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All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Biogenesis: Jurnal Ilmiah Biologi Global Medical and Health Communication Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Berkala Kedokteran Universa Medicina Medical Laboratory Technology Journal Journal Of Vocational Health Studies JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Smart Medical Journal Jurnal Pengabdian Pada Masyarakat Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Jurnal Kesehatan Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Mandala of Health : A Scientific Journal Jurnal Pengabdian Pada Masyarakat Medical and Health Journal Jurnal Tumbuhan Obat Indonesia Linggamas: Jurnal Pengabdian Masyarakat
Fitranto Arjadi
Universitas Jenderal Soedirman Purwokerto
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Endothelial Nitric Oxide Synthase 3 (eNOS3) Gene Polymorphisms and Essential Hypertension in Javanese Ethnic Group Arjadi, Fitranto; Aziz, Saefuddin; Muntafiah, Alfi
Jurnal Kedokteran Brawijaya Vol 28, No 3 (2015)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (466.205 KB) | DOI: 10.21776/ub.jkb.2015.028.03.4

Abstract

Hypertension is still a major public health problem in Indonesia and in several other countries. This disease is caused by multi factorial components involving both environmental and genetic factors. eNOS3 gene is one of the enzymes related to the high prevalence of hypertension. This gene expresses the NOS enzyme which regulates the synthesis of NO. NOS enzyme causes vasodilatation which decreases peripheral resistance and lowers blood pressure. This cross sectional study compared hypertension patients to those with normal blood pressure in the age group of 40-80 years old. The main purpose of this study is to evaluate the influence of eNOS3 gene Glu298Asp allele expression in Javanese ethnic group patients with hypertension. The samples consist of 50 respondents with hypertension and 50 respondents with normotension as control. Data of eNOS3 gene polymorphisms and NO plasma levels from the respondents were analyzed using t-test and chi-square test. Glu298Asp allele genotype variation in eNOS3 gene was detected by PCR-FRLP using primers G894TF and G894TR and the PCR products were cut using Mbol restriction enzymes. Sequencing result of each polymorphism band shows a typical nucleotide sequence compared to the nucleotide sequence of eNOS3 gene in Gen Bank. The results of this study showed no connection between Glu298Asp allele polymorphism in eNOS3 gene with hypertension in Javanese. There was also no relation between eNOS3 gene polymorphisms with high levels of respondents' NO plasma. Average NO plasma level of hypertension patients is 34,53 µmol/L, whereas average NO level of normal blood pressure is 32,5 µmol/L.Keywords: Allele Glu298Asp, eNOS3 gene, G894T, hypertension, Javanese ethnic, NO plasma level 
Jumlah Sel Piramidal CA3 Hipokampus Tikus Putih Jantan pada Berbagai Model Stres Kerja Kronik Arjadi, Fitrianto; Soejono, Sri Kadarsih; Maurits, Lientje Setyawati; Pangestu, Mulyoto
Majalah Kedokteran Bandung Vol 46, No 4 (2014)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (556.626 KB)

