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All Journal Jurnal Farmasi Sains dan Komunitas Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JURNAL FARMASIMED (JFM) Pharmaceutical Sciences and Research (PSR) Indonesian Journal of Jamu
Efendi, Kriana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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Antidiabetics activity of salam koja (murraya koenigii ) leaves tea bag Widayanti, Ari; Srifiana, Yudi; Efendi, Kriana
Pharmaceutical Sciences and Research Vol. 6, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Koja bay leaves (Murraya koenigii) which mostly cultivated in Indonesia and the leaves usually used by Aceh people as a flavoring agent for food, has been known to have an antidiabetic effect.. In this study, we analyzed the antidiabetic effect of koja bay leaves tea bags which commercially available. Methods: The two variant doses of koja bay leaves tea bag (411.11 mg/g body weight and 822.22 mg/g body weight) were administered to 25 male rats which divided into five groups. The antidiabetic activity was determined by measuring blood glucose of rats administered by koja bay leaves tea bag compared to blood glucose of rats in positive control which was given glibenclamide negative control, and normal control. Results: The results showed that dose 1 and 2 decreased blood glucose level by 51.27% and 45.17%, respectively, fairly similar to the glibenclamide (63.38%). Conclusion: Koja bay leaves tea bag have comparable activity with glibenclamide in reducing the blood glucose level.
Aktivitas Ekstrak Etanol 70% Biji Nangka (Artocarpus heterophyllus Lam.) dalam Penurunan Kadar Gula Darah Tikus Diabetes Gestasional Yang Diinduksi Streptozotocin Dwitiyanti, Dwitiyanti; Efendi, Kriana; Rachmania, Rizky Arcinthya; Septiani, Riri
Jurnal Jamu Indonesia Vol. 4 No. 1 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v4i1.84

Abstract

Biji Buah Nangka (Artocarpus heterophyllus L.) dilaporkan memiliki aktivitas sebagai antihiperglikemia. Pada penelitian ini bertujuan menguji ekstrak etanol 70% biji nangka dan diharapkan dapat dimanfaatkan sebagai penurun kadar gula darah tikus diabetes gestasional yang diinduksi streptozotocin. Hewan uji tikus betina bunting galur Sprague dawley dibagi 6 kelompok perlakuan, masing-masing terdiri dari 4 ekor tikus. Kelompok I (kontrol normal), kelompok II (kontrol negatif), kelompok III (kontrol positif) diberi metformin dosis 51.37 mg/kgBB, kelompok IV (Dosis Uji 100 mg/kgBB), kelompok V (Dosis Uji 200 mg/kgBB) dan kelompok VI (Dosis Uji 400 mg/kgBB), kelompok IV,V dan VI diberi sediaan uji biji buah nangka secara oral. Tikus diinduksi terlebih dahulu dengan streptozotocin agar tikus mengalami hiperglikemia, kemudian diberi perlakuan sediaan uji selama 14 hari. Pengambilan darah dilakukan pada hari ke-14, untuk menghitung kadar glukosa darah menggunakan fotometer klinikal. Hasil uji ANOVA satu arah menunjukkan adanya perbedaan antar kelompok perlakuan. Semua kelompok sediaan uji ekstrak biji buah nangka memiliki aktivitas menurunkan kadar glukosa darah terhadap tikus diabetes gestasional. Hasil uji Tukey penurunan kadar glukosa darah menunjukan kelompok uji sediaan biji nangka dosis 400 mg/kg BB sebanding dengan kelompok positif yang diberikan Metformin 51.37 mg/kgBB.
Curcumin Transethosome Gel: Anti-inflammatory Activity Test in Carrageenan-Induced Sprague Dawley Rat Amalia, Anisa; Efendi, Kriana; Novianti, Amelia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005618

