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All Journal Buletin Penelitian Tanaman Rempah dan Obat Pharmascience Jurnal Ilmu Kefarmasian Indonesia Buletin Penelitian Tanaman Rempah dan Obat Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Penelitian Farmasi dan Herbal JUSTE (Journal of Science and Technology)
Desy Muliana Wenas
Institut Sains Dan Teknologi Nasional
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Energy Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Formula of Yellow Kepok Banana (Musa acuminata x Musa balbisiana) Corm Extracts As Antiinflamation Desy Muliana Wenas; Lisana Sidqi Aliya; Wisma Merry Anjani
Buletin Penelitian Tanaman Rempah dan Obat Vol 30, No 2 (2019): Buletin Penelitian Tanaman Rempah dan Obat
Publisher : Pusat Penelitian dan Pengembangan Perkebunan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21082/bullittro.v30n2.2019.100-110

Abstract

Bananas have many types and benefits. One of them is the Yellow Kepok Banana. Banana stem, leaf midrib, and corm contain phytochemicals compound as medicinal properties. The study aimed to determine the effect of the yellow kepok banana corm extract formula as an anti-inflammatory. Banana corm was cut into 0.3 x 1 x 3 cm pieces, dried in the oven with temperature 60 °C for 6 hours, then made 40 mesh powder. The powder extracted using 70 % ethanol by maceration technique for 24 hours, repeated three times. Anti-inflammatory testing was carried out on male Sprague Dawley white rats. A total of 24 white rats were divided into six treatment groups, consists of different concentrations of the extract (10, 15, and 20 %), positive control (commercial ointment), negative control, and a normal control (giving a wound without being given any formula). The experiment was designed as a randomized complete, with four replications, data were analyzed using ANOVA and the Post Hoc Games Howell Test. The results showed that the yellow kepok banana extract formula had the potential for wound healing. The 20 % extract formula can accelerate wound healing in a day than the 10 and 15 % formulas. The  speed  is  shown  by  wound  healing  without  scars  from  the   20 % extract formula, which  occurs  earlier  than other formulas. The anti-inflammatory activity of the 20 % formula was comparable to the positive control of commercial ointment. The anti-inflammatory activity of the yellow kepok banana ointment formula is related to the compound of saponins, flavonoids, and tannins. The results indicate that the yellow kepok banana corm extract has the potential to be developed as an anti-inflammatory drug.
AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN KOPI ARABIKA (Coffea arabica L.) PADA EDEMA TIKUS Desy Muliana Wenas; Lisana Sidqi Aliya; Nita Usikatul Janah
Buletin Penelitian Tanaman Rempah dan Obat Vol 31, No 2 (2020): Buletin Penelitian Tanaman Rempah dan Obat
Publisher : Pusat Penelitian dan Pengembangan Perkebunan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21082/bullittro.v31n2.2020.75-84

Abstract

The coffee leaf contains flavonoid compounds that are known as an antiinflammation agent. The study aimed to determine antiinflammatory activity of arabica coffee's leaf extract (Coffea arabica L.) against edema on white rat soles of carrageenan-induced rats. The research began with the maceration extraction of coffee leaf in 70% ethanol. The inflammation test was held by measuring the formation of edema using a plethysmometer. The dosages of arabica coffee leaf extract used were 60 mg.kg-1, 120 mg.kg-1, and 180 mg.kg-1 rat weight of white Sprague Dawley rat (Rattus norvegicus). The data were analyzed by Kruskal Wallis and Mann Whitney non-parametric tests. Phytochemical screening showed that arabica coffee leaf extract contained flavonoid, saponin, alkaloid, tannin and triterpenoids compound. The arabica coffee leaf extract showed the best antiinflammatory activity at the dose of 180 mg.kg-1 rat weight with 71.66% inhibition percentage at the 5th hour, which was better than the positive control (66.91% edema inhibition at the same hour). This result determined that the leaf extract of arabica coffee had antiinflammatory activity. However, it is necessary to study the acute and chronic toxicity and formulates the arabica coffee leaf extract as a pharmacy product.
Formula of Yellow Kepok Banana (Musa acuminata x Musa balbisiana) Corm Extracts As Antiinflamation Desy Muliana Wenas; Lisana Sidqi Aliya; Wisma Merry Anjani
Buletin Penelitian Tanaman Rempah dan Obat Vol 30, No 2 (2019): Buletin Penelitian Tanaman Rempah dan Obat
Publisher : Pusat Penelitian dan Pengembangan Perkebunan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21082/bullittro.v30n2.2019.100-110

