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Umboh, Octavianus
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Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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PROFIL GAMBARAN ENDOSKOPI DI PUSAT ENDOSKOPI KSM ILMU PENYAKIT DALAM RSUP PROF. DR. R. D. KANDOU PERIODE JANUARI 2016 – DESEMBER 2017 Dewantara, Fadil; Waleleng, Bradley J.; Umboh, Octavianus
e-CliniC Vol 6, No 2 (2018): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.6.2.2018.22114

Abstract

Abstract: Gastrointestinal endoscopy in the upper gastrointestinal tract is performed to obtain the condition of gastrointestinal mucosa. This study was aimed to obtain the profile of UGIB among endoscopy patients at the Gastrointestinal Endoscopy Center of Prof. Dr. R. D. Kandou Hospital Manado from January 2016 to December 2017. This was a descriptive retrospective study using medical records of patients who were registered at the Gastro-intestinal Endoscopy Center from January 2016 to December 2017. The result shows that from 420 cases, there were 7 diagnoses after endoscopy, as follows: esophagitis, gastritis, erosive gastritis, gastric ulcer, gastric polyp, duodenitis, and hiatal hernia. The most common diagnosis of UGIB was gastritis in 155 cases (37%), esophagitis in 124 cases (30%), duodenitis in 40 cases (10%), gastric polyp in 36 cases (9%), hiatal hernia in 22 cases (5%), erosive gastritis in 21 cases (4%), gastric ulcer in 17 cases (4%), and the other diagnoses (varices esophagus, esophagus ulcer, duodenum ulcer, achalasia) in 5 cases (1%). UGIB occured more common in males with 227 cases (54%) compared to female with 193 cases (46%). The most frequent age group was 56-65 years old with 86 cases, and the most rare case was >75 years old. Conclusion: Upper gastrointestinal bleeding occured more common among males, aged 56-65 years. Gastritis was the most common diagnosis in endoscopy.Keywords: endoscopy, upper gastrointestinal bleeding Abstrak: Pemeriksaan endoskopi pada saluran cerna bagian atas berfungsi untuk mengeva-luasi keadaan mukosa saluran cerna atas dan sekitarnya. Penelitian ini bertujuan untuk mendapatkan profil gambaran endoskopi di Pusat Endoskopi KSM Ilmu Penyakit Dalam RSUP Prof. Dr. R. D. Kandou Manado periode Januari 2016 ? Desember 2017. Jenis penelitian ialah deskriptif retroskpektif menggunakan data rekam medik pasien perdarahan SCBA yang melakukan pemeriksaan endoskopi periode Januari 2016 ? Desember 2017. Hasil penelitian mendapatkan dari 420 kasus, ditemukan 7 diagnosis setelah tindakan endoskopi (EGD), yaitu esofagitis, gastritis, gastritis erosiva, gastric ulcer, polip gaster, duodenitis dan hernia hiatus. Diagnosis perdarahan SCBA terbanyak ialah gastritis 155 kasus (37%), esofagitis yaitu 124 kasus (30%), duodenitis 40 kasus (10%), polip gaster 36 kasus (9%), hiatus hernia 22 kasus (5%), gastritis erosiva 21 kasus (4%), gastric ulcer 17 kasus (4%), dan kasus dengan dignosis lainnya (varices esophagus, esophagus ulcer, duodenum ulcer, achalasia) sebanyak 5 kasus (1%). Perdarahan SCBA banyak terjadi pada pasien dengan jenis kelamin laki-laki berjumlah 227 pasien (54%) dibandingkan dengan pasien perempuan berjumlah 193 pasien (46%). Berdasarkan usia, terbanyak pada kelompok usia 56-65 tahun sebanyak 139 kasus dan terendah pada kelompok usia >75 tahun. Simpulan: Perdarahan SCBA lebih sering terjadi pada laki-laki, kelompok usia 56-65 tahun, dengan gastritis sebagai diagnosis terbanyak pada pasien perdarahan SCBA yang melakukan pemeriksaan endoskopi.Kata kunci: endoskopi (EGD), perdarahan SCBA
Pengaruh penggunaan angiotensin converting enzyme inhibitor (ACEI) dan angiotensin receptor blocker (ARB) pada pasien coronavirus disease 2019 (covid-19) dengan hipertensi Linelejan, Briando; Umboh, Octavianus; Wantania, Frans E. N.
e-CliniC Vol 9, No 1 (2021): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v9i1.31963