Abstract

Curcumin has anti-inflammatory activities, and is formulated into the transethosome (TE) system to improve penetration. The TE system's stability can be increased by incorporating it into a gel dosage form. This study aims to determine the anti-inflammatory activities of curcumin TE gel. Curcumin TE gel was produced in 3 compositions, each having a curcumin content of 10 mg (F1), 40 mg (F2), or 160 mg (F3). On TE gels, organoleptic, viscosity, pH, particle size, and zeta potential were evaluated. The test animals were divided into five groups for anti-inflammatory activity testing. A 1% carrageenan solution was used to induce edema in the animals, and the volume of edema was measured for comparison with p0.05set as significant difference. Curcumin TE gel's physical properties showed a yellow and homogenous gel with viscosity values of 31.173 – 33.626 cPs, pH 4.75 – 4.84, particle size 208.3 – 319.4 nm, and zeta potential (-) 40.03 – (-) 51.12 mV. On anti-inflammatory tests, the edema volume in the group given curcumin TE gel decreased in the 270th minute. According to statistical analysis, the test group had a significant difference (p 0.05) from negative controls and no significant difference (p 0.05) from positive controls in F1 and F2 anti-inflammatory activity. According to these results, the curcumin TE gel exhibited anti-inflammatory activity equivalent to the positive control, while F3 had anti-inflammatory activity better than the positive control. 
Cream Formulation of Ampelas Twig Extract (Tetracera macrophylla Wall. Ex Hook.f. & Thomson) as a Wound Healer Ladeska, Vera; Nabela, Trisantia; Efendi, Kriana
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/y0n7tx23

Abstract

The island of Kalimantan is where the native Indonesian plant known as ampelas originated. The twigs of this plant offer a variety of pharmacological properties, including the ability to treat fever, gout, and diabetes, according to scientific and empirical research. In order to assess the anti-inflammatory properties of ampelas twig ethyl acetate extract in the healing phase of open wounds, this study was conducted. A cream containing ethyl acetate extract of ampelas twigs at concentrations of 2%, 4%, and 6% was applied to the wounds of male Wistar strain white rats in five groups: group I was the negative control, group II was the positive control hydrocortisone 2.5 percent, and groups III, IV, and V were the test animal models. Until the fourteenth day, the rats' backs were shaved, wounds were formed to the dermis layer, and the wounds were treated and monitored for shrinking. ANOVA statistical analysis revealed that the proportion of open wound healing varied significantly between test groups. The Tukey test revealed that ampelas twig ethyl acetate extract at a concentration of 6% could heal wounds on par with the positive control. For all test groups, the best time to heal open wounds was on day 14.
Uji Teratogenitas Ekstrak Etanol 70% Daun Kelor (Moringa oleifera Lam.) Terhadap Mencit Putih Bunting Hiperglikemia Rindita, Rindita -; Efendi, Kriana; Armelia, Tiska Dwi
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 7 No. 2 (2020)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v7i2.5618

Abstract

Diabetes selama kehamilan merupakan kondisi yang sangat berpengaruh terhadap janin, di antaranya menyebabkan keguguran, kecacatan, berat badan bayi berlebih, lahir prematur, serta kematian. Maka perlu dilakukan pencegahan dampak buruk tersebut bagi janin. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian ekstrak etanol 70% daun kelor terhadap perkembangan fetus serta mengetahui efektivitasnya dalam menurunkan kadar glukosa darah pada mencit putih bunting hiperglikemia. Penelitian ini menggunakan metode eksperimen dengan desain Rancangan Acak Lengkap (RAL), menggunakan 30 ekor mencit betina yang dibagi menjadi 6 kelompok. Seluruh kelompok diinduksi aloksan kecuali kelompok kontrol normal. Kelompok kontrol normal dan kontrol negatif hanya diberi Na-CMC. Sebagai bahan pembanding digunakan metformin dengan dosis 65 mg/KgBB pada kelompok kontrol positif. Sediaan ekstrak diberikan secara oral pada hari ke-6 hingga ke-15 kehamilan dengan 3 variasi dosis, yaitu: dosis 300 mg/KgBB, 600 mg/KgBB, dan 1200 mg/KgBB. Mencit dilaparatomi pada hari ke-18 kehamilan. Efek teratogenik dilihat dari jumlah fetus (hidup, mati, dan resorpsi), berat, panjang, dan kelainan morfologi. Berdasarkan hasil penelitian, ekstrak etanol 70% daun kelor tidak menimbulkan kecacatan pada fetus yang dilahirkan, serta mampu menurunkan kadar glukosa darah mencit sebesar 50,50%, 51,68%, dan 56,56% berturut-turut pada mencit putih (Mus musculus) bunting hiperglikemia.
Co-Authors Anisa Amalia Ari Widayanti Armelia, Tiska Dwi Dwitiyanti Dwitiyanti Ladeska, Vera Nabela, Trisantia Novianti, Amelia Rindita, Rindita - Rizky Arcinthya Rachmania Septiani, Riri Srifiana, Yudi