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All Journal Indonesian Journal of Medicine MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Jurnal Kedokteran Universitas Palangka Raya Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Smart Society Empowerment Journal
Adhiputri, Artrien
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Humanities Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Effectiveness of Zingiber officinale to reduce inflammation markers and the length of stay of patients with community-acquired pneumonia: An open-label clinical trial Reviono, Reviono; Hapsari, Brigitta DA.; Sutanto, Yusup S.; Adhiputri, Artrien; Harsini, Harsini; Suryawati, Betty; Marwoto, Marwoto; Syaikhu, Akhmad
Narra J Vol. 3 No. 1 (2023): April 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i1.142

Abstract

Examination of the interleukin 6 (IL-6) and procalcitonin levels, and neutrophil-lymphocyte ratio (NLR) might could help to diagnosis and predict the duration of therapy and prognosis of pneumonia cases. Zingiber officinale var rubrum could be used as an adjunct therapy in infectious diseases as it has anti-inflammatory activity. The aim of study was to assess the effect of Z. officinale on levels of IL-6 dan procalcitonin, NLR, and the length of hospitalization of patients with community-acquired pneumonia (CAP). An open-label clinical trial was conducted among CAP cases regardless of the etiology at Dr Moewardi Hospital and Universitas Sebelas Maret Hospital, Surakarta, Indonesia from July to September 2022. A total of 30 inpatient CAP cases were recruited and were randomly divided into two groups: (1) received Z. officinale capsule 300 mg daily for five days in addition to CAP standard therapy; and (2) received CAP standard therapy only, as control group. The data were compared using a paired Student t-test, Chi-squared test, Mann-Whitney test and Wilcoxon signed-rank test as appropriate. In Z. officinale group, the mean difference between post- and pre-treatment as follow: IL-6 level was 9.93 pg/mL, procalcitonin level -471.31 ng/mL, and NLR value -4.01. In control group, the difference was 18.94 pg/mL for IL-6, 339.39 ng/mL for procalcitonin, and 1.56 for NLR. The change of IL-6 was not statistically significant between treatment and control groups with p=0.917. The changes of procalcitonin level and NLR were significant between treatment and control group with p=0.024 and p=0.007, respectively, of which the treatment had better improvement. In addition, our data indicated that the length of stay was not statistically significant between the treatment and control groups (4.13 vs 4.47 days, p=0.361). In conclusion, Z. officinale could reduce serum inflammatory markers such as procalcitonin and NLR but it has little impact in reducing IL-16 level and the length of hospitalization of CAP patients.
Effects of secretome supplementation on interleukin-6, tumor necrosis factor-α, procalcitonin, and the length of stay in acute exacerbation COPD patients Fahlevie, Fahlevie; Apriningsih, Hendrastutik; Sutanto, Yusup S.; Reviono, Reviono; Adhiputri, Artrien; Aphridasari, Jatu; Prasetyo, Windu
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.171

Abstract

Acute exacerbation chronic obstructive pulmonary disease (AECOPD) is associated with significant poor survival. Mesenchymal stem cells (MSC) therapy has been a promising treatment for COPD; therefore, it has the potential to be an additional therapy for AECOPD. Its potential is associated with its secretome since it has anti-inflammatory and immunomodulator activities. The aim of this study was to determine the effect of the secretome as an adjuvant therapy in reducing the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), procalcitonin, and the length of stay in AECOPD patients. A clinical control trial study was conducted among 28 moderate and severe AECOPD patients who were hospitalized from January to February 2023. The control group (n=14) received standard therapy of AECOPD while the treatment group (n=14) received standard therapy plus secretome 1 ml twice daily for three days. The levels of IL-6, TNF-α, and procalcitonin were measured at admission and on the fourth day of treatment. The length of stay was calculated from the time the patient was admitted until the patient was discharged from hospital. The data were compared using a paired Student t-test, chi-squared test and Mann-Whitney test as appropriate. In the treatment group, the levels of IL-6, TNF-α and procalcitonin after the treatment reduced 13.09 pg/mL, 5.00 pg/mL and 751.26 pg/mL, respectively compared to pre-treatment. In contrast, the levels of IL-6, TNF-α and procalcitonin increased 48.56 pg/mL, 44.48 pg/mL and 346.96 pg/mL, respectively after four days of treatment. There was a significant reduction of IL-6, TNF-α and procalcitonin in treatment group compared to the control group with p=0.022, p=0.009 and p=0.001, respectively. However, there was no significant reduction of the length of stay (p=0.072). In conclusion, administration of secretome to AECOPD patients could reduce the levels of IL-6, TNF-α and procalcitonin.
HUBUNGAN DERAJAT SESAK DAN OBSTRUKSI SALURAN NAPAS DENGAN KUALITAS HIDUP PASIEN PPOK Nadiya Aliyah Roselyn; Adhiputri, Artrien; Munawaroh, Siti; Aphridasari, Jatu
Jurnal Kedokteran Universitas Palangka Raya Vol 11 No 2 (2023): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v11i2.9850