Abstract

Abstract: Hypertension is considered as one of the highest death-caused disease worldwide. Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) most frequently occurred in elderly and those who had comorbid diseases, one of them is hypertension. The first line drugs that are usually used in hypertension are angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs). It is assumed that these drugs coud influence the progress of COVID-19 due to the similiar target receptor. This study was aimed to evaluate the influence of ACEIs and ARBs to patients with COVID-19 and hypertension. This was a literature review study using literatures published in medical journal databases such as PubMed and ClinicalKey. The results obtained 10 literatures that fulfilled the inclusion and exclusion criteria. These ten literatures stated that there was no influence of using ACEIs and ARBs in COVID-19 patients. In conclusion, ACEIs and ARBs do not influence the mortality or progresivity of COVID-19 disease and are suggested to be consumed continually.Keywords: ACEIs, ARBs, COVID-19, hypertension, hypertension in COVID-19 Abstrak: Hipertensi merupakan salah satu penyebab kematian tertinggi di dunia. Pandemik coronavirus disease 2019 (COVID-19) dengan severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sebagai etiologinya kebanyakan terjadi pada usia tua serta yang memiliki penyakit komorbid, salah satu yang tersering ialah hipertensi. Obat lini pertama yang biasa digunakan untuk hipertensi yaitu angiotensin converting enzyme inhibitor (ACEI) dan angiotensin receptor blockers (ARB) dikatakan dapat memengaruhi perkembangan penyakit COVID-19 karena memiliki reseptor atau tempat kerja yang mirip. Penelitian ini bertujuan untuk mengevaluasi pengaruh penggunaan ACEI dan ARB pada pasien COVID-19 dengan hipertensi. Jenis penelitian ialah literature review dengan menggunakan literatur-literatur yang dipublikasi dalam database jurnal kedokteran PubMed dan ClinicalKey sesuai dengan kriteria inklusi dan eksklusi penelitian. Hasil penelitian mendapatkan 10 literatur; kesemuanya menyatakan bahwa tidak terdapat pengaruh penggunaan ACEI dan ARB terhadap pasien COVID-19. Simpulan penelitian ini penggunaan ACEI dan ARB tidak memengaruhi mortalitas maupun progresivitas penyakit COVID-19 dan disarankan untuk tetap dilanjutkan.Kata kunci: ACEI, ARB, COVID-19, hipertensi, hipertensi pada COVID-19
Faktor Risiko Terjadinya Coronavirus Disease 2019 (Covid-19) pada Penyandang Diabetes Melitus Tipe 2 Roeroe, Pomantow A. L.; Sedli, Bisuk P.; Umboh, Octavianus
e-CliniC Vol 9, No 1 (2021): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v9i1.32301

Abstract

Abstract: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by SARS-CoV-2 and has been declared as a pandemic by WHO in March 11, 2020. This disease is an additional problem in people with type 2 diabetes mellitus (T2DM). Several studies have shown that diabetes is a risk factor for COVID-19. This study was aimed to determine the risk factors for the occurrence of Coronavirus Disease 2019 (COVID-19) in T2DM patients. This was a literature review study using several journal databases, namely Google Scholar, PubMed, and Science Direct. Literature searching was performed by using the PICOS method and the analysis was carried out qualitatively The results obtained 10 literatures reporting that T2DM would increase the severity and mortality of COVID-19 patients related to elderly age, obesity, chronic systemic inflammation, increased coagulation activity, potential direct damage to the pancreas, changes in expression of ACE2 receptors, dysregulation of the number, activity of immune cells, alveolar dysfunction, and endothelial dysfunction. There was not yet strong evidence regarding discontinuation or continuation of various diabetes drugs in COVID-19 patients, but insulin remains the recommended agent for blood glucose control. In conclusion, T2DM increases the severity and mortality rate of COVID-19 patients Keywords: diabetes mellitus; COVID-19; risk factors Abstrak: Coronavirus Disease 2019 (COVID-19) merupakan salah satu penyakit infeksi yang disebabkan oleh SARS-CoV-2 dan telah ditetapkan sebagai pandemi oleh WHO pada 11 Maret 2020. Penyakit ini menjadi masalah tambahan bagi penyandang diabetes melitus tipe 2 (DMT2). Beberapa penelitian menunjukkan bahwa diabetes merupakan salah satu faktor risiko terjadinya COVID-19. Penelitian ini bertujuan untuk mengetahui faktor risiko terjadinya COVID-19 pada penyandang DMT2. Jenis penelitian ialah literature review menggunakan laporan penelitian dari beberapa database jurnal, yaitu google scholar, PubMed, dan ClinicalKey. Pencarian artikel menggunakan metode PICOS dan analisis dilakukan secara kualitatif. Hasil penelitian mendapatkan 10 laporan penelitian yang melaporkan bahwa DMT2 meningkatkan tingkat keparahan dan mortalitas pasien COVID-19 akibat adanya mekanisme terkait dengan usia lanjut, obesitas, peradangan sistemik kronis, peningkatan aktivitas koagulasi, potensi kerusakan langsung pankreas, perubahan ekspresi reseptor ACE2, disregulasi jumlah dan aktivitas sel imun, disfungsi alveolar, dan disfungsi endotel. Belum terdapat bukti kuat mengenai penghentian atau pelanjutan berbagai obat diabetes pada pasien COVID-19, tetapi insulin tetap menjadi obat yang disarankan untuk mengontrol glukosa darah. Simpulan penelitian ini ialah DMT2 meningkatkan tingkat keparahan dan mortalitas dari pasien COVID-19.Kata kunci: diabetes melitus tipe 2 (DMT2), COVID-19, faktor risiko
Estimated Glomerular Filtration Rate and Sleep Quality in Stage 3-5 Non-Dialysis Chronic Kidney Disease Patients: Is There a Correlation? Umboh, Octavianus; Palar, Stella; Moeis, Emma Syarifih
Indonesian Journal of Kidney and Hypertension Vol 1 No 2 (2024): Volume 1 No. 2, August 2024
Publisher : PERNEFRI (PERHIMPUNAN NEFROLOGI INDONESIA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32867/inakidney.v1i2.136