Abstract

Bananas have many types and benefits. One of them is the Yellow Kepok Banana. Banana stem, leaf midrib, and corm contain phytochemicals compound as medicinal properties. The study aimed to determine the effect of the yellow kepok banana corm extract formula as an anti-inflammatory. Banana corm was cut into 0.3 x 1 x 3 cm pieces, dried in the oven with temperature 60 °C for 6 hours, then made 40 mesh powder. The powder extracted using 70 % ethanol by maceration technique for 24 hours, repeated three times. Anti-inflammatory testing was carried out on male Sprague Dawley white rats. A total of 24 white rats were divided into six treatment groups, consists of different concentrations of the extract (10, 15, and 20 %), positive control (commercial ointment), negative control, and a normal control (giving a wound without being given any formula). The experiment was designed as a randomized complete, with four replications, data were analyzed using ANOVA and the Post Hoc Games Howell Test. The results showed that the yellow kepok banana extract formula had the potential for wound healing. The 20 % extract formula can accelerate wound healing in a day than the 10 and 15 % formulas. The  speed  is  shown  by  wound  healing  without  scars  from  the   20 % extract formula, which  occurs  earlier  than other formulas. The anti-inflammatory activity of the 20 % formula was comparable to the positive control of commercial ointment. The anti-inflammatory activity of the yellow kepok banana ointment formula is related to the compound of saponins, flavonoids, and tannins. The results indicate that the yellow kepok banana corm extract has the potential to be developed as an anti-inflammatory drug.
AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN KOPI ARABIKA (Coffea arabica L.) PADA EDEMA TIKUS Desy Muliana Wenas; Lisana Sidqi Aliya; Nita Usikatul Janah
Buletin Penelitian Tanaman Rempah dan Obat Vol 31, No 2 (2020): Buletin Penelitian Tanaman Rempah dan Obat
Publisher : Pusat Penelitian dan Pengembangan Perkebunan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21082/bullittro.v31n2.2020.75-84

Abstract

The coffee leaf contains flavonoid compounds that are known as an antiinflammation agent. The study aimed to determine antiinflammatory activity of arabica coffee's leaf extract (Coffea arabica L.) against edema on white rat soles of carrageenan-induced rats. The research began with the maceration extraction of coffee leaf in 70% ethanol. The inflammation test was held by measuring the formation of edema using a plethysmometer. The dosages of arabica coffee leaf extract used were 60 mg.kg-1, 120 mg.kg-1, and 180 mg.kg-1 rat weight of white Sprague Dawley rat (Rattus norvegicus). The data were analyzed by Kruskal Wallis and Mann Whitney non-parametric tests. Phytochemical screening showed that arabica coffee leaf extract contained flavonoid, saponin, alkaloid, tannin and triterpenoids compound. The arabica coffee leaf extract showed the best antiinflammatory activity at the dose of 180 mg.kg-1 rat weight with 71.66% inhibition percentage at the 5th hour, which was better than the positive control (66.91% edema inhibition at the same hour). This result determined that the leaf extract of arabica coffee had antiinflammatory activity. However, it is necessary to study the acute and chronic toxicity and formulates the arabica coffee leaf extract as a pharmacy product.
Formulasi Gel Peel Off Pewarna Kuku yang Mengandung Ekstrak Daun Pacar Air (Impatiens balsamina L.) dan Sodium Carboxy Methyl Cellulose Teti Indrawati; Titih Ayunda Larasati; Anggun Nia Mulyani; Desy Muliana Wenas
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.816

Abstract

Leaves of Pacar air or Impatiens balsamina L. (IB) are directly pounded and then placed on the surface of the nail to color the nails traditionally. It’s preferred by Moslem because wudu water can penetrate to the nail. The traditional way of using the leaves is unpleasant and these leaves should be used in the fresh form. The IB leaves contain fl avonoids, quinones and tannins that provide a natural orange color. A formulation of a nail polish containing the leaf’s extract is needed so it’s easy to use and stable during storage. The aim of this research is to make nail color gel peel off from IB extract which is easy to use and stable. Nail color gel peel off is made using Sodium Carboxy Methyl Cellulose (Na-CMC) as a gel base. This research was carried out by making six formula of gel peel off using swelling and mixing methods at various IB extract concentrations of 5%, 10% and 15% using 1% and 3 % of Na-CMC as the base respectively and the prepared product was evaluated. The IB leaves can be made into cosmetic preparations that have a good quality. All preparations have a yellow to orange red, odorous and homogeneous, pH 4.7-5.4, viscosities 630-3600 cps, has a pseudo plastic thixotropic fl ow properties. When nail color gel peel off used in nails, the base can remove from nail and only the coloring agent attached to the nail.
Uji Aktivitas Antimikroba Ekstrak Metanol Daun Sirih (Piper betle L.) Terhadap Pertumbuhan Bakteri Propionibacterium acnes dan Khamir Malassezia furfur Rachmayanti Dewi; Amelia Febriani; Desy Muliana Wenas
SAINSTECH FARMA Vol 12 No 1 (2019): Sainstech Farma Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (492.899 KB) | DOI: 10.37277/sfj.v12i1.415

