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All Journal Nexus Kedokteran Klinik Journal of Biomedicine and Translational Research Indonesian Journal of Medicine Jurnal Respirologi Indonesia Jurnal Kedokteran Universitas Palangka Raya Respiratory Science Narra J Kieraha Medical Journal Cermin Dunia Kedokteran
Jatu Aphridasari
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Hubungan antara Penggunaan Obat Nyamuk dengan Tingkat Kontrol Asma Astuti, Astari Rindu; Aphridasari, Jatu; Widardo, .
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.046 KB)

Abstract

Background: Asthma is a chronic inflammatory disorder of the airways with episodic symptoms such as cough, shortness of breath, wheezing, and uplifted chest. Mosquito repellent consists of chemical synthetic chemical materials that can prevent mosquito’s bite towards. This study is to find out if there is or not any correlation between mosquito repellent usage and rate of asthma control. Methods: This study was an analytic observational study using cross sectional approach conducted on May to July 2013. Sixty samples were taken by using purposive sampling from outpatients who visited Pulmonary Clinics of Local Public Hospital Dr. Moewardi and fulfilled the inclusive criteria. The data was collected via interview by using a set of questionnaire. The data was then analyzed using Chi-Square test on Statistical Product and Service Solution (SPSS) 20.00 for Windows. Results: There is no significant correlation between mosquito repellent usage and rate of asthma control. From the Chi-Square test result, it was obtained that the significance value is p = 0,817. Conclusions: Based on this research, it can be concluded that there is no correlation between mosquito repellent usage and rate of asthma control. Keywords: mosquito repellent, rate of asthma control  
Uji Fungsi Paru pada Muscular Dystrophy Aphridasari, Jatu; Harnanda, Dicki
Cermin Dunia Kedokteran Vol 42, No 1 (2015): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.379 KB) | DOI: 10.55175/cdk.v42i1.1052

Abstract

Muscular dystrophy terdiri atas beberapa tipe, perbedaan tipe muscular dystrophy menyebabkan hasil uji fungsi paru yang berbeda. Komplikasi pada sistem pernapasan merupakan penyebab utama morbiditas dan mortalitas penderita muscular dystrophy. Pemeriksaan dan analisis fungsi paru perlu dilakukan pada pasien muscular dystrophy pada awal diagnosis dan selama proses perjalanan penyakit. Pemeriksaan tersebut membantu monitoring progresifitas dan perjalanan penyakit, menilai respons terhadap terapi intervensi, dan menentukan prognosis.There are several types of muscular dystrophy with different pulmonary function characteristics. Respiratory complication is a major cause of morbidity and mortality ini muscular dystrophy patients. Lung function test and analysis ought to be performed in patients with the disease as a basic examination for diagnosis and throughout the course of the disease. The test helps to monitor disease progresivity, assess theurapeutic response, and evaluate disease prognosis.
THE RELATIONSHIP BETWEEN OBESITY WITH RISK INCIDENT OF OBSTRUCTIVE SLEEP APNEA Helmi Fakhruddin; Jatu Aphridasari; Heni Hastuti
Nexus Kedokteran Klinik Vol 5, No 2 (2016): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Introduction : The purpose of this research is to determine the relationship between obesity and risk incident of Obstructive Sleep Apnea (OSA). This research was conducted at the Medical Faculty Sebelas Maret University of Surakarta from October 2015 to November 2015. Methods : This research was an analytical research using cross sectional approach. The size of population was 200 while the size of sample was 100 people. The sampling techniques used purposive random sampling. The data were obtained by questionnaire, research instrument with a guided interview technique using weighting machine, and microtoise. The obtained data were presented in tabular form and analyzed using the Chi Square Test at the level of significance ? = 0,05. Results : From the result of research conducted in the Medical Faculty of Sebelas Maret University Surakarta from October 2015 to November 2015, it was obtained that subjects with obesity who had high risk of OSA was 29 people (78%). This number was more than the number of subjects with obesity who had low risk of OSA of 21 people (33%) from the total of 50 subjects with obesity. While the number of subjects who didnt have obesity with high risk of OSA was 8 people (22%). This number was fewer than the number of subjects who didnt have obesity with low risk of OSA of 42 people (67%). The results of data analysis obtained X2= 18,198 and OR= 7,25; so that it could be concluded statistically, that there was a relationship between obesity and risk incident of OSA. Conclusions : The conclusion from this research was there was relationship between obesity and risk incident of OSA. Keyword: Obesity Obstructive pulmonary disease Obstructive Sleep Apnea (OSA)
Association between Characteristics and Behaviors of Workers that Exposed to Chemicals with ARI Symptoms in Artificial Nails Industry Oktavera Tri Kurniasih; Jatu Aphridasari; Sumardiyono .
Nexus Kedokteran Klinik Vol 5, No 2 (2016): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Abstract

