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The Effect of Extra Virgin Olive Oil (EVOO) on Fetal Birth Weight in Preeclampsia Rat Model Silvani, Yulia; Maharani, Afniari; Lovita, Agnestia Naning Dian
Jurnal Kedokteran Brawijaya Vol 31, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (163.79 KB) | DOI: 10.21776/ub.jkb.2020.031.01.3

Abstract

Preeclampsia, as one of the most common pregnancy-specific diseases, causes high maternal-fetal morbidity and mortality in almost every country. Placental vascular abnormalities in preeclamptic women can cause chronic hypoxia and impaired fetal nutrition, so fetal growth retardation often occurs. EVOO has strong antioxidant effect is assumed to prevent nutritional disorders in the fetus. This study aimed to determine the effect of EVOO on fetal birth weight in a preeclampsia rat model. This research was laboratory research conducted in vivo with a Post Test Only Control Group design which consisted of five groups; negative control group, positive control group (pre-eclampsia rat model), dose 1, 2, and 3 groups that were preeclampsia rats given EVOO in 3 different doses (0.5 mL/day, 1 mL/day and 2 mL/day respectively). Blood pressure and proteinuria measurements were carried out at the 12, 15 and 19 day of pregnancy. After sacrificed, fetal weight was measured immediately using analytical balance. The result of this study showed that there was a significant reduction of fetal weight between negative control and positive control group (p=0.020), meanwhile no significant differences among positive control, dose 1 and dose 2 group (p=0.90 and p=0.142) but statistically significant to dose 3 group (p=0.005). EVOO administration increases fetal weight in doses group by its AA and DHA in Long-Chain Poly Unsaturated Fatty Acids (LCPUFA) within. The optimal dose of EVOO to increase fetal weight is 2 mL/day.
Evaluasi Tingkat Pelaksanaan Manajemen Praktik Kebidanan Berbasis Midwifery Led Care di Wilayah Kabupaten Malang Dewi, Mustika; Windari, Era Nurisa; Sari, Ningrum Paramita; Fatmawati, Fatmawati; Silvani, Yulia; Ulfah, Mega; Maharani, Afniari
Journal of Issues in Midwifery Volume 8 No 3 Tahun 2024
Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.JOIM.2024.008.03.4

Abstract

Penelitian ini bertujuan untuk mengevaluasi tingkat pelaksanaan manajemen praktik kebidanan berbasis Midwifery Led Care (MLC) di Kabupaten Malang, yang berfokus pada empat aspek utama: partnership, women care, normality, dan continuity of care. Desain penelitian menggunakan metode deskriptif kuantitatif dengan pendekatan survei. Data dikumpulkan dari 40 bidan di Kabupaten Malang yang dipilih secara purposive sampling. Pengumpulan data dilakukan melalui kuesioner terstruktur yang mengukur implementasi keempat aspek MLC. Analisis data menggunakan teknik statistik deskriptif untuk mengidentifikasi pola pelaksanaan serta analisis inferensial untuk menentukan hubungan antar variabel. Hasil penelitian menunjukkan bahwa mayoritas bidan telah menerapkan MLC dengan baik, meskipun terdapat beberapa tantangan dalam penerapan continuity of care. Temuan ini diharapkan dapat menjadi dasar perbaikan manajemen praktik kebidanan untuk meningkatkan kualitas pelayanan kesehatan ibu dan anak di Kabupaten Malang.
Analysing Continuity of Care Implementation in the Midwifery-Led Care Model in Malang Regency Fatmawati, Fatmawati; Maharani, Afniari; Silvani, Yulia; Dewi, Mustika; Sari, Ningrum Paramita; Windari, Era Nurisa; Ulfa, Mega
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 13, No 1 (2025): EDITION MARCH 2025
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v13i1.6444