Abstract

Indonesia memiliki beraneka ragam jenis tumbuhan yang dapat dimanfaatkan sebagai obat tradisional, diantaranya adalah daun sirih (Piper betle L.) yang mengandung senyawa tanin, flavonoid, alkaloid, saponin, dan terpenoid. Tujuan penelitian ini adalah untuk mengetahui aktivitas antimikroba dari ekstrak metanol daun sirih (Piper betle L.) terhadap pertumbuhan Propionibacterium acnes dan Malassezia furfur. Uji aktivitas antibakteri dilaukan dengan mengukur Diameter Daya Hambat (DDH) melalui metode difusi cakram dan Konsentrasi Hambat Minimum (KHM) melalui metode dilusi agar padat. Uji DDH dilakukan pada konsentrasi 6,25%; 12,5%; 25% dan 50%, kontrol negatif yaitu DMSO 10% serta kontrol positif yaitu cakram klindamisin 2 μg/disk (P. acnes) dan cakram ketokonazol 20 μg/disk (M. furfur). Pengujian KHM dilakukan terhadap konsentrasi 6,25%; 5,25%; 4,25%; 3,25%; 2,25% dan 1,25% untuk P. acnes, sedangkan untuk M. furfur pada konsentrasi 12,5%; 10%; 7,5% dan 6,25%. Hasil menunjukkan nilai DDH untuk P. acnes sebesar 9,05 mm ± 0,62; 11,50 mm ± 0,36 ; 12,18 mm ± 0,16 ; 13,53 mm ± 0,36 dan kontrol positif sebesar 17,55 mm ± 0,13; sedangkan pada M. furfur nilai DDH sebesar 0,00 mm ± 0,00 ; 9,47 mm ± 0,28; 15,19 mm ± 2,60; 28,70 mm ± 0,72 dan kontrol positif sebesar 44,60 mm ± 0,22. Hasil KHM untuk P. acnes yaitu pada konsentrasi 3,25%, sedangkan pada M. furfur yaitu pada konsentrasi 10%. Uji statistik menunjukkan ekstrak metanol daun sirih memiliki perbedaan akivitas antimikroba terhadap pertumbuhan P. acnes dan M. furfur (p<0,05).
Pengaruh Ekstrak Bonggol Pisang Kepok terhadap Kadar Gula Darah Tikus yang Diinduksi Aloksan Desy Muliana Wenas; Ika Septiana; Lisana Sidqi Aliya
SAINSTECH FARMA Vol 13 No 1 (2020): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.132 KB) | DOI: 10.37277/sfj.v13i1.516

Abstract

Bonggol pisang telah dikenal berpotensi sebagai bahan obat tradisional. Tujuan penelitian yaitu untuk mengetahui kemampuan ekstrak bonggol pisang dalam mengurangi Kadar Gula Darah (KGD). Bonggol pisang kepok diekstrak menggunakan metode maserasi dengan pelarut etanol 70%, serta disiapkan dengan dosis konsentrasi 50, 100, 200 mg/200 g berat badan tikus yang diberikan secara oral pada tikus yang diinduksi dengan aloksan monohidrat (diabetes). Hasil penelitian menunjukkan ekstrak bonggol pisang kepok dapat mengurangi kadar gula dalam darah pada tikus yang telah diinduksi aloksan. Konsentrasi terbaik dalam penurunan KGD ialah 200 mg/200 g berat badan tikus, namun ekstrak bonggol pisang kepok masih kalah dibandingkan kontrol positif glibenklamid. Hasil penelitian tersebut dimaksudkan untuk membantu pengembangan produk obat antidiabetes yang berguna bagi bidang kesehatan di kalangan masyarakat.
Uji Antibakteri Ekstrak Bonggol dari Beberapa Varietas Pisang terhadap Staphylococcus aureus dan Pseudomonas aeruginosa Desy Muliana Wenas; Herdini Herdini; Wahidin Wahidin; Rifa Pujiati Irawan; Dini Nur Kamaliah
SAINSTECH FARMA Vol 13 No 2 (2020): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v13i2.757

