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All Journal JURNAL PHOTON AS-SHIHA: JURNAL KESEHATAN Journal Of Pharmacy
Herli, Muhammad Azhari
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Cervical Cancer with Radiotherapy Treatment Novita Ariani; Herli, Muhammad Azhari; Laila, Nurul
As-Shiha: Jurnal Kesehatan Vol. 4 No. 2 (2024): As-Shiha: Jurnal Kesehatan
Publisher : Fakultas MIPA dan Kesehatan, Universitas Muhammadiyah Riau

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Abstract

Cervical cancer is an abnormal growth of cells in the cervix, which its etiological agent is infected by the human papillomavirus. Globally, cervical cancer is the fourth most common cancer in women, one of the most frequently diagnosed cancer, and a cause of cancer-related death. The Global Cancer Statistics 2022, censused approximately 660,000 new cases and 350,000 deaths worldwide. Therefore, to contrast cervical cancer as a public health problem, the World Health Organization in 2020, conducted a global health strategy with tertiary interventions: (1) prevention through HPV vaccination; (2) screening and precancerous lesions treatment; and (3) adequate treatment of invasive cervical. Currently, there are three therapeutic modalities which are surgery, chemotherapy, and radiotherapy. These may include one or a combination of surgery, chemotherapy and radiotherapy. Radiotherapy is a major treatment in the management of cervical cancer, which uses high energy x-rays.
Desain Primer PCR Sebagai Biomarker COVID-19 Strain Terbaru Yang Di Identifikasi Di Januari 2021 Herli, Muhammad Azhari; Hari, Dewi Gulyla; Rahmawati, Ayu
Photon: Jurnal Sain dan Kesehatan Vol. 11 No. 2 (2021): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v11i2.3645

Abstract

Coronavirus disease 2019 (COVID-19) is a contagious disease caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS CoV-2). The disease first spread in Wuhan, Hubei Province, China in December 2019. SARS-CoV-2 is highly contagious and has grown rapidly around the world since its discovery. Until January 2021, a total of 101,406,059 confirmed cases of SARS-CoV-2 infection worldwide with a death toll of 2,191,898 and still growing. Diagnosis of COVID-19 is carried out in two common ways, namely a rapid test and PCR (polymerase chain reaction). This study aims to design a PCR primer for the latest COVID-19 strain isolated in January 2021 with the insilico method (computer simulation) so that the primer used as a COVID-19 biomarker is fast and accurate. The results of this study obtained 10 of the best primers from the latest COVID-19 strains with codes MW454767, MW454771, MW460582, MW454660 which were identified on 11 Jan 2021.
Pharmacokinetic Prediction, Drug-Like Properties, and Molecular Docking of Bioactive Compounds from Ethanol Extract of Uncaria nervosa Elmer Leaves Rahmawati, Noveri; Herli, Muhammad Azhari; Delvi Andrianingsih; Rahmi Amini
The Journal Of Pharmacy Vol. 3 No. 1 (2025): Journal Of Pharmacy UMRI
Publisher : LPPM, Universitas Muhammadiyah Riau

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Abstract

Uncaria nervosa Elmer leaves are known to contain bioactive compounds with potential as natural drug candidates, yet their pharmacokinetic profiles, drug-likeness, and molecular affinity toward target proteins remain limitedly explored. This study aimed to evaluate the pharmacokinetic properties, drug-likeness, and molecular interaction potential of bioactive compounds from the ethanol extract of Uncaria nervosa leaves. An in silico approach was employed using SwissADME to analyze pharmacokinetic parameters (absorption, distribution metabolism, and excretion) and drug-likeness based on Lipinski’s and Veber’s rules, followed by molecular docking against proteins 6O0K and 2W3L using MOE software. The results showed that most compounds exhibited high gastrointestinal absorption, did not inhibit major CYP enzymes, and several complied with drug-likeness rules. Docking analysis revealed that ceratodictyol displayed the closest binding energy to the positive controls (doxorubicin and obatoclax), indicating strong molecular affinity, while N-formamide showed superior pharmacokinetic and drug-likeness properties. In conclusion, the combination of pharmacokinetic and docking data highlights ceratodictyol as the main candidate supported by N-formamide as a potential compound, suggesting that Uncaria nervosa leaf extract may serve as a promising natural source for anticancer drug development.
Co-Authors AYU RAHMAWATI Delvi Andrianingsih Hari, Dewi Gulyla Noveri Rahmawati Novita Ariani Nurul Laila, Nurul Rahmi Amini