Abstract

Paparan stres kronik dan berkepanjangan mengakibatkan hilangnya neuron di regio  CA3 (cornu ammonis) hipokampus dan  penurunan kognitif. Tujuan penelitian  mengetahui perbedaan jumlah sel piramidal CA3 hipokampus tikus putih jantan pada model stres kerja meliputi   paradoxical sleep deprivation (PSD), imobilisasi, dan footshock kronik. Metode penelitian adalah  post-test only with control group design experimental dengan rancangan acak lengkap  menggunakan 24 ekor tikus putih jantan galur Wistar usia 3–4 bulan yang dibagi 4 kelompok:  KI kontrol tanpa perlakuan,  KII (stres PSD), KIII (stres imobilisasi), dan KIV (stres footshock) dan sel piramidal CA3 hipokampus  diwarnai dengan toluidine-blue. Jumlah sel dihitung menggunakan  perangkat lunak Image raster v2.1, perbesaran 400x tiap 10 lapangan pandang. Penelitian dilakukan  6 bulan (April–September 2012) di Laboratorium Hewan Coba, Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jenderal Soedirman. Analisis data menggunakan analysis of variance (ANOVA) dengan Post-Hoc least significant difference (LSD) menunjukkan  perbedaan jumlah sel piramidal CA3 hipokampus signifikan (p=0,037) pada minimal dua kelompok perlakuan. Uji statistik dengan Post-Hoc LSD menunjukkan perbedaan signifikan jumlah sel piramidal CA3 hipokampus antara  kelompok kontrol (12,9±2,47) dan kelompok imobilisasi (9,00±1,53) (p<0,05). Simpulan, kelompok imobilisasi kronik memiliki jumlah sel piramidal CA3 hipokampus terendah dibandingkan dengan ketiga kelompok lainnya.Kata kunci:  Model stres kerja kronik, sel piramidal CA3 hipokampus, tikus putih jantanNumber of CA3 Pyramidal Cell in Male Albino Rat   Hippocampus Exposed to Various Chronic Work Stress Models AbstractProlonged and chronic exposure to stress leads to the loss of neurons at the CA3 (cornu ammonis) hippocampus region and spatial memory deficits. The aim of this study was to study the number of CA3 pyramidal cells in albino rats that were exposed to chronic stress of works model consisting of paradoxical sleep deprivation (PSD), immobilization, and foot shock stresses. The method applied was the post-test only method with control group experimental design using completed randomized design (CRD on 24 3–4 month old male Wistar rats . The rats were divided into 4 groups: group I (control), group II (PSD stress), group III (immobilization stress), and group IV (footshock stress). The CA3 pyramidal cell hippocampus was stained with toluidine-blue. The number of CA3 pyramidal cell of hippocampus was counted using Image raster v2.1 software at 400x magnification in 10 duplicates for each sample. The study was conducted in six months (April–September 2012) at the Animal Laboratory, Faculty of Medical and Health Sciences, Jenderal Soedirman University. Analysis for the differences in the number of CA3 pyramidal cells was conducted using analysis of variance (ANOVA) with Post-Hoc LSD. The results of the ANOVA  showed a p value=0.037, meaning that there was significant difference in at least two groupsof treatment. Further statistical test using Post-Hoc LSD showed a significant difference  between the control group (12.9 ± 2.47) and the chronic immobillization group (9,00 ± 1,53) (p<0.05). In conclusion, the chronic immobillization stress group has the lowest average number of hippocampus CA3 pyramidal cells compared to other groups Key words: CA3 pyramidal cell in hippocampus, chronic works stress model, male albino rats DOI: 10.15395/mkb.v46n4.337
Ektrak Daging Buah Mahkota Dewa Meregenerasi Sel Pulau Langerhans Pada Tikus Putih Diabetes Fitranto Arjadi; Mustofa Mustofa
Biogenesis: Jurnal Ilmiah Biologi Vol 5 No 1 (2017)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v5i1.3430

Abstract

In Indonesia, the increasing prevalence of diabetes mellitus is accompanied by the increasing financial burden to the patients. It is necessary to find alternative herbal treatment for diabetes, which is effective, cheap, and easy to find: the mahkota dewa. This research aims to find out the histological regeneration of Langerhans islet cells after given by flesh extract of mahkota dewa.This experimental research used complete randomized design (CRD). There were 5 treatments given to the twenty five mice; the negative control group (the normal one), the positive control (male white mice (Rattus norvegicus which were made diabetic by administering injection of 70 mg/kg of body mass of diabetogenic alloxan), the group of diabetic male white mice given 3, 6 and 9 grams/day/200 bodyweights), then were measured glucose in blood at 0, 1st and 4th week and counted Langerhans islet cells every 5 overviews.Statistically results showed that flesh extracts of mahkota dewa can decreased glucose in diabetic mice (r=0,75) with contribute 56,89% in decreasing, regenerated Langerhans islet cells of pankreas {Fcount(17,558)>Ftab(2,870)} with the highest increasing is 3,84 amount and started with 3grams/day/200 bodyweights doses, and the best effectiveness in regenerating was 11,81% consentration or 0,1181grams/day (6.56 grams/day in human).
Hepatoprotective Effect of Sun Chlorella as an Antioxidant in Rattus norvegicus Induced Carbon Tetrachloride Wahyu Siswandari; Fitranto Arjadi; Hernayanti Hernayanti; Vitasari Indriani
Global Medical & Health Communication (GMHC) Vol 9, No 1 (2021)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (587.408 KB) | DOI: 10.29313/gmhc.v9i1.6341

