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All Journal Alchemy : Journal of Chemistry CHEMPUBLISH JOURNAL Pharmascience Jurnal Geografi Indonesian Journal of Chemical Analysis (IJCA) Molekul: Jurnal Ilmiah Kimia Journal of Appropriate Technology for Community Services Jurnal ABDINUS : Jurnal Pengabdian Nusantara Bubungan Tinggi: Jurnal Pengabdian Masyarakat Community Empowerment Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Experimental and Clinical Pharmacy (JECP) Welfare: Jurnal Pengabdian Masyarakat Bohr: Jurnal Cendekia Kimia NAWASENA: Journal of Community Service
Rizki Rachmad Saputra
Department Of Chemistry, Faculty Of Mathematics And Science, Universitas Palangka Raya, Palangka Raya 73112, Central Kalimantan, Indonesia
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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POTENSI BIOAKTIF EKSTRAK ALGA MERAH (Gracillaria verrucosa) TERHADAP KADAR MALONDIALDEHIDA (MDA) DAN GAMBARAN HISTOLOGI PARU TIKUS PUTIH (Rattus novergicus) PASCA INDUKSI FORMALIN Anggun Tanduwinata; Helmi Auliyah Istiqomah; Jamilah Jamilah; Ni Luh Kemmy Caesaria; Rizki Rahmat Saputra; Aulanni'am Aulanni'am
Molekul Vol 10, No 2 (2015)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.85 KB) | DOI: 10.20884/1.jm.2015.10.2.8

Abstract

Indonesia merupakan negara megabiodiversitas yang banyak mengandung kekayaan alam, salah satunya alga merah. Alga merah (Glacillaria verrucosa) mengandung senyawa fikosianin, fikoeretin dan karotenoid yang berperan sebagai antioksidan. Penelitian ini dilakukan untuk mengetahui potensi bioaktif ekstrak alga merahuntuk terapi hewan coba tikus putih (Rattus novergicus) berdasarkan kadar malondialdehida (MDA) dan gambaran histologi paru. Metode penelitian yang dilakukan meliputi ekstraksi alga merah dan karakterisasi, induksi  hewan coba (R. novergicus) dengan formalin, kemudian terapi ekstrak alga merah dengan variasi dosis. Berdasarkan uji fitokimia, analisis dengan FTIR dan LCMS, ekstrak alga merah mengandung senyawa flavonoid, terpenoid, alkaloid, β-karoten , β-apo-8’-carotenal dan α-tokoferolyang berperan sebagai antioksidan. Formalin dapat meningkatkan kadar MDA serta menyebabkan kerusakan sel epitel bronkus dibandingkan dengan keadaan normal. Pemberian terapi dengan dosis yang sesuai akan menurunkan kadar MDA dan memperbaiki keadaan sel epitel bronkus. Berdasarkan pengamatan parameter penelitan, diketahui bahwa dosis optimum yang sesuai untuk terapi kanker paru adalah 100 mg/kg BB
Study Natural Compound of Eleutherine americana as a SaR-CoV-2 Therapeutic Agent : In Silico Approach Mokhamat Ariefin; Rizki Rachmad Saputra
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.18018

Abstract

Sar-CoV-2 (COVID-19) has rapidly spread globally where it has killed thousands of individuals and infected almost 1,016,395 others. Numerous people have died as a result of what the World Health Organization (WHO) has deemed a top worldwide health issue, which has also had severe detrimental social and economic impacts. Some Eleutherin americana are said to possess antiviral effects. Children's colds and nasal congestion can be treated with eleutherin americana. Naphthalene, anthraquinone, and naphtoquinone are the three main chemical families that have been identified from E. americana. Eleutherol, hongconin, isoeleutherol, and eleutherin were the compounds that were identified from E. Americana. Drug-receptor interactions are simulated using computational techniques toward 14 compounds isolated from E. americana. The docking method has been validated by redocking the N3 molecule as a native ligand to the Mpro of Sar-CoV-2 (PDB ID: 7BQY) as a receptor protein. The smaller the RMSD value 0.651 Å, the better the pose obtained through the docking process. Compound 12 has a more negative binding energy are showed -8.6 kcal mol-1, regarding to hydrogen bond interaction toward Thr26, His41, Leu141, Asn142, Gly143, Ser144, His163. The stability of the association between the ligand and receptor increases with decreasing binding energy value (∆G). On the other hand, Compounds 11 and 2 are depicted -8.2 kcal mol-1 and -8.1 kcal mol-1 respectively which close to N3 -8.3 kcal mol-1. Undergoing hydrogen bond interaction between 11 with Gly143,Thr26, Leu141, Glu166, Ser144, Cys145, His163, and less hydrogen bond interaction 2 toward Arg188 and Asn 142. Those result resembling hydroxy group have the best interaction with 7BQY. According to fulfilled data from three candidates 2, 11, 12, it can be expected that compound with many hydroxy groups are within realm of possibility as antiviral agent for Sar-CoV-2 through inhibit replication of this virus.
Anticaries Potential of Temu Kunci-Serai Ethyl Acetate Extract Combination: In Vitro and Molecular Studies Approach Muhammad Priyadi; Rizki Rachmad Saputra
Chempublish Journal Vol. 7 No. 1 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i1.26098