Background: Artifical nails industry workers are potentially exposed to chemicals that can irritate the respiratory tract. Irritation of the respiratory tract may facilitate the occurrence of Acute Respiratory Infection (ARI). Worker characteristics and worker behaviors affect the occurrence of ARI. This research aimed to know the association between characteristics and behaviors of workers that exposed to chemicals with ARI symptoms in artificial nails industry. Methods: This research was an observational analytic with cross-sectional approach. The research was held in artificial nails industry of Purbalingga on November-December 2015 with 80 samples of workers which consisted of 48 workers of injection department and 32 workers of airbrush department. Independent variables of this research were worker characteristics and worker behaviors. Worker characteristics included gender, age, department of work, period of work, and length of work. Worker behaviors included behavior of the use of Personal Protective Equipment (PPE) such as masks and smoking behavior. Dependent variable of this research was ARI symptoms. Moderator variable of this research was chemicals exposure. Data were collected using questionnaires. Data were analyzed by multiple logistic regression analysis. Results: The results of multiple logistic regression analysis showed that variables that influence ARI symptoms were length of work (p = 0.000; PR = 13.28) and age (p = 0.001; PR = 10.53). Conclusions: Length of work and age influenced ARI symptoms of workers that exposed to chemicals in artificial nails industry. The strength of the relationship of length of work was greater than age. Keywords: Worker characteristics, worker behaviors, chemicals exposure, ARI symptoms.
Hubungan antara Penggunaan Obat Nyamuk dengan Tingkat Kontrol Asma Astari Rindu Astuti; Jatu Aphridasari; . Widardo
Nexus Kedokteran Klinik Vol 2, No 3 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Asthma is a chronic inflammatory disorder of the airways with episodic symptoms such as cough, shortness of breath, wheezing, and uplifted chest. Mosquito repellent consists of chemical synthetic chemical materials that can prevent mosquitos bite towards. This study is to find out if there is or not any correlation between mosquito repellent usage and rate of asthma control. Methods: This study was an analytic observational study using cross sectional approach conducted on May to July 2013. Sixty samples were taken by using purposive sampling from outpatients who visited Pulmonary Clinics of Local Public Hospital Dr. Moewardi and fulfilled the inclusive criteria. The data was collected via interview by using a set of questionnaire. The data was then analyzed using Chi-Square test on Statistical Product and Service Solution (SPSS) 20.00 for Windows. Results: There is no significant correlation between mosquito repellent usage and rate of asthma control. From the Chi-Square test result, it was obtained that the significance value is p = 0,817. Conclusions: Based on this research, it can be concluded that there is no correlation between mosquito repellent usage and rate of asthma control. Keywords: mosquito repellent, rate of asthma control
Neutrophil–Lymphocyte and Platelet–Lymphocyte Ratios are Predictors of Lung Malignancy Sutanto, Yusup S.; Rudiannor, Muhammad; Aphridasari, Jatu; Kurniawan, Hendra
Journal of Biomedicine and Translational Research Vol 10, No 2 (2024): August 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i2.20330

Abstract

Background: Inflammatory cells play an essential role in the neoplastic process by stimulating cancer proliferation, survival, and migration. Neutrophil-lymphocyte and platelet-lymphocyte levels can be used as the inflammatory tissue damage markers in cancer patients.Objective: This study aimed to analyze the increase of neutrophil-lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) as the predictive factors for lung malignancy.Methods: This study was a diagnostic cross-sectional study design in lung tumor patients at Dr. Moewardi Hospital Surakarta from August to October 2018. The subjects (60) were selected with consecutive sampling who take lung cancer diagnostic tests and divided into two groups of patients with lung tumors (30) and healthy (30) as control. The diagnostic procedures and neutrophil–lymphocyte and platelet–lymphocyte ratios calculation were performed on both groups. The optimum cutoff values for the NLR and PLR were calculated from the receiver operating curve analysis.Results: The statistical test found a significant difference in the neutrophil–lymphocyte and platelet–lymphocyte ratios between cancer patients and control (p = 0.0000). The lung cancer group exhibited an increase in the NLR with 90.0% sensitivity and 96.7% specificity with a cutoff of 2.71. The platelet–lymphocyte ratio had a cutoff of 136.63 at 83.3% sensitivity and 80.0% specificity.Conclusion: The increase of neutrophil-lymphocyte and the platelet-lymphocyte ratio can be used as a predictive predictor of lung malignancy.
Effects of secretome supplementation on interleukin-6, tumor necrosis factor-α, procalcitonin, and the length of stay in acute exacerbation COPD patients Fahlevie, Fahlevie; Apriningsih, Hendrastutik; Sutanto, Yusup S.; Reviono, Reviono; Adhiputri, Artrien; Aphridasari, Jatu; Prasetyo, Windu
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.171

