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All Journal Alchemy : Journal of Chemistry CHEMPUBLISH JOURNAL Pharmascience Jurnal Geografi Indonesian Journal of Chemical Analysis (IJCA) Molekul: Jurnal Ilmiah Kimia Journal of Appropriate Technology for Community Services Bubungan Tinggi: Jurnal Pengabdian Masyarakat Community Empowerment Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Experimental and Clinical Pharmacy (JECP) Welfare: Jurnal Pengabdian Masyarakat Bohr: Jurnal Cendekia Kimia NAWASENA: Journal of Community Service
Rizki Rachmad Saputra
Department Of Chemistry, Faculty Of Mathematics And Science, Universitas Palangka Raya, Palangka Raya 73112, Central Kalimantan, Indonesia
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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POTENSI BIOAKTIF EKSTRAK ALGA MERAH (Gracillaria verrucosa) TERHADAP KADAR MALONDIALDEHIDA (MDA) DAN GAMBARAN HISTOLOGI PARU TIKUS PUTIH (Rattus novergicus) PASCA INDUKSI FORMALIN Anggun Tanduwinata; Helmi Auliyah Istiqomah; Jamilah Jamilah; Ni Luh Kemmy Caesaria; Rizki Rahmat Saputra; Aulanni'am Aulanni'am
Molekul Vol 10, No 2 (2015)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (258.85 KB) | DOI: 10.20884/1.jm.2015.10.2.8

Abstract

Indonesia merupakan negara megabiodiversitas yang banyak mengandung kekayaan alam, salah satunya alga merah. Alga merah (Glacillaria verrucosa) mengandung senyawa fikosianin, fikoeretin dan karotenoid yang berperan sebagai antioksidan. Penelitian ini dilakukan untuk mengetahui potensi bioaktif ekstrak alga merahuntuk terapi hewan coba tikus putih (Rattus novergicus) berdasarkan kadar malondialdehida (MDA) dan gambaran histologi paru. Metode penelitian yang dilakukan meliputi ekstraksi alga merah dan karakterisasi, induksi  hewan coba (R. novergicus) dengan formalin, kemudian terapi ekstrak alga merah dengan variasi dosis. Berdasarkan uji fitokimia, analisis dengan FTIR dan LCMS, ekstrak alga merah mengandung senyawa flavonoid, terpenoid, alkaloid, β-karoten , β-apo-8’-carotenal dan α-tokoferolyang berperan sebagai antioksidan. Formalin dapat meningkatkan kadar MDA serta menyebabkan kerusakan sel epitel bronkus dibandingkan dengan keadaan normal. Pemberian terapi dengan dosis yang sesuai akan menurunkan kadar MDA dan memperbaiki keadaan sel epitel bronkus. Berdasarkan pengamatan parameter penelitan, diketahui bahwa dosis optimum yang sesuai untuk terapi kanker paru adalah 100 mg/kg BB
Study Natural Compound of Eleutherine americana as a SaR-CoV-2 Therapeutic Agent : In Silico Approach Mokhamat Ariefin; Rizki Rachmad Saputra
ALCHEMY:Journal of Chemistry Vol 11, No 1 (2023): ALCHEMY: JOURNAL OF CHEMISTRY
Publisher : Department of Chemistry, Faculty of Science and Technology UIN Maulana Malik Ibrahim Malan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/al.v11i1.18018

