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Uji Fungsi Paru pada Muscular Dystrophy Aphridasari, Jatu; Harnanda, Dicki
Cermin Dunia Kedokteran Vol 42, No 1 (2015): Neurologi
Publisher : PT. Kalbe Farma Tbk.

Muscular dystrophy terdiri atas beberapa tipe, perbedaan tipe muscular dystrophy menyebabkan hasil uji fungsi paru yang berbeda. Komplikasi pada sistem pernapasan merupakan penyebab utama morbiditas dan mortalitas penderita muscular dystrophy. Pemeriksaan dan analisis fungsi paru perlu dilakukan pada pasien muscular dystrophy pada awal diagnosis dan selama proses perjalanan penyakit. Pemeriksaan tersebut membantu monitoring progresifitas dan perjalanan penyakit, menilai respons terhadap terapi intervensi, dan menentukan prognosis.There are several types of muscular dystrophy with different pulmonary function characteristics. Respiratory complication is a major cause of morbidity and mortality ini muscular dystrophy patients. Lung function test and analysis ought to be performed in patients with the disease as a basic examination for diagnosis and throughout the course of the disease. The test helps to monitor disease progresivity, assess theurapeutic response, and evaluate disease prognosis.

Neutrophil–Lymphocyte and Platelet–Lymphocyte Ratios are Predictors of Lung Malignancy Sutanto, Yusup S.; Rudiannor, Muhammad; Aphridasari, Jatu; Kurniawan, Hendra
Journal of Biomedicine and Translational Research Vol 10, No 2 (2024): August 2024
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v10i2.20330

Background: Inflammatory cells play an essential role in the neoplastic process by stimulating cancer proliferation, survival, and migration. Neutrophil-lymphocyte and platelet-lymphocyte levels can be used as the inflammatory tissue damage markers in cancer patients.Objective: This study aimed to analyze the increase of neutrophil-lymphocyte ratio (NLR) and platelet–lymphocyte ratio (PLR) as the predictive factors for lung malignancy.Methods: This study was a diagnostic cross-sectional study design in lung tumor patients at Dr. Moewardi Hospital Surakarta from August to October 2018. The subjects (60) were selected with consecutive sampling who take lung cancer diagnostic tests and divided into two groups of patients with lung tumors (30) and healthy (30) as control. The diagnostic procedures and neutrophil–lymphocyte and platelet–lymphocyte ratios calculation were performed on both groups. The optimum cutoff values for the NLR and PLR were calculated from the receiver operating curve analysis.Results: The statistical test found a significant difference in the neutrophil–lymphocyte and platelet–lymphocyte ratios between cancer patients and control (p = 0.0000). The lung cancer group exhibited an increase in the NLR with 90.0% sensitivity and 96.7% specificity with a cutoff of 2.71. The platelet–lymphocyte ratio had a cutoff of 136.63 at 83.3% sensitivity and 80.0% specificity.Conclusion: The increase of neutrophil-lymphocyte and the platelet-lymphocyte ratio can be used as a predictive predictor of lung malignancy.

Effects of secretome supplementation on interleukin-6, tumor necrosis factor-α, procalcitonin, and the length of stay in acute exacerbation COPD patients Fahlevie, Fahlevie; Apriningsih, Hendrastutik; Sutanto, Yusup S.; Reviono, Reviono; Adhiputri, Artrien; Aphridasari, Jatu; Prasetyo, Windu
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.171

Acute exacerbation chronic obstructive pulmonary disease (AECOPD) is associated with significant poor survival. Mesenchymal stem cells (MSC) therapy has been a promising treatment for COPD; therefore, it has the potential to be an additional therapy for AECOPD. Its potential is associated with its secretome since it has anti-inflammatory and immunomodulator activities. The aim of this study was to determine the effect of the secretome as an adjuvant therapy in reducing the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), procalcitonin, and the length of stay in AECOPD patients. A clinical control trial study was conducted among 28 moderate and severe AECOPD patients who were hospitalized from January to February 2023. The control group (n=14) received standard therapy of AECOPD while the treatment group (n=14) received standard therapy plus secretome 1 ml twice daily for three days. The levels of IL-6, TNF-α, and procalcitonin were measured at admission and on the fourth day of treatment. The length of stay was calculated from the time the patient was admitted until the patient was discharged from hospital. The data were compared using a paired Student t-test, chi-squared test and Mann-Whitney test as appropriate. In the treatment group, the levels of IL-6, TNF-α and procalcitonin after the treatment reduced 13.09 pg/mL, 5.00 pg/mL and 751.26 pg/mL, respectively compared to pre-treatment. In contrast, the levels of IL-6, TNF-α and procalcitonin increased 48.56 pg/mL, 44.48 pg/mL and 346.96 pg/mL, respectively after four days of treatment. There was a significant reduction of IL-6, TNF-α and procalcitonin in treatment group compared to the control group with p=0.022, p=0.009 and p=0.001, respectively. However, there was no significant reduction of the length of stay (p=0.072). In conclusion, administration of secretome to AECOPD patients could reduce the levels of IL-6, TNF-α and procalcitonin.