Abstract

Acute exacerbation chronic obstructive pulmonary disease (AECOPD) is associated with significant poor survival. Mesenchymal stem cells (MSC) therapy has been a promising treatment for COPD; therefore, it has the potential to be an additional therapy for AECOPD. Its potential is associated with its secretome since it has anti-inflammatory and immunomodulator activities. The aim of this study was to determine the effect of the secretome as an adjuvant therapy in reducing the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), procalcitonin, and the length of stay in AECOPD patients. A clinical control trial study was conducted among 28 moderate and severe AECOPD patients who were hospitalized from January to February 2023. The control group (n=14) received standard therapy of AECOPD while the treatment group (n=14) received standard therapy plus secretome 1 ml twice daily for three days. The levels of IL-6, TNF-α, and procalcitonin were measured at admission and on the fourth day of treatment. The length of stay was calculated from the time the patient was admitted until the patient was discharged from hospital. The data were compared using a paired Student t-test, chi-squared test and Mann-Whitney test as appropriate. In the treatment group, the levels of IL-6, TNF-α and procalcitonin after the treatment reduced 13.09 pg/mL, 5.00 pg/mL and 751.26 pg/mL, respectively compared to pre-treatment. In contrast, the levels of IL-6, TNF-α and procalcitonin increased 48.56 pg/mL, 44.48 pg/mL and 346.96 pg/mL, respectively after four days of treatment. There was a significant reduction of IL-6, TNF-α and procalcitonin in treatment group compared to the control group with p=0.022, p=0.009 and p=0.001, respectively. However, there was no significant reduction of the length of stay (p=0.072). In conclusion, administration of secretome to AECOPD patients could reduce the levels of IL-6, TNF-α and procalcitonin.
HUBUNGAN DERAJAT SESAK DAN OBSTRUKSI SALURAN NAPAS DENGAN KUALITAS HIDUP PASIEN PPOK Nadiya Aliyah Roselyn; Adhiputri, Artrien; Munawaroh, Siti; Aphridasari, Jatu
Jurnal Kedokteran Universitas Palangka Raya Vol 11 No 2 (2023): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v11i2.9850

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is still a national and global health problem. In 2018, COPD cases in Central Java ranked seventh. COPD is characterized by airway obstruction that leads to shortness of breath. This disease causes worsening of health conditions and affects quality of life. The purpose of this study was to determine the correlation between the dyspnea scale and the airflow limitation severity with the quality of life of COPD patients at UNS Hospital. The method used in this research was analytic observational study with cross sectional design. The subjects in this study were COPD patients at the Pulmonary Polyclinic of UNS Hospital in February-March who had fulfil the criterias. The sampling technique of this research was purposive sampling. Data were collected using the mMRC questionnaire, SGRQ-C questionnaire, and spirometry data from medical records. The obtained data were analyzed with the Spearman correlation test. Spearman correlation test for 37 respondents obtained a p-value of 0,001 and a correlation coefficient (r) of 0,527 for the dyspnea scale and quality of life variable, which means that both variables are significant and moderately correlated. As for the airflow limitation severity and quality of life variable, the p-value is 0,000 and the correlation coefficient (r) is 0,808, which means that the two variables are significant and very strongly correlated. There is a significant correlation between dyspnea scale with the quality of life and airflow limitation severity with the quality of life of COPD patients at UNS Hospital.
The Relation between D-Dimer, Hs-CRP, and ACE Inhibitor to Severity, Reinfection, and Mortality of COVID-19 Patients Thomas, Novita Silvana; Aphridasari, Jatu; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 44, No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.465