Abstract

Dental caries is one of the problems in dental disorders suffered by many people. There have been many ways of handling such as using temu kunci and lemongrass plants. This study aims to determine the antibacterial activity of caries in vitro and predict the mechanism of action of the bacteria that cause caries Streptococcus mutans.  Temu kunci and lemongrass were extracted using ethyl acetate solvent. antibacterial tests against Streptococcus mutans were carried out using diffusion tests with a combination treatment of temu kunci: serai extracts 5% b/v: 5% b/v, 5% b/v: 10% b/v, and 10% b/v: 5% b/v. The positive control used amoxicillin and DMSO as a negative control. Potency as an anticaries drug of drived compound from Temu Kunci and Serai were evaluated by molecular docking using glucosyltransferase (3AIC). The results showed that the combination of temu kunci and serai with concentration 10% b/v: 5% b/v has potential as anticaries against Streptococcus mutans. Molecular studies depicted that Panduratin A, Isopanduratin, and 1,3-O-di-p-coumaroylglycerol have great activity toward 3AIC, respectively. Especially for Panduratin A and Isopanduratin, those compound depicted great and similar binding affinity (-8.4 kcal mol-1) that lower than Acarbose as native ligand  (-8.3 kcal mol-1). Furthermore, those compound binding similarity ilustrated activity mechanism similarly with native ligand toward receptor. Additionally, the profiling drug-target interaction suggested Temu Kunci’s derived compounds have great potential as anticaries treatment.   
Training on the Making of Eco-Enzyme Disinfectants as a Sustainable Strategy for Processing Organic Waste Retno Agnestisia; Erwin Prasetya Toepak; Yuliana Yuliana; Rizki Rachmad Saputra; Marvin Horale Pasaribu; Abed Nego Purba; Okta Prianus
Bubungan Tinggi: Jurnal Pengabdian Masyarakat Vol 6, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/btjpm.v6i2.10369

Abstract

The community in Habaring Hurung Urban Village, Bukit Batu District, Palangka Raya City, is grappling with the issue of accumulating household waste, primarily composed of organic waste. The prevalent practices of managing this waste, such as landfilling, burning, or haphazardly piling it around residential areas and roadsides, pose environmental and health risks. In response to this challenge, an initiative was undertaken to empower families in Habaring Hurung Urban Village through training sessions on creating disinfectants using eco enzymes derived from fermented organic waste. The method of implementing community service consists of the preparation stage, namely digging up information on training needs, and preparing materials and teaching aids; the implementation stage in the form of pre-final tests and training; and the last stage in the form of evaluation and reporting, took place on September 4, 2023, at the office hall of Habaring Hurung Urban Village. A total of 39 participants actively engaged in the training, displaying enthusiasm and a positive response. The results of the questionnaire also showed a fairly good level of satisfaction of all participants regarding the theme of the activity, the presentation was easy to understand, the participants' knowledge increased, and this activity should be continued by all participants where the percentage of participants who agreed showed a value of 56.4%. 51.3%, 66.7%, and 53% respectively. The ultimate goal of this initiative is to educate the local community on transforming organic waste into multifunction products for everyday use.
Claisen Rearrangement Toward Cyclic Compound on Different Organic Synthesis Methods: Short Review Rizki Rachmad Saputra; Reny Rosalina; Dimas Pramudita; Oktavia Rahmi Wulandari; Yuneta Yuneta; Amanda Natania Gracia; Tina Sugiyani; Marsya Imelya
Chempublish Journal Vol. 7 No. 2 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i2.26053