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is still a national and global health problem. In 2018, COPD cases in Central Java ranked seventh. COPD is characterized by airway obstruction that leads to shortness of breath. This disease causes worsening of health conditions and affects quality of life. The purpose of this study was to determine the correlation between the dyspnea scale and the airflow limitation severity with the quality of life of COPD patients at UNS Hospital. The method used in this research was analytic observational study with cross sectional design. The subjects in this study were COPD patients at the Pulmonary Polyclinic of UNS Hospital in February-March who had fulfil the criterias. The sampling technique of this research was purposive sampling. Data were collected using the mMRC questionnaire, SGRQ-C questionnaire, and spirometry data from medical records. The obtained data were analyzed with the Spearman correlation test. Spearman correlation test for 37 respondents obtained a p-value of 0,001 and a correlation coefficient (r) of 0,527 for the dyspnea scale and quality of life variable, which means that both variables are significant and moderately correlated. As for the airflow limitation severity and quality of life variable, the p-value is 0,000 and the correlation coefficient (r) is 0,808, which means that the two variables are significant and very strongly correlated. There is a significant correlation between dyspnea scale with the quality of life and airflow limitation severity with the quality of life of COPD patients at UNS Hospital.
The Effect of Neutrophil Lymphocyte Ratio and Bacterial Co-Infection on Mortality and Length of Hospital Stay of COVID-19 Patients Renata, Felicia; Adhiputri, Artrien; Suyatmi, Suyatmi
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.122-129

Abstract

Background:  The new coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious disease. The disease has spread rapidly and widely around the world, and was declared as pandemic in March 2020 by WHO. The neutrophil lymphocyte ratio (NLR) is a biomarker that provides important information about the status of systemic inflammation, including in COVID-19. Bacterial co-infection is commonly identified in viral respiratory tract infections such as SARS-CoV-2 and is an important cause of morbidity and mortality.Objective: This study aims to retrospectively analyze clinical data of COVID-19 patients who were treated at Dr. Moewardi General Hospital in Surakarta, to determine the effect of NLR and bacterial co-infection with mortality and length of hospital stay of COVID-19 patients.Methods: This study is an analytical observational study with a cross-sectional design using secondary data from 87 adult COVID-19 patients at Dr. Moewardi Hospital in August 2021. The sampling method used was purposive sampling of all adult patients aged 18 years or above who had been diagnosed with COVID-19 and hospitalized.Results: It was found that there was a strong effect of bacterial co-infection on NLR (r= 0.528). It was also found that NLR and bacterial co-infection simultaneously affected the length of hospital stay (Sig.= 0.02) and mortality (Sig.= 0.027). Partially, the effect of NLR on length of hospital stay was found (Sig.= 0.045).Conclusion: NLR and bacterial co-infection have an effect on mortality and length of hospital stay of COVID-19 patients.
Long Covid-19, Radiological Findings, and Its Management: A Systematic Review Soewondo, Widiastuti; Putro, Prasetyo Sarwono; Hermansah, Muhamad Lukman; Lestari, Lilik; Reviono, Reviono; Harsini, Harsini; Adhiputri, Artrien
Indonesian Journal of Medicine Vol. 6 No. 4 (2021)
Publisher : Masters Program in Public Health, Sebelas Maret University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2021.6.4.446

