Article Per Year (5 Year)
p-Index From 2020 - 2025
1.235
P-Index
This Author published in this journals
All Journal Indonesian Journal of Cancer eJournal Kedokteran Indonesia Neurona Acta Neurologica Indonesia
Sofyan, Henry Riyanto
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 7 Documents
Search

 1 
An Overview of The Spinal Metastasis Pain with Opioid Therapy and The Affecting Factor Djohansjah, Joice Rosewitasari Aryanti; Andriani, Rini; Aninditha, Tiara; Sofyan, Henry Riyanto
Indonesian Journal of Cancer Vol 18, No 2 (2024): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i2.1065

Abstract

Background: Spinal metastasis is the most frequent type of spinal tumor. Opioid is the first line of treatment for cancer pain despite a multitude of side effects. This study aimed to evaluate the effectiveness of opioids as the latest ladder in the treatment of spinal cancer pain. Methods: A retrospective cross-sectional study was performed comprising 89 spinal metastasis patients at the National Cancer Centre, Dharmais Hospital from November 2021 to March 2022. The demographic and clinical data were retrieved from medical records. This study used the Numerical Rating Scale (NRS) to evaluate the improvement of pain. The change of NRS ≥ 2 was considered significant. The data was analyzed using bivariate (Wilcoxon, Mann-Whitney, and Fisher Exact test) and multivariate (linear regression) analysis. Results: A total of 89 subjects were included in the study (median age = 51 years, 57,3% females). There was a significant decrease in the severity of cancer pain (p0.005) between admission (initial NRS 7) and treatment completion (final NRS 2) in the first hospitalization of all groups. There was no correlation between the clinical characteristics of the participants and the NRS score determined upon admission and at the end of the course of treatment. Conclusions: There was a significant improvement in the cancer pain intensity in the subjects with spinal metastasis cancer pain who received opioid naive therapy.
Characteristics of Brain Tumor Metastases at dr. Cipto Mangunkusumo National Referral Hospital Sari, Riska Nanda; Aninditha, Tiara; Rachman, Andhika; Ranakusuma, Teguh A. S; Andriani, Rini; Yesnuar Safri, Ahmad; Sofyan, Henry Riyanto; Wiratman, Winnugroho
eJournal Kedokteran Indonesia Vol. 12 No. 3 (2024): Vol. 12 No. 3 - Desember 2024
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Metastatic brain tumors, surpassing primary brain tumors in prevalence by tenfold, are the most common brain neoplasms, emphasizing the role of early diagnosis in improving the patient's quality of life. This study aimed to identify the characteristics of brain tumor metastases at Cipto Mangunkusumo National Referral Hospital.  With consecutive sampling, a cross-sectional design study using secondary brain tumor data was conducted at dr. Cipto Mangunkusumo National Referral Hospital from January 2016 to December 2020. Characteristics data were presented in percentages, and bivariate analysis was conducted using Chi-square or Fisher's test. Among 222 subjects (mean age 50.9 ± 10.4 years, 60.8% women), metastases were predominantly supratentorial (50.6%), multiple (65.8%), and associated with mass effects (51.4%), particularly midline shift (69.6%). Primary tumors were predominantly lung (36.5%) , breast (34.2%), and 55.9% experienced metastases in other organs. Brain metastases manifested metachronously in 67.6% of cases, with primary breast tumors showing a higher propensity for metatentorial and infratentorial metastases, while primary lung tumors showed a synchronous onset. The study highlighted associations between mass effects, loss of consciousness -, and poor performance in subjects. Primary lung and breast tumors exhibited the highest incidence of brain metastases.
Educating General Practitioners about Medication-overuse Headache: Importance and Call to Action Sofyan, Henry Riyanto; Madjid, Irma Savitri; Faiq, Ahmad Rafi; Indrapriambada, Ery Riady; Humaira, Sarah; Aninditha, Tiara
Acta Neurologica Indonesia Vol. 3 No. 01 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i01.49

Abstract

Medication overuse headache (MOH) is a secondary headache that frequently accompanied chronic primary headaches which poses a great burden in an individual and systemic level. Globally, it is recognized as one of the relevant headaches for primary care. However, in Indonesia, it has not been included in the standard competence for doctors, and therefore has been underrecognized by general practitioners who encountered headache patients in primary care. In this policy brief, we mapped the problems regarding MOH and proposed several action plans, including educating GPs, as the recommendations.
Cerebrospinal Fluid Profile in Suspected Leptomeningeal Metastases in Dr. Cipto Mangunkusumo National Referral Hospital and Dharmais National Cancer Center Hospital Aninditha, Tiara; Maulina, Lisa; Andriani, Rini; Susanto, Eka; Ranakusuma, Teguh; Sofyan, Henry Riyanto
Indonesian Journal of Cancer Vol 19, No 1 (2025): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i1.1286

