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All Journal IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Science and Technology Indonesia Indonesian Journal of Chemistry
Alfarado, Daniel
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Materials Science & Nanotechnology Physics

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Bioactivity of Endophytic Fungi Isolates from Syzygium malaccense Twigs Hapida, Yustina; Widjajanti, Hary; Salni; Habisukan, Ummi Hiras; Alfarado, Daniel; Elfita
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.448-456

Abstract

Searching for medicinal raw materials derived from the isolation of secondary metabolite compounds is still being carried out to cure a range of illnesses, including infections and degenerative diseases caused by bacteria and free radicals. This research used endophytic fungi extract from the twig of Syzygium malaccense. The diffusion method was used for antibacterial activity and 2,2-diphenyl-1-picrylhydrazyl (DPPH) was used for antioxidant activity. Chemical compound was identified by using NMR spectroscopic method. This research found 5 isolate of endophytic fungi from twig of S. malaccense (YR1 – YR5). Strong antibacterial and antioxidant activity were showed by YR5. Based on molecular identification, YR5 was Fusarium verticillioides. Pure compound prodeced by endophytic fungi F. verticilloides was naphthalene (3-methoxy-7 methylnaphthalene-1,6-diol). This finding can be used as a basis for drug development.
Study of Potential α-Glucosidase Inhibitor from Tithonia diversifolia: In Vitro, Pharmacokinetics, Toxicology, and Molecular Docking Alfarado, Daniel; Shiyan, Shaum; Ferlinahayati, Ferlinahayati
Indonesian Journal of Chemistry Vol 25, No 2 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.103111

Abstract

The kipahit plant (Tithonia diversifolia) is commonly used in traditional medicine to treat various diseases, particularly diabetes. Investigating the bioactive compounds of T. diversifolia as α-glucosidase enzyme inhibitors is very promising to be carried out for antidiabetic drug development. A combination of in vitro and in silico studies was conducted to determine the inhibitory interaction of these compounds. In vitro assay was performed using the spectrophotometry method on methanol extracts and revealed that the stems (IC50 = 105.0 ppm) exhibited higher bioactivity than the leaves (IC50 > 500 ppm). Metabolite profiling of the methanol extract of the T. diversifolia stems revealed 94 compounds, which continued for in silico methods (pharmacokinetics and toxicology, followed by molecular docking with flexible-rigid method) for antidiabetic activity and drug-likeness parameters. Among the identified compounds, eight showed promise as drug candidates for inhibiting the α-glucosidase enzyme. The compound 1-(7-hydroxy-2-(hydroxymethyl)-2-methyl-2H-chromen-6-yl)ethanone was the most effective candidate among the eight candidates, based on its high similarity liked positive control, the lowest binding affinity value (−7.739 kcal/mol), and the inhibition constant (97.0 μM). The research findings suggested that the compounds in T. diversifolia had the potential to inhibit the α-glucosidase enzyme and could be developed into antidiabetic drugs.
Adsorption and Photocatalytic Activity of Bentonite–Titanium Dioxide on The Degradation of Methylene Blue Dyes Said, Muhammad; Erlangga, Niko; Alfarado, Daniel; Suheryanto, Suheryanto; Nurnawati, Elisa
IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Vol 8, No 3 (2023): October 2023
Publisher : IJFAC (Indonesian Journal of Fundamental and Applied Chemistry)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24845/ijfac.v8.i3.126

Abstract

The aim of this research is to determine the effect of bentonite-Titanium dioxide (Benonite-TiO2) composite on the degradation process of methylene blue. It was carried out by synthesizing the composite through the impregnation of Titanium dioxide (TiO2) on bentonite and then characterizing the obtained compound using XRD and SEM-EDX. The results of the XRD characterization showed that there was a shift in the diffraction angle (2θ), which indicated the success of the impregnation procedure. The morphology of the composite showed that the bentonite surface had been filled with TiO2, as evidenced by the results of the EDX analysis, which showed a 7.03% increase in Titanium. Furthermore, the degradation process was carried out using various variables, including contact time, the ratio of composite weight to dye, and by irradiation with a UV lamp at a wavelength of 352 nm UV. It was discovered that the best degradation in the concentration of methylene blue occurred at a maximum contact time of 90 minutes and at a maximum weight of 10 mg of benonite-TiO2, with an effectiveness of 99.91% after irradiation and 92.26% without irradiation.
Co-Authors Elfita Elisa Nurnawati Erlangga, Niko Ferlinahayati Ferlinahayati Hary Widjajanti MUHAMMAD SAID Salni Shaum Shiyan Suheyanto Suheryanto Ummi Hiras Habisukan, Ummi Hiras Yustina Hapida, Yustina