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All Journal Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Acta Pharmaceutica Indonesia AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia Eruditio : Indonesia Journal of Food and Drug Safety

Miftahurrohmah, Nur

Universitas Pancasila

Author-ID : 3683173

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Antimicrobial Activity Comparison Profile of Piper betle L., Pluchea indica L. and Citrus aurantifolia [Christm.] Swingle against Bacterial Isolates from Human Axillary Sweat with Odor Problem Miftahurrohmah, Nur; Syarmalina, Syarmalina
Acta Pharmaceutica Indonesia Vol 38, No 2 (2013)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (888.325 KB)

The research to compare the antimicrobial activity profile of Piper betle L. leaf, Pluchea indica L. leaf, and Citrus aurantifolia [Christm.] Swingle fruit against bacteria isolated from axillary sweat of six probandus having axillary odor problem had been done. Eight pure bacterial isolates came from this process, and then identified with Gram stain and several biochemical reactions. Staphylooccus aureus, S. epidermidis, and S. haemolyticus, known as bacteria that usually present in a large amount at human axilla skin with odor problem, were used also in this research. The tested plants were prepared with procedures that usually used by the Indonesian people as traditional home medicine to face the axillary odor problem. Furthermore, fucidic acid and potassium alumunium phosphate were used as reference drugs. Antimicrobial activity of all of the plants and the reference drugs against 11 bacteria were studied using agar diffusion method. The results showed that liquid extracted from Citrus aurantifolia [Christm.] Swingle. fructus had the highest antimicrobial activity compared to the two other plants against bacteria isolated from axillary sweat with odor problem, which was equal with the antimicrobial activity of potassium alumunium phosphate 20% w/v solution. Antimicrobial activity of betel leaf and beluntas leaf were equal with the antimicrobial activity of 19.06 Î¼g/mL of fusidic acid solution.Keywords: betel leaf, Piper betle L., beluntas leaf, Pluchea indica L., lime fruit, Citrus aurantifolia [Christm.] Swingle, antimicrobial, axillary odor.Â AbstrakTelah dilakukan penelitian untuk membandingkan aktivitas antimikroba dari daun sirih (Piper betle L.), daun beluntas (Pluchea indica L.), dan buah jeruk nipis (Citrus arantifolia [Christm.] Swingle) terhadap bakteri yang diisolasi dari keringat ketiak enam sukarelawan yang memiliki masalah bau ketiak. Delapan isolat bakteri murni didapat dari proses ini dan kemudian diidentifikasi dengan pewarnaan Gram dan uji-uji biokimia. Bakteri Staphylooccus aureus, S. epidermidis, dan S. haemolyticus yang umumnya terdapat dalam jumlah banyak di kulit ketiak yang berbau juga digunakan dalam penelitian ini. Tanaman-tanaman uji disiapkan dengan cara yang biasa dilakukan oleh masyarakat Indonesia untuk mengatasi bau badan secara tradisional. Sebagai senyawa antimikroba standar, digunakan asam fusidat dan tawas (kalium aluminium fosfat) untuk dibandingkan aktivitasnya dengan tiga tanaman uji. Aktivitas antimikroba seluruh tanaman uji dan larutan senyawa antimikroba terhadap 11 bakteri diteliti dengan menggunakan metode difusi agar. Hasil uji menunjukkan bahwa air perasan jeruk nipis memiliki aktivitas antimikroba terbesar dibandingkan dengan dua tanaman uji lainnya terhadap bakteri yang diisolasi dari keringat ketiak yang berbau, yang sebanding dengan aktivitas antimikroba larutan tawas 20% b/v. Aktivitas antimikroba daun sirih dan daun beluntas sebanding dengan aktivitas antimikroba larutan asam fusidat 19,06 Î¼g/mL.Kata kunci: sirih, Piper betle L., beluntas, Pluchea indica L., jeruk nipis, Citrus aurantifolia [Christm.] Swingle, antimikroba, bau ketiak.

