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All Journal Indonesian Journal of Chemical Analysis (IJCA) Jurnal Kajian Gender dan Anak Helium: Journal of Science and Applied Chemistry
Maknun, Luluil
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Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Materials Science & Nanotechnology Social Sciences

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Advancements in NMR and IR Spectroscopy: Enhancing Metabolomics and Disease Diagnostics in the Health Sector: A Comprehensive Review Saputra, Rizki Rachmad; Ariefin, Mokhamat; Kumalasari, Meiyanti Ratna; Dongoran, Junita; Tampubolon, Mulani Jeni Lestari; Sulistiawati, Putri; Simangunsong, Sri Yulandari; Ariska, Risya; Paksi, Pandu Gizta Rapi; Siska, Amelia; Yanti, Jeddah; Maknun, Luluil
Indonesian Journal of Chemical Analysis (IJCA) Vol. 7 No. 2 (2024): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol7.iss2.art6

Abstract

Metabolomics has emerged as a critical field in understanding biological processes and disease mechanisms, necessitating advancements in analytical techniques to handle complex biological samples. This review explores the global landscape of metabolomics, with a focus on the use of spectroscopy and spectrometry. Techniques such as UV-Vis and Fourier Transform InfraRed (FTIR) spectroscopy offer fast and cost-effective metabolite tracing but are limited by their sensitivity, particularly for low-abundance metabolites. Nuclear Magnetic Resonance (NMR) spectroscopy, despite being less sensitive than mass spectrometry (MS), provides unparalleled structural information, distinguishing metabolites with similar mass-to-charge ratios. NMR's capability to detect metabolites in the 1-10 µM range highlights its effectiveness in metabolomics. This review categorizes advancements in these techniques, starting with global contributions to spectroscopy, followed by detailed discussions on FTIR strategies for metabolite tracing, and concluding with NMR's qualitative and quantitative applications in metabolomics and disease diagnostics. The review underscores the continuous development in sample preparation and data integration, enhancing the accuracy and applicability of these techniques, positioning NMR and FTIR as essential tools in modern metabolomic research.
Reinterpretation of Gender Values in Islam: A Critical Study from a Contemporary Feminist Perspective Maknun, Luluil; Zakaria, Muhammad Fadhlurrahman
Jurnal Kajian Gender dan Anak Vol 9, No 1 (2025)
Publisher : Universitas Islam Negeri Syekh Ali Hasan Ahmad Addary Padangsidimpuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24952/jkga.v9i1.15758

Abstract

Reinterpretation of gender values in Islam has the potential to continue to shine and develop more widely to uphold gender equality despite the many challenges that must be faced. The purpose of this study is to find out in detail about the reinterpretation and interpretation of gender values in Islam based on religious texts such as the Qur'an and Hadith, to find out how the relationship between gender values from the perspective of Islamic feminism and the perspective of contemporary feminism, and to find out the challenges and solutions that Islamic feminism must do in fighting for Islamic gender values so that they continue to shine on the world stage. The method used in this article is descriptive-analytical using a comparative theory between Islamic feminist theory and contemporary feminism. And in this article the researcher reveals several findings including: Muslim feminists argue that many traditional interpretations do not fully reflect the original message of the Qur'an, especially regarding gender equality issues. Therefore, a deeper interpretation of religious texts that discuss these issues must be carried out. However, a significant challenge comes from conservative resistance in the Muslim community, who consider this approach a threat to Islamic teachings and culture. This research is very important to be reviewed in depth because the urgency of this research must be disseminated so that many people know the struggle of Islamic feminism to raise Islamic gender values in the modern era.
Targeting Dopamine Transporter (DAT) with Peronema canescens Bioactives: A Molecular Docking Study for Stroke-Related Pain and Sedation Management Saputra, Rizki Rachmad; Fahmi, Rifaldi Lutfi; Novitasari, Eka; Maknun, Luluil; Yanti, Jeddah; Fairozi, Raiyan
Helium: Journal of Science and Applied Chemistry Vol. 5 No. 1 (2025): Helium: Journal of Science and Applied Chemistry
Publisher : Study Program of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/helium.v5i1.19

Abstract

Pain and drowsiness are common symptoms of stroke recovery, which can be difficult to manage owing to neurochemical abnormalities in the dopamine system. The Dopamine Transporter (DAT) controls dopamine levels, which influences pain perception and neurological recovery. This study examines bioactive chemicals found in Peronema canescens leaves and their possible interactions with DAT. AutoDock Vina was used to perform molecular docking simulations to determine the binding affinities of Peronemin derivatives (A2, A3, and B2) to the Dopamine Transporter (DAT). The receptor structure (PDB ID: 4M48) was created by eliminating water molecules, introducing polar hydrogens, and optimizing the structure using AutoDockTools. Ligand structures were translated to the proper format, and docking was conducted using a grid box centered on DAT's active site, with an exhaustiveness value of 10. The Peronemin derivatives A2, A3, and B2 demonstrated binding affinities stronger than nortriptyline, native ligand (−10.6, −10.5, and −10.3 kcal/mol, respectively) and binding similarities ranging from 72.2% to 94.4%. These findings suggest that Peronema canescens bioactives may be promising candidates for stroke-related pain and sedative control, warranting further experimental validation.
Co-Authors Ariska, Risya Dongoran, Junita eka novitasari Fahmi, Rifaldi Lutfi Fairozi, Raiyan Jeddah Yanti Mokhamat Ariefin Paksi, Pandu Gizta Rapi Rizki Rachmad Saputra Sari, Meiyanti Ratna Kumala Simangunsong, Sri Yulandari Siska, Amelia Sulistiawati, Putri Tampubolon, Mulani Jeni Lestari Zakaria, Muhammad Fadhlurrahman