Abstract

Background: COVID-19 is a disease caused by SARS-CoV-2 and has numerous clinical spectrums. Mild respiratory infection is the common clinical manifestation of COVID-19, and the less common is pneumonia accompanied by fever, cough, and breathing difficulty. Long COVID can be defined as prolonged signs and symptoms which cannot be explained for other reasons 4 weeks after being diagnosed with SARS-CoV-2. This study aimed to describe the cause of illness is confirmed or suspected COVID-19 patients, specifically on long COVID.Subjects and Method: We performed literature searches of the latest articles with Medline, CINAHL (EBSCO), Global Health (Ovid), WHO Global Research on COVID-19 database, LitCovid and Google Scholar databases published from 2019 to 2020. Two reviewers searched all articles independently (P and W, with 7 and 10 years of experience, respectively). We conducted a systematic review to provide recent evidence of symptoms and complications in long COVID. We followed PRISMA guidelines.Results: A total of 22 papers was identified and screened for eligibility from medical databases. There were 15 papers included in this review. Reason for the continuous symptoms covid an extent of organ destruction, continuous response of chronic inflammation or immunology reaction, non-specific effect of hospital admission, some critical disease, post ICU syndrome, complications from COVID-19 infection,  morbidities and adverse effects of medications used. Common symptoms are fatigue, shortness of breath, cough, chest pain, palpitations, dizziness, arthralgia, myalgia and weakness, sleep problems, sharp pain, gastrointestinal problems, rash and hair loss, impaired balance and ataxia, neurologic problems such as dementia, concentration disorders and poor quality of life.Conclusion: The incidence of long-term manifestations of COVID-19 has been increasing and systemic clinical symptoms affect many organs and systems. This can be due to numerous reasons like post-ICU syndrome, post-viral fatigue syndrome, permanent organ deterioration or others. Correspondence: Widiastuti Soewondo. Department of Radiology, Dr. Moewardi General Hospital/ Faculty of Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Indonesia. Email: widiastuti.sprad56@staff.uns.ac.idIndonesian Journal of Medicine (2021), 06(04): 387-392https://doi.org/10.26911/theijmed.2021.06.04.04
Thyroid hormone as a clinical predictor in acute exacerbation of COPD: Relationship with %FEV1, exacerbation severity, and hospital stay duration Yanuar; Apriningsih, Hendrastutik; Setijadi, Ana Rima; Reviono; Adhiputri, Artrien
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 1, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss1.art9

Abstract

Background: Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of mortality worldwide. Acute Exacerbations of COPD (AECOPD) significantly impact patient outcomes and healthcare costs. Thyroid hormone dysregulation has been proposed as a potential systemic effect of AECOPD. However, the relationship between thyroid hormones and AECOPD clinical predictors, such as %FEV1, exacerbation severity, and hospitalization duration, remains unclear.Objective: This study aimed to investigate the relationship between thyroid hormones and key clinical predictors in patients with Acute Exacerbation of COPD (AECOPD), including %FEV1, exacerbation severity, and Length of Stay (LOS).Method: This is a cross-sectional study which included 32 patients admitted for AECOPD from November 2023 to January 2024 at Sebelas Maret University Hospital. Thyroid function was assessed by measuring serum levels of Thyroid-Stimulating Hormone (TSH), Free Triiodothyronine (FT3), and Free Thyroxine (FT4). We evaluated the association between thyroid hormone levels and Forced Expiratory Volume in 1 second (FEV1), severity of exacerbation, and Length of Stay (LOS).Results: The study found a significant positive correlation between FT3 and %FEV1 (r=0.414, p=0.019), indicating a relationship between higher FT3 and better lung function. A significant negative correlation was observed between FT3 and exacerbation severity (r=-0.506, p=0.003), then FT3 and LOS (r=-0.350, p=0.050). FT4 also negatively correlated with exacerbation severity (r=-0.367, p=0.039). The optimal cut-off for FT3 to predict severe exacerbation was <2.65 pmol/L, with a sensitivity of 80.8% and specificity of 100%.Conclusion: The study indicates a significant relationship between thyroid hormones, particularly FT3, and clinical outcomes in AECOPD patients. These findings suggest that thyroid hormone assessment could be useful in predicting the severity of acute COPD exacerbations, contributing to more targeted management strategie.
Effect of Balloon Inflation Exercise on Lung Function, Resilience, and Quality of Life in Patients Stable Copd RS UNS Pratiwi, Atmasari; Apriningsih, Hendrastutik; Setijadi, Ana Rima; Adhiputri, Artrien; Rahardjo, A. Farih
Jurnal Respirologi Indonesia Vol 45 No 3 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i3.492

