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All Journal E-Jurnal Medika Udayana Indonesian Journal of Cancer Physical Therapy Journal of Indonesia
Ruma, I Made Winarsa
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : E-Jurnal Medika Udayana

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Hubungan Mutasi Gen K-RAS terhadap Respon Terapi pada Pasien Kanker Kolorektal di RSUP Prof. DR. IGNG. Ngoerah Tahun 2017-2019. Bramantya, Putu Arya Rahadi; Wihandani, Desak Made; Dewi, Ni Nyoman Ayu; Ruma, I Made Winarsa
E-Jurnal Medika Udayana Vol 13 No 3 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i03.P13

Abstract

K-RAS is one of the most frequently mutated genes found in colorectal cancer cases. The K-RAS gene has about 30%-40% contribution to the formation of colorectal cancer. This research is an analytic observational study with a cross-sectional design to explain the characteristics of patients with colorectal cancer at Prof. dr. IGNG. Ngoerah 2017-2019 and assessed the relationship between K-RAS gene mutations and response to therapy. The results of the chi-square test showing a significant relationship between the type of KRAS gene mutation and the response to therapy where p=0.035 (p<0.05). This shows that there is a significant relationship between mutations in the K-RAS gene in colorectal cancer and the response to therapy in colorectal cancer patients at Prof. Dr. IGNG. Ngoerah General Hospital in 2017-2019.
EFEKTIVITAS JUS BUAH SEBAGAI TERAPI KOMPLEMENTER TERHADAP TEKANAN DARAH PASIEN HIPERTENSI : A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS Mahendra, Bayu; Surudarma, I Wayan; Wihandani, Desak Made; Ruma, I Made Winarsa
E-Jurnal Medika Udayana Vol 11 No 9 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i9.P17

Abstract

Hypertension treatment can be helped through complementary therapies, one of which is fruit juices. This study aimed to systematically review the evidence from various study regarding the effect of fruit juices on blood pressure in hypertensive patients and the types of fruit juices that are proven to be effective in reducing hypertension.This study is systematic review. Literature searching was conducted in four electronic databases, namely CINAHL, EMBASE, Pubmed, and Sciencedirect with the phrase fruit juices AND (hypertension OR blood pressure). Studies obtained from searching will be selected based on a screening title and abstract, eligibility criteria, and assesment risk of bias. The results of the study obtained 21 final studies with RCT research designs that passed the screening with complete eligibility criteria. However, the studies with valid results only amounted to 8 studies. These data show that as many as 5 studies prove fruit juices can reduce blood pressure in hypertensive patients and 3 other studies have stated the opposite. Thus, it can be concluded that there is strong evidence that fruit juices has a significant effect on reducing blood pressure in hypertensive patients. Fruit juices that have been shown to be effective are orange juice and queen garnet plum juice
Co-Authors Bramantya, Putu Arya Rahadi Desak Made Wihandani Dewi, Anak Ayu Nyoman Trisna Narta Dhananjaya, Gede Arya Diva Mulya, Happy Kusuma Ni Nyoman Ayu Dewi Nila Wahyuni Nyoman Bayu Mahendra Surudarma, I Wayan Thongiratama, Gregorius William wahyu, I Made Wahyu Pranatha Putra