Abstract

Carbon tetrachloride (CCl₄) is a chemical that can cause damage to liver cells. One of the natural ingredients developed to reduce liver damage due to chemicals and infections is Chlorella sp. The research aimed to explore the hepatoprotective effect of the antioxidant superoxide dismutase (SOD) by administering Sun Chlorella in Rattus norvegicus CCl₄ induced rats. The study design used a post-test with a control group design with a completely randomized design trial on 30 male rats of Wistar strains, aged 2–3 months, 200–250 grams in weight. The research was conducted in November 2016–January 2017 in Purwokerto. Rats were divided into five groups and treated for four weeks as follows: K1 group was given aquades; K2 was given CCl₄; K3, K4, K5 were given CCl₄ and Sun Chlorella 3.6 mg/200 gBW, 7.2 mg/200 gBW, and 14.4 mg/200 gBW respectively, by the gastric probe. Statistical analysis with correlation test and one way ANOVA multivariate test showed that Sun Chlorella 7.2 and 14.4 mg/200 gBW significantly increased SOD levels in rats induced CCl₄ (p=0.004, p=0.009). SOD rates were significantly strong associated with aspartate aminotransferase/AST (r=−0.685, p=0.000) and alanine aminotransferase/ALT (r=−0.659, p=0.000). The conclusion is Sun Chlorella increases SOD levels in CCl₄-induced rats. Increased SOD levels may decrease AST and ALT levels. EFEK HEPATOPROTEKTIF SUN CHLORELLA SEBAGAI ANTIOKSIDAN PADA RATTUS NORVEGICUS YANG DIINDUKSI KARBON TETRAKLORIDAKarbon tetraklorida (CCl₄) merupakan bahan kimia yang dapat menyebabkan kerusakan sel hati. Berbagai bahan alami telah dikembangkan untuk mengurangi kerusakan hati baik akibat bahan kimia maupun infeksi, salah satunya adalah Chlorella sp. Penelitian ini bertujuan melihat efek hepatoprotektif  dengan pemberian Sun Chlorella pada tikus Rattus norvegicus yang diinduksi CCl₄. Desain penelitian menggunakan post-test with a control group dengan rancangan percobaan rancangan acak lengkap pada 30 tikus jantan galur Wistar, usia 2–3 bulan, dan berat 200–250 gram. Penelitian ini dilakukan di Purwokerto pada periode November 2016–Januari 2017. Tikus dibagi menjadi lima kelompok dan mendapatkan perlakuan per oral dengan sonde lambung selama 4 minggu sebagai berikut: kelompok K1 sebagi kontrol negatif diberikan aquades; kelompok control positif K2 diberikan CCl₄; kelompok perlakuan K3, K4, dan K5 diberikan CCl4 dan Sun Chlorella 3,6 mg/200 gBB; 7,2 mg/200 gBB; 14,4 mg/200 gBB tikus berurutan. Uji statistik dengan menggunakan uji korelasi dan ANOVA satu arah menunjukkan bahwa pemberian Sun Chlorella 7,2 mg dan 14,4 mg meningkatkan kadar SOD pada tikus yang diinduksi CCl₄ secara bermakna (p=0,004; p=0,009). Kadar SOD berhubungan kuat dengan kadar aspartat aminotransferase/AST (r=−0,685; p=0,000) dan alanin aminotransferase/ALT (r=−0,659; p=0,000). Kesimpulan penelitian ini adalah pemberian Sun Chlorella meningkatkan kadar SOD pada tikus yang diinduksi CCl₄. Peningkatan kadar SOD menyebabkan penurunan kadar AST dan ALT.
Paradoxical sleep deprivation changes testicular malondialdehyde and caspase-3 expression in male rats Fitranto Arjadi; Ginus Partadireja; Lientje Setyawan Maurits; Mulyono Pangestu
Universa Medicina Vol. 34 No. 2 (2015)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2015.v34.87-95

