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All Journal Medicinus : Jurnal Kedokteran Majalah Patologi Indonesia JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Cancer Barista : Jurnal Kajian Bahasa dan Pariwisata
Susanto, Eka
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Other

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Tourism And Fashion: Interpreting Tourism Resources Into Fashion Product Designs in Alamendah Tourism Village Nabilla, Affra Siti; Vyana Lohjiwa; Sukma, Mestika Nawang; Susanto, Eka; Anggrenesia, Yayang
Barista : Jurnal Kajian Bahasa dan Pariwisata Vol. 11 No. 02 (2024): December
Publisher : Unit Bahasa, Politeknik Pariwisata NHI Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34013/barista.v11i02.1739

Abstract

The future of tourism destinations focuses on local communities' creativity in developing their tourist attractions, one of which is through MSMEs (Micro, Small, and Medium Enterprises). When an attraction goes viral, booming, or popular suddenly, it is followed by other destinations who imitate products without bringing out the uniqueness of the destination. On the other side, local communities want to explore new things, but on the other side, there is a fear that no tourists will be interested in visiting or purchasing products from MSMEs. This dialectical condition is the focus of the research. This research explores the various signs and meanings of tourism resources in Alamendah Tourism Village, which are realized through the creativity of MSMEs in designing fashion products. The results of this research are useful for generating product innovations that represent the village. Data were collected through field observations using a checklist, followed by data on tourism resources from the views of managers, communities, and MSME actors using in-depth interviews and integrated discussions. The results show that the resources of Alamendah Tourism Village focuses on cultural life, landscape, and coolness that symbolizes harmony and peace. The symbol was transformed into a fashion product design in the form of an outer, tote bag, and shoes with an eco print design patterned with strawberry leaves, coloured in a combination of brown, red, and green with ornaments and clump stitching techniques, the meaning are harmony and peace. This product can be applied to MSMEs actors as a creative innovation that can attract tourists to visit. This innovation is seen to be the main capital in the development of sustainable tourism that is not affected by temporary viral trend. Keywords: Alam Endah, Fashion Product Design, Innovation, MSMEs.
The Profile of P63 Expression and Epstein-Barr-Encoded RNA (EBER) Distribution in Primary Central Nervous System Lymphoma: A Retrospective Bi-Center Study Kristiani, Erna; Marisca, Stephanie; Suharyani, Sally; Dermawan, Kevin; Widodo, Stephanie T.; Ham, Maria F.; Harahap, Agnes S.; Susanto, Eka; Tjahjadi, Hartono; July, Julius
Medicinus Vol. 14 No. 2 (2025): February
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v14i2.9545

Abstract

Background : Primary central nervous system lymphoma (PCNSL) is a type of lymphoma occurring around 0.5 – 1.2% of all intracranial neoplasms. However, recent epidemiological research shows a threefold increase in the number of cases. The Epstein-Barr virus (EBV) and PCNSL are both associated with the condition of immunosuppression or immunodeficiency, which often found to have a significant relationship with each other. Moreover, the TP63 mutation is associated with a poor prognosis. Methods : This is a descriptive study to assess the expression of TP63 and EBER on PCNSL, and present the characteristics of the disease. The study was conducted on 25 cases from two health centers with the most cases of brain tumors in Indonesia, Siloam Hospital Lippo Village and Cipto Mangunkusumo Hospital (CMH) from 2014 to 2018, the P63 expression and EBER-1 examinations were done by 4 pathologists. A total of 25 patients, 13 (52%) patients were male, ranging from age 30 – 79, with average 57,6 years old, located mostly in the frontal lobe in 8 patients (30.9%). Result : From the research results obtained positive P63 results in 20 cases (80%), while the EBER test was negative for all 25 patients. Further analysis with software SPSS 25 proving that P63 expression is not associated with germinal center B-cell type (GCB) or non-GCB type (p-value 0,87). Neither, P63 have any association with Ki67 with p-value of 1.00. Conclusions : This study concludes that there is a possibility that PCNSL cases in Indonesia are not associated with Epstein-Barr virus infection, but most of the cases will have a poor prognosis as indicated by P63 expression.
Cerebrospinal Fluid Profile in Suspected Leptomeningeal Metastases in Dr. Cipto Mangunkusumo National Referral Hospital and Dharmais National Cancer Center Hospital Aninditha, Tiara; Maulina, Lisa; Andriani, Rini; Susanto, Eka; Ranakusuma, Teguh; Sofyan, Henry Riyanto
Indonesian Journal of Cancer Vol 19, No 1 (2025): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i1.1286

