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All Journal Pharmaciana: Jurnal Kefarmasian Berkala Kedokteran SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Devi, Wivina Riza
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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PERBEDAAN KADAR UREUM DAN KREATININ PADA PREEKLAMPSIA DAN PREEKLAMPSIA BERAT Annisa, Haima; Yuseran, Hariadi; Hendriyono, Fransiskus Xaverius; Abimanyu, Bambang; Devi, Wivina Riza
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12379

Abstract

Abstract: Preeclampsia is pregnancy disorder (>20 weeks) characterized by hypertension with or without proteinuria. Failure trophoblast invasion in preeclampsia results impaired spiral artery remodeling, hypoxia, placental ischemia, endothelial dysfunction and kidney dysfunction. Kidney dysfunction cause urea and creatinine increase. This research aims determine the difference in urea and creatinine of preeclampsia versus severe preeclampsia at RSUD Ulin Banjarmasin 2020-2022. Analytical observational, retrospective cross-sectional. There were 60 preeclampsia and severe preeclampsia subjects at RSUD Ulin 2020-2022 according inclusion and exclusion criteria, non-probability sampling. Research results for median preeclampsia urea 13.0 mg/dL, minimum value 5.0 mg/dL, maximum value 75.0 mg/dL and median severe preeclampsia 30 mg/dL, minimum value 9.0 mg/dL, maximum value 100 mg/dL. Median preeclampsia creatinine 0.6 mg/dL, minimum value 0.14, maximum value 1.51 mg/dL and mean severe preeclampsia 1.0 mg/dL, standard deviation 0.41 mg/dL. There is significant difference in urea and creatinine in preeclampsia and severe preeclampsia, p=0.000 and p=0.001. Keywords: preeclampsia, severe preeclampsia, ureum, creatinine, RSUD Ulin Banjarmasin. Abstrak: Preeklampsia merupakan kelainan kehamilan (>20 minggu) ditandai hipertensi dengan atau tanpa proteinuria. Gagalnya invasi trofoblas pada preeklampsia mengakibatkan gangguan remodeling arteri spiralis, hipoksia, iskemia plasenta, disfungsi endotel dan berakhir pada disfungsi ginjal. Gangguan ginjal menyebabkan ureum dan kreatinin meningkat. Tujuan penelitian mengetahui perbedaan ureum dan kreatinin preeklampsia terhadap preeklampsia berat di RSUD Ulin Banjarmasin 2020-2022. Metode observasional analitik studi cross sectional retrospektif. Terdapat 60 subjek preeklampsia dan preeklampsia berat di RSUD Ulin Banjarmasin 2020-2022 sesuai kriteria inklusi dan eksklusi, teknik non-probability sampling. Hasil penelitian ureum preeklampsia median 13,0 mg/dL, nilai minimum 5,0 mg/dL, nilai maksimum 75,0 mg/dL dan preeklampsia berat median 30 mg/dL, nilai minimum 9,0 mg/dL, nilai maksimum 100 mg/dL. Kreatinin preeklampsia median 0,6 mg/dL, nilai minimum 0,14, nilai maksimum 1,51 mg/dL dan preeklampsia berat rerata 1,0 mg/dL, simpang baku 0,41 mg/dL. Kesimpulan: Terdapat perbedaan bermakna ureum dan kreatinin pada preeklampsia dan preeklampsia berat, nilai p=0,000 dan p=0,001. Kata-kata kunci: preeklampsia, preeklampsia berat, ureum, kreatinin, RSUD Ulin Banjarmasin
PERBEDAAN AKTIVITAS SGOT, SGPT DAN LDH PADA PREEKLAMPSIA DAN PREEKLAMPSIA BERAT Amelia, Fakhrina; Yuseran, Hariadi; Hendriyono, Fransiskus Xaverius; Abimanyu, Bambang; Devi, Wivina Riza
Homeostasis Vol 7, No 1 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i1.12376

