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All Journal JURNAL BIOMEDIK AKSELERASI: Jurnal Ilmiah Nasional Jurnal EduHealth International Journal of Science and Society (IJSOC) Research Horizon
Tamon, Oktavian
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Arts Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Public Health Social Sciences Veterinary

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Injeksi asam hialuronat di lapisan dermis menghambat peningkatan ekspresi MMP-1 tikus yang dipajan sinar ultraviolet-B (UVB) Tamon, Oktavian; Wiraguna, A A G P; Pangkahila, Wimpie
Jurnal Biomedik : JBM Vol 9, No 1 (2017): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.9.1.2017.15315

Abstract

Abstract: Ultraviolet B (UVB) is a source of free radicals that accelerate aging process, especially in the skin, through the increase of MMP-1. Hyaluronic acid contained in the dermal filler injection may provide a protective effect against skin exposure to UV rays. This study was aimed to prove that intradermal injection of hyaluronic acid could prevent the increase of MMP-1 in UVB-induced rats (Rattus norvegicus). This was a true experimental study with the post test only control group design. Subjects were 30 male Wistar rats (Rattus norvegicus), aged 2,5-3 months, weighing 160-180 g, and divided into 3 groups. The control group (P0) was exposed to UV-B only; the treatment group 1 (P1) was exposed to UVB and treated with placebo (aquadest intradermal injection); and the treatment group 2 (P2) was exposed to UVB and treated with hyaluronic acid intradermal injection. After 15 days of treatment, all rats were anesthetized and their skin tissues were prepared for examination of MMP1 levels. The statistic analysis showed that the average level of MMP1 in the P0 group was 24.54±4.39%; in the P1 group was 21.35±2.48% (P < 0.01). The average level of MMP-1 in P2 group was 15.40±3.87%, and was statistically lower than P0 group (P < 0.01) and P1 group (P < 0.01). Conclusion: Injection of hyaluronic acid in the dermal layer could prevent the increase of MMP-1 in UVB-induced rats (Rattus norvegicus).Keywords: hyaluronic acid, MMP-1, UVBAbstrak: Ultraviolet B (UVB) merupakan salah satu sumber radikal bebas yang dapat mempercepat proses penuaan, khususnya penuaan pada kulit melalui peningkatan MMP-1. Asam hialuronat yang terkandung dalam dermal filler injection dapat memberi efek perlindungan kulit terhadap pajanan sinar ultraviolet. Tujuan penelitian ini untuk membuktikan bahwa pemberian asam hialuronat intradermal menghambat peningkatan ekspresi MMP-1 tikus yang dipapar sinar UVB. Jenis penelitian ialah eksperimental murni menggunakan post test only control group design. Subjek penelitian ialah 30 ekor tikus putih (Rattus norvegicus), jantan, galur Wistar, berumur 2,5-3 bulan, dengan berat badan 160-180 gram yang terbagi menjadi 3 kelompok masing-masing berjumlah 10 ekor tikus. Kelompok kontrol (P0) hanya diberi pajanan UVB; kelompok plasebo (P1) diberikan injeksi aquabidest intradermal serta pajanan UVB; dan kelompok perlakuan (P2) diberikan injeksi asam hialuronat intradermal dan pajanan UVB. Setelah 15 hari perlakuan, seluruh tikus dianestesi kemudian jaringan kulitnya diambil untuk pemeriksaan ekspresi MMP-1 dermis. Hasil analisis statistik menunjukkan bahwa rerata ekspresi MMP-1 pada kelompok P0 ialah 24,54±4,39% dan pada kelompok P1 21,35±2,48% (P > 0,05). Pada kelompok P2, rerata ekspresi MMP-1 ialah 15,40±3,87%, yang secara statistik lebih rendah dibandingkan dengan kelompok P0 (P < 0,01) dan kelompok P1 (P < 0,01). Simpulan: Pemberian asam hialuronat intradermal menghambat peningkatan ekspresi MMP-1 tikus yang dipapar sinar UVB.Kata kunci: asam hialuronat, MMP-1, UVB
Legal Protection for Doctors Under Law Number 17 of 2023 Concerning Health Tamon, Oktavian; Setiawan, Eko Wahyuddin; Sapsudin, Asep
Research Horizon Vol. 5 No. 4 (2025): Research Horizon - August 2025
Publisher : LifeSciFi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54518/rh.5.4.2025.720