Abstract

Background: His WHO data for 2019 puts him third in COPD deaths, at about 3.23 million. Decreased respiratory function is one of the symptoms of COPD that causes respiratory arrest that impacts quality of life. Pulmonary rehabilitation in COPD patients is a means of controlling and reducing symptoms and optimizing functional function.Method: Experimental study with pre-test and post-test groups design. The number of study participants was 30 stable COPD outpatient in group B and E of the Respiratory Clinic of the UNS Hospital during the period of February 2023 by targeted sampling. The control group (n = 15) received standard care and the treatment group (n=15) received standard care plus additional balloon-inflation exercises for 6 weeks. Comparisons between pretest and posttest groups were made on %VEP1 score, breathlessness symptoms, CAT questionnaire, exercise capacity, and EID.Result: Increased values of %VEP1 (p=0.001), decreased Borg scale (p=0.001), decreased CAT score (p = <0.001), and physical activity performance (p = 0.001) versus his EID (p = <0.001) increase.Conclusion: Inflating the balloon affects %VEP1, Borg scale, CAT score, training capacity increase, and EID values. Balloon blowing exercise increases the %VEP1 value, lowers the Borg scale, lowers the CAT score, increases exercise capacity, and EID.Keywords: %VEP1, Borg scale, training capacity, CAT, EID
The Effect of Magnesium Citrate on %FEV1, %PEFR, and Asthma Control Test Score in Patients with Controlled Asthma and Uncontrolled Asthma Atmojo, Anang Purwoko; Sutanto, Yusup Subagio; Adhiputri, Artrien; Reviono, Reviono; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 45 No 3 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i3.503

Abstract

Background: Asthma is one of the most common non-communicable diseases in the world and affected an estimated 262 million people in 2019. Magnesium is one of the nutrients known to improve lung function in asthma by inhibiting the production of proinflammatory cytokines, exhibiting anti-inflammatory benefits, and having beneficial muscle-relaxing and bronchodilatation effects. Measurement of percent predicted forced expiratory volume in 1 second (%FEV1), percent predicted peak expiratory flow rate (%PEFR), and asthma control test (ACT) score is are indicator of lung function. Magnesium citrate may be used as an adjunct therapy in patients with controlled and uncontrolled asthma. Methods: Clinical trial research with quasi quasi-experimental method using a pre-test and post-test design. The study subjects were 34 controlled and uncontrolled asthma patients at the outpatient clinic of Universitas Sebelas Maret Hospital and dr. Soehadi Prijonegoro Hospital in February - March 2023, using consecutive sampling. The control group (n=17) received standard therapy, while the treatment group (n=17) received standard therapy plus 300 mg magnesium citrate for 42 days. Serum magnesium level, %FEV1, %PEFR, and ACT score were measured at enrollment and on the forty-third day of treatment. Results: There were significant differences between the treatment group compared to the control group in increasing %PEFR (P=0.001), increasing ACT score (P=0.011), and increasing %FEV1 (P=0.071). Conclusion: Administration of magnesium citrate to patients with controlled and uncontrolled asthma can increase levels of %PEFR, ACT score, and %FEV1.
Concordance Level between Impulse Oscillometry and Spirometry for Pulmonary Function Test Hapsari, Brigitta Devi Anindita; Melita , Melita; Siregar, Sihsusetyaningtyas Tiominar; Apriningsih, Hendrastutik; Adhiputri, Artrien
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.920