Abstract

Sar-CoV-2 (COVID-19) has rapidly spread globally where it has killed thousands of individuals and infected almost 1,016,395 others. Numerous people have died as a result of what the World Health Organization (WHO) has deemed a top worldwide health issue, which has also had severe detrimental social and economic impacts. Some Eleutherin americana are said to possess antiviral effects. Children's colds and nasal congestion can be treated with eleutherin americana. Naphthalene, anthraquinone, and naphtoquinone are the three main chemical families that have been identified from E. americana. Eleutherol, hongconin, isoeleutherol, and eleutherin were the compounds that were identified from E. Americana. Drug-receptor interactions are simulated using computational techniques toward 14 compounds isolated from E. americana. The docking method has been validated by redocking the N3 molecule as a native ligand to the Mpro of Sar-CoV-2 (PDB ID: 7BQY) as a receptor protein. The smaller the RMSD value 0.651 Å, the better the pose obtained through the docking process. Compound 12 has a more negative binding energy are showed -8.6 kcal mol-1, regarding to hydrogen bond interaction toward Thr26, His41, Leu141, Asn142, Gly143, Ser144, His163. The stability of the association between the ligand and receptor increases with decreasing binding energy value (∆G). On the other hand, Compounds 11 and 2 are depicted -8.2 kcal mol-1 and -8.1 kcal mol-1 respectively which close to N3 -8.3 kcal mol-1. Undergoing hydrogen bond interaction between 11 with Gly143,Thr26, Leu141, Glu166, Ser144, Cys145, His163, and less hydrogen bond interaction 2 toward Arg188 and Asn 142. Those result resembling hydroxy group have the best interaction with 7BQY. According to fulfilled data from three candidates 2, 11, 12, it can be expected that compound with many hydroxy groups are within realm of possibility as antiviral agent for Sar-CoV-2 through inhibit replication of this virus.
Training on the Making of Eco-Enzyme Disinfectants as a Sustainable Strategy for Processing Organic Waste Retno Agnestisia; Erwin Prasetya Toepak; Yuliana Yuliana; Rizki Rachmad Saputra; Marvin Horale Pasaribu; Abed Nego Purba; Okta Prianus
Bubungan Tinggi: Jurnal Pengabdian Masyarakat Vol 6, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/btjpm.v6i2.10369

Abstract

The community in Habaring Hurung Urban Village, Bukit Batu District, Palangka Raya City, is grappling with the issue of accumulating household waste, primarily composed of organic waste. The prevalent practices of managing this waste, such as landfilling, burning, or haphazardly piling it around residential areas and roadsides, pose environmental and health risks. In response to this challenge, an initiative was undertaken to empower families in Habaring Hurung Urban Village through training sessions on creating disinfectants using eco enzymes derived from fermented organic waste. The method of implementing community service consists of the preparation stage, namely digging up information on training needs, and preparing materials and teaching aids; the implementation stage in the form of pre-final tests and training; and the last stage in the form of evaluation and reporting, took place on September 4, 2023, at the office hall of Habaring Hurung Urban Village. A total of 39 participants actively engaged in the training, displaying enthusiasm and a positive response. The results of the questionnaire also showed a fairly good level of satisfaction of all participants regarding the theme of the activity, the presentation was easy to understand, the participants' knowledge increased, and this activity should be continued by all participants where the percentage of participants who agreed showed a value of 56.4%. 51.3%, 66.7%, and 53% respectively. The ultimate goal of this initiative is to educate the local community on transforming organic waste into multifunction products for everyday use.
Measuring The Spatio-Temporal Distribution of Sulfur Dioxide (SO2) with Copernicus Sentinel-5P Near Real Time in Medan City Jeddah Yanti; Togi Tampubolon; Chian-Yi Liu; Titus Adeyemi Alonge; Dinil Qaiyimah; Muh Rais Abidin; Abdul Mannan; Rizki Rachmad Saputra
JURNAL GEOGRAFI Vol 16, No 1 (2024): JURNAL GEOGRAFI
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jg.v16i1.55297

Abstract

This study aims to monitor the impact of sulfur dioxide (SO2), a significant contributor to atmospheric corrosion and associated with air pollution, in urban and industrial areas through empirical models of spatial distribution and temporal estimation in Medan. Datasets of Sentinel 5P NRTI are worth using to monitor the formation of sulfate aerosols or SO2 emissions from natural sources and anthropogenic origin in near real-time from 2019 until 2023 on the local scale, Medan. The source dataset covers 1,11 km of spatial image resolution on orbital in daily revisit time with a spectral bound between the ultraviolet and the shortwave infrared. The measurement of atmospheric SO2 concentrations is generated by enumerating the SO2 vertical column density technique at the soil surface with the cloud-based platform The Earth Engine (EE) Code Editor to handle large data sizes and produce interactive mapping. Based on the availability of auxiliary results, the number of spreading SO2 concentrations fell from 0,92 mmol/m2 in 2019 to 0,41 mmol/m2 in 2023, a reduction of 49.98 percent. The average of SO2 concentrations has decreased substantially over the years. Consequently, these pollutants have recorded long-term health and meteorological parameters impact that substances can rise or reduce acid rain.Keywords: Air pollution, Meteorological parameters, Sentinel 5P NRTI, SO2
Gambaran Histopatologi Hati dan Ginjal Mencit (Mus musculus) Setelah Pemberian Ekstrak Daun Bajakah Kalalawit (Uncaria gambir Roxb.) Gunawan, Yohanes Edy; Priyadi, Muhammad; Citrariana, Shesanthi; Saputra, Rizki Rachmad; Decenly, Decenly; Fauziah, Anisa Rahma; Febrianto, Yahya; Suprayogi, Thathit
Jurnal Pharmascience Vol 11, No 2 (2024): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v11i2.17733

