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Effects of Momordica charantia (MC) Extract on Clinical Symptoms, Parasite Account, Thrombocytes, Total Bilirubin and Direct Bilirubin in Patients with Uncomplicated Plasmodium falciparum Malaria: A Case Report Yudianto, Dian; Syamsudin Abdillah; Hesty Utami Ramadaniaty; Erni Juwita Nelwan
Archives of The Medicine and Case Reports Vol. 5 No. 1 (2024): Archives of The Medicine and Case Reports
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/amcr.v5i1.417

Abstract

Clinical symptoms during the treatment of uncomplicated P. falciparum malaria have been reported in several studies. Parasite density in the blood is associated with clinical symptoms, platelet, and bilirubin count. A 52-year-old male, weighing 52 kg, was given one capsule containing 325 mg bitter melon (Momordica charantia) extract for 3 days of treatment. Patients were followed up for 28 days, days 1,2,3,4,7,14,21,28, and peripheral blood microscopic examination and clinical symptoms were carried out. Measurement of platelets, total bilirubin, direct bilirubin D0, D14 and D28. Naranjo Scale, adverse events measurements were taken on D7, no signs of severe malaria, no comorbidities, no history of malaria, blood pressure 110/80 mmHg, peripheral blood parasite examination on D0 found P. falciparum parasites of 31,714/µL, D0 platelet value of 94x10 /mm3, D0 total bilirubin value of 1.3 mg% and D0 direct bilirubin value of 0.6 mµ/mL. On D1 parasite count was 2,400/µL, D2 was 372/µL, D3, D4, D7, D14, D21, D28 no asexual parasites were found again. Clinical symptoms that arose on D0 were nausea, no appetite, sweating, chills, sleep disturbance, dizziness, headache, and weakness with a body temperature of 37°C. After D3 of bitter melon extract treatment, no clinical symptoms were found again. Naranjo scale score based on nurse and pharmacist agreement was 6 (probable) at D7 for the adverse events of nausea and vomiting. There were no reported adverse events such as nausea, vomiting, diarrhea, abdominal pain, cough, sleep disturbance, dizziness, headache and weakness on D2 treatment. Bitter melon extract is effective for uncomplicated malaria P. falciparum, reduces clinical symptoms, and is safe.
BISNIS FARMASI MENJADI PENGUSAHA SKIN CARE SAMBIL KULIAH? BISA! Noordam, Errol Rakhmad; Permadi, Trisna; Sutyono, Bangun; Yudianto, Dian; Wilapangga, Anjas; Thaha, Atifah; Paramita, Gemala; Sundawa, Rachmat Dimas; Syahiruddin, Syahiruddin
TRIDHARMADIMAS: Jurnal Pengabdian Kepada Masyarakat Jayakarta Vol 4 No 2 (2024): PKM-TRIDHARMADIMAS (Desember 2024)
Publisher : Sekolah Tinggi Manajemen Informatika dan Komputer Jayakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52362/tridharmadimas.v4i2.1723

Abstract

Berwirausaha atau menjadi pengusaha adalah proses memulai dan mengelola bisnis. Berwirausaha melibatkan risiko dan pengambilan keputusan bisnis, serta memerlukan perencanaan, inovasi, dan penguasaan berbagai keterampilan bisnis. Bahwa banyak pemuda yang tidak mau berwirausaha padahal sebagai tunas bangsa para pemuda merupakan aset penting bagi kehidupan sosial maupun nasional untuk meningkatkan kualitas hidup masyarakat dan negara. Seharusnya pada saat masa muda harus ditanamkan jiwa kewirausahaan yaitu jiwa berani berusaha mendapatkan ide dan melakukan tindakan yang akan menghasilkan nilai ekonomis tapi itu sangat jarang sekali ditemukan pada pemuda masa kini, hal tersebut bisa disebabkan tidak tahu harus mulai dari mana dan dimana tempat atau wadah untuk mengemukakan ide-ide tersebut. Oleh karena hal – hal tersebut diatas maka Kami berniat mengadakan Seminar Pengabdian Kepada Masyarakat dengan tema “Jadi Pengusaha Skin Care Sambil Kuliah? Bisa”.
Phylogenetic Analysis of Selected Chrysanthemum Species Using matK Gene Sequences: An In Silico Approach Wilapangga, Anjas; Rakhmad Noordam, Errol; Yudianto, Dian
Journal Syifa Sciences and Clinical Research Vol 7, No 3 (2025): Volume 7 Number 3 2025
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v7i3.31516

Abstract

This study evaluated the effectiveness of the matK gene as a molecular marker for identifying and establishing phylogenetic relationships among species within the genus Chrysanthemum. DNA sequence data were retrieved from the NCBI database and analysed using MEGA X software with the UPGMA method and 1000 bootstrap replicates. The resulting phylogenetic tree showed clear species differentiation, with strong clustering between C. indicum and C. × morifolium, and distinct divergence among other species such as C. zawadskii, C. chanetii, and C. lucidum. These findings confirm that matK is a reliable DNA barcoding marker for systematic and taxonomic studies of Chrysanthemum, particularly in addressing the limitations of morphological identification caused by phenotypic variation and hybridisation. However, this study was limited to a single marker, and future research should incorporate additional loci or genomic approaches to obtain a more comprehensive understanding of Chrysanthemum phylogeny.