HUBUNGAN DERAJAT SESAK DAN OBSTRUKSI SALURAN NAPAS DENGAN KUALITAS HIDUP PASIEN PPOK Nadiya Aliyah Roselyn; Adhiputri, Artrien; Munawaroh, Siti; Aphridasari, Jatu
Jurnal Kedokteran Universitas Palangka Raya Vol 11 No 2 (2023): Jurnal Kedokteran Universitas Palangka Raya
Publisher : Fakultas Kedokteran, Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jkupr.v11i2.9850

Chronic Obstructive Pulmonary Disease (COPD) is still a national and global health problem. In 2018, COPD cases in Central Java ranked seventh. COPD is characterized by airway obstruction that leads to shortness of breath. This disease causes worsening of health conditions and affects quality of life. The purpose of this study was to determine the correlation between the dyspnea scale and the airflow limitation severity with the quality of life of COPD patients at UNS Hospital. The method used in this research was analytic observational study with cross sectional design. The subjects in this study were COPD patients at the Pulmonary Polyclinic of UNS Hospital in February-March who had fulfil the criterias. The sampling technique of this research was purposive sampling. Data were collected using the mMRC questionnaire, SGRQ-C questionnaire, and spirometry data from medical records. The obtained data were analyzed with the Spearman correlation test. Spearman correlation test for 37 respondents obtained a p-value of 0,001 and a correlation coefficient (r) of 0,527 for the dyspnea scale and quality of life variable, which means that both variables are significant and moderately correlated. As for the airflow limitation severity and quality of life variable, the p-value is 0,000 and the correlation coefficient (r) is 0,808, which means that the two variables are significant and very strongly correlated. There is a significant correlation between dyspnea scale with the quality of life and airflow limitation severity with the quality of life of COPD patients at UNS Hospital.

The Relation between D-Dimer, Hs-CRP, and ACE Inhibitor to Severity, Reinfection, and Mortality of COVID-19 Patients Thomas, Novita Silvana; Aphridasari, Jatu; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 44, No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.465

Background: COVID-19 reinfection has been found, although the data is not clear yet. Pandemic conditions bring about limited facilities and infrastructure, so biomarkers are an option. Research on biomarkers and the use of ACE inhibitor drugs in COVID-19 patients has not been widely conducted in Indonesia.Methods: This was a retrospective cohort study that used medical record data of confirmed COVID-19 patients treated at dr. Moewardi General Hospital for the period of January to March 2022. Surviving patients were observed for reinfections until November 2022.Results: This study involved 524 medical records of confirmed COVID-19 patients. After exclusion and inclusion criteria, 517 medical records were obtained. D-Dimer cut-off values of ≥2435 were significantly related to severity (OR=2.05; 95% CI=1.38-3.06; P≤0.001) and mortality (OR=2.89; 95% CI=1.95-4.27; P≤0.001) of COVID-19 patients. Hs-CRP levels ≥4.59 were significantly associated with mortality in COVID-19 patients (OR=1.82; 95% CI=1.23-2.69; P=0.003). The use of ACE inhibitors (OR=0.55; 95% CI=0.33-0.89; P=0.015) was a protective factor from mortality but increased the risk of reinfection (OR=3.11; 95% CI=1.16-8.36; P=0.034). Conclusion: D-Dimer and Hs-CRP biomarkers could be considered as predictor biomarkers for the severity and mortality of COVID-19 patients. Although the use of ACE inhibitors increased the risk of reinfection, it reduced the risk of mortality due to COVID-19.

