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All Journal Indonesian Journal of Biotechnology and Biodiversity Journal Syifa Sciences and Clinical Research (JSSCR) Edu Masda Journal Tridharmadimas: Jurnal Pengabdian Kepada Masyarakat Jayakarta
Wilapangga, Anjas
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Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Electrical & Electronics Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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ANALISIS FITOKIMIA DAN ANTIOKSIDAN METODE DPPH EKSTRAK METANOL DAUN SALAM (EUGENIA POLYANTHA) Wilapangga, Anjas; Sari, Lina Puspita
Indonesian Journal of Biotechnology and Biodiversity Vol 2, No 1 (2018): Indonesian Journal of Biotechnology and Biodiversity
Publisher : Universitas Esa Unggul

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Abstract

AbstractDaun Salam contains essential oil (sitral and eugenol), tannins and flavonoids. This research aims to understand the test results of Phytochemical and antioxidant activity. Daun Salam (Eugenia polyantha) extracted in maceration with methanol. Extract and tested Phytochemical and antioxidant activity of DPPH method. Results of the study showed extracts of leaves (Eugenia polyantha) have chemical contents, namely alkaloids, flavonoids, saponins, steroids, these terpenoids and tannins, test method of DPPH antioxidant activity of sample extract with the bay leaf in the get the value of IC-50 amounted to 19.97 ppm. Keywords:Daun salam, phytochemicals, antioxidants AbstrakDaunSalam mengandungminyakatsiri (sitral dan eugenol), tanin dan flavonoid.Penelitian ini bertujuan untuk mengetahuihasil uji fitokimia dan aktivitas antioksidan. Ekstrakdaunsalam (Eugenia polyantha)diekstraksisecaramaserasidenganmetanol. Ekstrakdipekatkan dan diujifitokimia dan aktivitasantioksidanmetode DPPH. Hasil penelitianmenunjukkanekstrakdaunsalam(Eugenia polyantha)mempunyaikandungankimiayaitualkaloid, flavonoid, saponin, steroid, terpenoid dan tanin, Uji aktivitasantioksidanmetode DPPH dengansampelekstrakdaunsalam di dapatkannilai IC-50 sebesar 19,97 ppm. Kata kunci :Daun salam, fitokimia, antioksidan
STUDI IN SILICO PREDIKSI TOKSISITAS DAN AKTIFITAS SENYAWA XANTHOANGELOL SEBAGAI INHIBISI ENZYM TIROSINASE Dewantoro, Agung; Wilapangga, Anjas
Edu Masda Journal Vol 7, No 1 (2023): Edu Masda Journal Volume 7 Nomor 1
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v7i1.181