Abstract

Abstract: Preeclampsia is characterized by hypertension and proteinuria at gestational age >20 weeks. Preeclampsia occurs when endothelial dysfunction triggers organ damage, one of which is the liver. Cellular damage in the liver causes an increase in SGOT, SGPT and LDH. The research aims to determine whether there are differences in SGOT, SGPT and LDH activity in pregnant women with preeclampsia and severe preeclampsia. This type of research is an analytical observational, retrospective cross-sectional study. There were 60 subjects who met the inclusion criteria. Preeclampsia SGOT, SGPT and LDH activity had a median of 22 units/L, 12 units/L and 429 units/L, minimum values of 13 units/L, 3 units/L and 37 units/L, maximum values of 55 units/L, 53 units /L and 989 units/L. SGOT, SGPT and LDH activity in severe preeclampsia had a median of 61 units/L, 40 units/L and 811 units/L, minimum values of 41 units/L, 15 units/L and 402 units/L, maximum values of 1161 units/L, 977 units/L and 1756 units/L. Conclusion: There was a significant difference in SGOT, SGPT and LDH activity in preeclampsia and severe preeclampsia (p=0.000). Keywords: preeklampsia, severe preeklampsia, Serum Glutamic Oxaloacetic Transaminase, Serum Glutamic Pyruvic Transaminase, Lactate Dehydrogenase Abstrak: Preeklampsia ditandai hipertensi dan proteinuria pada usia kehamilan >20 minggu. Preeklampsia terjadi disfungsi endotel memicu terjadinya kerusakan organ salah satunya organ hati. Kerusakan seluler di hati menyebabkan peningkatan SGOT, SGPT dan LDH. Penelitian bertujuan mengetahui apakah terdapat perbedaan aktivitas SGOT, SGPT dan LDH pada ibu hamil preeklampsia dan preeklampsia berat. Jenis penelitian observasional analitik, studi cross sectional retrospektif. Didapatkan 60 subjek yang sesuai kriteria inklusi. Aktivitas SGOT, SGPT dan LDH preeklampsia mempunyai median 22 unit/L, 12 unit/L dan 429 unit/L, nilai minimum 13 unit/L, 3 unit/L dan 37 unit/L, nilai maksimum 55 unit/L, 53 unit/L dan 989 unit/L. Aktivitas SGOT, SGPT dan LDH preeklampsia berat mempunyai median 61 unit/L, 40 unit/L dan 811 unit/L, nilai minimum 41 unit/L, 15 unit/L dan 402 unit/L, nilai maksimum 1161 unit/L, 977 unit/L dan 1756 unit/L. Kesimpulan : didapatkan perbedaan bermakna aktivitas SGOT, SGPT dan LDH pada preeklampsia dan preeklampsia berat (p=0,000). Kata-kata kunci: preeklampsia, preeklampsia berat, Serum Glutamic Oxaloacetic Transaminase, Serum Glutamic Pyruvic Transaminase, Laktat Dehidrogenase
Effect of Heavy Metal Polluted River Water on Body Weight and Hemoglobin Level in White Rats (Rattus novergicus) Hendriyono, Franciscus Xaverius; Devi, Wivina Riza; Rosida, Azma; Hidayat, Taufiq
Berkala Kedokteran Vol 20, No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v20i1.18783

Abstract

Contamination of heavy metal on the South Kalimantan River has become a well thrived issue. In the Barito River watershed, it is reported that there are heavy metals in the form of Pb, Hg and Cd. Heavy metals can affect physiological anatomical changes and the hematopoietic system. This study aims to determine the impact of heavy metal contamination on changes in body weight and hemoglobin levels. The research method is a true laboratory experiment using a pre-post-test group design. The subjects used were healthy male white rats (Rattus norvegicus), aged 2-6 months and weighing 250-300 gr. The research group was divided into two groups, the control group (K) was a group of experimental animals that were given distilled water while the treatment group (P) was a group of experimental animals that were given water contaminated with heavy metals (Pb, Cd, and Hg) ad libitum for 30 days. The results showed that there was no effect of giving Pb metal; 0.01 mg/l = 0.006 mg/kgBW, Cd; 0.003 mg/l = 0.018 mg/kgBW, Hg; 0.001 mg/l = 0.0006 mg/kgBW and Pb+Cd+Hg; 0.006 mg/kgBB + 0.018 mg/kgBB + 0.0006 mg/kgBB on body weight of white rats. There was a significant decrease in Hb levels in white rat hemoglobin after administration of Pb metal; 0.01 mg/l = 0.006 mg/kgBB. Pb metal in water can influence changes in decreasing Hb levels during sub-acute administration. It can be concluded that there was a significant difference in hemoglobin levels before and after giving water containing Pb/lead metal, whereas in the other groups there was no significant difference, as did the Hb levels.
The Difference between Coagulation Profile and Fibrinolysis in Acute and Chronic Leukemia Patients Limijadi, Edward Kurnia Setiawan; Devi, Wivina Riza; Tjitradinata, Cynthia
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 2 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i2.2331