Abstract

Background: Leptomeningeal metastases (LM) are a condition in which malignant cells spread to the leptomeninges and subarachnoid space, with an increasing incidence and poor prognosis. Cerebrospinal fluid (CSF) analysis is an important examination, with cytology as the gold standard for detecting malignant cells in CSF. We aim to describe the CSF profile (i.e. protein, glucose, cell count, and cytology) in detecting malignant cells among patients with suspected LM in Cipto Mangunkusumo National Referral Hospital and Dharmais National Cancer Center Hospital from January 2018 to December 2021. Method: A multicenter cross-sectional retrospective study was conducted to describe the CSF profile in suspected LM from January 2018 to December 2021. Suspected LM cases were established from clinical and radiological findings. The lumbal puncture was performed in those suspected LM cases. Clinical manifestations, radiological data, tumor type, some aspects from CSF routine analysis (i.e. protein, glucose, cell count), and lumbar puncture frequency were described. Their correlation with CSF cytology was analyzed. Results: There were 153 subjects with abnormalities on CSF routine analysis (75.2%), consisting of CSF cell count 5/uL (47.1%) with a median of 5 (1–3504)/uL, CSF protein 45 mg/dL (52.9%) with a median of 50 (5–820) mg/dL, and CSF glucose 50 mg/dL (15%) with a median of 68 (3–629) mg/dL. The positive CSF cytology result was 20.3%. Positive CSF flow cytometry immunophenotyping in hematological malignancy with suspected LM was 25.6%. There was a significant correlation between the increase in CSF cell count, hematological malignancy, and MRI results with CSF cytology (p 0.001; p = 0.03; p = 0.03). There was no significant correlation between clinical manifestations and lumbar puncture frequency with CSF cytology.Conclusion: Abnormalities in CSF routine analysis were found in the majority of subjects with suspected LM, but the CSF cytology positivity rate was considered low. The presence of varied clinical symptoms and repeated lumbar punctures didn’t increase the likelihood of positive CSF cytology
The Clinicopathological Profile and Recurrence of Meningioma at Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital Hastrina Mailani; Susanto, Eka
Majalah Patologi Indonesia Vol. 33 No. 1 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i1.598

Abstract

Background Meningioma represents the most frequent primary intracranial tumor, and some subtypes may demonstrate aggressive characteristics with a correspondingly elevated risk of recurrence. To predict the likelihood of recurrence, clinical and pathological parameters are essential. More aggressive treatment strategies and strict follow-up can be implemented using these parameters. Therefore, this study aims to determine clinicopathological characteristics of meningioma and its relationship with recurrence. Method This study adopted a retrospective cross-sectional approach using secondary data of meningioma cases from the archives of the Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital in 2019-2021. The clinical data were obtained through electronic medical records, and histopathological data assessment, including grade, mitosis, brain invasion, bone invasion, and dural invasion, was conducted through microscopic examination. Result The data indicate that a total of 219 cases of meningioma were reassessed. The mean age of patients was 45±11 years, and the majority (88.1%) were female. The mean tumor size was 5±1.8 cm, with the most common tumor location being the skull base (71%) and 38.6% of cases showed radiological evidence of bone invasion. Subtotal resection was the treatment of choice for most patients (67.8%). CNS WHO grade 1 was found in 91.8% of cases, while Mitotic index ≥4/10 HPF, microscopic evidence of bone invasion, brain invasion, and dural invasion were found in 5%, 33.6%, 3.2%, and 16.8%, respectively. A minimum follow-up of 6 months was fulfilled by 71 cases, and 28% experienced recurrence/progression. These findings showed a significant association between the extent of resection (p=0.007) and tumor size (p=0.02) with the incidence of recurrence. Conclusion Clinical parameters such as the extent of resection and tumor size play a role in predicting the likelihood of meningioma recurrence. The predictive factors knowledge for meningioma recurrence is important in determining treatment strategies and follow-up
Effects of different preparation protocols of blood serum eyedrops on corneal healing after alkali burn: Clinical evaluation and α-SMA expression Susiyanti, Made; Widyawati, Syska; Susanto, Eka; Louisa, Melva; Kania, Theresia
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art9

Abstract

Background: In cases of alkali burn, blood serum eyedrops may supply protein and growth factors. A standard preparation protocol is necessary for consistency in epitheliotropic capacity. Objective: We aim to evaluate how post-alkali-burn administration of blood serum eyedrops from different preparation protocols results in different outcomes on rabbits. Methods: This randomized experimental study used three treatments: placebo, non-diluted serum, and 25% concentration serum. We analyzed the corneal haziness, neovascularization degree, histopathological examination of neovascularization scores, and alpha-smooth muscle actin (α-SMA) expression. Results: Twelve rabbits (24 eyes) were split evenly into three treatment groups. On day 14, the group receiving the 25% concentration serum had the least corneal haziness (p = 0.005). No adverse effect was observed on the treated eyes. Histopathologically, no significant difference in neovascularization scores and α-SMA expression was observed. Conclusions: Treatment using the 25% concentration serum resulted in less corneal haziness, smaller defect size, and greater healing rate. There was also no significant difference in histopathological outcomes among the three treatment groups.
Co-Authors Anggrenesia, Yayang Aninditha, Tiara Dermawan, Kevin Hadian, M. Sapari Dwi Harahap, Agnes S. Hastrina Mailani Julius July Kania, Theresia Kristiani, Erna Made Susiyanti Maria F. Ham Marisca, Stephanie Maulina, Lisa Melva Louisa Nabilla, Affra Siti Ranakusuma, Teguh Rini Andriani Sofyan, Henry Riyanto Suharyani, Sally Sukma, Mestika Nawang Tjahjadi, Hartono Ute Lies Siti Khadijah Vyana Lohjiwa Widodo, Stephanie T. Widyawati, Syska