Abstract

BACKGROUNDSleep deprivation is a significant problem among adult men and is considered as a risk factor for several diseases. Paradoxical sleep deprivation (PSD) induces Leydig cell apoptosis through elevation of corticosterone, with testicular malondialdehyde (MDA) and Leydig cell caspase-3 expression as parameters. The aim of this study was to observe testicular MDA level and caspase-3 expression treated with paradoxical sleep deprivation (PSD), immobilization, and footshock stress and to determine the stress model with a significant effect in white male rats (Rattus norvegicus) . METHODSThis experimental randomized study of posttest only with control group design was conducted on 24 white male Wistar strain rats, randomly allocated into four treatment groups, i.e. control (K1) without any stress treatment, PSD (KII), immobilization (KIII), and footshock stress (KIV). Treatments were given for 25 days to produce chronic stress. Testicular MDA concentration was examined by the ELISA method while caspase-3 was examined by the TUNEL method.RESULTSMean testicular MDA concentration with one-way ANOVA test showed differences in means between the groups (p=0.000) and post hoc Tukey-HSD test showed significant results between PSD stress group versus control, immobilization and footshock stress groups. One-way ANOVA test showed a significant difference in caspase-3 expression in at least two treatment groups (p=0.008) and post-hoc Tuckey-LSD test showed significant differences between controls and all stress groups. CONCLUSIONSleep deprivation is a type of stress inducing changes in testicular MDA concentration and caspase-3 expression in male rat testes.
Paradoxical sleep deprivation decreases serum testosterone and Leydig cells in male rats Fitranto Arjadi; Sri Kadarsih Soejono; Mulyono Pangestu
Universa Medicina Vol. 33 No. 1 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.27-35

Abstract

BACKGROUND Chronic stress increases glucocorticoid levels and accelerates reduction in Leydig cells functions and numbers. Chronic stress models in the working place comprise sleep deprivation, sedentary stress, and physical stress. The aim of this study was to evaluate the effect of various work stress models, such as stress from paradoxical sleep deprivation (PSD), immobilization, and footshock, on serum testosterone levels and number of Leydig cells in male albino rats. METHODS This study was of experimental randomized post-test only with control group design using 24 male Wistar albino rats (Rattus norvegicus). The sample was divided into 4 groups: K1 (control), K2 (PSD), K3 (immobilization) and K4 (footshock), receiving treatment for 25 days. Measured parameters were serum testosterone level and Leydig cell number. Analysis of variance (ANOVA) was used for statistical analysis, followed by post hoc LSD. RESULTS Mean serum testosterone levels (0.07 ± 0.08 ng/ml) and Leydig cell numbers (4.22 ± l0.96) were lowest in the PSD stress model. Serum testosterone levels differed significantly between controls and PSD group (p=0.014), while there was a significant difference in numbers of Leydig cells between footshock stress and PSD (p=0.011) and between the three stress groups and controls (p=0.006). CONCLUSION This study demonstrated that PSD, immobilization and footshock stress significantly decreased serum testosterone levels and number of Leydig cells in male albino rats (Rattus norvegicus). The mechanism by which PSD affects serum testosterone is still unclear.
Metalloproteinase-9 gene variants and risk for hypertension among ethnic Javanese Fitranto Arjadi; Saefuddin Aziz; Alfi Muntafiah
Universa Medicina Vol. 33 No. 3 (2014)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2014.v33.213-220