Abstract

Secara empiris Bajakah Kalalawit (Uncaria gambir Roxb.) telah digunakan oleh masyarakat lokal Kalimantan karena dipercaya dapat menyembuhkan berbagai macam penyakit. Beberapa penelitian telah menunjukkan potensi aktivitas farmakalogis bajakah kalalawit dimulai dari bagian batang, akar dan lainnya. Namun, apabila tidak digunakan dengan tepat maka berpotensi dapat membahayakan penggunanya. Tujuan dari penelitian ini adalah menganalisis aspek toksikologi konsumsi ekstrak air daun bajakah kalalawit melalui gambaran histopatologi organ hati dan ginjal. Ekstraksi daun bajakah kalalawit menggunakan metode refluks dengan pelarut air dan uji histopatologi menggunakan pengamatan mikroskopis histologi pada organ hati dan ginjal mencit jantan (Mus musculus) melalui pemberian dosis ekstrak air daun bajakah kalalawit sebanyak 52,5 mg/KgBB, 105 mg/KgBB, dan 210 mg/KgBB selama 30 hari. Hasil penelitian menunjukkan bahwa pemberian ekstrak air daun bajakah kalalawit selama 30 hari dapat menimbulkan terjadinya degenerasi sel dan nekrosis sel pada organ hati maupun ginjal mencit. Dapat disimpulkan bahwa pemberian ekstrak air daun bajakah kalalawit dengan dosis 52,5 mg/KgBB, 105 mg/KgBB dan 210 mg/KgBB dapat menyebabkan perubahan histologi pada organ hati dan ginjal. Kata Kunci: Histologi, Ekstrak, Toksikologi, Mikroskopis, Nekrosis   Empirically, Bajakah Kalalawit (Uncaria gambir Roxb.) has been used by local Kalimantan communities because it is believed to cure various diseases. Several studies have shown the potential pharmacalogical activity of bajakah kalalawit starting from the stem, root and other parts. However, if not used properly, it can potentially harm the user.. The purpose of this study was to determine the toxicology aspects of consumption of bajakah kalalawit leaf water extract through histopathological images of liver and kidney organs. Extraction of bajakah kalalawit leaves using reflux method with water solvent and histopathology test using microscopic observation of liver and kidney histology of male mice (Mus musculus) which were treated with doses of bajakah kalalawit leaf water extract 52.5 mg/KgBW, 105 mg/KgBW, and 210 mg/KgBW for 30 days.  The results showed that the administration of bajakah kalalawit leaf water extract for 30 days can cause cell degeneration and cell necrosis in the liver and kidney organs of mice. It can be concluded that the administration of bajakah kalalawit leaf water extract at doses of 52.5 mg/KgBW, 105 mg/KgBW, and 210 mg/KgBW may contribute to histologic changes in the liver and kidney.
Phytochemical Profile and Antioxidant Activity of Bajakah Kalalawit Leaf Extract Priyadi, Muhammad; Gunawan, Yohanes Edy; Saputra, Rizki Rachmad; Decenly, Decenly; Citrariana, Shesanthi
Journal of Experimental and Clinical Pharmacy (JECP) Vol 5, No 1 (2025): February 2025
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v5i1.1321

