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All Journal JSFK (Jurnal Sains Farmasi & Klinis) Science Midwifery Sciences of Pharmacy
Aligita, Widhya
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Penambatan Molekul dan Dinamika Molekul beberapa Fitokimia dari Acalypha Indica L. sebagai Inhibitor Matriks Metalloproteinase9 Asnawi, Aiyi; Febrina, Ellin; Aligita, Widhya; Yuliantini, Anne; Arfan, Arfan
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 1 (2023): J Sains Farm Klin 10(1), April 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.1.62-70.2023

Abstract

Berbagai efek farmakologis telah dikaji terhadap ekstrak dan islolat dari Acalypha Indica L. terutama terkait dengan aktifitas anti kanker. Matrix metalloproteinases MMP9 merupakan contoh yang sangat baik dari kelompok proteinase terpenting yang terlibat dalam sel metastatic/kanker. MMP9 telah dikaitkan dengan berbagai macam penyakit, termasuk sistem pernapasan, sistem autoimun, dan bahkan kanker. Maka dari itu, makalah ini bertujuan untuk mendapatkan senyawa pemandu dari beberapa fitokimia Acalypha Indica L. yang bertanggung jawab dalam migrasi sel dengan menggunakan penambatan molekul dan dinamika molekul. Ligan ditambatkan ke situs aktif struktur kristal MMP9 (PDB ID: 5UE4) menggunakan aplikasi AutoDock Release 4.2.6. Proses penambatan molekul divalidasi dengan melakukan penambatan ulang ligan alami pada sisi aktif MMP9. Selanjutnya, menggunakan GROMACS dilakukan simulasi dinamika molekul (MD) ditandem dengan algoritma gmx_MMGBSA dan gmx_MMGBSA_ana untuk menghitung energi ikatan dan kontribusi residu terhadap terhadap kestabilan kompleks. Hasil menunjukkan hanya satu ligan dari 36 ligan yang dievaluasi tidak mampu berikatan dengan sisi aktif MMP9, dan enam dari ligan mampu mengikatnya lebih negatif daripada ligan alami. Kompleks dengan ligan S54 dan S56 yang memiliki energi paling negatif tetapi dari sisi parameter lainnya, kompleks S56 paling stabil. Dapat disimpulkan, g-sitosterol asetat (S56) memiliki potensi untuk berfungsi sebagai senyawa pemandu untuk MMP9
Formulation and evaluation of thin film nanoemultion from rose flower ethanol extract (rosa hybrida hort.) and antidiabetes mellitus type 2 activity test using in vitro enzyme Gustana, Erick Kurniawan; Jafar, Garnadi; Aligita, Widhya; Nurfaiza, Putri; Hanaya, Cicia Rosa; Salsabilla, Syifa
Science Midwifery Vol 13 No 2 (2025): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i2.1969

Abstract

Diabetes mellitus is a chronic disease with a rising global prevalence. Natural antidiabetic agents derived from plant bioactive compounds offer a promising therapeutic alternative. Rose flowers (*Rosa hybrida Hort*) contain flavonoids such as kaempferol, known for their antidiabetic activity. However, poor solubility and bioavailability limit their therapeutic potential. This study aimed to develop and characterize a nanoemulsion of rose flower extract to enhance the stability and bioavailability of its active compounds. The extract was obtained by maceration using 96% ethanol and analyzed using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). Nanoemulsion formulations were developed using various types and concentrations of nonionic surfactants. Characterization included particle size, polydispersity index (PDI), zeta potential, and morphology. The optimal nanoemulsion showed a particle size <300 nm, PDI <0.5, and zeta potential around ±20 mV, indicating good stability. Transmission Electron Microscopy (TEM) revealed uniformly distributed spherical globules. LC-MS/MS confirmed the presence of kaempferol as the main active compound. The formulated nanoemulsion was successfully incorporated into an oral thin film, exhibiting favorable characteristics such as appropriate particle size, PDI, zeta potential, morphology, and satisfactory evaluation results including organoleptic properties, moisture content, pH, weight uniformity, film thickness, folding endurance, and disintegration time.
Ethyl Acetate Fraction of Gynura procumbens Mitigates Hyperglycemia, Dyslipidemia, and Tissue Damage in Streptozotocin-Induced Diabetic Rats Mulyani, Yani; Kaniawati, Marita; Aligita, Widhya; Nugraha, Eka Rahmat
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404371

Abstract

Dyslipidemia is a lipid metabolism disorder frequently associated with diabetes mellitus and known to increase cardiovascular risk. Although Gynura procumbens has been reported to possess antidiabetic and antidyslipidemic properties, studies focusing on the specific effects of its ethyl acetate fraction remain limited. This study investigated the therapeutic potential of the ethyl acetate fraction of ethanol extract from G. procumbens in streptozotocin-induced diabetic rats, particularly its impact on blood glucose, lipid profiles, and histological changes in pancreatic and aortic tissues. Thirty rats were randomly assigned to six groups: normal control, diabetic control, glibenclamide, simvastatin, and extract-treated groups at 100 and 150 mg/kg body weight. After 28 days of treatment, the 150 mg/kg dose significantly reduced blood glucose by 61.3%, total cholesterol by 42.1%, triglycerides by 47.3%, and LDL by 55.0%, while increasing HDL by 6.3% compared to diabetic control (p < 0.05). Histological analysis demonstrated regeneration of pancreatic β-cells and improvement of vascular structure in the aorta. These findings suggest that the ethyl acetate fraction of G. procumbens may serve as a promising natural agent for managing diabetes and dyslipidemia.
Co-Authors Aiyi Asnawi Arfan Arfan Ellin Febrina Garnadi Jafar, Garnadi Gustana, Erick Kurniawan Hanaya, Cicia Rosa Marita Kaniawati Nugraha, Eka Rahmat Nurfaiza, Putri Salsabilla, Syifa Yani Mulyani Yuliantini, Anne