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All Journal Jurnal Farmasi Sains dan Komunitas AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Sciences of Pharmacy
Ariani, Lusiana
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Medicine & Pharmacology Public Health Social Sciences

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Antioxidant and anti-elastase activity of Tampui (Baccaurea macrocarpa) and Ketapong (Terminalia badamia) barks and leaves Ariani, Lusiana; Wulandari, Endah; Desmiaty, Yesi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1393

Abstract

Elastase is a protease that is involved in the breakdown of elastin in the dermis. Likewise, free radicals can cause elastin damage. Inhibition of elastase enzyme activity and scavenging of free radicals can prevent premature aging of the skin, especially wrinkles. The current study was to investigate the antioxidant and elastase inhibition properties of the leaves and bark of the Tampui (Baccaurea macrocarpa L.) and Ketapong (Terminalia badamia L.) plants, which may be employed as an anti-aging ingredient in cosmetics and nutraceuticals. B. macrocarpa and T. badamia's leaves and bark were extracted using reflux and 96% ethanol. Anti-elastase was examined using N-succ-(Ala)3-nitroanilide as a substrate, and the DPPH reagent was used to test the antioxidants' activity. Phytochemical screening indicated the presence of flavonoids, quinone, tannins, and steroids. Antioxidant activity of B. macrocarpa leaves (BML), B. macrocarpa bark (BMB), T. badamia leaves (TBL), and T. badamia bark (TBB) had IC50 values were 15.09±0.51; 22.89±1.51; 36.43±1.94; 39.23±1.76 ppm, respectively. The anti-elastase activity of BML, BMB, TBL, and TBB had IC50 values were 48.86±2.29; 52.03±9.54; 44.42±4.53; 40.16±1.32 ppm, respectively. The ethanol extract of B. macrocarpa and T. badamia's leaves and bark exhibits anti-elastase and antioxidant action, proposing that it may be used as an anti-aging agent.
Evaluation of Medication Errors in Transcribing and Dispensing Processes of Outpatient E-Prescriptions at Persahabatan General Hospital Khairani, Sondang; Nurhayati, Fitri; Kurnia, Mala; Manninda, Reise; Ariani, Lusiana
Sciences of Pharmacy Volume 4 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0402316

Abstract

Persahabatan General Hospital provides a variety of healthcare services, including outpatient care. Medication errors are errors in the prescribing, dispensing, and administration process that can be considered risk factors for patients. This study aims to evaluate medication errors in the transcription and dispensing phases of outpatient e-prescriptions at Persahabatan General Hospital during the period January - February 2024. This research is a descriptive observational study with a cross-sectional design. Data were collected through prospective observation and analyzed descriptively to determine the percentage of medication errors. Of the 363 e-prescriptions observed, the results showed no errors in the transcribing phase. However, in the dispensing phase, there were 50 (6.07%) incidents of incorrect preparing quantity of medicine, 8 (0.97%) incidents of incorrect medicine medical equipment, and 7 (0.85%) incidents of incorrect dosage. These findings suggest that although the implementation of e-prescribing is effective in reducing errors at the transcription phase, special attention must be paid to the dispensing phase to reduce the number of errors. There is a correlation between polypharmacy and medication errors in the dispensing phase, p-value <0.001. All of these errors are resolved before the medication is administered to the patient.
Pos Simulasi Profesi Interaktif untuk Meningkatkan Pengetahuan Siswa Sekolah Dasar terhadap Profesi Apoteker Miftahurrohmah, Nur; Ariani, Lusiana; Winarti, Wiwi
Aksiologiya: Jurnal Pengabdian Kepada Masyarakat Vol 7 No 1 (2023): Februari
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/aks.v7i1.10446

Abstract

Apoteker memiliki peran penting, karena peranannya tidak dapat dipisahkan dengan profesi lainnya dalam bidang kesehatan. Namun ternyata, profesi apoteker kurang dikenal oleh anak-anak sehingga perlu dilakukan program kemitraan masyarakat yang bertujuan untuk mengenalkan profesi apoteker sejak dini kepada siswa sekolah dasar melalui kegiatan pos simulasi profesi apoteker yang interaktif. Program dilakukan di Sekolah Alam Indonesia (SAI) Meruyung, Depok, Jawa Barat. Peserta kegiatan adalah siswa siswi kelas 5 dan 6 SD, yang total berjumlah 71 siswa. Metode yang dilaksanakan adalah pemberian materi singkat tentang profesi apoteker, kemudian dilanjutkan mengikuti kegiatan pos simulasi interaktif yang terdiri dari enam pos, meliputi pos pengenalan bentuk sediaan obat, pengenalan golongan obat, menonton video pembuatan obat di pabrik farmasi, meracik dan membungkus obat, menulis etiket obat, dan simulasi penyerahan obat serta pemberian informasi obat kepada pasien. Di awal dan akhir kegiatan, para siswa mengisi kuesioner sederhana sebagai bahan evaluasi. Hasil analisis menunjukkan terjadi peningkatan pengetahuan siswa tentang profesi apoteker dari 56,34% menjadi 95,77%. Melalui kegiatan ini, siswa peserta kegiatan dapat mengenal peran penting dari profesi apoteker, bahkan sebagian siswa peserta kegiatan (22,53%) kemudian memiliki cita-cita ingin menjadi seorang apoteker.
Evaluation of Drug Interactions in Polypharmacy: A Case Study of Patients with Heart Failure Hospitalized at Tangerang District Hospital Khairani, Sondang; Manninda, Reise Reise Manninda; Ariani, Lusiana
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.0010033

Abstract

Heart failure is a condition in which the heart is unable to pump enough blood to meet the body's metabolic needs. It is a clinical syndrome with signs and symptoms caused by abnormalities in the structure and/or function of the heart. Heart failure occurs when the heart can't pump enough blood to meet the body's needs. It is caused by problems with the structure or function of the heart. This can lead to polypharmacy, where several medications are often taken by patients with heart failure to manage their condition. This study aims to identify patient characteristics, treatment accuracy based on Indonesian Heart Association (PERKI) 2023 guidelines, and the relationship between drug interactions and polypharmacy in adult patients diagnosed with heart failure with or without comorbidities at Tangerang Regency Hospital in 2023. The research was conducted descriptively using a cross-sectional study design. A total of 78 samples specimens met the inclusion criteria, with a male majority of 37 (52.86%) patients. The most common age group was 56-65 years old with 25 (35.71%) patients. The most common length of stay was 1-5 days with 48 (68.57%) patients. Evaluation of the treatment accuracy showed that the appropriate drug class was achieved in 78 (100%) patients, the appropriate dose in 55 (70.51%) patients and the appropriate frequency in 45 (57.69%) patients. Statistical tests showed a correlation between polypharmacy and drug-drug interactions with p-value 0.05. Accordingly, it is important to enhance monitoring and assessment of drug interactions in heart failure patients to optimize treatment management and prevent the risk of complications
Co-Authors Endah Wulandari Fitri Nurhayati Kurnia, Mala Manninda, Reise Reise Manninda Miftahurrohmah, Nur Reise Manninda S.Farm., M.Farm., Apt, Sondang Khairani Wiwi Winarti Yesi Desmiaty, Yesi