Abstract

BackgroundHypertension is associated with endothelial-dependent vasodilation disorders, due to reduced nitric oxide (NO) availability and excessive angiotensin II (ANG-II) activation. The objective of this study was to determine the association between matrix metallopeptidase 9 (MMP-9) gene polymorphism and hypertension in ethnic Javanese in the 40-80 year age group. MethodsThis was a case-control study on 50 PROLANIS patients of family doctors meeting the inclusion criteria and 50 controls without hypertension. Subjects were hypertensive patients with constant systolic arterial pressure of >140 mmHg and diastolic arterial pressure of >90 mmHg, confirmed in three successive measurements The observed parameters were degree of MMP-9 polymorphism, and NO and ANG-II levels. Matrix metallopeptidase 9 polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using the SmaI restriction enzyme. MMP-9 polymorphisms were indicated by variation in band patterns. Degree of polymorphism in cases and controls were compared with NO and ANG-II levels in both groups. Data analysis was done using independent t-test.ResultsThe heterozygous (3 band) to normal (2 band) MMP-9 genotype ratio was 3:1 in hypertensives, but balanced in controls. In hypertensives, heterozygous GA and homozygous AA genotype frequencies were respectively 3.198 and 1.548 times higher than that of the GG genotype (p=0.008 and p=0.726). There was a statistically significant differences of NO and Ang-II levels between cases and controls (p=0.000 and p=0.000; respectively). ConclusionMatrix metallopeptidase 9 gene polymorphisms in hypertensive ethnic Javanese are associated with NO and angiotensin II levels.
Pelatihan PMR Sadar Thalassemia pada Kegiatan Jumbara XXV Kabupaten Banyumas Lantip Rujito; Diyah Woro Dwi Lestari; Fitranto Arjadi; Dinar Faiza
Jurnal Pengabdian Pada Masyarakat Vol 3 No 2 (2018)
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (535.728 KB) | DOI: 10.30653/002.201832.60

Abstract

TRAINING OF THALASSEMIA-AWARE PMR IN XXV JUMBARA EVENT OF BANYUMAS REGENCY. Thalassemia is a health condition that still needs treatment and serious attention for the Indonesian government. As part of the thalassemia belt, Indonesia must act immediately to prevent the addition of thalassemia patients in the future. One of the mass educations that can be done is by self-awareness movement among school students. Palang Merah Remaja (PMR) became a potential youth organization as the educator agent. Intense training and debriefing on them can be a superior program for prevention among school students. Students, in this case, the Red Cross Youth who are at the junior and senior high school level are potential cadres to spread the right information about thalassemia to their peers.
Purwoceng (Pimpinella pruatjan Molk.) nanosuspension repairs spatial white albino wistar strains’ spatial memory degeneration after sleep deprivation Rangga Wisnu Wardana; Tuti Sri Suhesti; Fitranto Arjadi
Biogenesis: Jurnal Ilmiah Biologi Vol 10 No 1 (2022)
Publisher : Department of Biology, Faculty of Sci and Tech, Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/bio.v10i1.26488

Abstract

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PERBEDAAN MORFOLOGI DAN FRAGMENTASI DNA PADA SPERMATOZOA TIKUS PUTIH (Rattus norvegicus) GALUR WISTAR PASCA INDUKSI BERBAGAI MODEL STRES SLEEP DEPRIVATION Norina Agatri; Fitranto Arjadi; Lantip Rujito
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 11, No 3, (2020)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol11.Iss3.art4

