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All Journal JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Biosel: Biologi Science and Education
Alfiana, Dessinta
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Energy Environmental Science Health Professions Medicine & Pharmacology

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PENGARUH WAKTU PENGADUKAN TERHADAP UKURAN PARTIKEL EMULSI MINYAK IKAN (OLEUM IECORIS ASELLI) Alfiana, Dessinta; Rahmadevi, Rahmadevi; Sagita, Desi
JOURNAL OF HEALTHCARE TECHNOLOGY AND MEDICINE Vol 6, No 1 (2020): APRIL 2020
Publisher : Universitas Ubudiyah Indonesia

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Abstract

Sediaan farmasi menggunakan minyak ikan yang cocok adalah emulsi. Emulsi merupakan sediaan cair, terdiri dari dua fase yang tidak bercampur, tidak stabil secara termodinamika, sehingga dikembangkan menjadi mikro emulsi. Penelitian ini bertujuan menghasilkan ukuran partikel yang kecil, menggunakan metoda variasi waktu pengadukan selama 20 menit, 40 menit dan 60 menit. Dilakukan evaluasi organoleptis, tipe emulsi, persen transmitan, viskositas dan pH. Emulsi dengan kombinasi surfaktan tween 80 dan span 60 (10 : 1) memiliki bentuk cair transparan, beraroma khas tween 80, ukuran partikel yaitu 0,376 µm dengan waktu pengadukan 60 menit, dengan transmitan 98%, viskositas 1,59 cPs dan memiliki pH 4,8.  
Analisis Fitokimia terhadap Senyawa Aktif dalam Daun Carica Papaya sebagai Dasar Formulasi Kapsul Kurniadi, Helman; Syafitri, Ulfah Eka; Alfiana, Dessinta; Framisa, Mentari; Hairani; Heldiana, Fitria
Biosel Biology Science and Education Vol. 14 No. 1 (2025): BIOSEL (Biology Science and Education: Jurnal Penelitian Science dan Pendidika
Publisher : INSTITUT AGAMA ISLAM NEGERI AMBON

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33477/bs.v14i1.9101

Abstract

Papaya leaves (Carica papaya L.) are rich in secondary metabolites with pharmacological potential as antioxidants, anti-inflammatories, and antimicrobials. This study aimed to identify bioactive compounds in papaya leaves, develop simplicia and extracts as a basis for capsule formulation, and evaluate the characteristics and stability of the resulting capsules. The methods used included simplicia preparation, extraction using maceration with 70% ethanol, phytochemical analysis using specific reagent tests, and capsule formulation with appropriate excipients. The results showed that papaya leaf simplicia had a moisture content of ≤ 5%, extraction yielded a rendement of 9.6%, and active compounds such as alkaloids, flavonoids, and polyphenols were detected. Capsule formulations containing papaya leaf extract showed good characteristics, with a dissolution time reaching 80% within 30 minutes, and good stability during storage. Papaya leaf extract can be developed as a stable, effective, and pharmaceutically standardized herbal phytopharmaceutical capsule preparation to support natural medicine. Keywords: C. papaya, Secondary Metabolites, Maceration, Herbal Capsule, Phytochemistry
Co-Authors Desi Sagita Framisa, Mentari Hairani Heldiana, Fitria Kurniadi, Helman Rahmadevi Syafitri, Ulfah Eka