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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indonesian Journal of Medicine SENADA : Semangat Nasional Dalam MengabdI The Hip and Knee Journal

Soetjahjo, Bintang

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Author-ID : 1432609

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Articles

Immunohistochemistry Evaluation of TGF-Î²1, SOX-9, Type II Collagen and Aggrecan in Cartilage Lesions Treated with Conditioned Medium of Umbilical Cord Mesencyhmal Stem Cells in Wistar Mice (Rattus novergicus) Soetjahjo, Bintang; Hidayat, Mohammad; Sujuti, Hidayat; Fibrianto, Yuda
Journal of Tropical Life Science Vol 8, No 1 (2018)
Publisher : Journal of Tropical Life Science

Currently, umbilical cord mesenchymal stem cells have the potential to be used as treatment options for any cartilage lesion. This research aimed to evaluate the effects of conditioned medium from umbilical cord mesenchymal stem cells (UC-MSC) on damaged cartilage through the expression of proteins TGF-Î²1, SOX-9, type II collagen and aggrecan, which are known to be related to chondrogenesis. UC-MSC were isolated from 19-days-pregnant Wistar mice and were cultured using the standard procedure to obtain 80% confluence. Subsequently, the culture was confirmed through a microscopic examination that was driven to be an embryoid body to obtain a pre-condition medium. This research utilized 3-month-old male Wistar mice and was categorized into 6 groups (3 control and 3 treatment groups). Each animal had surgery performed to create a femur condyle cartilage defect. The treatment groups were administered a dose of stem cells at 1 mL/kg. Next, immunohistochemical (IHC) staining was performed to examine the expression of TGF-Î²1, SOX-9, type II collagen and aggrecan in the 2nd, 3rd, and 4th month of evaluation. The results were analyzed statistically using ANOVA test. For each of the treatment groups, there was increased expression (p < 0.05) in all proteins TGF-Î²1, SOX-9, type II collagen and aggrecan when compared with control groups at the 2nd, 3rd, and 4th month of evaluation. Pre-conditioned medium from UC-MSC potentially increases the expression of TGF-Î²1, SOX-9, type II collagen and aggrecan in the damaged cartilage of Wistar mice.

Secondary Knee Osteoarthritis with Medial Instability and Tibial Defect due to Chronic Abscess Treated by Total Knee Arthroplasty with Metal Augmentation - Case Report Soetjahjo, Bintang; Hancoro, Udi Herunefi; Ermawan, Rieva; Saputra, Rhyan Darma; Akbar, Hillan
Indonesian Journal of Medicine Vol. 6 No. 2 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Background:Knee osteoarthritis (OA), known as degenerative joint disease, is typically the result of wear and tear and progressive loss of articular cartilage, most common in elderly women and men. Knee OA is a leading cause of disability and increase with an aging and overweight population. Total Knee Arthroplasty (TKA) is a common surgical treatment of OA knee that highly cost-effective procedure. Stable placement of components is difficult and thus it presents technical challenges for the surgeon but various options are available for managing these defects.Case Report: A 58 years-old housewife came to our clinic due to chronic left knee pain with associated instability since two years ago and getting worse in last three months. She already had knee joint supplementation injections and physical therapy but no improvements. Based on our clinical and radiological findings, our assessment was secondary left knee osteo-arthritis with medial instability and tibial defect due to chronic abscess. Patient underwent TKA to correct this condition. A revised implant was used to close the defect in the medial part of the tibia and soft tissue reconstruction procedure was used to correct the instability.Result: On the first postoperative month, the patient underwent rehabilitation and physical therapy to strengthen her lower limb muscles. On the second month, she started to walk using walking assisted device. On the ninth months follow-up, the patient was able to walk normally without assisted device, the pain disappeared and the symptoms of knee instability were reduced.Conclusion:Bone defects are commonly encountered during TKA, which still has no standard treatment to cure. In this case, the use of metal augmentation with revision implant give satisfactory results with good clinical outcome.Keywords: Osteoarthritis, Total Knee Arthro¬plasty, knee instability, tibial defect, metal augmentationCorrespondence:Bintang Soetjahjo. Dr. Moewardi Hospital. Jl. Kolonel Sutarto 132, Jebres, Surakarta, Central Java 57126, Indonesia. Mobile: +628122987359. Email: bjortho@yahoo.comIndonesian Journal of Medicine (2021), 06(02): 168-176https://doi.org/10.26911/theijmed.2021.06.02.06

Masalah Perioperatif pada Kasus Emergensi Ortopedik Selama Pandemi Covid-19: Laporan Kasus Amputasi Darurat Pasien Suspek Covid-19 Soetjahjo, Bintang; Hancoro, Udi Herunefi; Ermawan, Rieva; Saputra, Rhyan Darma; Nugroho, Bagus Jati; Abdulhamid, Muhammad
SENADA : Semangat Nasional Dalam Mengabdi Vol. 1 No. 3 (2021): SENADA: Semangat Nasional Dalam Mengabdi
Publisher : Perkumpulan Dosen Periset Indonesia