Abstract

The synthesis of functional and complex organic compounds is majorly performed by the Claisen rearrangement method. Claisen rearrangement is one of [3,3] sigmatropic rearrangements, a complex method in the synthesis of organic compounds, where it is mostly used to construct stereoselective compounds. It can be combined with other synthesis methods to synthesize organic compounds giving satisfactory results based on the method used, temperature, time, and yield produced. This review aimed to summarize several recent advances in synthesizing organic compounds through Claisen rearrangement reactions. An understanding of the mechanism and applications of this reaction might improve the ability to synthesize innovative and useful organic compounds in various fields of life sciences.
Exploring the Viability of Waste Durian (Durio zibethinus) Seeds and Cempedak (Artocarpus integer) Seeds as Nutritive Resources: An Analytical Study of Their Suitability via Alcohol and Glucose Assays Syarpin Syarpin; Rizki Rachmad Saputra; Nur Haliza; Anista Anista; Helda Yanti; Tahsya Amanda Sisilya; Rifaldi Lutfi Fahmi
Chempublish Journal Vol. 7 No. 2 (2023): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v7i2.27983

Abstract

Durian (Durio zibethinus) and Cempedak (Artocarpus integer), prominent staples in Indonesia, harbor seeds that can be harnessed for the production of 'Tapai', a traditional fermented product. This fermentation process within cempedak and durian seeds manifests in the generation of alcohol and glucose at discernible thresholds. Motivated by the prevalent underutilization of durian and cempedak seeds leading to wastage, this study aims to assess the viabilities of Tapai derived from these seeds by scrutinizing their alcohol and glucose profiles. Employing a quantitative descriptive approach, the research centers on cempedak and durian seed Tapais as the primary samples. Focusing on variables like alcohol and glucose content, the investigative technique incorporates distillation and titration using the Luff Schoorl method. Results are subsequently organized in frequency distribution tables following coding and tabulation. Observations reveal that alcohol and glucose levels in cempedak seed Tapai on the 10th day stand at 0.00% and 30.05%, respectively, while on the 15th day, they escalate to 4.88% and 41.92%. In the case of durian seed Tapai, levels on the 10th day are recorded at 4.88% for alcohol and 36.90% for glucose. On the 15th day, these figures rise to 16.57% for alcohol and 46.53% for glucose. Ultimately, this study underscores that the alcohol and glucose concentrations in cempedak and durian seed Tapais experience progressive augmentation over a 5-day period, rendering them safely consumable in moderate quantities.
Measuring The Spatio-Temporal Distribution of Sulfur Dioxide (SO2) with Copernicus Sentinel-5P Near Real Time in Medan City Jeddah Yanti; Togi Tampubolon; Chian-Yi Liu; Titus Adeyemi Alonge; Dinil Qaiyimah; Muh Rais Abidin; Abdul Mannan; Rizki Rachmad Saputra
JURNAL GEOGRAFI Vol 16, No 1 (2024): JURNAL GEOGRAFI
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jg.v16i1.55297

Abstract

This study aims to monitor the impact of sulfur dioxide (SO2), a significant contributor to atmospheric corrosion and associated with air pollution, in urban and industrial areas through empirical models of spatial distribution and temporal estimation in Medan. Datasets of Sentinel 5P NRTI are worth using to monitor the formation of sulfate aerosols or SO2 emissions from natural sources and anthropogenic origin in near real-time from 2019 until 2023 on the local scale, Medan. The source dataset covers 1,11 km of spatial image resolution on orbital in daily revisit time with a spectral bound between the ultraviolet and the shortwave infrared. The measurement of atmospheric SO2 concentrations is generated by enumerating the SO2 vertical column density technique at the soil surface with the cloud-based platform The Earth Engine (EE) Code Editor to handle large data sizes and produce interactive mapping. Based on the availability of auxiliary results, the number of spreading SO2 concentrations fell from 0,92 mmol/m2 in 2019 to 0,41 mmol/m2 in 2023, a reduction of 49.98 percent. The average of SO2 concentrations has decreased substantially over the years. Consequently, these pollutants have recorded long-term health and meteorological parameters impact that substances can rise or reduce acid rain.Keywords: Air pollution, Meteorological parameters, Sentinel 5P NRTI, SO2
Pemanfaatan Limbah dan Sumber Daya Lokal dalam Pelatihan Pembuatan Pakan Ikan Mandiri untuk Kelompok KUPS Perikanan Desa Tuwung Pasaribu, Marvin Horale; Ariefin, Mokhamat; Ompusunggu, Dicky Perwira; Saputra, Rızkı Rachmad; Agnestısıa, Retno; Yuliana, Yuliana; Purba, Abed Nego; Prianus, Okta
Jurnal ABDINUS : Jurnal Pengabdian Nusantara Vol 9 No 1 (2025): Volume 9 Nomor 1 Tahun 2025
Publisher : Universitas Nusantara PGRI Kediri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29407/ja.v9i1.23684

