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All Journal Medical Journal of Indonesia Journal of Biomedicine and Translational Research MNJ (Malang Neurology Journal) Kumawula: Jurnal Pengabdian Kepada Masyarakat AKSONA INDONESIAN JOURNAL OF URBAN AND ENVIRONMENTAL TECHNOLOGY Magna Neurologica Neurona
Susilawathi, Ni Made
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Antibiotic-Resistant Phenotype and Genotype of S. suis serotype 2 (SS2) Isolated from Humans in Bali, Indonesia MAYURA, I PUTU BAYU -; TARINI, NI MADE ADI; Susilawathi, Ni Made; YULIANDARI, PUTU
Journal of Biomedicine and Translational Research Vol 10, No 2 (2024): August 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i2.21985

Abstract

Background: In recent times, meningitis, an infection primarily attributed to the zoonotic bacteria Streptococcus suis, has emerged as a significant public health concern in Bali, Indonesia. Their resistance to a multitude of antibiotics has emerged as a contemporary threat, as opposed to their virulence. There is a current lack of reported information regarding the genetic or phenotypic susceptibility pattern of S. suis to antibiotics in Bali.Objective: The objective of this research endeavor was to ascertain the antibiotic susceptibility pattern of S. suis isolates in Bali, either through phenotypic or genetic means.Methods: The Clinical Microbiology Laboratory of Prof. I.G.N.G. Ngoerah Hospital was consulted for the acquisition of clinical specimens. Since April 2016 until April 2022, the antibiotic sensitivity of isolates was identified and assessed using the VITEK 2 Compact (Biomeriuex®). Determining the serotype and antibiotic resistance genes genetically required PCR employing multiple primers.Results: Successful isolation of sixty-six S. suis isolates occurred primarily from cerebrospinal fluid. The results demonstrated that all isolates exhibited phenotypic resistance to tetracycline, with one isolate demonstrating co-resistance to tetracycline and erythromycin/clindamycin. It is additionally corroborated genetically through the amplification of the tetM gene in every isolate, including those that exhibited concurrent resistance to erythromycin and tetracycline. The intTn gene, which is a member of the conjugate transposon Tn916 family, was amplified and utilized for horizontal media gene transfer on S. suis plasmids carrying the resistance genes ermB and tetM.Conclusion: This research represents the initial investigation into the antibiotic resistance phenotype and genotype of S. suis serotype 2 (SS2) isolated from human subjects in Bali, Indonesia. The findings suggest that the pathogenicity and widespread dissemination of SS2 in the community may have been influenced by the extensive use of tetracycline and the horizontal acquisition of the genetic element Tn916 with tetM.
PENYULUHAN KOMPLIKASI DIABETES PADA SISTEM SARAF UNTUK LANSIA DI WILAYAH KERJA PUSKESMAS I DENPASAR SELATAN Widyadharma, I Putu Eka; Adnyana, I Made Oka; Utami, Desak Ketut Indrasari; Widyastuti, Ketut; Tini, Kumara; Susilawathi, Ni Made; Wijayanti, Ida Ayu Sri; Mahadewi, Ni Putu Ayu Putri
Kumawula: Jurnal Pengabdian Kepada Masyarakat Vol 7, No 2 (2024): Kumawula: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/kumawula.v7i2.46978

