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All Journal Science Midwifery Jurnal Ilmiah Ekonomi dan Manajemen
Salsabilla, Syifa
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Formula development and characterization of nanostructured lipid carriers (NLC) vitamin E acetate with solid lipids compritol and precirol Salsabilla, Syifa; Jafar, Garnadi; Fatmawati, Fenti
Science Midwifery Vol 12 No 5 (2024): December: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v12i5.1752

Abstract

Vitamin E acetate has antioxidant activity that can prevent premature aging of the skin, but its nature is very lipophilic (log p±12.2) and has the potential to degrade. To overcome the problems of permeability and stability, vitamin E acetate needs to be developed in Nanostructured Lipid Carrier (NLC), which is a nano delivery system based on solid lipids and liquid lipids stabilized by surfactants as a colloidal system. The formulation of vitamin E acetate into NLC was carried out using the heat homogenization method, then sonicated using a probe sonicator. The materials used were 2% vitamin E acetate, 2-6% Compritol® and Precirol® solid lipids, 1% Myritol®, and 1-3% Chremophore and Plantacare® surfactants. The NLC results were then characterized by measuring particle size, zeta potential, polydispersity index, entrapment efficiency, and morphology. The characterization results showed that NLC vitamin E acetate had a particle size of 280-375 nm, a zeta potential of -23 mV to -28 mV, a polydispersity index <0.5, an entrapment efficiency of 92-97%, and a spherical morphology. The results showed that Nanostructured Lipid Carrier vitamin E acetate gave good results.
Formulation and evaluation of thin film nanoemultion from rose flower ethanol extract (rosa hybrida hort.) and antidiabetes mellitus type 2 activity test using in vitro enzyme Gustana, Erick Kurniawan; Jafar, Garnadi; Aligita, Widhya; Nurfaiza, Putri; Hanaya, Cicia Rosa; Salsabilla, Syifa
Science Midwifery Vol 13 No 2 (2025): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i2.1969

Abstract

Diabetes mellitus is a chronic disease with a rising global prevalence. Natural antidiabetic agents derived from plant bioactive compounds offer a promising therapeutic alternative. Rose flowers (*Rosa hybrida Hort*) contain flavonoids such as kaempferol, known for their antidiabetic activity. However, poor solubility and bioavailability limit their therapeutic potential. This study aimed to develop and characterize a nanoemulsion of rose flower extract to enhance the stability and bioavailability of its active compounds. The extract was obtained by maceration using 96% ethanol and analyzed using Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). Nanoemulsion formulations were developed using various types and concentrations of nonionic surfactants. Characterization included particle size, polydispersity index (PDI), zeta potential, and morphology. The optimal nanoemulsion showed a particle size <300 nm, PDI <0.5, and zeta potential around ±20 mV, indicating good stability. Transmission Electron Microscopy (TEM) revealed uniformly distributed spherical globules. LC-MS/MS confirmed the presence of kaempferol as the main active compound. The formulated nanoemulsion was successfully incorporated into an oral thin film, exhibiting favorable characteristics such as appropriate particle size, PDI, zeta potential, morphology, and satisfactory evaluation results including organoleptic properties, moisture content, pH, weight uniformity, film thickness, folding endurance, and disintegration time.
PENGARUH LIVE STREAMING TIKTOK DAN HARGA TERHADAP KEPUTUSAN PEMBELIAN PADA EL FLOWER STORE BUMI SERPONG DAMAI TANGERANG Salsabilla, Syifa; Hastono Hastono
JURNAL ILMIAH EKONOMI DAN MANAJEMEN Vol. 3 No. 10 (2025): Oktober
Publisher : CV. KAMPUS AKADEMIK PUBLISING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61722/jiem.v3i10.6853

Abstract

This study aims to analyze the influence of Live streaming and Price on Purchasing Decisions at El Flower Store Bumi Serpong Damai, both partially and simultaneously. The method used is quantitative with 96 respondents as a sample. This study also uses various tests such as validity, reliability, classical assumptions, correlation coefficients, regression, determination, and hypotheses. The results show that Live streaming has a significant effect on purchasing decisions, with a regression equation of Y = 14.818 + 0.648 X1. The t-count value of 9.516> t-table 1.661 and a significance of 0.000 <0.050, so H0 is rejected and H1 is accepted. This means that partially Live streaming has a positive and significant effect. Price also has a significant effect with a regression equation of Y = 9.212 + 1.294 X2. The t-count value of 12.646> t-table 1.661 and a significance of 0.000 <0.050, so H0 is rejected and H2 is accepted. Simultaneously, live streaming and price have a significant effect on purchasing decisions, with the regression equation Y = 2.678 + 0.361 X1 + 0.961 X2. The f-value is 137.343> f-table 3.09 and the significance is 0.000 < 0.050. Therefore, H0 is rejected and H3 is accepted.  
Co-Authors Aligita, Widhya Fatmawati, Fenti Garnadi Jafar, Garnadi Gustana, Erick Kurniawan Hanaya, Cicia Rosa Hastono Hastono Nurfaiza, Putri