Effect of Body Mass Index, Sputum Conversion Status, and Adverse Drug Events Severity On Health-Related Quality of Life of Drug-Resistant Tuberculosis Patients Kurniawan, Sandy; Aphridasari, Jatu; Raharjo, A Farih
Respiratory Science Vol. 5 No. 2 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i2.168

Background: Adherence to treatment guidelines and bacteriological conversion are the main indicators of successful treatment of drug-resistant tuberculosis patients. Evaluation of health-related quality of life (HRQoL) and the effect of treatment on HRQoL are often ignored. HRQoL assessment is an interesting outcome to evaluate and improve. Drug-resistant tuberculosis patients suffer not only from the disease but also from the effects of the treatment. Method: This study used a cross-sectional design to determine the correlation of body mass index (BMI), sputum conversion status, and adverse drug events severity with the HRQoL of drug-resistant tuberculosis patients. Quality of life assessment using the WHOQol-BREf questionnaire. The study was conducted in October 2022 at dr. Moewardi Hospital, Surakarta and Dr. Ario Wirawan, Salatiga. Determination of the sample by total sampling method. Results: HRQoL in 33 study subjects ie, 15 subjects had good HRQoL and 18 subjects had poor HRQoL. The media for each quality of life domain are the physical domain 43.00±6.20, psychological domain 33.21±8.83, social domain 28.21±11.01, and environmental domain 33.45±6.38. Statistical analysis with rank Spearman showed that there were a relationship between BMI (P=0.018), sputum conversion status (P=0.002), and adverse drug events severity (P=0.0001) with HRQoL of drug-resistant tuberculosis patients. Conclusion: BMI, sputum conversion status, and drug adverse events severity affect HRQoL of drug-resistant tuberculosis patients.

Effects of Hypnotherapy on Pain Scale, Interleukin-6 Levels, and Quality of Life in Lung Cancer Patients Who Experience Cancer Pain Widyasanti, Diana; Sutanto, Yusup Subagio; Septiawan, Debree; Aphridasari, Jatu; Reviono, Reviono
Jurnal Respirologi Indonesia Vol 45 No 3 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i3.624

Background: Pain is a common symptom in lung cancer patients and can affect their quality of life. Interleukin 6 (IL-6) plays a role in malignant cell proliferation and differentiation as well as the initiation and persistence of cancer pain. Hypnosis can reduce pain by reducing anxiety through relaxation and/or directly affecting neurophysiological activity that underlies the subjective experience of pain. This study aimed to evaluate hypnotherapy as a non-pharmacological method for managing cancer pain. Methods: Clinical trial of 30 subjects with quasi-experimental pre-test and post-test in treatment and control groups of lung cancer patients of NSCLC and SCLC stage III and IV who experienced cancer pain with pain scale ≥3 at RSUD Dr. Moewardi Surakarta in June to August 2023 with a consecutive sampling method. The treatment group received hypnotherapy intervention for 4 weeks. Subjects were assessed for pain scale, interleukin-6 levels, and FACT-L quality of life questionnaire. Results: A 4-week hypnotherapy intervention can significantly reduce the pain scale (P=0.0001) and improve the quality-of-life FACT-L (P=0.002) in lung cancer patients experiencing cancer pain. Hypnotherapy also significantly reduced IL-6 in the treatment group (P=0.008), but when compared with the control, the results were not significant (P=0.345). Conclusion: Hypnotherapy may reduce the pain scale and improve the quality of life of lung cancer patients who experience cancer pain, but does not significantly lower IL-6 levels.

Konsumsi Kafein dan Derajat Kontrol Asma Pada Pasien Asma Dewasa Bahari, Muh Arif Wira; Aphridasari, Jatu; Widardo, Widardo
Kieraha Medical Journal Vol 5, No 2 (2023): KIERAHA MEDICAL JOURNAL
Publisher : Fakultas Kedokteran, Universitas Khairun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33387/kmj.v5i2.7095

Asma merupakan penyakit inflamasi jalan nafasÂ yang bersifat kronik yang merupakan salah satu penyebab kematian dan kesakitan tertinggi di Indonesia. Kafein sendiri memiliki zat kimiaÂ theophyllineÂ yang memiliki efek sebagai bronkodilator sehingga dapat digunakan sebagai salah satu terapi asma yang dapat meningkatkan derajat kontrol asma. Penelitian ini ditujukan untuk mengetahui apakah terdapat hubungan antaraÂ konsumsi kafein dengan derajat kontrol asma pada pasien asma di RSUD Dr. Moewardi.Â Penelitian ini menggunakan rancangan penelitian observasional analitik denganÂ pendekatanÂ cross sectional.Â Subyek yangÂ digunakanÂ adalahpenderitaÂ asmaÂ yang berobat jalan di klinik Paru RSUD Dr. Moewardi. Subyek penelitian mengisi kuesioner mengenai konsumsi kafein dan derajat kontrol asma. Pengambilan sampel dilakukan dengan teknik accidental sampling sebanyak 50 responden.Data yang didapat dianalisis menggunakan uji normalitas data shapiro wilk dan uji korelasi pearson.Â Hasil analisis pada 42 sampel penelitian, hasil uji normalitas dengan uji shapiro wilk bahwa skor Asthma Control Test (ACT) terdistribusi normal dengan p= 0,331 dan skor Food Frequency Questionnaire (FFQ) terdistribusi normal dengan p= 0,165. Dengan uji hipotesis non-parametrik, yakni uji korelasi pearson didapatkan hasil p= 0,004 yang mana menunjukkan hasil bahwa antara konsumsi kafein dengan derajat kontrol asma terdapat korelasi yang bermakna secara statistik antara keduanya, dengan nilai r= 0,464 yang mana hal tersebut menunjukkan bahwa antara konsumsi kafein dengan derajat kontrol asma terdapat korelasi yang bernilai positif dan nilai korelasi lemah. Hasil ini sudah mengontrol variabel perancu yaitu penyakit lain, alkohol, merokok, kehamilan, dan obat-obatan.Â KesimpulanÂ Terdapat hubungan yang bermakna antara konsumsi kafein dengan derajat kontrol asma pada pasien asma dewasa dengan hubungan korelasi positif dan kekuatan korelasi lemah.