Abstract

This study aims to explore the implementation of Continuity of Care (CoC) within the Midwifery Led Care (MLC) model in Malang Regency. The maternal and child health indicators remain a concern due to high maternal mortality rates, exacerbated by complications such as preeclampsia and hemorrhage. CoC has been recognized for its ability to improve maternal and neonatal health outcomes by providing consistent care through midwives. This qualitative research, using a phenomenological approach, involved in-depth interviews with 20 mothers (10 primipara, 10 multipara) who experienced MLC, supported by observations and secondary data. Results revealed that both primipara and multipara mothers valued continuous midwifery care, though their experiences varied based on parity. Primipara mothers generally required more information and support, while multipara mothers exhibited greater confidence in midwife-led care. Barriers such as limited access to health services in remote areas, a lack of trained midwives, and insufficient community education on the benefits of MLC were identified. Recommendations include enhancing midwife training, improving access to healthcare in rural regions, and increasing public awareness of CoC benefits. The findings emphasize the importance of expanding MLC and CoC models to reduce maternal and neonatal morbidity and mortality in underserved areas.
Modulation of Endothelin-1 and Placental Microvascular Diameter by Extra Virgin Olive Oil in Preeclampsia Rat Model Dian Lovita, Agnestia Naning; Silvani, Yulia; Maharani, Afniari; Riawan, Wibi
Jurnal KESANS : Kesehatan dan Sains Vol 4 No 11 (2025): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v4i11.422

Abstract

Introduction: Preeclampsia is linked to abnormal placental vasoconstriction and elevated endothelin-1 (ET-1). Polyphenols in Extra Virgin Olive Oil (EVOO) has antioxidant and vasoprotective properties, but its impact on ET-1 and placental microvasculature in preeclampsia is unclear. Objective: Investigate whether EVOO can attenuate hypertension and improve placental vascular health in preeclampsia. Method: 20 pregnant rats randomly assigned to five groups: normal (K−), preeclampsia model (K+), and three EVOO-treated groups (D1, D2, D3) receiving 0.5, 1, and 2 mL/day, respectively. Preeclampsia was induced with L-NAME, blood pressure was monitored on gestational days 12, 15, and 19. Placental ET-1 expression and microvessel diameter were assessed on day 19 using immunohistochemistry. Result and Discussion: EVOO treatment normalized blood pressure by gestational day 19. ET-1 expression increased with EVOO dose suggesting a role in vascular remodelling. Microvessel diameter improved in D1 and D2 but slightly decreased in D3. Conclusions: EVOO mitigates hypertension and enhances placental microvasculature in preeclampsia, with optimal effects at moderate doses.
Mother-Daughter Relationship and Self-Esteem Levels in Undergraduate Midwifery Students at Brawijaya University Prasanti, Gayatri Anindya; Ariani, Dewi; Maharani, Afniari; Wardani, Diadjeng Setya
Jurnal KESANS : Kesehatan dan Sains Vol 5 No 8 (2026): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v5i8.628

Abstract

Introduction: Self-esteem plays an important role in mental health and personal development. However, limited evidence is available regarding the relationship between mother–daughter relationships and self-esteem among midwifery students, particularly in the Indonesian context. Objective: This study aims to examine the association between mother-daughter relationship and self-esteem among undergraduate midwifery students at Brawijaya University. Method: with a cross-sectional. A total of 174 female students were selected from cohorts 2022–2024. The Mother-Adult Daughter Questionnaire (MADQ) was used to assess mother-daughter relationship and the Rosenberg Self-Esteem Scale (RSES) was used to measure self-esteem. Data were analyzed using Spearman rank correlation and ordinal logistic regression. This study employed an observational analytical design. Results and Discussion: Most respondents had high self-esteem and strong mother-daughter relationships. All three dimensions connectedness (r 0.386; p < 0.05;), interdependency dimension has a significant relationship with self-esteem (p < r 0.189; p<0.05), and the trust in hierarchy (; r 0.278 ; p < 0.05) were significantly associated with self-esteem. In multivariate analysis, only connectedness remained a significant predictor. Conclusion: Mother-daughter relationship are significantly associated with self-esteem among midwifery students, with emotional connectedness emerging as the most influential factor. These findings highlight the importance of supportive family relationships in promoting students’ psychological well-being
Hubungan Kadar Albumin Serum dengan Tingkat Keparahan Preeklampsia pada Ibu Hamil Trimester Ketiga di RSUD Dr. Saiful Anwar Malang Kumalaratih, Odilia Endiza; Subandi; Maharani, Afniari
Journal of Issues in Midwifery Vol. 9 No. 3 (2025): Volume 9 No 3 Tahun 2025
Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.JOIM.2025.009.03.4

