma tikus jantan wistar menghasilkan persen kadar pada kisaran antara 80-100%. Telah dilakukan penelitian mengenai pengembangan metode KCKT dalam penetapan kadar tablet ibuprofen dalam plasma darah tikus jantan wistar secara in vitro. Metode  divalidasi berdasarkan parameter linearitas, akurasi, dan presisi. Kondisi KCKT yang digunakan adalah fase terbalik dengan kolom shim pack CLC ODS dan fase gerak asetonitril:bufer fosfat (35:65 v/v), laju alir 0,8 mL/min. Hasil uji linearitas menunjukan nilai r = 0,993 pada kisaran konsentrasi 0,5-5 μg/mL, presisi 0,93 (%RSD), dan perolehan kembali 92,9%. Penentuan ibuprofen dalam tablet generik dan merek pada matriks  plasma tikus jantan wistar menghasilkan persen kadar pada kisaran antara 80-100%
Bay leaf essential oils inhibited microbial growth and exerted potential preservation effects on tofu Alwani Hamad; Asmiyenti Djaliasrin Djalil; Eka Yuliani Saputri; Nur Yulianingsih; Dwi Hartanti
Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE) Vol 3, No 2 (2020)
Publisher : Advances in Food Science, Sustainable Agriculture and Agroindustrial Engineering (AFSSAAE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.afssaae.2020.003.02.2

Abstract

Cattle manure contains high organic matter, so that this material is commonly used as plant nutrients in a form of organic fertilizer. In order to get a better understanding on the use of cow manure, the objectives of this research are (1) to determine the influence of liquid waste and solid livestock as fertilizer on soil quality and (2) to study the effect of both liquid and solid fertilizer on coffee plant growth. In this research, Completely Randomized Design (CRD) was employed as a research design, while data analysis was conducted using ANOVA. The F statistical test was applied to measure whether all independent variables could influence the dependent variable by using 5% and 1% (Alpha) degrees. The results showed that one time application of livestock wastewater improved C-organic chemical properties, N, P, CEC, Ca and Mg while soil chemical properties of pH, K, Na decreased. Two times application of livestock liquid fertilizer treatment improved soil chemical properties pH, N total, Ca, Mg and saturation bases. As for solid waste, one time treatment increased chemical properties of pH, C organic, N total, Ca and saturation of the base. The two times treatment could improve soil chemical properties of pH, N. total, P, Ca, Mg, base number and base saturation. Liquid waste fertilizer also found to provide significant effect on plant height and coffee plants quality. Additionally, (3) solid waste (compost) was found to have a significant effect on plant height, plant height rate and number of buds.
Co-Authors Aditya Hanif Evridianto Agus Siswanto Aisyah Aisyah Alwani Hamad Andestia Sinaga, Risda Yunita Andestia Sinaga, Risda Yunita Andry Nur Hidayat Anna Nurlativah Arba, Muhammad Arinda Nur Cahyani Arry Yanuar Ayu Mulyani Azzahra, Ratu Balqis , Alifa Tiara Bayu Satria Nugroho Putra Daryono Hadi Tjahjono Dhanti , Kurnia Ritma Dhanti, Kurnia Ritma Dwi Hartanti Dwi Hartanti Dwi Hartanti Dwi Hartanti Eka Yuliani Saputri Eli Nurlaeli, Eli Fadhilah Zahra Nadia Fadlilah, Intan Nur Genatrika, Erza Hartanti, Dwi Hasnita Ika Diandana Yulia Asmara Ika Yuni Astuti Ika Yuni Astuti Indrawati, Uli Mas'uliyah Ivani, Adhika Rifki Kumala, Rosa Muhammad Sulaiman Zubair Mulyani, Ayu Nur Yulianingsih Nurul Fadhilah Deni Saputri Nurul Fadhilah Deni Saputri, Nurul Fadhilah Deni Pradani, Dea Yulinestria Pri Iswati Utami Rahmawati, Tias Eka Regawa Bayu Pamungkas Retno Sulistiyowati Retno Wahyuningrum Risda Yunita Andestia Sinaga Sanang Nur Safitri Siti Musyarofah Subagio, Resita Suparman Suparman Suparman Susanti, Susanti Syah Putri, Tina Tina Syah Putri Wahyu Utaminingrum Widyowati, Ulfi Wiranti Sri Rahayu Yulianingsih, Nur Zainur Rahman Hakim