Abstract

Background: Leptomeningeal metastases (LM) are a condition in which malignant cells spread to the leptomeninges and subarachnoid space, with an increasing incidence and poor prognosis. Cerebrospinal fluid (CSF) analysis is an important examination, with cytology as the gold standard for detecting malignant cells in CSF. We aim to describe the CSF profile (i.e. protein, glucose, cell count, and cytology) in detecting malignant cells among patients with suspected LM in Cipto Mangunkusumo National Referral Hospital and Dharmais National Cancer Center Hospital from January 2018 to December 2021. Method: A multicenter cross-sectional retrospective study was conducted to describe the CSF profile in suspected LM from January 2018 to December 2021. Suspected LM cases were established from clinical and radiological findings. The lumbal puncture was performed in those suspected LM cases. Clinical manifestations, radiological data, tumor type, some aspects from CSF routine analysis (i.e. protein, glucose, cell count), and lumbar puncture frequency were described. Their correlation with CSF cytology was analyzed. Results: There were 153 subjects with abnormalities on CSF routine analysis (75.2%), consisting of CSF cell count 5/uL (47.1%) with a median of 5 (1–3504)/uL, CSF protein 45 mg/dL (52.9%) with a median of 50 (5–820) mg/dL, and CSF glucose 50 mg/dL (15%) with a median of 68 (3–629) mg/dL. The positive CSF cytology result was 20.3%. Positive CSF flow cytometry immunophenotyping in hematological malignancy with suspected LM was 25.6%. There was a significant correlation between the increase in CSF cell count, hematological malignancy, and MRI results with CSF cytology (p 0.001; p = 0.03; p = 0.03). There was no significant correlation between clinical manifestations and lumbar puncture frequency with CSF cytology.Conclusion: Abnormalities in CSF routine analysis were found in the majority of subjects with suspected LM, but the CSF cytology positivity rate was considered low. The presence of varied clinical symptoms and repeated lumbar punctures didn’t increase the likelihood of positive CSF cytology
The Correlation of Inflammatory Markers with Clinical Manifestation, Peritumoral Edema, and Recurrence in Meningioma Patients Aninditha, Tiara; Auliya, Putri; Mulyadi, Rahmad; Aman, Renindra Ananda; Andriani, Rini; Sofyan, Henry Riyanto
Indonesian Journal of Cancer Vol 19, No 2 (2025): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i2.1287