Abstract

The security and safety of doctors is a serious concern in the health sector, especially after the occurrence of various violence against health workers. This issue has become increasingly important with the new Health Law, which is expected to provide stronger legal protection for doctors in carrying out their professional duties. This study aims to examine how legal protection for doctors is regulated in the new regulation and identify whether the protection is sufficient to ensure a sense of security at work. This research uses a normative juridical method with a statutory approach and a case approach. Data collection techniques were carried out through literature study of legal documents, laws and regulations, and relevant court decisions. Data analysis was conducted qualitatively with a descriptive-analytical approach. The findings indicate that the new Health Law contains several important provisions regarding legal protection for doctors, but there are still some legal gaps and weaknesses in implementation in the field. Therefore, it is recommended that the government strengthen legal protection mechanisms and clarify law enforcement procedures in cases of violence against doctors in order to create a safe and conducive work environment.
Civil Law In Health Services Practice In Indonesia: Systematic Review Tamon, Oktavian; Yuyut Prayuti
Jurnal EduHealth Vol. 14 No. 04 (2023): Jurnal eduHealt, 2023, December
Publisher : Sean Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Health services are one of the efforts that can be made to improve the health status of both individuals and groups or society as a whole. In its implementation it cannot be separated from legal rules and regulations. So it is hoped that this health service practice will not go off track. The aim of this systematic review is to examine journals that explain how civil law applies to health service practices in Indonesia. This systematic review uses articles in the PubMed, Google Scholar, and ProQuest databases published in 2018-2023, getting 759 articles then reviewed using the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) diagram and getting 5 articles that meet the requirements to be applied. From the results of 5 articles, it was found that civil law in health service practice includes laws that regulate protecting patient rights, doctors' legal responsibilities regarding patient lawsuits, doctors' responsibilities towards patients and maintaining patient information confidentiality. It can be concluded that civil law in health service practice has provisions that regulate the rights and obligations of doctors and health workers to patients. Civil health law is also a tool or collection of rules. Civil law is the regulation of rights, property and anything related between individuals and legal entities. So it is important for doctors and health workers to understand and carry out health services in accordance with applicable procedures and laws as well as health norms.
PERBANDINGAN POLIKAPROLAKTON, ASAM POLILAKTAT DAN POLIDIOKSANON DALAM PROSES NEOKOLAGENESIS: SYSTEMATIC REVIEW AND META-ANALYSIS Tamon, Oktavian
AKSELERASI: Jurnal Ilmiah Nasional Vol 6 No 1 (2024): AKSELERASI: JURNAL ILMIAH NASIONAL
Publisher : GoAcademica Research dan Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/jin.v6i1.913

Abstract

Penuaan merupakan suatu proses yang dipengaruhi oleh lingkungan, yang merupakan kecenderungan genetik, terdiri dari proses biologis dan seluler yang menyebabkan penurunan aktivitas fisiologis intrinsik sel. Dalam mencegah proses penuaan dapat dengan merangsang kolagen baru melalui penggunaan bahan yang dapat meningkatkan kolagen baru. Tujuan systematic review ini yaitu untuk mengetahui perbandingan polikaprolakton, asam polilaktat dan polidioksanon dalam proses neokolagenesis. Systematic review ini menggunakan artikel pada database PubMed, Google Scholar, dan ProQuest yang diterbitkan pada 2019-2023, didapatkan 592 artikel kemudian direview menggunakan diagram Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) dan mendapat 5 artikel yang memenuhi syarat untuk dianalisis. Hasil 5 artikel diperoleh bahwa bahan polidiaxanone lebih baik dan aman serta dapat merangsang proses neokolagenensis. Jahitan ini memiliki kekuatan tarikan awal yang lebih besar dibandingkan asam poliglikolat. Dari segi bentuk injeksi maupun benang PCL dan PLLA juga baik dalam proses neokolagenensis namun lebih efekif dan lebih baik PDO. Dapat disimpulkan bahwa pada proses neokolagenesis ini bahan yang memiliki sifat biofisik, keamanan, dan kemanjuran adalah bahan pengisi polidioksanon (PDO) dibandingkan dengan bahan pengisi asam poli-L-laktat (PLLA), polikaprolakton (PCL), PDO juga dapat menstimulasi kolagen baru dibandingkan dengan PCL dan PLLA. Bagi penggunaan bahan tersebut dapat memperhatikan tingkat keefektifannya untuk menghasilkan proses neokolagenenesis yang baik.
Comparative Analysis of Perceptions of Doctors, Management, Nurses and Patients on the Use of the Enhanced Recovery After Caesarean Surgery Method Based on the Concept of Perceived Value Tamon, Oktavian; Hasyim; Indrawati, Ratna; Erni, Nofi
International Journal of Science and Society Vol 6 No 2 (2024): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v6i2.1111

Abstract

In this era of modernization, several companies, one of which is hospitals, are adopting E-Service Quality because currently patients prefer services that are quickly accessible wherever and whenever they are, so this adds to the main function of a service. One of the services of the Obstetrics and Gynecology unit, especially the delivery service using the ERACS (Enhanced Recovery After Caesarean Surgery) method, is a surgical procedure that increases profits for hospital Agencies. So, it can influence consumer value perceptions, perceived quality and hospital imAge and patient satisfaction. The aim of this research is to analyze differences in perceptions between the components of doctors, management, nurses and patients based on perceived value in implementing ERACS actions. This research method uses a quantitative research approach, survey method and the type of research is hypothesis testing with descriptive analysis and comparative analysis. The sampling technique used was a saturated sampling technique. The number of samples used was 50 respondents. The research results show that the Mann Whitney test analysis on the combination of all components which compares benefits and costs, shows that the p-value is 0.000 (p < 0.05), meaning there is a significant difference between benefits and costs on the combination of all components. It can be concluded that there is a significant difference between benefits and costs in the doctor, management, nurse and patient components.
Co-Authors Asep Sapsudin Hasyim Nofi Erni Prayuti, Yuyut Ratna Indrawati, Ratna Setiawan, Eko Wahyuddin Wimpie I Pangkahila Wiraguna, A A G P