Peningkatan Pengetahuan tentang Tanaman Obat Keluarga kepada Siswa Sekolah Dasar melalui Konseling, Flash Card, dan Berkebun Bersama Lusiana Ariani; Nur Miftahurrohmah; Wiwi Winarti
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 6, No 1 (2020): Maret
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Upaya pelayanan kesehatan yang dapat dilakukan oleh masyarakat adalah kegiatan promotif, preventif, kuratif dan rehabilitatif. Upaya promotif dan preventif dapat dilakukan dengan pemanfaatan tanaman obat keluarga (Toga). Pemahaman mengenai jenis Toga dan pemanfaatannya perlu dilakukan sejak dini, yaitu pada anak-anak agar kecintaan anak-anak terhadap obat asli Indonesia meningkat. Kami melakukan kegiatan pengabdian kepada masyarakat pada 71 siswa dan siswi sekolah dasar (SD) kelas 5 dan 6 di Sekolah Alam Indonesia (SAI) Meruyung, Depok. Dalam kegiatan tersebut dikenalkan 15 jenis tanaman obat dan khasiatnya. Kegiatan tersebut bertujuan untuk meningkatkan pengetahuan tentang jenis tanaman obat dan khasiatnya kepada siswa dengan metode konseling, media flashcard informatif dan kegiatan berkebun Toga bersama. Setelah kegiatan dilaksanakan persentase siswa dan siswi kelas 5 dan 6 yang mengetahui definisi Toga meningkat dari 41,2% menjadi 88,2% dan 91% menjadi 100%. Siswa dan siswi kelas 5 dan 6 mampu menyebutkan jenis Toga yang semula maksimal hanya 3 tanaman menjadi lebih dari 5 tanaman.

Antimicrobial Activity Comparison Profile of Piper betle L., Pluchea indica L. and Citrus aurantifolia [Christm.] Swingle against Bacterial Isolates from Human Axillary Sweat with Odor Problem Nur Miftahurrohmah; Syarmalina Syarmalina
Acta Pharmaceutica Indonesia Vol. 38 No. 2 (2013)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

The research to compare the antimicrobial activity profile of Piper betle L. leaf, Pluchea indica L. leaf, and Citrus aurantifolia [Christm.] Swingle fruit against bacteria isolated from axillary sweat of six probandus having axillary odor problem had been done. Eight pure bacterial isolates came from this process, and then identified with Gram stain and several biochemical reactions. Staphylooccus aureus, S. epidermidis, and S. haemolyticus, known as bacteria that usually present in a large amount at human axilla skin with odor problem, were used also in this research. The tested plants were prepared with procedures that usually used by the Indonesian people as traditional home medicine to face the axillary odor problem. Furthermore, fucidic acid and potassium alumunium phosphate were used as reference drugs. Antimicrobial activity of all of the plants and the reference drugs against 11 bacteria were studied using agar diffusion method. The results showed that liquid extracted from Citrus aurantifolia [Christm.] Swingle. fructus had the highest antimicrobial activity compared to the two other plants against bacteria isolated from axillary sweat with odor problem, which was equal with the antimicrobial activity of potassium alumunium phosphate 20% w/v solution. Antimicrobial activity of betel leaf and beluntas leaf were equal with the antimicrobial activity of 19.06 Î¼g/mL of fusidic acid solution.Keywords: betel leaf, Piper betle L., beluntas leaf, Pluchea indica L., lime fruit, Citrus aurantifolia [Christm.] Swingle, antimicrobial, axillary odor. AbstrakTelah dilakukan penelitian untuk membandingkan aktivitas antimikroba dari daun sirih (Piper betle L.), daun beluntas (Pluchea indica L.), dan buah jeruk nipis (Citrus arantifolia [Christm.] Swingle) terhadap bakteri yang diisolasi dari keringat ketiak enam sukarelawan yang memiliki masalah bau ketiak. Delapan isolat bakteri murni didapat dari proses ini dan kemudian diidentifikasi dengan pewarnaan Gram dan uji-uji biokimia. Bakteri Staphylooccus aureus, S. epidermidis, dan S. haemolyticus yang umumnya terdapat dalam jumlah banyak di kulit ketiak yang berbau juga digunakan dalam penelitian ini. Tanaman-tanaman uji disiapkan dengan cara yang biasa dilakukan oleh masyarakat Indonesia untuk mengatasi bau badan secara tradisional. Sebagai senyawa antimikroba standar, digunakan asam fusidat dan tawas (kalium aluminium fosfat) untuk dibandingkan aktivitasnya dengan tiga tanaman uji. Aktivitas antimikroba seluruh tanaman uji dan larutan senyawa antimikroba terhadap 11 bakteri diteliti dengan menggunakan metode difusi agar. Hasil uji menunjukkan bahwa air perasan jeruk nipis memiliki aktivitas antimikroba terbesar dibandingkan dengan dua tanaman uji lainnya terhadap bakteri yang diisolasi dari keringat ketiak yang berbau, yang sebanding dengan aktivitas antimikroba larutan tawas 20% b/v. Aktivitas antimikroba daun sirih dan daun beluntas sebanding dengan aktivitas antimikroba larutan asam fusidat 19,06 Î¼g/mL.Kata kunci: sirih, Piper betle L., beluntas, Pluchea indica L., jeruk nipis, Citrus aurantifolia [Christm.] Swingle, antimikroba, bau ketiak.