The Role of Omega-3 on the IL-6 Levels, Malondialdehyde, and Clinical Improvement in Adults with Community-Acquired Pneumonia Astarini, Dewi; Aphridasari, Jatu; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 44 No 1 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i1.402

Background: Acute lung parenchymal infection, known as pneumonia, can be carried on by multiple microorganisms, including bacteria, viruses, fungi, and parasites. Globally, community-acquired pneumonia is a major factor of morbidity, mortality, and health issues. Malondialdehyde (MDA) is a marker of oxidative stress in pneumonia patients, and interleukin 6 (IL-6) is a marker of inflammatory process. Effect of Omega-3 as an immunomodulator, anti-inflammatory, and antioxidant may be implemented as adjunctive therapy in patient with community-acquired pneumonia.Methods: Clinical trial research with a true experimental method and pretest-posttest design. The study involved 30 community-acquired pneumonia patients who were admitted at Moewardi Hospital in Surakarta and Dr. Soehadi Prijonegoro Hospital in Sragen from August to September 2022 by consecutive sampling. The control group (n=15) received standard therapy, and the treatment group (n=15) received standard therapy plus Omega-3 at a dose of 1600 mg/day. IL-6 and MDA levels were measured when the subject was admitted to the hospital and there was clinical improvement.Results: There was a significant difference in reduced IL-6 levels (P=0.001), decreased MDA levels (P=0.001), and the duration of clinical improvement (P=0.042) between the treatment group and the control group. There was a moderate correlation between the decrease in IL-6 (R=0.480) and MDA (R=0.459), while the duration of clinical improvement had a strong correlation (R=0.756) in the treatment group.Conclusion: Supplementation of Omega-3 was effective in reducing IL-6, MDA levels, and the duration of clinical improvement in community-acquired pneumonia patients.

The Relation between D-Dimer, Hs-CRP, and ACE Inhibitor to Severity, Reinfection, and Mortality of COVID-19 Patients Thomas, Novita Silvana; Aphridasari, Jatu; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 44 No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.465

Background: COVID-19 reinfection has been found, although the data is not clear yet. Pandemic conditions bring about limited facilities and infrastructure, so biomarkers are an option. Research on biomarkers and the use of ACE inhibitor drugs in COVID-19 patients has not been widely conducted in Indonesia.Methods: This was a retrospective cohort study that used medical record data of confirmed COVID-19 patients treated at dr. Moewardi General Hospital for the period of January to March 2022. Surviving patients were observed for reinfections until November 2022.Results: This study involved 524 medical records of confirmed COVID-19 patients. After exclusion and inclusion criteria, 517 medical records were obtained. D-Dimer cut-off values of ≥2435 were significantly related to severity (OR=2.05; 95% CI=1.38-3.06; P≤0.001) and mortality (OR=2.89; 95% CI=1.95-4.27; P≤0.001) of COVID-19 patients. Hs-CRP levels ≥4.59 were significantly associated with mortality in COVID-19 patients (OR=1.82; 95% CI=1.23-2.69; P=0.003). The use of ACE inhibitors (OR=0.55; 95% CI=0.33-0.89; P=0.015) was a protective factor from mortality but increased the risk of reinfection (OR=3.11; 95% CI=1.16-8.36; P=0.034). Conclusion: D-Dimer and Hs-CRP biomarkers could be considered as predictor biomarkers for the severity and mortality of COVID-19 patients. Although the use of ACE inhibitors increased the risk of reinfection, it reduced the risk of mortality due to COVID-19.

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