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All Journal Jurnal MIPA PHARMACON Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ The Studies of Social Sciences Jurnal Lentera Farma
Wiyono, Weny Indayany
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Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Environmental Science Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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Journal : Jurnal MIPA

 1 
Identifikasi Potentially Inappopriate Medication (PIM) Pada Resep Pasien Diabetes Melitus Usia Yang Keluar Dari 3 Rumah Sakit di Sulawesi Utara Wiyono, Weny Indayany; Lolo, Widya Astuty; Citraningtyas, Gayatri
Jurnal MIPA Vol 8, No 3 (2019)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jmuo.8.3.2019.25777

Abstract

Latar Belakang. Penduduk lanjut usia atau geriatrik tidak dapat dipisahkan dari kondisi kesehatan. Hal tersebut mendorong pentingnya mengidentifikasi adanya ketidaktepatan peresepan bagi pasien lanjut usia khususnya pada pasien yang menderita Diabetes Mellitus (DM). Prevalensi DM di Sulawesi Utara mengalami kenaikan. Penelitian ini bertujuan untuk mengidentifikasi Potentially Inapopriate Medication (PIM) pada Resep pasien DM lanjut usia yang keluar dari Tiga Rumah sakit (RS) terletak di kota dengan prevalensi DM terbanyak di Sulawesi Utara. Metode. Penelitian dilakukan pada RS A Kota Manado, RS B Bitung dan RS C Tomohon. Penelitian ini menggunakan metode deskriptif kuantitatif secara retrospektif dengan mengambil data rekam medis setiap 3 bulan per Rumah Sakit lalu membandingkan dengan Beers Criteria 2015. Hasil. Kejadian PIM pada Resep Keluar Pasien DM Lanjut Usia di RS A, RS B dan RS C sebesar 81,26 %, 40,91 % dan 37,38%  secara berturut-turut. Klasifikasi PIM terbanyak yaitu PIM dan Kelas Obat yang harus dihindari pada lanjut usia (50,00%, 66,67%, 73,91%). Golongan Obat terbanyak dalam PIM yaitu Sistem Gastrointestinal khususnya Pemblok Pompa Proton (30,47 %)Background. Elderly or geriatric population can’t be separated from health conditions. This encourages the importance to identifying the inaccuracy of prescribing for elderly patients, especially in patients with Diabetes Mellitus (DM). The prevalence of DM in North Sulawesi has increased. This study aims to identify Potentially Inapopriate Medication (PIM) in prescriptions for elderly DM patients who are discharged from the Three Hospitals (RS) located in the city with the highest prevalence of DM in North Sulawesi. Method. The study was conducted at Hospital A at Manado City, Hospital B at Bitung and Hospital C at Tomohon. This study used quantitative descriptive method retrospectively by taking medical record data every 3 months/Hospital and then comparing with the 2015 Beers Criteria. Results. The incidence of PIM in the Out Prescription for Elderly DM Patients in Hospital A, Hospital B and Hospital C was 81.26%, 40.91% and 37.38%, respectively. Most PIM classifications are PIM and Drug Class which must be avoided in the elderly (50.00%, 66.67%, 73.91%). The most drug group in PIM is Gastrointestinal System especially Proton Pump Inhibitors (30.47%)
Profil Penetrasi Sediaan Gel Antioksidan Ekstrak Kayu Manis (Cinnamomum burmanii) dengan Variasi Hydrocolloid sebagai Gelling agent Siampa, Jainer Pasca; Wiyono, Weny Indayany; Lestari, Utami Sasmita; Lebang, Julianri Sari; Antasionasti, Irma
Jurnal MIPA Vol 11, No 1 (2022)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jm.v11i1.35787

Abstract

The exposure of sunlight consisting UV radiation has been reported to be the main cause of skin cancer and contribute about 80% of the incidence of skin damage. In an attempt to overcome this problem, antioxidant agents have been used both orally and topically. Compared to oral administration, topical route has been found to be preferred due to the direct action to the desired site. Amongst topical preparation, gel possesses numerous because it provides a cool and fresh sensation. Here, we developed gel antioxidant containing cinnamon extract as active ingredient. Cinnamon was selected as it has a very strong antioxidant activity. This study aimed to obtain the penetration profile of the antioxidant gel of cinnamon extract prepared from two different hydrocolloid agents. The gels were made using various concentrations of Carbopol 940 and NaCMC. The prepared gels were further characterized for their antioxidant capacities using the DPPH free radical scavenging method and their total phenolic contents using the spectrophotometric method. The formulation possessing the strongest antioxidant capacity was continued for ex vivo penetration study using Franz diffusion cells. The results exhibited that the total phenolic value of the cinnamon extract obtained was 908.38 ± 6.54 mg GAE/g extract. The penetration percentages for the formula with Carbopol and NaCMC bases were 53.310 ± 1.217% and 27.969 ± 1.151%, respectively, and the retention percentages were 28.495 ± 0.031% and 18.356 ± 0.191%, respectively. Based on these findings, we concluded that cinnamon extract could potentially be formulated into antioxidant gel preparations and formulas based on Carbopol showed the best penetration profile.
Co-Authors Antasionasti, Irma Bidulang, Crunny Bidhya DEBY AFRIANI MPILA Fridly Manawan Gayatri Citraningtyas Gunawan, Lea Nathaniela Agneta Heedy Tjitrosantoso Jayanti, Melani Julianri Sari Lebang, Julianri Sari Kawengian, Sartika Lestari, Utami Sasmita Marina Mamarimbing Meilani Jayanti Poana, Nony Porogoi, Vionita L. Purwoko, Agus Rumambi, Gadis Siampa, Jainer Pasca Tandjung, Hendra Tatuh, Heru Andika Tinungki, Syalomita Esther Waworuntu, Injilia Sharon Queen Wenas, Glori Anjelina Preysi Widya Astuty Lolo, Widya Astuty Wori, Preicy Augenia