Abstract

Diabetes melitus (DM) merupakan salah satu penyakit metabolik menahun yang paling sering di dunia, dengan tren yang semakin meningkat dan juga berdampak pada masyarakat di Indonesia. Komplikasi dari penyakit DM dapat berdampak pada angka morbiditas dan mortalitas yang tinggi. Penyakit DM memiliki komplikasi yang berdampak ke sistem saraf seperti stroke, gangguan fungsi kognitif, gangguan tidur, serta nyeri neuropati diabetik (NND). Komplikasi diabetes sering tidak diketahui oleh masyarakat. Kurangnya pemahaman masyarakat indonesia terhadap DM, komplikasi dan upaya pencegahan menjadi salah satu kendala yang masih terjadi. Komplikasi ini semakin meningkat risikonya pada kelompok usia lanjut (lansia) dan menganggu kualitas hidup hingga segi ekonomi di masyarakat. Peran fase kesehatan pertama yaitu Puskesmas sangat berperan penting dalam upaya pencegahan penyakit diabetes, seperti deteksi dini sehingga dapat pencegahan dan penanganan kepada pasien diabetes. Tujuan dari kegiatan ini yaitu untuk meningkatkan pengetahuan masyarakat tentang komplikasi DM pada sistem saraf di area kerja Puskesmas I Denpasar Selatan. Metode kegiatan yang akan dilakukan yaitu ceramah, diskusi, hand-on dalam penegakan diagnosis dan kuisioner pre dan post-test terselenggara pada tanggal 30 Oktober 2022 di Banjar Pegok, Denpasar. Hasil kuisioner pre dan post-test didapatkan adanya peningkatan nilai pengetahuan peserta setelah dilakukan pelatihan. Simpulan dan implikasi yang didapatkan yaitu diharapkan setelah adanya pelatihan ini, para masyarakat di Puskesmas I Denpasar Selatan dapat lebih memahami tentang penyakit DM dan komplikasinya terhadap sistem saraf.
CEREBRAL VENOUS SINUS THROMBOSIS WITH GOOD RESPONSE TO HEPARINIZATION THERAPY: TWO CASE REPORT AND DIAGNOSTIC ALGORITHM Indah, Carolin Tiara Lestari; Tini, Kumara; Susilawathi, Ni Made; Wijayanti, Ida Ayu Sri; Mahadewi, Ni Putu Ayu Putri; Pramaswari, Anak Ayu Agung; Mahaalit Aribawa, I Gusti Ngurah; Dewi, Putu Utami; Krisnawardhani Kumbara, Cokorda Istri Yuliandari
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.17

Abstract

Cerebral venous sinus thrombosis (CVST) is an uncommon condition of cerebral venous sinus thrombosis with a varied clinical presentation that can be diagnostically challenging. Intravenous heparin is the optimal immediate anticoagulant according to the European Academy of Neurology (EAN) guideline 2017. This report aims to describe highly suspicious CVST clinical features and suggest a diagnostic algorithm based on two cases of CVST found in our center. The first case is a 52-year-old man who presented with serial seizures preceded by subacute headache and diparesis. Non-contrast head CT (NCCT) showed multifocal haemorrhages and cord signs. The second case is a 19-year-old woman who presented with slowly decreased consciousness, headache, and a history of upper respiratory infection. Diffuse cerebral edema was revealed in NCCT. Both of these patients had thrombosis in superior sagittal sinus, right transverse, and sigmoid sinus. Heparinization was conducted and continued with rivaroxaban with a good response. CVST is rare case and often unrecognized; since it has serious complications, early diagnosis and treatment improve prognosis and survival.
Profile of HIV/AIDS Patients with Neurological Manifestations in The Tertiary Referral Hospital in Bali Suryapraba, Anak Agung Ayu; Vania, Aurelia; Sudewi, Anak Agung Raka; Sukmawati, Ni Made Dewi Dian; Susilawathi, Ni Made
Magna Neurologica Vol. 2 No. 2 (2024): July
Publisher : Department of Neurology Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/magnaneurologica.v2i2.1097

Abstract

Background: Neurological manifestations in approximately half of Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/AIDS) patients are related to high morbidity and mortality worldwide. Therefore, there is a need for epidemiological data on HIV/AIDS patients with neurological manifestations in Bali, as an international tourism destination.  Objective: This study aimed to describe the clinical profile of neurological manifestations among patients with HIV/AIDS in the tertiary referral hospital for Bali and Nusa Tenggara region. Methods: A descriptive-retrospective study was conducted on HIV/AIDS patients presenting with neurological manifestations hospitalized in the Neurology Department of Prof. Dr. I.G.N.G Ngoerah Hospital Denpasar from January 2018 to December 2021. Results: Among the 227 subjects included in this study, the majority were male (69.9%) and HIV positive newly diagnosed (69.2%). Furthermore, out of 126 subjects who had CD4 data, the majority were with CD4 <200 cells/mm3 (85.7%) and 53.1% were <50 cells/mm3, with ages ranging from 18 to 67 years old, at a median of 36 years old. The most common neurological signs and symptoms found were paresis/paralysis (61.7%), headache (54.6%), decreased consciousness (52.9%), and cranial nerve palsy (52%). Cerebral toxoplasmosis (67.4%) and tuberculous meningoencephalitis (20.3%) were the prevalent opportunistic infections, while the mortality rate was 39.6% with sepsis as the major cause. Conclusions: Neurological manifestations are common initial symptoms in diagnosing HIV infection. Therefore, better awareness and earlier detection are required among people with risk factors of HIV transmission, particularly in groups of young and productive age with signs of immunocompromised condition as well as neurological manifestations.
NF-κB, neutrophil extracellular traps, and microglial in mice with Streptococcus suis serotype 2 meningitis infection Susilawathi, Ni Made; Adi Tarini, Ni Made; Arijana, I Gusti Kamasan Nyoman; Sriwidyani, Ni Putu; Pramitasuri, Tjokorda Istri; Sudewi, Anak Agung Raka; Mahardika, I Gusti Ngurah Kade
Medical Journal of Indonesia Vol. 33 No. 3 (2024): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.247394