Abstract

Background: Chronic kidney disease (CKD) is a growing health issue that significantly affects patients' quality of life. CKD patients are prone to sleep disturbances, which can lead to chronic fatigue and a decrease in their quality of life. The Pittsburgh Sleep Quality Index (PSQI) is a parameter that can be used to assess the sleep quality of CKD patients. Objective: This study aims to determine the relationship between estimated glomerular filtration rate (eGFR) and sleep quality in non-dialysis CKD patients. Methods: The research design is an observational analytic study with a cross-sectional approach. The research subjects were stage 3-5 non-dialysis CKD patients aged 18 to 60 years at Prof. Dr. R. D. Kandou Hospital Manado from March to May 2022. The sleep quality of CKD patients was assessed using the PSQI score. Data analysis was performed with a significance level of p < 0.05. Results: A total of 30 patients with stage 3-5 non-dialysis CKD were found. They consisted of 20 males and 10 females, aged 38-59 years, with an average of 59.80 ± 9.86 years. In the normality test using Shapiro-Wilk, the patient samples were not normally distributed (p = .000). For statistical analysis using the Spearman test, a negative correlation was found between eGFR and PSQI scores (r = -0.554), which was statistically significant (p = 0.002). Conclusion: This study found a significant relationship between eGFR and PSQI scores, which shows that a decrease in eGFR worsens the sleep quality of non-dialysis CKD patients.
Gambaran Penggunaan Obat Antihipertensi pada Pasien Hipertensi di Instalasi Rawat Inap Salah Satu Rumah Sakit Swasta di Sulawesi Utara Rue, Puella; Mambo, Christi D.; Nangoy, Edward; Umboh, Octavianus; Purwanto, Diana S.; Masengi, Angelina S. R.
e-CliniC Vol. 13 No. 2 (2025): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v13i2.61019

Abstract

Abstract: Management of hypertension is conducted to control the  blood pressure in patients with hypertension. There are a variety of antihypertensie agents that can be used in patients with hypertension.  This study aimed to evaluate the pattern of antihypertensive drug use among patients with hypertension in the Inpatient Ward. This was a retrospective and descriptive study using a cross-sectional design. The results showed that the  dominant characteristics were female gender (64.29%), age ≥60 years (71.43%), housewife (51.43%), and completed senior high school education (34.29%). The most commonly prescribed drugs were amlodipine (25.71%), and the combination of amlodipine and candesartan (22.86%). In conclusion, the majority of patients with hypertension are females, aged ≥60 years, working as housewives, and have high school education. The most frequently used single antihypertensive drug is calcium channel blocker group, specifically amlodipine, while the combination therapy involve both a calcium channel blocker and an ARB, namely amlodipine and candesartan. Keywords: hypertension; antihypertensive drugs    Abstrak: Tatalaksana hipertensi dilakukan dengan tujuan untuk mengontrol tekanan darah pada pasien hipertensi. Terdapat bermacam jenis obat antihipertensi yang dapat digunakan pada pasien hipertensi.  Penelitian ini bertujuan untuk mengetahui gambaran penggunaan obat antihipertensi pada pasien hipertensi di Instalasi Rawat Inap. Jenis penelitian ialah deskriptif retrospektif dengan desain potong lintang. Hasil penelitian mendapatkan karakteristik yang dominan ialah jenis kelamin perempuan (64,29%), usia ³60 tahun (71,43%), pekerjaan sebagai ibu rumah tangga (IRT) (51,43%), dan pendidikan terakhir SMA (34,29%). Penggunaan obat terbanyak ialah amlodipin (25,71%), serta kombinasi amlodipin dan candesartan (22,86%) Simpulan penelitian ini ialah pasien hipertensi paling banyak terdapat pada jenis kelamin perempuan, kelompok usia ³60 tahun, pekerjaan IRT, dan tingkat pendidikan terakhir SMA. Penggunaan obat antihipertensi tunggal terbanyak dari golongan antagonis kalsium yaitu amlodipin, sedangkan kombinasi obat antihipertensi ialah antagonis kalsium dan ARB, yaitu amlodipin dan candesartan. Kata kunci: hipertensi; obat antihipertensi
Co-Authors Angelina Stevany Regina Masengi Bradley J. Waleleng Dewantara, Fadil Diana S. Purwanto Edward Nangoy, Edward Frans E. N. Wantania, Frans E. N. Linelejan, Briando Mambo, Christi D. Moeis, Emma Syarifih Roeroe, Pomantow A. L. Rue, Puella Sedli, Bisuk P. Stella Palar