Formulasi Gel NLC Ekstrak Kalus Daun Murbei Hasil Induksi dengan NAA dan BAP Faizatun Faizatun; Erlindha Gangga; Sarah Anindita; Titiek Martati; Nur Miftahurrohmah
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Mulberry Leaf (Morus alba L.) contains oxyresveratrol has the potential as a skin lightener. The activity of mulberry leaf callus from tissue culture is unknown as an inhibitor of the tyrosinase enzyme. The purpose of this study was to determine the activity callus extracts of mulberry leaf which obtained from tissue culture with the addition of growth regulator NAA 1.0 ppm and BAP 2.5 ppm and to formulate callus extract in Nanostructured Lipid Carrier and its characteristics. Callus was extracted by maceration-sonication. NLC is made by solvent evaporation method, NLC characterization including particle size, polydispersity index, zeta potential and particle morphology. The best NLC was made into a gel and evaluated organoleptic, viscosity, flow properties, pH, and tyrosinase enzyme inhibitory on extracts and NLC gels. The characterization of NLC includes particle size of 189.8 nm-632.8 nm; polydispersity index, 0.387-0.582. The morphology of NLC were spherical and zeta potential of -7.37 mV. NLC gel was semi-solid, greenish yellow, homogeneous, viscosity 530000 cPs, plastic thixotropic flow properties, pH 5.26, and inhibitory activity of tyrosinase enzymes (IC50) of callus extract and NLC gel has 72.51 µg/ml and 79.69 µg/ml, respectively. It can be concluded that callus extract of Mulberry leaf can be prepared into Nanostructured Lipid Carriers, NLC gels are physically and chemically stable and have the potential of lightening activity.

Karakterisasi Isolat JS-1, Bakteri Alkalofilik Penghasil Siklodekstrin Glikosiltransferase (CGTase) dari Sumedang, Jawa Barat NUR MIFTAHURROHMAH; MOORDIANI MOORDIANI
JURNAL ILMU KEFARMASIAN INDONESIA Vol 12 No 2 (2014): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (482.541 KB)

Cyclodextrin glycosyltransferase (CGTase) is an extracellular enzyme which is produced by some bacteria and archae that converts starch into cyclodextrin (CD). This enzyme has a high commercial value because of its product (CD) is widely used in several industries, such as pharmaceutical, chemistry, cosmetic, food, textile and also for environment protection. In Indonesia, there are still a few bacteria as CGTase producer were discovered and observed. The aim of this research was to find bacteria as CGTase producer from soil of corn farm land in Sumedang, West Java, and further characterized the isolate in produce CGTase. Horikoshi agar media was used as screening media. An alkalophylic bacteria as CGTase producer, JS-1 was successfully gained from this process. This isolate was characterized in the term of Gram staining, oxygen demand, motility and catalase test. The characterization results showed that JS-1 is a bacillus, Gram positive, facultative anaerob, motil and catalase positive. JS-1 isolate was also further characterized in order to determine optimum incubation period and temperature for CGTase production. The results were showed that JS-1 isolate was produced CGTase in maximum level if incubated for 48h at 37 °C.

Produk Esktraseluler Isolat Kapang Endofi t C.1.1 dan C.3.3 dari Ranting Cempaka Kuning (Michelia champaca L.) Sebagai Antimikroba Adefira Elisyia Juniharti; Desi Nadya Aulena; Novi Yantih; Nur Miftahurrohmah; Shirly Kumala
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.985

