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All Journal Jurnal Farmasi Sains dan Komunitas Pharmaceutical Sciences and Research (PSR) Indonesian Journal of Jamu
Efendi, Kriana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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Antidiabetics activity of salam koja (murraya koenigii ) leaves tea bag Widayanti, Ari; Srifiana, Yudi; Efendi, Kriana
Pharmaceutical Sciences and Research Vol. 6, No. 2
Publisher : UI Scholars Hub

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Abstract

Koja bay leaves (Murraya koenigii) which mostly cultivated in Indonesia and the leaves usually used by Aceh people as a flavoring agent for food, has been known to have an antidiabetic effect.. In this study, we analyzed the antidiabetic effect of koja bay leaves tea bags which commercially available. Methods: The two variant doses of koja bay leaves tea bag (411.11 mg/g body weight and 822.22 mg/g body weight) were administered to 25 male rats which divided into five groups. The antidiabetic activity was determined by measuring blood glucose of rats administered by koja bay leaves tea bag compared to blood glucose of rats in positive control which was given glibenclamide negative control, and normal control. Results: The results showed that dose 1 and 2 decreased blood glucose level by 51.27% and 45.17%, respectively, fairly similar to the glibenclamide (63.38%). Conclusion: Koja bay leaves tea bag have comparable activity with glibenclamide in reducing the blood glucose level.
Aktivitas Ekstrak Etanol 70% Biji Nangka (Artocarpus heterophyllus Lam.) dalam Penurunan Kadar Gula Darah Tikus Diabetes Gestasional Yang Diinduksi Streptozotocin Dwitiyanti, Dwitiyanti; Efendi, Kriana; Rachmania, Rizky Arcinthya; Septiani, Riri
Jurnal Jamu Indonesia Vol. 4 No. 1 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v4i1.84

Abstract

Biji Buah Nangka (Artocarpus heterophyllus L.) dilaporkan memiliki aktivitas sebagai antihiperglikemia. Pada penelitian ini bertujuan menguji ekstrak etanol 70% biji nangka dan diharapkan dapat dimanfaatkan sebagai penurun kadar gula darah tikus diabetes gestasional yang diinduksi streptozotocin. Hewan uji tikus betina bunting galur Sprague dawley dibagi 6 kelompok perlakuan, masing-masing terdiri dari 4 ekor tikus. Kelompok I (kontrol normal), kelompok II (kontrol negatif), kelompok III (kontrol positif) diberi metformin dosis 51.37 mg/kgBB, kelompok IV (Dosis Uji 100 mg/kgBB), kelompok V (Dosis Uji 200 mg/kgBB) dan kelompok VI (Dosis Uji 400 mg/kgBB), kelompok IV,V dan VI diberi sediaan uji biji buah nangka secara oral. Tikus diinduksi terlebih dahulu dengan streptozotocin agar tikus mengalami hiperglikemia, kemudian diberi perlakuan sediaan uji selama 14 hari. Pengambilan darah dilakukan pada hari ke-14, untuk menghitung kadar glukosa darah menggunakan fotometer klinikal. Hasil uji ANOVA satu arah menunjukkan adanya perbedaan antar kelompok perlakuan. Semua kelompok sediaan uji ekstrak biji buah nangka memiliki aktivitas menurunkan kadar glukosa darah terhadap tikus diabetes gestasional. Hasil uji Tukey penurunan kadar glukosa darah menunjukan kelompok uji sediaan biji nangka dosis 400 mg/kg BB sebanding dengan kelompok positif yang diberikan Metformin 51.37 mg/kgBB.
Curcumin Transethosome Gel: Anti-inflammatory Activity Test in Carrageenan-Induced Sprague Dawley Rat Amalia, Anisa; Efendi, Kriana; Novianti, Amelia
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.005618

Abstract

Curcumin has anti-inflammatory activities, and is formulated into the transethosome (TE) system to improve penetration. The TE system's stability can be increased by incorporating it into a gel dosage form. This study aims to determine the anti-inflammatory activities of curcumin TE gel. Curcumin TE gel was produced in 3 compositions, each having a curcumin content of 10 mg (F1), 40 mg (F2), or 160 mg (F3). On TE gels, organoleptic, viscosity, pH, particle size, and zeta potential were evaluated. The test animals were divided into five groups for anti-inflammatory activity testing. A 1% carrageenan solution was used to induce edema in the animals, and the volume of edema was measured for comparison with p0.05set as significant difference. Curcumin TE gel's physical properties showed a yellow and homogenous gel with viscosity values of 31.173 – 33.626 cPs, pH 4.75 – 4.84, particle size 208.3 – 319.4 nm, and zeta potential (-) 40.03 – (-) 51.12 mV. On anti-inflammatory tests, the edema volume in the group given curcumin TE gel decreased in the 270th minute. According to statistical analysis, the test group had a significant difference (p 0.05) from negative controls and no significant difference (p 0.05) from positive controls in F1 and F2 anti-inflammatory activity. According to these results, the curcumin TE gel exhibited anti-inflammatory activity equivalent to the positive control, while F3 had anti-inflammatory activity better than the positive control. 
Co-Authors Anisa Amalia Ari Widayanti Dwitiyanti Dwitiyanti Novianti, Amelia Rizky Arcinthya Rachmania Septiani, Riri Srifiana, Yudi