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All Journal Medical Journal of Indonesia Neurona
Pramitasuri, Tjokorda Istri
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Health Professions Medicine & Pharmacology Neuroscience

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NF-κB, neutrophil extracellular traps, and microglial in mice with Streptococcus suis serotype 2 meningitis infection Susilawathi, Ni Made; Adi Tarini, Ni Made; Arijana, I Gusti Kamasan Nyoman; Sriwidyani, Ni Putu; Pramitasuri, Tjokorda Istri; Sudewi, Anak Agung Raka; Mahardika, I Gusti Ngurah Kade
Medical Journal of Indonesia Vol. 33 No. 3 (2024): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247394

Abstract

BACKGROUND Streptococcus suis is the most frequent etiology of zoonotic bacterial meningitis, potentially initiating an outbreak. Acute bacterial meningitis caused by S. suis has various manifestations, often accompanied by sepsis with multiple organ involvement. This study aimed to evaluate the pattern of S. suis outgrowth in the brain, which is associated with nuclear factor-κappaB (NF-κB) activation, neutrophil extracellular traps (NETs) release (NETosis), and microglial activation as three crucial pathological mechanisms of bacterial meningitis. METHODS This study used 64 female BALB/c mice aged 6 weeks and weighed 18−20 g, grouped into infected and non-infected as the control group. Both groups were administered 1 ml of S. suis serotype 2 suspension (1 × 107 colony forming-unit/ml) and normal saline intraperitoneally. The bacterial colony count of S. suis was evaluated, along with NF-κB and NET levels in blood and brain, as well as meningeal inflammation and microglial activation in the brain at Days 1, 3, 5, and 7 post-infection. RESULTS The invasion of S. suis into the brain slightly induced NF-κB activation, leading to a burst of inflammatory responses, neutrophil infiltration with NET releases, and microglia activation that co-occurred, showing their peaks on Days 3 and 5 after onset. CONCLUSIONS The S. suis invasion into the mice’s brain increased NF-κB activation, NETosis, and microglia activation during S. suis meningitis infection.
Tuli Sensorineural Pasca Meningitis Streptococcus Suis: Sebuah Topik Kajian Strategis Bidang Ilmu Neuroinfeksi Sudewi, AA Raka; Pramitasuri, Tjokorda Istri; Susilawathi, Ni Made; Adi Tarini, Ni Made; Mahardika, I Gusti Ngurah Kade; Sukrama, I Dewa Made
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 3 (2022): Vol 39 No 3 (2022)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i3.341

Abstract

Sensorineural deafness as a result of Streptococcus suis (S. suis) meningitis is a serious hazard to worldwide public health and one of the strategic study concerns in neuroscience. There is currently no treatment plan for sensorineural deafness brought on by S. suis meningitis that can significantly enhance quality of life. Controlling S. suis meningitis-related sensorineural deafness is therefore vital for the area of neurology. This review of the literature seeks to provide an overview of the scientific literature on the epidemiology, etiology, and features of deafness as they pertain to sensorineural hearing loss brought on by S. suis meningitis. Spiral Ganglion Neurons, hair cells in the cochlea, and brain-derived neurotrophic factor in the peripheral auditory system interact with one another in the etiology of sensorineural deafness, according to recent studies.
Co-Authors I Dewa Made Sukrama I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Kade Mahardika Ni Made Adi Tarini Ni Putu Sriwidyani Raka-Sudewi A. A. Susilawathi, Ni Made