Abstract

Background: A stress, sleep deprivation, can cause imbalance of reactive oxygen species (ROS) that can damage DNA, lipids and proteins of spermatozoa, consequently leading to infertility.Objective: The aim of this study is to investigate differences of morphology and DNA fragmentation with some models of sleep deprivation in spermatozoa of white male Wistar rat strain (Rattus novergicus).Methods: This study was an experimental study with post-test-only with control group design. There were 30 male Wistar rats which were randomly divided into 5 groups: control group, paradoxical sleep deprivation (PSD) group, total sleep deprivation (TSD) group, sleep recovery (SR) group, PSD group + SR group, and TSD group + SR group. Stress induction was conducted for 5 days. Morphological abnormality of spermatozoa was observed by creating sperm removal tinged by eosin and nigrosine. DNA fragmentation was performed by determining DNA fragmentation index (DFI). Morphological data of spermatozoa were analysed by One-Way Annova and Post-Hoc Turkey test, and DNA fragmentation of spermatozoa was analysed by Kruskal Wallis and Mann Whitney test to determine differences among the groups.Results: The highest mean of the abnormal morphology was in PSD Group (89.5 %, p=0.004). The normal mean of DNA fragmentation was found in control group, PSD+SR group and TSD+SR group, PSD and TSD groups. Bad DNA fragmentation index was found in PSD and TSD groups (30.16% and 31.4%, p=0.023).Conclusion: There were differences of morphology and DNA fragmentation of the spermatozoa in the male Wistar rat strain induced by various models of sleep deprivation.
Co-Authors . HERNAYANTI Agatri, Norina Ahmad, Faiq Alaika Ailsa, Shafa Alfi Muntafiah Amilia Ramadhani Aminuyati Andromeda Andromeda Christiana Cahyani Prihastuti Denok Tri Hardiningsih Diah Krisnansari Dinar Faiza Dita Ayu Dewi Laras Sati Diyah Woro Dwi Lestari Dody Novrial Dzicky Rifqi Fuadi Edy Priyanto Edy Priyanto Fani Tuti Handayani, Fani Tuti Fidnillah, Diva Azka Fitri Diah Oktadewi Ginus Partadireja Hajid Rahmadianto Harini, Ika Murti Haris Budi Widodo Hernayanti Hernayanti Hidi, Aulli Rahman Ika Murti Harini Joko Mulyanto, Joko Joko Setyono Kasum Kasum Khusnul Muflikhah Kuncoro, Prasetyo Tri Lantip Rujito Lientje Setyawan Maurits Lientje Setyawati Maurits Mae Sri Hartati Wahyuningsih Mahardhika, Gembong Satria Mahindra Awwaludin Romdlon Mas'ud, Ahmad Fawzy Maulida, Adzkia Mubayinul Khoeroh Muhamad Rifqi Setyanto Mulyono Pangestu Mulyono Pangestu Mulyoto Pangestu MULYOTO PANGESTU Mustofa Mustofa Mustofa Mustofa Mustofa Mustofa Nenden Nursyamsi Agustina Nia Krisniawati Nitiprodjo, Abdul Hakim Norina Agatri Norina Agatri Nur Signa Aini Gumilas Nursan Saad Pauzi, Rizqi Yanuar Prasetyo Tri Kuncoro Pratama, Radya Putra Pugud Samodro Putri, Prima Maharani Qodri Santosa Rangga Wisnu Wardana Rizak Tiara Yusan Saefuddin Aziz Saefuddin Aziz Samodro, Pugud Setiawati Setiawati Sindhu Wisesa Sindhu Wisesa Sindhu Wisesa Sirajuddin, Mohammad Salman Slamet Riyanto Soegianto, Jap Yulius Billy Sri Kadarsih Soejono Sri Kadarsih Soejono Susiana Candrawati Tirta Wardana Tuti Sri Suhesti Vitasari Indriani Vitasari Indriani Vitasari Indriani Wahyu Siswandari Wahyu Siswandari Wahyu Siswandari Wahyudin Wahyudin Widiartini, Catharina Widyaningsih, Pratiwi Nur Wisesa, Sindhu Yudhi Wibowo Yulia Fauziyah Zhafira, Adistya Hasna