Abstract

Natural products have long been recognized for their significant role in supporting human health, with natural ingredients playing an essential part in disease treatment and wellness across generations. The bajakah species, particularly bajakah kalalawit (Uncaria gambir Roxb.), has gained attention in recent research due to its potential bioactive compounds. Especially, its antioxidant properties from any part of plant has potential to explore. This study aims to determine the various secondary metabolite compounds possessed by bajakah kalalawit leaves and test their antioxidants. Bajakah kalalawit leaves were extracted using reflux with aqueous solvents, checked for phytochemical profiles using GC-MS, and conducted antioxidant tests using the DPPH method. Based on the phytochemical test, there are 22 predicted compounds in the extract and the antioxidant test results showed an IC50 value of 14.44 ppm. In conclusion, bajakah kalalawit leaf aqueous extract has antioxidant activity and is supported by bioactive compounds.
Education on the integration of probiotic fish pellet production with aquaponic technology as a solution for food self-sufficiency Praja, Rian Ka; Dwijayanti, Rts. Sherly; Saputra, Rizki Rachmad; Decenly, Decenly; Suma, Joy Angel Aria; Harianja, Henrigen
Community Empowerment Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.12345

Abstract

This community service program was carried out in Talian Kereng Village, Katingan Regency, Central Kalimantan, with the aim of enhancing food self-sufficiency through training on probiotic-based fish pellet production and the implementation of aquaponic technology. The program involved 15 participants and included theoretical training sessions, practical fish feed production, and aquaponic system installation. Evaluation results indicated a significant increase in knowledge, with the average score rising from 40% to 85%. A total of 90% of participants successfully practiced fish pellet production with the correct composition, while 80% were able to independently operate the aquaponic system. The program also featured the handover of fish pellet production technology and the aquaponic system to the local fish farming group. Despite challenges related to the availability of probiotic ingredients and aquaponic system management, this initiative has opened opportunities for further development in rural fisheries and agriculture.
Advancements in NMR and IR Spectroscopy: Enhancing Metabolomics and Disease Diagnostics in the Health Sector: A Comprehensive Review Saputra, Rizki Rachmad; Ariefin, Mokhamat; Kumalasari, Meiyanti Ratna; Dongoran, Junita; Tampubolon, Mulani Jeni Lestari; Sulistiawati, Putri; Simangunsong, Sri Yulandari; Ariska, Risya; Paksi, Pandu Gizta Rapi; Siska, Amelia; Yanti, Jeddah; Maknun, Luluil
Indonesian Journal of Chemical Analysis (IJCA) Vol. 7 No. 2 (2024): Indonesian Journal of Chemical Analysis
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/ijca.vol7.iss2.art6

Abstract

Metabolomics has emerged as a critical field in understanding biological processes and disease mechanisms, necessitating advancements in analytical techniques to handle complex biological samples. This review explores the global landscape of metabolomics, with a focus on the use of spectroscopy and spectrometry. Techniques such as UV-Vis and Fourier Transform InfraRed (FTIR) spectroscopy offer fast and cost-effective metabolite tracing but are limited by their sensitivity, particularly for low-abundance metabolites. Nuclear Magnetic Resonance (NMR) spectroscopy, despite being less sensitive than mass spectrometry (MS), provides unparalleled structural information, distinguishing metabolites with similar mass-to-charge ratios. NMR's capability to detect metabolites in the 1-10 µM range highlights its effectiveness in metabolomics. This review categorizes advancements in these techniques, starting with global contributions to spectroscopy, followed by detailed discussions on FTIR strategies for metabolite tracing, and concluding with NMR's qualitative and quantitative applications in metabolomics and disease diagnostics. The review underscores the continuous development in sample preparation and data integration, enhancing the accuracy and applicability of these techniques, positioning NMR and FTIR as essential tools in modern metabolomic research.
Aktivitas Psikostimulan Tanaman Bajakah (Spatholobus suberectus) : Studi In Silico Terhadap Protein 4M48-Dopamine Transporter Priyadi, Muhammad; Saputra, Rizki Rachmad; Gunawan, Yohanes Edy; Citrariana, Shesanthi; Decenly, Decenly; Febrianto, Yahya
Jurnal Farmasi & Sains Indonesia Vol 6 No 2 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no2p149-154