Abstract

The incidence of acute and chronic leukemia has been increasing for years resulting in many complications, one of them being hypercoagulability. Evaluation can be conducted using coagulation testing, including PT, aPTT, and fibrinogen levels, as well as fibrinolysis assays, such as D-dimer levels. Studies about these parameters between acute and chronic leukemia in the first diagnosis of leukemia need to be evaluated. This study aimed to evaluate the difference in coagulation and fibrinolysis profiles between acute and chronic leukemia. This study was a cross-sectional observational analysis of 34 acute and chronic leukemia patients in Ulin Government Hospital, Banjarmasin from October 2019 to February 2020. PT, aPTT, fibrinogen level, and D-dimer were analyzed on COA Lab 1000. Independent T-test and Mann-Whitney test were used to analyze data. The test results of PT, aPTT, fibrinogen, and D-dimer levels, for acute and chronic leukemia, were 13.96±1.86 vs. 16.73±4.74 seconds (p=0.029); 39.63±2.43 vs. 45.87±13.98 seconds (p=0.154); 286,18±180,58 vs. 328,81±150,63 mg/dL (p=0.459); and 746±3.392 vs. 1,466.56±445,86 µg/L (p=0.731), respectively. Significant differences were found in Prothrombin Time (PT) between acute and chronic leukemia patients, while no notable distinctions were observed in activated Partial Thromboplastin Time (aPTT), fibrinogen levels, or D-dimer levels.
Acute oral toxicity test and determination of lethal dose (LD50) of Garcinia forbesii King leaf extract in wistar rats Rudiansyah, Mohammad; Rosida, Azma; Kania, Nia; Devi, Wivina Riza; Nirmalasari, Nila
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.29616

Abstract

Garcinia forbesii King, an endemic plant from Sumatra and Kalimantan, is traditionally used for treating skin infections and inflammation. Its potential use as a raw material for medicines needs to be supported by safety tests. The purpose of this study is to assess the acute toxicity of its 70% leaf extract in male Wistar rats, evaluating clinical symptoms, body weight changes, organ indices, and the lethal dose (LD50). The study administered extract doses orally at 5 (G2), 50 (G3), 300 (G4), and 2,000 (G5) mg/kg BW, monitoring toxicity signs over 14 days. Symptoms such as piloerection, respiratory distress, and soft feces were noted. Significant weight loss was observed at doses of 2,000 mg/kg BW. There was no significant effect on the kidney index, but the liver and heart indices exhibited significantly lower changes compared to the control. The LD50 value was estimated to be between 2,000-5,000 mg/kg BW. Further studies are recommended to assess histopathological effects and identify harmful chemicals in the plant.
Erratum to “The Difference between Coagulation Profile and Fibrinolysis in Acute and Chronic Leukemia Patients”[Published Issue of Indonesian Journal of Clinical Pathology and Medical Laboratory March 2025, 31(2) : p. 136] Limijadi, Edward Kurnia Setiawan; Devi, Wivina Riza; Tjitradinata, Cynthia
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2873

Abstract

This erratum is to explain a typographical error in Table 2 occurred in the published issue of Indonesian Journal of Clinical Pathology and Medical Laboratory Volume 31, Number 2 in March 2025, pages 136. The error was in writing the Fibrinogen level which should be a period, not a comma and D-dimer level in the table, which should be a comma, not a period.
Sosialisasi manfaat daun Mundar (Garcinia forbesii King) meningkatkan daya tahan tubuh dan melindungi kesehatan ginjal pada kelompok tani wanita di Desa Biih, Kecamatan Karang Intan, Kabupaten Banjar Rosida, Azma; Rudiansyah, Mohammad; Fujiati, Fujiati; Kania, Nia; Nirmalasari, Nila; Devi, Wivina Riza; Hutasoit, Rain Sastiani; Wijaya, Cecilia Octa; Putri, Felicia Cindy Tjoa
SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Vol 9, No 6 (2025): November
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jpmb.v9i6.34650