Abstract

BACKGROUND Streptococcus suis is the most frequent etiology of zoonotic bacterial meningitis, potentially initiating an outbreak. Acute bacterial meningitis caused by S. suis has various manifestations, often accompanied by sepsis with multiple organ involvement. This study aimed to evaluate the pattern of S. suis outgrowth in the brain, which is associated with nuclear factor-κappaB (NF-κB) activation, neutrophil extracellular traps (NETs) release (NETosis), and microglial activation as three crucial pathological mechanisms of bacterial meningitis. METHODS This study used 64 female BALB/c mice aged 6 weeks and weighed 18−20 g, grouped into infected and non-infected as the control group. Both groups were administered 1 ml of S. suis serotype 2 suspension (1 × 107 colony forming-unit/ml) and normal saline intraperitoneally. The bacterial colony count of S. suis was evaluated, along with NF-κB and NET levels in blood and brain, as well as meningeal inflammation and microglial activation in the brain at Days 1, 3, 5, and 7 post-infection. RESULTS The invasion of S. suis into the brain slightly induced NF-κB activation, leading to a burst of inflammatory responses, neutrophil infiltration with NET releases, and microglia activation that co-occurred, showing their peaks on Days 3 and 5 after onset. CONCLUSIONS The S. suis invasion into the mice’s brain increased NF-κB activation, NETosis, and microglia activation during S. suis meningitis infection.
Tuli Sensorineural Pasca Meningitis Streptococcus Suis: Sebuah Topik Kajian Strategis Bidang Ilmu Neuroinfeksi Sudewi, AA Raka; Pramitasuri, Tjokorda Istri; Susilawathi, Ni Made; Adi Tarini, Ni Made; Mahardika, I Gusti Ngurah Kade; Sukrama, I Dewa Made
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 3 (2022): Vol 39 No 3 (2022)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i3.341

Abstract

Sensorineural deafness as a result of Streptococcus suis (S. suis) meningitis is a serious hazard to worldwide public health and one of the strategic study concerns in neuroscience. There is currently no treatment plan for sensorineural deafness brought on by S. suis meningitis that can significantly enhance quality of life. Controlling S. suis meningitis-related sensorineural deafness is therefore vital for the area of neurology. This review of the literature seeks to provide an overview of the scientific literature on the epidemiology, etiology, and features of deafness as they pertain to sensorineural hearing loss brought on by S. suis meningitis. Spiral Ganglion Neurons, hair cells in the cochlea, and brain-derived neurotrophic factor in the peripheral auditory system interact with one another in the etiology of sensorineural deafness, according to recent studies.
Todd’s Paresis as a Postictal Phenomenon in Post-Traumatic Epilepsy: A Case Report Yusari, I Gusti Agung Ayu Andra; Susilawathi, Ni Made; Mahadewi, Ni Putu Ayu Putri
AKSONA Vol. 5 No. 2 (2025): JULY 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v5i2.54758