Michelia champaca L. is known to have effi cacy as an antimicrobial, antioxidant, and anticancer.In general, endophytic fungi that live in plant tissues is capable of producing secondary metabolites as theirhost plant. The objective of this research is to examine the antimicrobial potential of endophytic mold isolates C.1.1 and C.3.3 from yellow cempaka branches (Michelia champaca L.). Isolates obtained from previous research, fi rst was rejuvenated on PDA. Fermentation was carried out on each isolate for 12 days. The fermented supernatant was then extracted partially with n-hexane, ethyl acetate, and n-butanol solvent. The extract was then concentrated and tested for antimicrobial activity using disk diff usion and microdilution methods. N-butanol extract of endophytic fungi isolates of yellow champaca branches was able to inhibit the microbial growth with the largest inhibition area in isolate C.1.1 in Staphylococcus aureus ATCC 6538 (12.26 mm), Escherichia coli ATCC 8739 (11.40 mm), Candida albicans ATCC 10231 (10.50 mm), and Metichillin-Resistant Staphylococcus aureus (11.30 mm) with Minimum Inhibitory Concentration and Minimum Concentration of 12,5% . It was concluded that both endophytic fungi isolates of yellow champaca branches had the potential to inhibit the growth of pathogenic microbes.

Formulasi Krim Minyak Biji Bunga Matahari (Helianthus annuus L.) dengan Variasi Konsentrasi Setil Alkohol sebagai Anti Jerawat Lusiana Ariani; Nur Miftahurrohmah; Kartiningsih Kartiningsih; Meilisa Ang
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 2 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v18i2.828

Acne is an inflammatory condition that was caused by Propionibacterium acnes. Sunfl owerseeds (Helianthus annuus L.) with terpenoids and linoleic acid could prevent and treat acne. In theprevious study, sunfl ower seed oil had a Minimum Inhibitory Concentration (MIC) value for P. acnesbacteria ≥1.5% with a Diameter Inhibitory Zone 15.27 mm which was classifi ed as a strong antibacterialagent. This study was intended to develope cream formula (F1-F4) using variations of cetyl alcoholconcentrations of 8, 10, 12% and blanko respectively. The creams were formulated by heating the waterphase and the oil phase separately at 70˚C, then stirred to form the cream. The prepared formulations wereevaluated for organoleptic, homogeneity, type of cream, viscosity and rheology, spread ability, globulesize, centrifugation, and pH. The organoleptic results showed that the cream was white, odorless, softin texture and homogeneous with the type of oil in water (O/W) cream. The viscosity test showed thatthe viscosity of F1-F3 formulas were 490.29; 3886.29; 22510.67 cP and F4 of 111.04 cP with plasticthixotropic fl ow properties. Formula F1-F4 had a spread ability of 8.9; 5,4; 4,4; 7.3 cm2, the globulesizes were 137.78; 133,33; 151.11; 94.44 μm, did not show phase separation during centrifugation andthe pH of the F1-F3 formula were 6.3 and F4 was 5.93. It may be concluded that the evaluation of thephysical and chemical quality of sunfl ower seed oil cream are within the acceptable standard.

Pos Simulasi Profesi Interaktif untuk Meningkatkan Pengetahuan Siswa Sekolah Dasar terhadap Profesi Apoteker Nur Miftahurrohmah; Lusiana Ariani; Wiwi Winarti
Aksiologiya: Jurnal Pengabdian Kepada Masyarakat Vol 7 No 1 (2023): Februari
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/aks.v7i1.10446

Apoteker memiliki peran penting, karena peranannya tidak dapat dipisahkan dengan profesi lainnya dalam bidang kesehatan. Namun ternyata, profesi apoteker kurang dikenal oleh anak-anak sehingga perlu dilakukan program kemitraan masyarakat yang bertujuan untuk mengenalkan profesi apoteker sejak dini kepada siswa sekolah dasar melalui kegiatan pos simulasi profesi apoteker yang interaktif. Program dilakukan di Sekolah Alam Indonesia (SAI) Meruyung, Depok, Jawa Barat. Peserta kegiatan adalah siswa siswi kelas 5 dan 6 SD, yang total berjumlah 71 siswa. Metode yang dilaksanakan adalah pemberian materi singkat tentang profesi apoteker, kemudian dilanjutkan mengikuti kegiatan pos simulasi interaktif yang terdiri dari enam pos, meliputi pos pengenalan bentuk sediaan obat, pengenalan golongan obat, menonton video pembuatan obat di pabrik farmasi, meracik dan membungkus obat, menulis etiket obat, dan simulasi penyerahan obat serta pemberian informasi obat kepada pasien. Di awal dan akhir kegiatan, para siswa mengisi kuesioner sederhana sebagai bahan evaluasi. Hasil analisis menunjukkan terjadi peningkatan pengetahuan siswa tentang profesi apoteker dari 56,34% menjadi 95,77%. Melalui kegiatan ini, siswa peserta kegiatan dapat mengenal peran penting dari profesi apoteker, bahkan sebagian siswa peserta kegiatan (22,53%) kemudian memiliki cita-cita ingin menjadi seorang apoteker.