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Penyakit Coronavirus 2019 (COVID-19), yang disebabkan oleh severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), telah menyebar ke seluruh dunia. Selama epidemi COVID-19 yang sedang berlangsung, banyak rumah sakit yang menunda sebagian besar operasi elektif. Namun, beberapa operasi darurat, terutama untuk pasien trauma, tidak bisa dihindari. Untuk pasien yang dicurigai atau dikonfirmasi COVID-19, protokol standar yang terkait persiapan pra operasi, manajemen intraoperatif, dan pengawasan pasca operasi harus diterapkan untuk menghindari infeksi nosokomial dan memastikan keselamatan pasien juga tenaga Kesehatan yang terlibat. Dalam artikel ini kami melaporkan kasus seorang pasien berusia 65 tahun dengan crush injury tungkai bawah dan suspek covid-19. Pasien direncanakan untuk menjalani CITO debridemen dan amputasi di atas lutut. Artikel ini kemudian membahas pertimbangan perioperatif dan teknis yang penting untuk menangani pasien COVID-19 yang membutuhkan perawatan darurat, tanpa mengesampingkan hasil klinis sembari memastikan keselamatan staf yang ada

Mesenchymal Stem Cells Secretome and Osteoarthritis: A State of The Art Soetjahjo, Bintang; Utomo, Dwikora Novembri
The Hip and Knee Journal Vol 3, No 2 (2022): August
Publisher : Indonesian Hip and Knee Society (IHKS)

No agreed cure or procedure can prevent the damage caused by OA. Current treatments such as physiotherapy, anti-inflammatory drugs, and viscous supplements are symptomatic and are aimed solely at pain relief. Mesenchymal stem cells, on the other hand, refer to a population of cells with immunomodulatory and homing properties. Recent studies have shown that stem cells produce secretomes with tissue regeneration, immunomodulation, anti-inflammatory, and anti-apoptotic capacities.Secretomes in conditioned media produced by mesenchymal stem cells can stimulate the repair of cartilage defects. There are many evidence from many studies both in vitro and in vivo which provide potential results. The improvement can be seen from the morphology, in the form of thickening of the cartilage, an increase in the number of chondrocyte cells, regular joint surfaces, and histologically it can be seen that there is an improvement in the joint cartilage matrix. Likewise, histological studies using immunohistochemistry also showed an increase in the expression of TGF-β, SOX-9, aggrecan, and type II collagen which is a pathway for the formation of hyaline cartilage repair. Not only improvement, other studies have also shown that the secretome can provide a protective effect on joint cartilage by increasing the expression of the COL2A1 gene which functions to form collagen matrix components and reduces apoptosis in chondrocyte cells.Secretomes produced by mesenchymal stem cells can stimulate the repair of cartilage damage, anti-inflammatory, immunomodulator, angiogenesis, and anti-apoptotic abilities from their cytokines and extra vesicles contains miRNA. MSCs secretomes are more stable and provide simpler manufacturing than MSCs themselves.

Functional Outcome Evaluation of Grade III Open Tibial Fracture Treated by External Fixation as Definitive Treatment Soetjahjo, Bintang; Ermawan, Rieva; Saputra, Rhyan Darma; Hancoro, Udi Herunefi; Nugroho, Bagus Jati; Anugra, Jiva Yori
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2021.6.4.381

Background: Tibial shaft fractures including open tibial fractures grade III are one of the most common fractures of long bones. There are many methods of conservative and operative treatment, one of them is external fixation. External fixation is more common used temporary in polytraumatized patients with tibial shaft fractures. The study was undertaken to see if the patient can be treated with external fixation as the definitive treatment and evaluate the functional outcome after the treatment.Subjects and Method: A retrospective review of a prospectively-collected database was performed. Data was taken from the Orthopaedic Department of RSUD Dr. Moewardi Hospital patients’ database. The study included all patients who underwent grade III open tibial fracture treatment from May 2018 to May 2019. A total of 8 patients who were included in our study were a patient with open tibial fractures grade III planned for external fixaton as definitive treatment. They were evaluated radiographically and clinically to determine the union rate. The data were reported descriptively.Results: External fixator time ranged in this study around 240 days. In this study, there were a few patients whose progress were remain unknown due to loss of contact. Fractures studied 5 out of 8, no patient were union after 8 months of external fixator used. 4 out of 8 patients were reported non-union after 8 months based on their radiological examination (50%) and 1 out of 8 patients were reported has been performed Removal of External Fixation (ROEF) after 5 months of treatment. The rest of the 3 patients’ results were remain unknown.Conclusion: Open tibial fractures grade III of the leg can be managed with use of external fixator as a definitive treatment. However, the use of external fixation does not provide maximum results in grade III A tibial fractures.Keywords: open tibial fractures, external fixation, union, malunionCorrespondence: Bintang Soetjahjo. Dr. Moewardi General Hospital. Jl. Kolonel Sutarto 132, Jebres, Surakarta, Central Java, Indonesia. 57126. Email: bjortho@yahoo.com. Indonesian Journal of Medicine (2021), 06(04): 452-459https://doi.org/10.26911/theijmed.2021.06.04.11

Co-Authors Akbar, Hillan Anugra, Jiva Yori Dwikora Novembri Utomo Ermawan, Rieva Fibrianto, Yuda Hancoro, Udi Herunefi Hidayat Sujuti Mohammad Hidayat Muhammad Abdulhamid Nugroho, Bagus Jati Saputra, Rhyan Darma

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