Abstract

The tyrosinase enzyme plays an important role in the synthesis of melanin, which caused the process of skin hyperpigmentation. One of the main chemical constituent in the Ashitaba plant is Xanthoangelol which has antioxidant properties. The antioxidant activity of  Xanthoangelol compound is also thought to have the activity of inhibiting the tyrosinase enzyme. In silico test is a method in the development of new drugs. The in silico method provides an evaluation of the potential farmacologyc activities of chemical compound by docking using the Molegro Virtual Docker computer program. The receptor used uses Protein Tyrosinase PDB Code 3NQ1 with KOJ_B_1351 Ligand. Xanthoangelol and Kojic Acid toxicity prediction was carried out using the pkCSM online tool program. Data analysis was performed by comparing the bond energies of the docking results between Xanthoangelol, Kojic Acid, and Ligands at the target receptors. The in silico test results showed that the bond energy of Xanthoangelo was -96.1232 kcal/mol, Kojic Acid -43.6097 kcal/mol, and Ligand KOJ_B_1351 -48.2213 kcal/mol. The in silico test results using the Mollegro program and the pkCSM online tool show that the Xanthoangelol compound has the potential to inhibit the tyrosinase enzyme and has relatively low toxicity, so it can be used as a candidate as a face lightening agent. ABSTRAKEnzim tirosinase berperan penting pada sintesis melanin.yang berperan pada proses hiperpigmentasi kulit., Salah satu kandungan utama Pada tanaman Ashitaba ialah Xanthoangelol yang mempunyai sifat Antioksidan. Aktifitas Antioksidan pada senyawa Xanthoangelol ini diperkirakan juga memiliki aktifitas menginhibisi enzyme tirosinase. Uji in silico merupakan metode dalam pengembangan obat baru. Metode in silico memberikan evaluasi terhadap potensi aktifitas farmakologis suatu senyawa obat dengan melakukan docking menggunakan program komputer Molegro Virtual Docker. Reseptor yang digunakan menggunakan Protein Tirosinase Kode PDB 3NQ1 dengan Ligan KOJ_B_1351. Prediksi toksisitas Xanthoangelol dan Asam Kojic dilakukan menggunakan program pkCSM online tool. Analisis data dilakukan dengan membandingkan energi ikatan hasil docking antara Xanthoangelol, Asam Kojic, dan Ligan pada reseptor target. Hasil uji in silico menunjukkan bahwa energi ikatan Xanthoangelo -96.1232 kkal/mol, Asam Kojic -43.6097 kkal/mol, dan Ligan KOJ_B_1351 -48.2213 kkal/mol. Hasil uji in silico menggunakan program mollegro dan pkCSM online tool menunjukkan bahwa senyawa Xanthoangelol mempunyai potensi untik menginhibisi enzim tirosinase dan memiliki toksisitas yang relatif rendah, sehingga dapat dijadikan kandidat sebagai Bahan pencerah wajah.
BISNIS FARMASI MENJADI PENGUSAHA SKIN CARE SAMBIL KULIAH? BISA! Noordam, Errol Rakhmad; Permadi, Trisna; Sutyono, Bangun; Yudianto, Dian; Wilapangga, Anjas; Thaha, Atifah; Paramita, Gemala; Sundawa, Rachmat Dimas; Syahiruddin, Syahiruddin
TRIDHARMADIMAS: Jurnal Pengabdian Kepada Masyarakat Jayakarta Vol 4 No 2 (2024): PKM-TRIDHARMADIMAS (Desember 2024)
Publisher : Sekolah Tinggi Manajemen Informatika dan Komputer Jayakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52362/tridharmadimas.v4i2.1723

Abstract

Berwirausaha atau menjadi pengusaha adalah proses memulai dan mengelola bisnis. Berwirausaha melibatkan risiko dan pengambilan keputusan bisnis, serta memerlukan perencanaan, inovasi, dan penguasaan berbagai keterampilan bisnis. Bahwa banyak pemuda yang tidak mau berwirausaha padahal sebagai tunas bangsa para pemuda merupakan aset penting bagi kehidupan sosial maupun nasional untuk meningkatkan kualitas hidup masyarakat dan negara. Seharusnya pada saat masa muda harus ditanamkan jiwa kewirausahaan yaitu jiwa berani berusaha mendapatkan ide dan melakukan tindakan yang akan menghasilkan nilai ekonomis tapi itu sangat jarang sekali ditemukan pada pemuda masa kini, hal tersebut bisa disebabkan tidak tahu harus mulai dari mana dan dimana tempat atau wadah untuk mengemukakan ide-ide tersebut. Oleh karena hal – hal tersebut diatas maka Kami berniat mengadakan Seminar Pengabdian Kepada Masyarakat dengan tema “Jadi Pengusaha Skin Care Sambil Kuliah? Bisa”.
Phylogenetic Analysis of Selected Chrysanthemum Species Using matK Gene Sequences: An In Silico Approach Wilapangga, Anjas; Rakhmad Noordam, Errol; Yudianto, Dian
Journal Syifa Sciences and Clinical Research Vol 7, No 3 (2025): Volume 7 Number 3 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i3.31516

Abstract

This study evaluated the effectiveness of the matK gene as a molecular marker for identifying and establishing phylogenetic relationships among species within the genus Chrysanthemum. DNA sequence data were retrieved from the NCBI database and analysed using MEGA X software with the UPGMA method and 1000 bootstrap replicates. The resulting phylogenetic tree showed clear species differentiation, with strong clustering between C. indicum and C. × morifolium, and distinct divergence among other species such as C. zawadskii, C. chanetii, and C. lucidum. These findings confirm that matK is a reliable DNA barcoding marker for systematic and taxonomic studies of Chrysanthemum, particularly in addressing the limitations of morphological identification caused by phenotypic variation and hybridisation. However, this study was limited to a single marker, and future research should incorporate additional loci or genomic approaches to obtain a more comprehensive understanding of Chrysanthemum phylogeny.
Co-Authors Agung Dewantoro Errol Rakhmad Noordam Paramita, Gemala Sari, Lina Puspita Sundawa, Rachmat Dimas Sutyono, Bangun Syahiruddin, Syahiruddin Thaha, Atifah Trisna Permadi Yudianto, Dian