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All Journal Jurnal Kedokteran Brawijaya Care : Jurnal Ilmiah Ilmu Kesehatan Journal of Issues in Midwifery KESANS : International Journal of Health and Science
Maharani, Afniari
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Nursing Physics Public Health

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The Effect of Extra Virgin Olive Oil (EVOO) on Fetal Birth Weight in Preeclampsia Rat Model Silvani, Yulia; Maharani, Afniari; Lovita, Agnestia Naning Dian
Jurnal Kedokteran Brawijaya Vol 31, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (163.79 KB) | DOI: 10.21776/ub.jkb.2020.031.01.3

Abstract

Preeclampsia, as one of the most common pregnancy-specific diseases, causes high maternal-fetal morbidity and mortality in almost every country. Placental vascular abnormalities in preeclamptic women can cause chronic hypoxia and impaired fetal nutrition, so fetal growth retardation often occurs. EVOO has strong antioxidant effect is assumed to prevent nutritional disorders in the fetus. This study aimed to determine the effect of EVOO on fetal birth weight in a preeclampsia rat model. This research was laboratory research conducted in vivo with a Post Test Only Control Group design which consisted of five groups; negative control group, positive control group (pre-eclampsia rat model), dose 1, 2, and 3 groups that were preeclampsia rats given EVOO in 3 different doses (0.5 mL/day, 1 mL/day and 2 mL/day respectively). Blood pressure and proteinuria measurements were carried out at the 12, 15 and 19 day of pregnancy. After sacrificed, fetal weight was measured immediately using analytical balance. The result of this study showed that there was a significant reduction of fetal weight between negative control and positive control group (p=0.020), meanwhile no significant differences among positive control, dose 1 and dose 2 group (p=0.90 and p=0.142) but statistically significant to dose 3 group (p=0.005). EVOO administration increases fetal weight in doses group by its AA and DHA in Long-Chain Poly Unsaturated Fatty Acids (LCPUFA) within. The optimal dose of EVOO to increase fetal weight is 2 mL/day.
Evaluasi Tingkat Pelaksanaan Manajemen Praktik Kebidanan Berbasis Midwifery Led Care di Wilayah Kabupaten Malang Dewi, Mustika; Windari, Era Nurisa; Sari, Ningrum Paramita; Fatmawati, Fatmawati; Silvani, Yulia; Ulfah, Mega; Maharani, Afniari
Journal of Issues in Midwifery Volume 8 No 3 Tahun 2024
Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.JOIM.2024.008.03.4

Abstract

Penelitian ini bertujuan untuk mengevaluasi tingkat pelaksanaan manajemen praktik kebidanan berbasis Midwifery Led Care (MLC) di Kabupaten Malang, yang berfokus pada empat aspek utama: partnership, women care, normality, dan continuity of care. Desain penelitian menggunakan metode deskriptif kuantitatif dengan pendekatan survei. Data dikumpulkan dari 40 bidan di Kabupaten Malang yang dipilih secara purposive sampling. Pengumpulan data dilakukan melalui kuesioner terstruktur yang mengukur implementasi keempat aspek MLC. Analisis data menggunakan teknik statistik deskriptif untuk mengidentifikasi pola pelaksanaan serta analisis inferensial untuk menentukan hubungan antar variabel. Hasil penelitian menunjukkan bahwa mayoritas bidan telah menerapkan MLC dengan baik, meskipun terdapat beberapa tantangan dalam penerapan continuity of care. Temuan ini diharapkan dapat menjadi dasar perbaikan manajemen praktik kebidanan untuk meningkatkan kualitas pelayanan kesehatan ibu dan anak di Kabupaten Malang.
Analysing Continuity of Care Implementation in the Midwifery-Led Care Model in Malang Regency Fatmawati, Fatmawati; Maharani, Afniari; Silvani, Yulia; Dewi, Mustika; Sari, Ningrum Paramita; Windari, Era Nurisa; Ulfa, Mega
Care : Jurnal Ilmiah Ilmu Kesehatan Vol 13, No 1 (2025): EDITION MARCH 2025
Publisher : Universitas Tribhuwana Tunggadewi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33366/jc.v13i1.6444

Abstract

This study aims to explore the implementation of Continuity of Care (CoC) within the Midwifery Led Care (MLC) model in Malang Regency. The maternal and child health indicators remain a concern due to high maternal mortality rates, exacerbated by complications such as preeclampsia and hemorrhage. CoC has been recognized for its ability to improve maternal and neonatal health outcomes by providing consistent care through midwives. This qualitative research, using a phenomenological approach, involved in-depth interviews with 20 mothers (10 primipara, 10 multipara) who experienced MLC, supported by observations and secondary data. Results revealed that both primipara and multipara mothers valued continuous midwifery care, though their experiences varied based on parity. Primipara mothers generally required more information and support, while multipara mothers exhibited greater confidence in midwife-led care. Barriers such as limited access to health services in remote areas, a lack of trained midwives, and insufficient community education on the benefits of MLC were identified. Recommendations include enhancing midwife training, improving access to healthcare in rural regions, and increasing public awareness of CoC benefits. The findings emphasize the importance of expanding MLC and CoC models to reduce maternal and neonatal morbidity and mortality in underserved areas.
Modulation of Endothelin-1 and Placental Microvascular Diameter by Extra Virgin Olive Oil in Preeclampsia Rat Model Dian Lovita, Agnestia Naning; Silvani, Yulia; Maharani, Afniari; Riawan, Wibi
Jurnal KESANS : Kesehatan dan Sains Vol 4 No 11 (2025): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v4i11.422

Abstract

Introduction: Preeclampsia is linked to abnormal placental vasoconstriction and elevated endothelin-1 (ET-1). Polyphenols in Extra Virgin Olive Oil (EVOO) has antioxidant and vasoprotective properties, but its impact on ET-1 and placental microvasculature in preeclampsia is unclear. Objective: Investigate whether EVOO can attenuate hypertension and improve placental vascular health in preeclampsia. Method: 20 pregnant rats randomly assigned to five groups: normal (K−), preeclampsia model (K+), and three EVOO-treated groups (D1, D2, D3) receiving 0.5, 1, and 2 mL/day, respectively. Preeclampsia was induced with L-NAME, blood pressure was monitored on gestational days 12, 15, and 19. Placental ET-1 expression and microvessel diameter were assessed on day 19 using immunohistochemistry. Result and Discussion: EVOO treatment normalized blood pressure by gestational day 19. ET-1 expression increased with EVOO dose suggesting a role in vascular remodelling. Microvessel diameter improved in D1 and D2 but slightly decreased in D3. Conclusions: EVOO mitigates hypertension and enhances placental microvasculature in preeclampsia, with optimal effects at moderate doses.
Co-Authors Fatmawati Fatmawati Fatmawati, Fatmawati Lovita, Agnestia Naning Dian Mega Ulfah, Mega Mustika Dewi Ningrum Paramita Sari Silvani, Yulia Ulfa, Mega Wibi Riawan Windari, Era Nurisa