Abstract

Background: COVID-19 reinfection has been found, although the data is not clear yet. Pandemic conditions bring about limited facilities and infrastructure, so biomarkers are an option. Research on biomarkers and the use of ACE inhibitor drugs in COVID-19 patients has not been widely conducted in Indonesia.Methods: This was a retrospective cohort study that used medical record data of confirmed COVID-19 patients treated at dr. Moewardi General Hospital for the period of January to March 2022. Surviving patients were observed for reinfections until November 2022.Results: This study involved 524 medical records of confirmed COVID-19 patients. After exclusion and inclusion criteria, 517 medical records were obtained. D-Dimer cut-off values of ≥2435 were significantly related to severity (OR=2.05; 95% CI=1.38-3.06; P≤0.001) and mortality (OR=2.89; 95% CI=1.95-4.27; P≤0.001) of COVID-19 patients. Hs-CRP levels ≥4.59 were significantly associated with mortality in COVID-19 patients (OR=1.82; 95% CI=1.23-2.69; P=0.003). The use of ACE inhibitors (OR=0.55; 95% CI=0.33-0.89; P=0.015) was a protective factor from mortality but increased the risk of reinfection (OR=3.11; 95% CI=1.16-8.36; P=0.034). Conclusion: D-Dimer and Hs-CRP biomarkers could be considered as predictor biomarkers for the severity and mortality of COVID-19 patients. Although the use of ACE inhibitors increased the risk of reinfection, it reduced the risk of mortality due to COVID-19.
Convalescent Plasma Treatment for Moderate to Critical Ill COVID-19 Patients – A Safe but Futile Treatment: A Non-Randomized Comparative Study Aphridasari, Jatu; Soetjahjo, Bintang; Joko, Agus; Sidharta, Rina; Harsini, Harsini; Arifin, Arifin; Permana, Septian Adi; Saraswati, Kunti; Adhiputri, Artrien; Marwanta, Sri; Laqif, Abdurahman; Danuaji, Rivan
Indonesian Journal of Medicine Vol. 8 No. 4 (2023)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26911/theijmed.2023.8.4.620

Abstract

Background: In a number of cases of viral infection, convalescent plasma therapy has been effective. Reportedly, the use of convalescent plasma as a therapy for COVID-19 patients with severe and life-threatening disorders is beneficial at this time. This study aims to assess the effectiveness and safety of convalescent plasma transfusions in hospitalized COVID-19 patients. Subjects and Method: This was a clinical trial employing a non-randomized comparative study. A historical control group (21 samples) and convalescent plasma transfusions (21 samples) was selected consecutively from hospitalized COVID-19 patients between May 6th, 2020, and May 6th, 2021 at Dr. Moewardi General Hospital. We assessed and quantified viral clearance in the laboratory. Statistical analysis is performed in SPSS version 20.0. Results: Plasma was taken from fifteen convalescent donors. In the plasma convalescent treatment group, there was a statistically significant difference between outcome and severity degree (p = 0.005). In addition, there was a substantial discrepancy between the result group and the control group (p 0.005). Significant differences in post-treatment NLR between the control and treatment groups (p 0.005). In addition, there were statistically significant differences between the control and treatment groups in post-treatment hsCRP levels (p 0.005). In addition, there were statistically significant differences (p 0.005) between all groups' inflammatory markers and outcomes. Conclusion: Using convalescent plasma to treat patients with COVID-19 is a rather safe practice. Our analysis demonstrated that the administration of convalescent plasma did not enhance survival or clinical outcomes for COVID-19 patients with moderate to severe disease. Keywords: COVID-19, convalescent therapy, critical ill
Co-Authors . Widardo AA Sudharmawan, AA Adhiputri, Artrien Alfarizi, Aditya Ana Rima Setijadi Apriningsih, Hendrastutik Arifin Arifin Astari Rindu Astuti Astarini, Dewi Bahari, Muh Arif Wira Fachry Abda El Rahman Fahlevie, Fahlevie Harnanda, Dicki Harsini Harsini Helmi Fakhruddin Heni Hastuti Joko, Agus Laqif, Abdurahman Marwanta, Sri Mochammad Imron Awalludin Nadiya Aliyah Roselyn Novita Silvana Thomas, Novita Silvana Oktavera Tri Kurniasih Permana, Septian Adi Raharjo, A Farih Reviono Reviono Rivan Danuaji Rudiannor, Muhammad Saraswati, Kunti Septiawan, Debree Sidharta, Rina Siti Munawaroh Soetjahjo, Bintang Sumardiyono . Sutanto, Yusup S. widardo, Widardo Widyasanti, Diana Windu Prasetyo, Windu Yusup Subagio Sutanto