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All Journal Bioeksperimen: Jurnal Penelitian Biologi Jambura Journal of Chemistry Jurnal Farmasi Higea Jurnal Medikes (Media Informasi Kesehatan) Bantenese Jurnal Pengabdian Masyarakat SANITAS: Jurnal Teknologi dan Seni Kesehatan Jurnal Ilmiah Kesehatan Lumbung Farmasi : Jurnal Ilmu Kefarmasian Journal of Medical Laboratory Research
Anliza, Syarah
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Potensi Antibakteri Kombinasi Ekstrak Daun Mangga (Mangifera indica L.) dan Daun Kirinyuh (Chromolaena odorata L.) Terhadap Staphylococcus aureus Anliza, Syarah; Marwin, Deisya Tyas; Rachmawati, Nurmeily; Hamtini
Journal of Medical Laboratory Research Vol. 4 No. 1 (2025): Journal of Medical Laboratory Research
Publisher : Politeknik Kesehatan Kementerian Kesehatan Banten

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Abstract

Infectious diseases caused by Staphylococcus aureus are one of the health problems occurring in Indonesia. Infectious diseases can be treated with antibiotics. However, antibiotics used without proper prescription can trigger antibiotic resistance. To overcome antibiotic resistance, a combination of natural ingredients such as kirinyuh leaves (Chromolaena odorata L.) and mango leaves (Mangifera indica L.) can be used. This study aims to determine the inhibitory activity and effective concentration of the combination of mango leaves extract (Mangifera indica L.) and kirinyuh leaves  extract (Chromolaena odorata L.) as antibacterial agents against Staphylococcus aureus. The methods used in this study included maceration to prepare mango leaves and kirinyuh leaves extract, phytochemical screening to identify the presence of secondary metabolites in the kirinyuh leaves and mango leaves extract, and the disk diffusion method for antibacterial testing. The results showed inhibitory activity at all concentrations due to the presence of secondary metabolites in the kirinyuh leaves and mango leaves extracts. At a 1:3 concentration, an inhibition zone of 18 mm was obtained; at a 1:1 concentration, an inhibition zone of 19 mm was obtained; at a 3:1 concentration, an inhibition zone of 20 mm was obtained. The effective concentration of the combination as an antibacterial agent is the 3:1 concentration. The results of this study fall into the strong category, indicating that the combination of mango leaves and kirinyuh leaves extracts has antibacterial efficacy against Staphylococcus aureus.
Co-Authors Afriani, Rachmi Aminah Aminah Bangun Wijonarko, Bangun Fadillah, M.Arief Hamtini - Hamtini Marwin, Deisya Tyas Nuraeni, Ira Rachmawati, Nurmeily Rahmawati, Nurmeily Shufiyani, Shufiyani Trisna, Citra Zulkifli, M. Zidan