Abstract

Tanaman pisang diketahui memiliki kandungan metabolit sekunder. Bonggol pisang merupakan salah satu limbah dapat dimanfaatkan sebagai antibakteri diperlukan untuk melawan bakteri patogen. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak bonggol dari 4 varietas pisang yaitu pisang ambon, pisang kepok putih, pisang mas muli dan pisang raja terhadap Staphylococcus aureus dan Pseudomonas aeruginosa. Bonggol pisang diekstraksi dengan metode maserasi dalam etanol 96%. Ekstrak etanol bonggol pisang dari 4 varietas dilakukan pengujian penapisan fitokimia. Hasil penapisan fitokimia menunjukkan bahwa serbuk dan ekstrak bonggol pisang ambon, pisang kepok putih, pisang mas muli, pisang raja mengandung senyawa flavonoid, saponin dan tanin. Metode yang digunakan dalam uji aktivitas antimikroba yaitu metode difusi cakram untuk mengukur Diameter Daya Hambat (DDH) dan metode dilusi padat untuk pengujian Konsentrasi Hambat Minimum (KHM). Ekstrak etanol 96% bonggol pisang mas muli dengan dosis 50% menunjukkan kemampuan penghambatan terbaik terhadap Staphylococcus aureus (16,63 mm) dan Pseudomonas aeruginosa (12,65 mm) dibandingkan dengan ekstrak bonggol pisang kepok putih, pisang ambon dan pisang raja. Pengujian konsentrasi hambat minimum (KHM) terbaik ditunjukkan oleh ekstrak etanol 96% bonggol pisang kepok putih dan pisang mas muli masing-masing pada konsentrasi 5,25% terhadap Staphylococcus aureus.
Kajian Ulasan Aktivitas Farmakologi dari Limbah Pisang Ambon dan Pisang Kepok Desy Muliana Wenas
SAINSTECH FARMA Vol 10 No 1 (2017): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v10i1.801

Abstract

Pisang merupakan salah satu tanaman terpenting dan sangat berguna di dunia. Buah pisang banyak disukai karena mudah dikupas dan seringkali dimanfaatkan untuk energi tambahan bagi kaum penyuka olahraga. Tanaman monokotil perenial tersebut menghasilkan buah hanya satu kali seumur hidupnya dan kemudian mati. Sebagai salah satu produsen pisang terbanyak di dunia, perkebunan pisang di Indonesia menghasilkan limbah organik (kulit buah, pelepah maupun bonggol) yang dapat mengakibatkan masalah pencemaran lingkungan. Beberapa bagian dari tanaman pisang telah dikenal sebagai obat tradisional di masyarakat. Hal tersebut menjadi dasar yang kuat bagi penelitian pengembangan produk fitofarmaka atau industri farmasi lainnya. Informasi mengenai khasiat farmakologi (antibakteri, penyembuhan luka, antidiabetes) maupun kandungan senyawa fitokimia ini diharapkan dapat mendukung penelitian lebih lanjut mengenai pemanfaatan bagian-bagian tanaman pisang yang tidak terpakai tersebut lainnya
Antioxidant Test of Red and Green Colored-Leaves Infusions of Pucuk Merah (Syzygium myrtifolium Walp.) with DPPH method Desy Muliana Wenas; Putrisa Anggun Meilani; Herdini Herdini
Jurnal Penelitian Farmasi & Herbal Vol 5 No 1 (2022): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v5i1.969

Abstract

Red and green leaves of the pucuk merah (Syzygium myrtifolium Walp.) contain flavonoids, saponins, and tannins which have the potential as antioxidants. The purpose is test out the antioxidant activity of red leaves and green leaves infusions of red shoots (S. myrtifolium). Test material is extracted using infusion method. The testing of antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The free radical concentration of DPPH was analyzed using UV-Vis spectrophotometer after addition of various concentrations of S. myrtifolium leaves infusion extracts. Various concentrations of S. myrtafolium leaves infusion extracts used were 20 ppm; 10 ppm; 5 ppm; 2.5 ppm; 1.25 ppm; 0.625 ppm. Vitamin C solutions as the positive control were prepared on 5; 2.5; 1.25; 0,625; 0.3125 ppm. The result of the experiment showed the thick red and green leaf extract has IC50 value of 11,130 ppm and 10,522 ppm. The antioxidant activity of green leaf extract is higher than the red leaf extract. Research on green leaves extract of S. myrtafolium is suggested for further research as anticancer.
Co-Authors Anggun Nia Mulyani Dini Nur Kamaliah Fadilah Ramadania Fajrin, Muhammad Nur Febriani, Amelia Feby Ramdhony H Herdini Herdini Herdini Herdini Herdini Ika Septiana Irawan, Rifa Pujiati Jessica Suardi Kamaliah, Dini Nur Lisana Sidqi Aliya Lisana Sidqi Aliya Lisana Sidqi Aliya Nita Usikatul Janah Putrisa Anggun Meilani Rachmayanti Dewi Rifa Pujiati Irawan Subaryanti Subaryanti Subaryanti, Subaryanti Teti Indrawati Titih Ayunda Larasati Wahidin Wahidin Wahidin Wahidin Wahidin Wahidin Wisma Merry Anjani