Abstract

Highlight: Todd’s paresis presented as transient hemiparesis in a case of untreated post-traumatic epilepsy. Proposed pathomechanisms of Todd’s paresis include neuronal exhaustion, active inhibition, and postictal hypoperfusion. Todd’s paresis was commonly misdiagnosed as acute ischemic stroke due to the similar clinical presentation   ABSTRACT Introduction: Todd’s paresis is defined as a paralysis state after an epileptic seizure that lasts for several hours to days and recovers completely afterwards. It usually manifests as a transient hemiparesis after a focal or generalized seizure. Todd’s paresis cases and its mechanisms were still widely discussed. Case: A 48-year-old man with history of post-traumatic epilepsy presented with right-sided hemiparesis and facial weakness after a general motor tonic-clonic seizure. The location of the hemiparesis was contralateral to the post-trauma lesion in left frontal lobe which was suspected to be the focus of the seizure. The postictal weakness resolved completely after 30 hours without any specific intervention. It was revealed that the patient had been having several seizures beforehand after the epidural and subdural hematoma due to head trauma. The patient was diagnosed as Todd’s paresis following a post ictal condition in patient with post-traumatic epilepsy. Conclusion: Todd’s paresis should be considered as a diagnosis in patients with seizure and stroke-like syndrome such as hemiparesis due to its similar manifestations, especially if it resolves within hours. Several mechanisms were suggested to be the pathophysiology of Todd’s paresis including neuronal exhaustion, active inhibition, and postictal hypoperfusion.  
UNDERSTANDING LEVEL OF PKK BANJAR PURWA SANTHI BENOA ON MEDICAL MASK WASTE MANAGEMENT AND STRENGTHENING HEALTH PROTOCOLS IN CONTROLLING COVID-19 INFECTION Adiputra, I Komang Hotra; Harmayani, Kadek Diana; Susilawathi, Ni Made; Purnamasidhi, Cokorda Agung Wahyu; Witarini, Komang Ayu; Biantara, I Wayan Arya; Sukrama, I Dewa Made; Weisnawa, I Gede Purna; Jerry; Wulandari, Putu Kintan; Junior, Darren; Shanti, Dewa Ayu Fony Prema; Warmadewanthi, I Dewa Ayu Agung
INDONESIAN JOURNAL OF URBAN AND ENVIRONMENTAL TECHNOLOGY VOLUME 6, NUMBER 1, APRIL 2023
Publisher : Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/urbanenvirotech.v6i1.15335

Abstract

The increase in mask waste and a lack of understanding about the management of single-use mask waste raises the potential for environmental pollution and COVID-19 transmission. Aim: This study aimed to assess the level of understanding of medical mask waste management and strengthening health protocols in controlling COVID-19 infection in Banjar Purwa Santhi, Benoa, Badung Regency. Methodology and Results: A cross-sectional method and descriptive study design were used with a sample of 100 respondents selected via stratified sampling. The research and service activities at Banjar Purwa Santhi Benoa include public campaign and assessment of the level understanding of medical mask waste management. Based on univariate analysis, 91% of respondents know that mask waste contains hazardous and toxic substances. If mask waste is disposed carelessly, 98% of respondents stated that it can pollute the environment, and 98% of respondents also stated that it has the potential to become a means of transmitting COVID-19. However, 85% of respondents disposed of the masks in the household trash. Conclusion, significance and impact study: Respondents had a good level of knowledge about health protocols and mask waste management but have not separated masks from household waste. By holding the community service activity, it is hoped that changes in community behavior will occur.
Co-Authors Adiputra, I Komang Hotra Biantara, I Wayan Arya Cokorda Agung Wahyu Purnamasidhi Desak Ketut Indrasari Utami Dewi, Putu Utami I Dewa Made Sukrama I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Kade Mahardika I Gusti Ngurah Mahaalit Aribawa I Made Oka Adnyana I Putu Eka Widyadharma I.D.A.A Warmadewanthi Ida Ayu Sri Wijayanti Indah, Carolin Tiara Lestari Jerry Junior, Darren Kadek Diana Harmayani Komang Ayu Witarini Krisnawardhani Kumbara, Cokorda Istri Yuliandari Mahadewi, Ni Putu Ayu Putri MAYURA, I PUTU BAYU - Ni Made Adi Tarini Ni Putu Sriwidyani Pramaswari, Anak Ayu Agung Pramitasuri, Tjokorda Istri Raka-Sudewi A. A. Shanti, Dewa Ayu Fony Prema Sukmawati, Ni Made Dewi Dian Suryapraba, Anak Agung Ayu Tini, Kumara Vania, Aurelia Weisnawa, I Gede Purna Widyastuti, Ketut Wulandari, Putu Kintan YULIANDARI, PUTU Yusari, I Gusti Agung Ayu Andra