Abstract

Bajakah plants (Spatholobus suberectus) have been widely used by Dayak tribes in Kalimantan with various properties that are believed and have also been studied for various tests of phytochemical compound content and pharmacological tests. Secondary metabolite compounds from bajakah (Spatholobus suberectus) have potential as psychostimulant compounds. The purpose of this study was to investigate the psychostimulant activity of bajakah plants (Spatholobus suberectus) through analysis of the interaction between bajakah secondary metabolite compounds and the 4M48-Dopamine Transporter receptor (PDB: 4M48), which is one of the dopamine transporter proteins. Ligand and receptor interactions were analyzed using molecular docking method with Autodock Vina 4 application with nortriptyline compound as native ligand and 15 secondary metabolite compounds for testing. The results of docking analysis showed that the standard ligand nortriptyline compound has an affinity value of -10.2 kcal/mol. There are 3 compounds from bajakah that have affinity values close to the standard compounds plathymenin, butein and eriodictyol with affinity values of -9.7 kcal/mol, -9.4 kcal/mol and -9.2 kcal/mol respectively. Based on the analysis conducted, it can be concluded that bajakah plants (Spatholobus suberectus) have the potential to be developed as psychostimulant therapy.
Aplikasi Instrumen Spektroskopi FTIR dan Spektrometri Massa di Dunia Kesehatan: Review Rizki Rachmad Saputra; Mokhamat Ariefin; Esintia Kristia; Bela D; Dominikus Diki Wahyudi; Ansori Rahman; Ni Wayan Prema Mulya Sari; Ayu Puspita Sari; Siti Misbah Aisah
Bohr: Jurnal Cendekia Kimia Vol 2 No 01 (2023): Bohr: Jurnal Cendekia Kimia Vol 02 No 01
Publisher : Program Studi Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kesehatan adalah suatu hal penting dari sebuah kehidupan seorang manusia. Kualitas pelayanan kesehatan merupakan tingkat keunggulan pelayanan kesehatan yang dapat memenuhi kebutuhan pasien. Salah satu pelayanan penunjang kesehatan pasien. Ilmu kedokteran saat ini mulai canggih, mulai dengan cara herbal atau dengan cara medis. Namun seiring dengan kebutuhan penyakit manusia makin lama makin tidak menentu jenis penyakit, maka dari itu dokter pun banyak yang memulai mempelajari banyak cara pengobatan. Salah satu pengobatan atau pendekteksi penyakit yang banyak di teliti dengan cara instrumen. Oleh karena itu, Pada penelitian ini kami mereview Aplikasi Instrumen Spektroskopi FTIR dan Spektrometri Massa di Dunia Kesehatan.
Co-Authors Abdul Mannan Abed Nego Purba Abidin, Muh Rais Alfanaar, Rokiy Alonge, Titus Adeyemi Anggun Tanduwinata Anista, Anista Ansori Rahman Ariska, Risya Aulanni'am Aulanni'am Ayu Puspita Sari Bela D Chian-Yi Liu Citrariana, Shesanthi Decenly Decenly Decenly, Decenly Dicky Perwira Ompusunggu Dominikus Diki Wahyudi Dongoran, Junita Dwijayanti, Rts. Sherly Erwin Prasetya Toepak Esintia Kristia Fahmi, Rifaldi Lutfi Fauziah, Anisa Rahma Gracia, Amanda Natania Gunawan, Yohanes E Gunawan, Yohanes Edy Haliza , Nur Harianja, Henrigen Helmi Auliyah Istiqomah Imelya, Marsya Jamilah Jamilah Jeddah Yanti Junita Dongoran Kalalinggi, Septaria Yolan Liu, Chian-Yi Maknun, Luluil Mannan, Abdul Marvin Horale Pasaribu Mokhamat Ariefin Muh Rais Abidin Muhammad Priyadi Ni Luh Kemmy Caesaria Ni Wayan Prema Mulya Sari Oksal, Efriyana Okta Prianus Paksi, Pandu Gizta Rapi Pramudita, Dimas Prianus, Okta Purba, Abed Nego Qaiyimah, Dinil Reny Rosalina, Reny Retno Agnestisia Rian Ka Praja Riandy Putra Sari, Meiyanti Ratna Kumala Simangunsong, Sri Yulandari Sisilya, Tahsya Amanda Siska, Amelia Siti Misbah Aisah Sugiyani, Tina Sulistiawati, Putri Suma, Joy Angel Aria syarpin, syarpin Tampubolon, Mulani Jeni Lestari Thathit Suprayogi Titus Adeyemi Alonge Togi Tampubolon Togi Tampubolon Wulandari, Oktavia Rahmi Yahya Febrianto Yanti, Helda Yuliana Yuliana Yuliana Yuneta, Yuneta