Validasi Metode Deteksi Shigella dalam Tablet Hisap Obat Kuasi Herawati, Desty; Aprianto, Eko; Cahyaningsih, Eni; Miftahurrohmah, Nur
Eruditio : Indonesia Journal of Food and Drug Safety Vol 4 No 2 (2024): June Edition
Publisher : Badan Pengawas Obat dan Makanan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54384/eruditio.v4i2.199

Lozenges, a quasi-drug used to relieve sore throats, must meet the safety and quality requirements according to Indonesian FDA Regulation No. 7 of 2023 concerning the criteria and procedures for quasi-drug registration, which stipulates that oral preparations of quasi-drugs must be free from Shigella spp—microbial contamination. Contamination by Shigella bacteria can cause diseases such as shigellosis, characterized by symptoms such as diarrhoea, vomiting, and fever. This study aims to validate the Shigella spp—detection method in quasi-drug lozenges using the WHO (Quality Control Methods for Herbal Materials) reference method. Validation was carried out to ensure that this method can be used for routine analysis in the Indonesian FDA laboratory. The guidelines used to validate the microbiological method are the Singapore Accreditation Council (SAC) Guidance Notes C&B AND ENV 002 of 2019 and refer to pharmacopoeias. The study results showed that the WHO (Quality Control Methods for Herbal Materials) method in detecting Shigella sp. has a sensitivity and specificity of 100%, with false positive and false negative rates of 0% each. The detection limit obtained was 3 cfu/g, which meets the requirements (below 10 cfu/g). The method suitability test (optimization) showed that the initial solvent used for sample homogenization in Shigella detection was sufficient using Tryptone Soya Broth (1:10) without additional neutralization or modification procedures at the sample homogenization stage. Based on these results, the Shigella spp. The WHO reference (Quality Control Methods for Herbal Materials) detection method is accurate. It can be applied for routine microbial contamination testing analysis in the Food and Drug Supervisory Agency laboratories.

Formulation and Antioxidant Activity Test of Gel from Fermented Red Pomegranate Peel Juice (Punica Granatum L) Faizatun, Faizatun; Miftahurrohmah, Nur; Rosmawati, Rosmawati
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 2 (2024): J Sains Farm Klin 11(2), August 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.2.136-144.2024

Red pomegranate (Punica granatum L.) peel has secondary metabolites such as phenolics, flavonoids, and tannins which are known to have antioxidant potential. The purpose of this study was to see the comparison of antioxidant activity of juice before and after fermentation and then formulated into a gel preparation that is physically and chemically stable. Red pomegranate peel juice was dried by freeze drying method and then fermented with Lactobacillus plantarum ATCC 8014 bacteria and measured OD600, pH, and antioxidant activity using DPPH reagent. The results showed that pomegranate peel juice before fermentation had strong antioxidant activity with a value (of IC50 35.64 ± 0.68 ppm) and after fermentation, it was in the very strong category (IC50 8.00 ± 0.01 to 8.11 ± 0.06 ppm); pH before and after (3.96 ± 0.02 and 3.33 ± 0.01). Formula II with juice concentration of 300 x IC50 has the highest antioxidant activity with IC50 values (64.37 ± 1.13 ppm); pH (6.33); spreadability (6.20 ± 0.07); and viscosity (31333.3 ± 577.35 dPas). There was an increase in antioxidant activity of red pomegranate peel juice after fermentation, the resulting gel is physically and chemically stable based on the results of accelerated stability tests for 4 weeks .

Co-Authors Adefira Elisyia Juniharti Ariani, Lusiana Cahyaningsih, Eni Desi Nadya Aulena Eko Aprianto Erlindha Gangga Faizatun FAIZATUN, FAIZATUN Herawati, Desty Kartiningsih Kartiningsih Lusiana Ariani Lusiana Ariani Martati, Titiek Meilisa Ang Moordiani Moordiani Noviyantih, Noviyantih Rosmawati Rosmawati Sarah Anindita Shirly Kumala Syarmalina Syarmalina Syarmalina, Syarmalina Wiwi Winarti

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