Abstract

Tuwung Village, Pulang Pisau Regency, possesses significant potential in the fisheries sector. However, the development of this sector is hindered by the reliance on expensive commercial fish feed, which limits profit margins from fish sales. Furthermore, organic waste generated from agricultural and livestock activities remains underutilized, posing a potential environmental pollution problem. To address these challenges, a training program on independent fish feed production utilizing organic waste and local resources has been implemented. This program aims to equip the KUPS Fisheries Group in Tuwung Village with the knowledge and skills to produce high-quality fish feed at a more affordable cost. Through this training, participants were introduced to the concept of utilizing household vegetable waste and motan fish from Lake Sabuah as alternative feed ingredients. Additionally, they received training in both conventional and mechanical fish feed production processes, employing a specially designed mixer unit. The program outcomes indicate that participants successfully grasped the concept of waste and local resource utilization and are now capable of producing fish feed independently. It is anticipated that this program will enhance the productivity and efficiency of fish farming businesses in Tuwung Village, while simultaneously mitigating the environmental impact of organic waste.
Gambaran Histopatologi Hati dan Ginjal Mencit (Mus musculus) Setelah Pemberian Ekstrak Daun Bajakah Kalalawit (Uncaria gambir Roxb.) Gunawan, Yohanes Edy; Priyadi, Muhammad; Citrariana, Shesanthi; Saputra, Rizki Rachmad; Decenly, Decenly; Fauziah, Anisa Rahma; Febrianto, Yahya; Suprayogi, Thathit
Jurnal Pharmascience Vol 11, No 2 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i2.17733

Abstract

Secara empiris Bajakah Kalalawit (Uncaria gambir Roxb.) telah digunakan oleh masyarakat lokal Kalimantan karena dipercaya dapat menyembuhkan berbagai macam penyakit. Beberapa penelitian telah menunjukkan potensi aktivitas farmakalogis bajakah kalalawit dimulai dari bagian batang, akar dan lainnya. Namun, apabila tidak digunakan dengan tepat maka berpotensi dapat membahayakan penggunanya. Tujuan dari penelitian ini adalah menganalisis aspek toksikologi konsumsi ekstrak air daun bajakah kalalawit melalui gambaran histopatologi organ hati dan ginjal. Ekstraksi daun bajakah kalalawit menggunakan metode refluks dengan pelarut air dan uji histopatologi menggunakan pengamatan mikroskopis histologi pada organ hati dan ginjal mencit jantan (Mus musculus) melalui pemberian dosis ekstrak air daun bajakah kalalawit sebanyak 52,5 mg/KgBB, 105 mg/KgBB, dan 210 mg/KgBB selama 30 hari. Hasil penelitian menunjukkan bahwa pemberian ekstrak air daun bajakah kalalawit selama 30 hari dapat menimbulkan terjadinya degenerasi sel dan nekrosis sel pada organ hati maupun ginjal mencit. Dapat disimpulkan bahwa pemberian ekstrak air daun bajakah kalalawit dengan dosis 52,5 mg/KgBB, 105 mg/KgBB dan 210 mg/KgBB dapat menyebabkan perubahan histologi pada organ hati dan ginjal. Kata Kunci: Histologi, Ekstrak, Toksikologi, Mikroskopis, Nekrosis   Empirically, Bajakah Kalalawit (Uncaria gambir Roxb.) has been used by local Kalimantan communities because it is believed to cure various diseases. Several studies have shown the potential pharmacalogical activity of bajakah kalalawit starting from the stem, root and other parts. However, if not used properly, it can potentially harm the user.. The purpose of this study was to determine the toxicology aspects of consumption of bajakah kalalawit leaf water extract through histopathological images of liver and kidney organs. Extraction of bajakah kalalawit leaves using reflux method with water solvent and histopathology test using microscopic observation of liver and kidney histology of male mice (Mus musculus) which were treated with doses of bajakah kalalawit leaf water extract 52.5 mg/KgBW, 105 mg/KgBW, and 210 mg/KgBW for 30 days.  The results showed that the administration of bajakah kalalawit leaf water extract for 30 days can cause cell degeneration and cell necrosis in the liver and kidney organs of mice. It can be concluded that the administration of bajakah kalalawit leaf water extract at doses of 52.5 mg/KgBW, 105 mg/KgBW, and 210 mg/KgBW may contribute to histologic changes in the liver and kidney.
Phytochemical Profile and Antioxidant Activity of Bajakah Kalalawit Leaf Extract Priyadi, Muhammad; Gunawan, Yohanes Edy; Saputra, Rizki Rachmad; Decenly, Decenly; Citrariana, Shesanthi
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 1 (2025): February 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i1.1321