Abstract

AbstrakPemanfaatan tanaman obat tradisional merupakan praktik budaya yang penting untuk kesehatan mandiri masyarakat. Mundar (Garcinia forbesii King) sebagai tanaman asli Kalimantan, memiliki potensi farmakologis, namun bagian daunnya selama ini kurang dimanfaatkan. Kandungan fitokimia seperti alkaloid, flavonoid, dan fenol pada daun Mundar telah diidentifikasi memiliki manfaat kesehatan. Kegiatan pengabdian masyarakat ini bertujuan untuk menyebarluaskan pengetahuan ilmiah mengenai manfaat daun Mundar sebagai imunomodulator dan nefroprotektor kepada Kelompok Tani Wanita di Desa Biih, Kabupaten Banjar. Sosialisasi diberikan kepada 39 peserta dari kelompok tersebut menggunakan media informasi berupa poster. Peserta diberikan kuesioner untuk mengukur efektivitas kegiatan, dilakukan survei tingkat pengetahuan sebelum (pre-test) dan sesudah (post-test) sosialisasi. Hasilnya menunjukkan peningkatan pengetahuan yang signifikan dari distribusi pengetahuan awal yang “sedang“(38,5%) ke peningkatan pengetahuan yang “tinggi” (94,9% peserta). Kegiatan ini secara efektif berhasil meningkatkan literasi kesehatan berbasis kearifan lokal Kata kunci: Garcinia forbesii King; Mundar; imunomodulator; nefroprotektor; pengabdian AbstractTraditional medicinal plants is an important cultural practice for community self-care in the region. Mundar (Garcinia forbesii King), a plant native to Kalimantan, has pharmacological potential, although its leaves have been underutilized. Phytochemical compounds in Mundar leaves, such as alkaloids, flavonoids, and phenols, have been identified to have health benefits. This community service activity aimed to disseminate scientific knowledge about the benefits of Mundar leaves as an immunomodulator and nephroprotector to the Women Farmers Group in Biih Village, Banjar Regency. Outreach was delivered to 39 participants using posters. Participants were given questionnaires to measure the effectiveness of the activity, with a knowledge survey conducted before (pre-test) and after (post-test) the outreach program. The results showed a significant increase in knowledge, from an initial “moderate” knowledge distribution (38.5%) to a “high” level of knowledge (94.9% of the participants). This activity effectively improved health literacy based on local wisdom. Keywords: Garcinia forbesii King; Mundar; imunomodulator; nefroprotector; devotion
Peran Pemeriksaan Mutasi Gen Dead-Box Helicase 41 (DDX41) pada Sindroma Mielodisplasia Hipoplastik Raharjo, Budiono; Linggawan, Stephani; Sumarpo, Anton; Imannuel, Erica Valencia; Supriadi, Vegy; Lukito, Diane; Raharjo, Yohanes Timothy; Devi, Wivina Riza; Bintoro, Siprianus Ugroseno Yudho
Majalah Kedokteran Indonesia Vol 75 No 5 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.5-2025-1847

Abstract

Introduction: DDX41 gene mutations can occur in hematopoietic malignancies, especially acute myeloid leukemia (AML) and myelodysplastic syndrome. The average incidence of myelodysplastic syndrome (MDS) in the general population is 4.5 out of 100,000 people per year. Myelodysplastic syndrome (MDS) can occur with different genetic mutations and will provide different prognoses and therapy results. Hypoplastic myelodysplastic syndrome (MDS) is often found in 10-15% of MDS patients. There have been no case reports or research studies in Indonesia that have reported a case of hypoplastic myelodysplastic syndrome associated with a mutation in the Dead Box Helicase 41 (DDX41) gene.Case Report: A 66-year-old man presented with complaints of weakness. The patient had a history of myelodysplastic syndrome diagnosed two years earlier. Bone marrow aspiration revealed cellularity with decreased granulopoiesis and thrombopoiesis, and myeloblasts accounted for 2.0%. Genetic testing using a Next Generation Sequencing (NGS) panel identified DDX41 p.(Pro258Leu) at 47.9%, DDX41 p.(Arg525His) at 1.7%, and ASXL1 p.(Gln977Ter) at 1.6%. The patient was treated with a combination therapy of venetoclax and azacitidine. Follow-up bone marrow aspiration showed improved cellularity, increased erythropoiesis activity, and a reduction in the number of dysplastic cells. Case Discussion: Mutations in the DDX41 gene can mostly be found in cases of hypoplastic myelodysplastic syndrome, while in normocellular or hypercellular myelodysplastic syndrome, genetic mutations such as SF3B1, TET2, STAG2, ASXL1, and BCOR are mostly found. The DDX41 gene is related to cellular molecules and innate immunity. The DDX41 gene mutation is a determining factor in the administration of chemotherapy. The DDX41 gene mutation is a determining factor in the selection of chemotherapy drugs.Conclusion: DDX41 genetic testing with NGS method is essential for determining the prognosis and appropriate therapy in the management of hypoplastic myelodysplastic syndrome cases.
Co-Authors Abimanyu, Bambang Amelia, Fakhrina Annisa, Haima Anton Sumarpo Azma Rosida, Azma Bintoro, Siprianus Ugroseno Yudho Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Fachry Abda El Rahman Fujiati ., Fujiati Hendriyono, Franciscus Xaverius Hendriyono, Fransiskus Xaverius Hutasoit, Rain Sastiani Imannuel, Erica Valencia LINGGAWAN, STEPHANI Lukito, Diane Mohammad Rudiansyah Nia Kania Nila Nirmalasari, Nila Putri, Felicia Cindy Tjoa RAHARJO, BUDIONO Raharjo, Yohanes Timothy Supriadi, Vegy Tjitradinata, Cynthia Wijaya, Cecilia Octa Yuseran, Hariadi