Abstract

Background: Meningiomas can induce inflammation in their tumorigenesis process, thereby linking inflammation with clinical symptoms, peritumoral edema, and recurrence of meningiomas. Easily accessible and cost-effective inflammatory markers include the neutrophillymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR). This study aims to investigate the relationship between peripheral inflammation markers, specifically the NLR and MLR, and their association with clinical symptoms, peritumoral edema, and meningioma recurrence.Method: A retrospective cohort study was conducted at Cipto Mangunkusumo National General Hospital from January 2016 to December 2019, utilizing a consecutive non-probability sampling method. Inclusion criteria were patients aged 18 years or older with meningiomas(gradesI-III), first surgery. Peripheral inflammatory markers were derived from differential blood counts, peritumoral edema data from radiological reports, and other data from medical records. The cut-off valuesfor NLR and MLR were determined to be 2.415 and 0.295, respectively. Bivariate analyses using ChiSquare and Mann-Whitney tests were followed by multivariate logistic regression analysis. Results: 173 patients were eligible for analysis. Of these, 27 had preoperative CT scans, 126 had MRIs, and 20 had no preoperative radiology data. Clinical and recurrence analyses were performed on all 173 patients, with radiology and tumor size analyses conducted on subsets of 153 and 126 patients, respectively. The majority of meningiomasin thisstudy were grade I, found in 94.2% of subjects, with the remainder being grade II and III. Higher NLR and MLR values were significantly associated with headaches (p 0.001). Elevated NLR and MLR were also correlated with peritumoral edema (p 0.001). MLR was independently associated with recurrence, with an adjusted odds ratio (aOR) of 12.647 (95% CI 2.355–67.919); p = 0.003.Conclusion: NLR and MLR as peripheral inflammatory markers demonstrated higher median values in meningioma patients with headaches and peritumoral edema. Additionally, inflammation in meningiomas was associated with the occurrence of recurrence.
Neuro-Ophthalmology Manifestations in Brain Tumor Patients and Its Related Factors at dr. Cipto Mangunkusumo Hospital Ariafini, Ni Nengah Rida; Aninditha, Tiara; Sinthia, Novita Ayu; Zairinal , Ramdinal Aviesena; Sitorus, Freddy; Imran, Darma; Prawiroharjo, Pukovisa; Sofyan, Henry Riyanto; Diafiri, Dinda
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The visual system has complex connections with all brain areas and can be affected by a brain tumor. Neuro-ophthalmological examinations are important because early diagnosis and managing small tumors will improve outcomes. This study aimed to investigate brain tumors' neuro-ophthalmic (NO) manifestation and the affecting factors. A cross-sectional study using total sampling was conducted in patients undergoing pre-operative examinations from January 2014 to December 2019 in dr. Cipto Mangunkusumo National Referral Hospital. Variables studied in this paper are brain tumor characteristics, NO manifestations, and the relationship between them. Analysis was conducted using chi-square or Fisher's exact test and post hoc analysis. All subjects presented with NO manifestations, with fundoscopic abnormalities (72.9%) as the most common manifestation. The relationships between the tumor type with visual field disturbances (p=0.002) and multiple tumor lesions with funduscopic abnormalities (p=0.043) were significant. Lesion location also had a significant relationship with all NO variables (p<0.05). The NO manifestations were found in all subjects, predominantly the fundoscopic abnormalities. The tumor type, number of lesions, and location of lesions had a significant relationship with NO manifestations.
Gambaran Status Gizi Penderita Tumor Otak Primer dan Metastasis serta Faktor-faktor yang Memengaruhinya Aninditha, Tiara; Tanjung, Gloria; Andayani, Diyah Eka; Aman, Renindra Ananda; Estiasari, Riwanti; Yanuar, Ahmad; Sofyan, Henry Riyanto
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 39 No 3 (2022): Vol 39 No 3 (2022)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v39i3.280

Abstract

Introduction: According to the pathophysiology, weight loss is a specific marker for suspected malignancy. However, this is rarely found in cases of brain tumors. The presence of the blood brain barrier is thought to play a role in differentiating nutritional status in primary and metastatic brain tumors. Therefore, it is necessary to do this research. Aim: Knowing the description, prevalence, differences in nutritional status of patients with primary and secondary brain tumors, and the affecting factors. Methods: Cross-sectional study in patients with primary and secondary brain tumors at Cipto Mangunkusumo General Hospital in 2017-2019. Malnutrition was diagnosed using the GLIM (Global Leadership Initiative on Malnutrition) criteria. Data analysis used Chi-Square/Fisher and multivariate logistic regression. There were 333 subjects: 246 primary and 87 secondary brain tumors. Description of nutritional status of patients with primary brain tumors: 47.6% obese; 6.1% malnutrition; the rest were normal, while in secondary brain tumors: 25.3% were malnourished; 24.1% obese; the rest is normal. Secondary brain tumor at risk of malnutrition with RR 1.257 (95% KI 1.108-1.426), p<0.001. Factors influencing malnutrition were the type of primary/secondary brain tumor, gender, age, decreased consciousness, anorexia, gastrointestinal complaints, intraaxial lesions, multiple lesions, and the location of the lesions involving the frontal lobes. The independently related factor was multiple lesions with an aOR of 3,423 (95% KI 1.124-10.426), p 0.03. Conclusion: The nutritional status of patients with primary and secondary brain tumors was different, with higher levels of malnutrition in secondary brain tumors and higher obesity in primary brain tumors. The number of multiple lesions in the brain affects the occurrence of malnutrition.
Co-Authors Ahmad Yanuar Aman, Renindra Ananda Andayani, Diyah Eka Andhika Rachman Aninditha, Tiara Ariafini, Ni Nengah Rida Diafiri, Dinda Djohansjah, Joice Rosewitasari Aryanti Faiq, Ahmad Rafi Humaira, Sarah Imran, Darma Indrapriambada, Ery Riady Madjid, Irma Savitri Maulina, Lisa Pukovisa Prawiroharjo, Pukovisa Putri Auliya, Putri Rahmad Mulyadi, Rahmad Ranakusuma, Teguh Ranakusuma, Teguh A. S Rini Andriani Riwanti Estiasari Sari, Riska Nanda Sinthia, Novita Ayu Sitorus, Freddy Susanto, Eka Tanjung, Gloria Wiratman, Winnugroho Yesnuar Safri, Ahmad Zairinal , Ramdinal Aviesena