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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences International Journal of Health and Information System (IJHIS)
Sofiana, Kristianingrum Dian
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Agriculture, Biological Sciences & Forestry Computer Science & IT Environmental Science Health Professions Library & Information Science Medicine & Pharmacology Public Health

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Ambon Banana-Tree Sap stimulated Endothelial Cell Migration in Human Umbilical Vein Endothelial Cells (HUVECs) Induced with Inflammatory Mediator IL-1 Wulan, Provisia Marthalita Yuning; Dorothy, Maria Juliana; Alinda, Resha; Sofiana, Kristianingrum Dian; Prihardina, Bunga; Permaasari, Nur; Widodo, M. Aris
Journal of Tropical Life Science Vol 9, No 1 (2019)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4517.627 KB)

Abstract

Ambon banana-tree (Musa paradisiaca var.sapientum) sap (ABT sap) contains active substances that can stimulate the wound healing process such as: flavonoid, saponin, ascorbic acid. Those substances are needed in an important phase of wound healing called angiogenesis through activation of Vascular Endothelial Growth Factor (VEGF) pathway that stimulates actin reorganization in endothelial cell migration and proliferation. The aim of this study is to evaluate the effectiveness of banana-tree sap in stimulating cells migration, VEGF and nitric oxide (NO) level in Human Umbilical Vein Endothelial Cells (HUVECs) culture that induced by pro-inflammatory cytokine IL-1 (Interleukin-1). The ABT sap was obtained by pressing a fresh Ambon banana stem, then was mixed with culture medium into 0.125%, 0.25% and 0.5% concentration. The ABT sap then was used for treating HUVECs cell that induced by IL-1 200 ng/mL for 48-hours. The result of this study shows that Ambon banana-tree sap increased HUVECs cell migration. However, after 48-hours treatment with ABT sap showed no difference in the VEGF and NO level in the culture media. These results suggested ABT sap able to increase migration to HUVECs that promising for wound healing agent. Therefore, the further research to elucidate the detailed mechanism and identify the active compound warrant to be done.
Cardiac Tamponade in a Chronic Renal Failure Patient with Suspicion of Dialysis Pericarditis: A Case Report Wulandari, Pipiet; Suryono, Suryono; Prasetyo, Aris; Firdaus, Jauhar; Sofiana, Kristianingrum Dian; Indreswari, Laksmi; Handoko, Adelia; Setia, Bagus
International Journal of Health and Information System Vol. 2 No. 1 (2024): May
Publisher : Indonesian Journal Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47134/ijhis.v2i1.39

Abstract

Pericardial effusion is a condition characterized by fluid accumulation in the pericardial cavity. This fluid accumulation can cause disturbances in cardiac contractility, affecting hemodynamic stability. Fluid accumulation is caused by several factors, ranging from the amount of fluid, the speed of fluid accumulation, and the ability of the pericardium to accommodate fluid. One of the causes of pericardial effusion is pericarditis. Pericarditis can be caused by infection and non-infection, such as in patients with chronic renal failure with an incidence of 2-21%, which can lead to cardiac tamponade. In this study, a 46-year-old male patient who came to the emergency room of Dr. Soebandi Hospital, Jember with complaints of shortness of breath in the last 2 months. The patient also complained of heartburn. The patient had a history of chronic renal failure and routinely performed hemodialysis. On examination of vital signs, thoracic photographs, and echocardiography, a picture of cardiac tamponade was found. Cardiac tamponade can occur in patients with chronic renal failure. This is due to the condition of uremia which causes pericarditis. Inflammation of the pericardium causes blood that is intravascular to enter the pericardial cavity, causing fluid accumulation there. If not treated immediately, it can lead to cardiac tamponade which endangers the patient's life.
Co-Authors Alinda, Resha Aris Prasetyo Dorothy, Maria Juliana Handoko, Adelia Jauhar Firdaus Laksmi Indreswari M. Aris Widodo Permaasari, Nur Pipiet Wulandari Prihardina, Bunga Provisia Marthalita Yuning Wulan Setia, Bagus Suryono Suryono