Abstract

Background: The most widely used lung function test, spirometry, requires constant coaching and more effort. An alternative modality of impulse oscillometry (IOS) was introduced, which is simpler than spirometry, requiring only basic tidal breathing and less cooperation, but with less stringent standards. Methods: This research was a diagnostic test research with medical records data of patients who underwent spirometry and oscillometry procedures within the same period. The study was conducted in Sebelas Maret University General Hospital from March to September 2024. Results: A total of 77% of examinations gave the same results, namely restriction in 32 people (30.8%) and obstruction in 48 people (46.2%). Meanwhile, as many as 23% of IOS examinations gave different results compared to spirometry examinations (discordance). Six normal results from spirometry showed the impression of obstruction in IOS. The agreement between the IOS examination and spirometry was moderately significant (P=0.0001). Conclusion: Impulse oscillometry is a useful adjunct to spirometry, which is still the gold standard, especially for patients who are incapable of performing forced maneuvers.
P/F Ratio is a Better Predictor for Non-Invasive Ventilation Failure and Length of Stay in Patients with Community-Acquired Pneumonia Hapsari, Brigitta Anindita Devi; Roxanne, Olivia Geraldine; Reviono, Reviono; Adhiputri, Artrien; Apriningsih, Hendrastutik; Rahayu, Nur Indah; Vagheggini, Guido
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.42-49

Abstract

Introduction: Community-acquired pneumonia (CAP) can deteriorate into respiratory failure requiring immediate ventilatory intervention. This study compared the performance of the PaO2/FiO2 (P/F) ratio, the ratio of oxygen saturation (ROX) index, and the heart rate, acidosis, consciousness, oxygenation, and respiratory rate (HACOR) score in predicting non-invasive ventilation (NIV) failure and length of hospital stay in patients diagnosed with CAP. Methods: This study was conducted at Universitas Sebelas Maret Hospital, Surakarta, from March to September 2023. All patients diagnosed with CAP who were eligible for NIV were recruited. Each patient's age, sex, comorbidities, vital signs, pneumonia severity index (PSI), blood urea, bilirubin, hematocrit, blood sodium, P/F ratio, ROX index, and HACOR score were measured within the first 24 hours of NIV. Subsequently, the correlations between these variables and NIV failure (intubation or mortality) and length of hospital stay were assessed. Results: The P/F ratio, ROX index, and HACOR score were not correlated with intubation or length of stay. The P/F ratio was correlated with mortality (p = 0.040), whereas the other scores were not. Higher body temperature was correlated with intubation (p = 0.032). PSI was correlated with both mortality (p = 0.033) and length of hospital stay (p = 0.009). Conclusion: The P/F ratio is superior to the ROX index and HACOR score in predicting mortality in patients with pneumonia-related respiratory failure treated with NIV. Since it is simple and accessible, measuring the P/F ratio within the first 24 hours of NIV is recommended to identify a patient's risk of NIV failure and apply appropriate monitoring.
Co-Authors Akhmad Syaikhu Alfarizi, Aditya Ana Rima Setijadi Anindita Hapsari, Brigitta Devi Apriningsih, Hendrastutik Atmojo, Anang Purwoko Damayanti, Raninditya Fahlevie, Fahlevie Hapsari, Brigitta Anindita Devi Hapsari, Brigitta DA. Hapsari, Brigitta Devi Anindita Harsini Harsini Hermansah, Muhamad Lukman Jatu Aphridasari Lilik Lestari marwoto marwoto Melita , Melita Mochammad Imron Awalludin Nadiya Aliyah Roselyn Nur Hafidha Hikmayani Pratiwi, Atmasari Putro, Prasetyo Sarwono Rahardjo, A. Farih Rahayu, Nur Indah Renata, Felicia Reviono Reviono Reviono Roxanne, Olivia Geraldine Siregar, Sihsusetyaningtyas Tiominar Siti Munawaroh Soewondo, Widiastuti SURYAWATI, BETTY Sutanto, Yusup S. Suyatmi Suyatmi Vagheggini, Guido Windu Prasetyo, Windu Yanuar Yudhi Prasetyo, Yudhi Yusup Subagio Sutanto