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All Journal E-Jurnal Medika Udayana Journal of Biomedicine and Translational Research Indonesian Journal of Cancer
Ruma, I Made Winarsa
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Hubungan Mutasi Gen K-RAS terhadap Respon Terapi pada Pasien Kanker Kolorektal di RSUP Prof. DR. IGNG. Ngoerah Tahun 2017-2019. Bramantya, Putu Arya Rahadi; Wihandani, Desak Made; Dewi, Ni Nyoman Ayu; Ruma, I Made Winarsa
E-Jurnal Medika Udayana Vol 13 No 3 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i03.P13

Abstract

K-RAS is one of the most frequently mutated genes found in colorectal cancer cases. The K-RAS gene has about 30%-40% contribution to the formation of colorectal cancer. This research is an analytic observational study with a cross-sectional design to explain the characteristics of patients with colorectal cancer at Prof. dr. IGNG. Ngoerah 2017-2019 and assessed the relationship between K-RAS gene mutations and response to therapy. The results of the chi-square test showing a significant relationship between the type of KRAS gene mutation and the response to therapy where p=0.035 (p<0.05). This shows that there is a significant relationship between mutations in the K-RAS gene in colorectal cancer and the response to therapy in colorectal cancer patients at Prof. Dr. IGNG. Ngoerah General Hospital in 2017-2019.
EFEKTIVITAS JUS BUAH SEBAGAI TERAPI KOMPLEMENTER TERHADAP TEKANAN DARAH PASIEN HIPERTENSI : A SYSTEMATIC REVIEW OF RANDOMIZED CONTROLLED TRIALS Mahendra, Bayu; Surudarma, I Wayan; Wihandani, Desak Made; Ruma, I Made Winarsa
E-Jurnal Medika Udayana Vol 11 No 9 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i9.P17

Abstract

Hypertension treatment can be helped through complementary therapies, one of which is fruit juices. This study aimed to systematically review the evidence from various study regarding the effect of fruit juices on blood pressure in hypertensive patients and the types of fruit juices that are proven to be effective in reducing hypertension.This study is systematic review. Literature searching was conducted in four electronic databases, namely CINAHL, EMBASE, Pubmed, and Sciencedirect with the phrase fruit juices AND (hypertension OR blood pressure). Studies obtained from searching will be selected based on a screening title and abstract, eligibility criteria, and assesment risk of bias. The results of the study obtained 21 final studies with RCT research designs that passed the screening with complete eligibility criteria. However, the studies with valid results only amounted to 8 studies. These data show that as many as 5 studies prove fruit juices can reduce blood pressure in hypertensive patients and 3 other studies have stated the opposite. Thus, it can be concluded that there is strong evidence that fruit juices has a significant effect on reducing blood pressure in hypertensive patients. Fruit juices that have been shown to be effective are orange juice and queen garnet plum juice
Activity of Matrix Metalloproteinase-7 (MMP-7) Related to Heparin-Binding Epidermal Growth Factor (HB-EGF) Activation in Squamous Cell as Diagnostic Biomarker for Early Detection And Treatment of Maxilarian Cancer: Review Article Thongiratama, Gregorius William; Dhananjaya, Gede Arya Diva; Mulya, Happy Kusuma; Ruma, I Made Winarsa
Indonesian Journal of Cancer Vol 18, No 1 (2024): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i1.1028

Abstract

Background: Squamous cell carcinoma (SCC) has a higher chance of occurance and progression in maxillary sinus cancer than other paranasal sinus cancers (80%). Matrix metalloproteinase-7 (MMP-7) is a protease specified in collagen type IV degradation and Heparin Binding Epidermal Growth Factor activation, which causes an increase in squamous cell carcinoma proliferation and metastasis Methods: This review aims to identify the potential role of MMP-7 as a target for prevention and therapeutic modality to manage SCC sinus maxillary cancer. We did literature searching in several databases to elucidate the importance of the MMP-7 pathway in SCC sinus maxillary cancer progression. Results: : Increasing expression and activity of MMP-7 are associated with maxillary sinus cancer progression. Squamous cells, the most impacted in maxillary sinus cancer, sustain dysplasia due to heparin-binding epidermal growth factor (HB-EGF) activation into EGF by MMP-7 and Cluster of Differentiation 44 (CD44) binding complexes that trigger high proliferation and mitogenic activity. The therapeutic function of MMP-7 occurs by affecting the protein 53 (p53) in cancer cell apoptosis initiation by specific interaction with CD44. Conclusion: MMP-7 could be an alternative therapeutic target and potential treatment option for maxillary sinus cancer. Furthermore, more trials should be done to test the relevancy of MMP-7 uses as an SCC sinus maxillary cancer modality
Administration of Ethanol Extract of Black Soybean Seeds (Glycine max (L.) Merr.) on the Number of Ovarian Tertiary Follicles and Serum Estradiol Levels in Wistar-Strain Rats (Rattus novergicus) Exposed to Cigarette Smoke Widjaja, Danielle Karen; Ruma, I Made Winarsa; Widianti, I Gusti Ayu
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.26755

Abstract

Background: Premature ovarian insufficiency is ovarian aging that occurs before the age of 40, with a global prevalence of 1.1%. Premature ovarian insufficiency can be induced by environmental exposures, particularly through free radicals generated by cigarette smoke.Objective: The purpose of this study was to prove that the administration of ethanol extract of black soybean (Glycine max (L.) Merr.) can inhibit the decrease in ovarian tertiary follicle count and serum estradiol levels in Wistar strain rats (Rattus norvegicus) exposed to cigarette smoke.Methods: This research is an experimental study with a post-test-only control group design involving 30 Wistar-strain rats (Rattus norvegicus) that met the inclusion criteria. The rats were divided into five groups: group N (normal), group K (control), and group P1-P3 which received black soybean seed extract (Glycine max (L.) Merr.) at doses of 375 mg/kgBW (P1), 750 mg/kgBW (P2), and 1500 mg/kgBW (P3) administered orally via gavage every day for 28 days. The control group and treatment groups were exposed to cigarette smoke, after the administration of the extract, for 2 hours per day, 5 days a week, for 28 days. Serum estradiol levels (ng/L) were measured using the ELISA method, and ovarian tissue samples were collected for counting the number of ovarian tertiary follicles.Results: There was a significant difference in serum estradiol levels (p < 0,001), with the highest serum estradiol level observed in Group P1 (564.4 ± 74.28) and the lowest in Group K (116,7 ± 38,01).  There was no significant difference in the number of ovarian tertiary follicles (p=0,645).Conclusion: The ethanol extract of black soybean seeds (Glycine max (L.) Merr.) at a dose of 375 mg/kg BW significantly inhibits the decrease in estradiol levels but did not affect the number of ovarian tertiary follicles in Wistar strain rats (Rattus norvegicus) exposed to cigarette smoke.
Co-Authors Bramantya, Putu Arya Rahadi Desak Made Wihandani Dhananjaya, Gede Arya Diva Mulya, Happy Kusuma Ni Nyoman Ayu Dewi Nyoman Bayu Mahendra Surudarma, I Wayan Thongiratama, Gregorius William Widianti, I Gusti Ayu Widjaja, Danielle Karen