Abstract

Natural products have long been recognized for their significant role in supporting human health, with natural ingredients playing an essential part in disease treatment and wellness across generations. The bajakah species, particularly bajakah kalalawit (Uncaria gambir Roxb.), has gained attention in recent research due to its potential bioactive compounds. Especially, its antioxidant properties from any part of plant has potential to explore. This study aims to determine the various secondary metabolite compounds possessed by bajakah kalalawit leaves and test their antioxidants. Bajakah kalalawit leaves were extracted using reflux with aqueous solvents, checked for phytochemical profiles using GC-MS, and conducted antioxidant tests using the DPPH method. Based on the phytochemical test, there are 22 predicted compounds in the extract and the antioxidant test results showed an IC50 value of 14.44 ppm. In conclusion, bajakah kalalawit leaf aqueous extract has antioxidant activity and is supported by bioactive compounds.
Co-Authors Abdul Mannan Abed Nego Purba Amanda Natania Gracia Amanda Natania Gracia Anggun Tanduwinata Anista Anista Ansori Rahman Ariska, Risya Aulanni'am Aulanni'am Ayu Puspita Sari Bela D Chian-Yi Liu Citrariana, Shesanthi Decenly Decenly Decenly, Decenly Dicky Perwira Ompusunggu Dimas Pramudita Dominikus Diki Wahyudi Dongoran, Junita Dwijayanti, Rts. Sherly Efriyana Oksal Erwin Prasetya Toepak Esintia Kristia Fauziah, Anisa Rahma Gunawan, Yohanes E Gunawan, Yohanes Edy Harianja, Henrigen Helda Yanti Helmi Auliyah Istiqomah Jamilah Jamilah Jeddah Yanti Junita Dongoran Maknun, Luluil Marsya Imelya Marsya Imelya Marvin Horale Pasaribu Mokhamat Ariefin Muh Rais Abidin Muhammad Priyadi Nama Penulis Ni Luh Kemmy Caesaria Ni Wayan Prema Mulya Sari Nur Haliza Okta Prianus Oktavia Rahmi Wulandari Oktavia Rahmi Wulandari Paksi, Pandu Gizta Rapi Prianus, Okta Purba, Abed Nego Qaiyimah, Dinil Reny Rosalina Retno Agnestisia Rian Ka Praja Riandy Putra Rifaldi Lutfi Fahmi Rokiy Alfanaar Sari, Meiyanti Ratna Kumala Septaria Yolan Kalalinggi Septaria Yolan Kalalinggi Simangunsong, Sri Yulandari Siska, Amelia Siti Misbah Aisah Sulistiawati, Putri Suma, Joy Angel Aria Syarpin Syarpin Tahsya Amanda Sisilya Tampubolon, Mulani Jeni Lestari Thathit Suprayogi Tina Sugiyani Titus Adeyemi Alonge Togi Tampubolon Yahya Febrianto Yuliana Yuneta Yuneta