Abstract

Background: Preeclampsia is a serious pregnancy complication marked by hypertension, proteinuria, and endothelial dysfunction, and remains a leading cause of maternal mortality in Indonesia. Severe proteinuria leads to albumin loss, reduced oncotic pressure, edema, and impaired organ perfusion, while resulting hypoproteinemia further worsens endothelial and renal-hepatic dysfunction. Thus, third-trimester albumin monitoring is crucial for evaluating disease risk and severity, making research on serum albumin and preeclampsia severity at Dr. Saiful Anwar General Hospital highly relevant.Objective: This study aims to examine the relationship between serum albumin levels and the severity of preeclampsia in women in their third trimester of pregnancy at Dr. Saiful Anwar Regional General Hospital, Malang. Methods: This study used an analytical observational design with a cross-sectional approach. The population in this study consisted of all pregnant women in their third trimester at Dr. Saiful Anwar Regional General Hospital in Malang in 2024-2025, with a sample size of 110 respondents. Data were obtained from medical records and analyzed using Spearman's rank correlation test. Results: The study results obtained a value of a p-value of 0.000, indicating a significant relationship between serum albumin levels and the severity of preeclampsia. The value of r = 0.620 indicates that the lower the serum albumin level, the higher the severity of preeclampsia. Conclusion: This study shows that serum albumin levels are significantly associated with the severity of preeclampsia in the third trimester, indicating that monitoring albumin can help detect risk earlier and support preventive care. Keywords: Albumin, Preeklampsia, Eklampsia, Hellp Syndrome ABSTRAK Latar Belakang: Preeklampsia adalah komplikasi kehamilan ditandai dengan hipertensi, proteinuria, dan disfungsi endotel, serta merupakan salah satu penyebab utama kematian ibu. Di Indonesia, angka kematian akibat preeclampsia hingga eklampsia masih tinggi. Proteinuria berat menyebabkan kehilangan albumin, penurunan tekanan onkotik, edema, dan gangguan perfusi organ. Hipoproteinemia memperparah kerusakan endotel, hipoperfusi, dan gangguan fungsi ginjal dan hati. Oleh karena itu, pemantauan kadar albumin pada trimester ketiga penting sebagai indikator risiko dan keparahan penyakit. Berdasarkan hal ini, penelitian tentang hubungan antara kadar albumin serum dan keparahan preeklampsia di RSUD Dr. Saiful Anwar Malang sangat relevan. Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan antara kadar albumin serum dan tingkat keparahan preeklampsia pada wanita hamil pada trimester ketiga di RSUD Dr. Saiful Anwar Malang. Metode: Penelitian ini menggunakan desain observasional analitis dengan pendekatan cross-sectional. Populasi dalam penelitian ini adalah semua wanita hamil pada trimester ketiga di RSUD Dr. Saiful Anwar Malang pada tahun 2024-2025 dengan ukuran sampel 110 responden . Data diperoleh dari catatan medis dan dianalisis menggunakan uji korelasi rank Spearman. Hasil: Hasil penelitian memperoleh nilai p = 0.000, yang menunjukkan adanya hubungan yang signifikan antara kadar albumin serum dan tingkat keparahan preeklampsia. Nilai r = 0.620 menunjukkan bahwa semakin rendah kadar albumin serum,semakin tinggi tingkat keparahan preeclampsia. Kesimpulan: Studi ini membuktikan bahwa kadar albumin serum memiliki hubungan yang signifikan dengan tingkat keparahan preeklampsia pada trimester ketiga. Pemantauan kadar albumin dapat menjadi langkah pencegahan yang penting yang membantu tenaga kesehatan mengidentifikasi risiko lebih awal. Kata Kunci: Albumin, Preeklampsia, Eklampsia, Hellp Syndrome