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Mulyani, Hanny
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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EVALUASI PROFIL PENGGUNAAN ANTIBIOTIK DEMAM TIFOID ANAK DI INSTALASI RAWAT INAP RSUD BUDHI ASIH JAKARTA TIMUR TAHUN 2023 Mulyani, Hanny; Sari, Dwi Puspita; Lukitasari, Nurraya
Jurnal Kesehatan Tambusai Vol. 5 No. 3 (2024): SEPTEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i3.29605

Abstract

Salmonella typhi merupakan bakteri penyebab penyakit tifoid yang ditandai dengan diare, muntah, anoreksia, dan mual. Di Indonesia, jumlah kasus demam tifoid setiap tahunnya dapat meningkat hingga 500 per 100.000 orang, dengan tingkat kematian sebesar 0,6 hingga 5%. 14,1 persen kasus penyakit tifoid di dunia mayoritas berasal dari Asia Tenggara. Jumlah kasus penyakit tifoid lebih tinggi terjadi pada anak, terutama anak usia sekolah. Peristiwa yang akan berdampak secara langsung pada hasil belajar anak. Dikarenakan antibiotik dapat diperoleh dengan mudah tanpa resep dokter, kasus yang sering terjadi pada pasien yaitu mengobati dengan antibiotik yang tidak rasional. Berdasarkan tinjauan diatas, maksud dari hasil observasi yaitu akan melaksanakan penelitian mengenai karakteristik pasien (umur, jenis kelamin, berat badan) dan profil pemberian antibiotik terhadap pasien demam tifoid terhadap usia anak di RSUD Budhi Asih Jakarta Timur tahun 2023.  Jenis penelitian tersebut adalah pengkajian observasi gambaran dan pengambilan sampel dengan cara total sampling, dokumentasi informasi dilaksanakan berdasarkan retrospektif dan metode analisis dalam bentuk tabel berupa persentase. Data yang didapatkan semua pasien demam tifoid anak (usia 6-10 tahun) sebanyak 112 pasien dan sesuai memenuhi kriteria inklusi. Karakteristik usia pasien terbanyak yaitu 6-7 tahun terdapat 58 pasien (52%), jenis kelamin terbanyak laki-laki yaitu 57 pasien (51%) dan berat badan dengan jumlah terbanyak terdapat pada berat badan 15-22 kg 58 pasien (52%) dan profil pemberian antibiotik yang digunakan yaitu ceftriaxone sebanyak 49 pasien (44%), cefixime sebanyak 31 pasien (28%), cefotaxime sebanyak 24 pasien (21%) dan azithromycin sebanyak 8 pasien (7%).
Identification of a New Compound as α-Glucosidase Inhibitor from Aspergillus aculeatus Dewi, Rizna Triana; Suparman, Asep; Mulyani, Hanny; Darmawan, Akhmad; Lotulung, Puspa Dewi N.
Annales Bogorienses Vol. 20 No. 1 (2016): Annales Bogorienses
Publisher : BRIN

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Abstract

Terestrial fungi are of great importance as potential sources of pharmaceutical agent. Aspergillus aculeatus, a fungus isolated from soil sample collected in Indonesia, was cultured in liquid media to investigate a novel compound as inhibitor -glucosidase. The mycelium extract of A. aculeatus shows potential activity against Saccharomyces cereviseae -glucosidase and mild activity against mammalian -glucosidase with IC50 values of 9.57 μg/mL and 470.76 mg/mL, respectively. Enzyme assay-guided fractionation of this extract afforded rubrofusarin (1). Rubrofusarin, a linear naphtho--pyrone, is a natural pigment from Aspergillus sp. Interestingly, compound 1 shows potential inhibitory activity against mammalian -glucosidase (IC50 of 92.7 μg/mL), but no to S. cereviseae -glucosidase. The results suggest that A. aculeatus is a promising natural source as a lead compound in the discovery of antidiabetic drug.
Bioactivities Screening of Indonesian Marine Bacteria Isolated from Sponges Artanti, Nina; Maryani, Faiza; Mulyani, Hanny; Dewi, Rizna Triana; Saraswati, Vienna; Murniasih, Tutik
Annales Bogorienses Vol. 20 No. 1 (2016): Annales Bogorienses
Publisher : BRIN

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Abstract

Currently marine bacteria are considered as important source of natural products for drug discovery. The objective of this study is to conduct an in vitro bioactivities (antidiabetic, antioxidant and antibacterial) screening of 9 Indonesian marine bacteria isolated from sponges that belongs to the Research Center for Oceanography, Indonesian Institute of Sciences collections. The marine bacteria were cultured for 2 days in liquid medium containing yeast, peptone and sea salt under shaking condition and extracted with ethyl acetate. Antidiabetic was measured using inhibition of -glucosidase inhibitory activity method; antioxidant was measured using DPPH free radical scavenging activity method; antibacterial was tested using disc diffusion method. Screening results showed that at sample concentration of 200 μg/mL, there was significant -glucosidase inhibitory activity detected in the extracts of strain Sp 7.9 (84 % inhibition) and Sp 8.10 (75 % inhibition), however the antioxidant activities of these two strains were low only around 30 % inhibition, antioxidant activities of other strains were very low. Screening for antibacterial activities using 10 μL samples show that extract of strain Sp 8.5 was best for Staphylococcus aureus (14 mm inhibition); Sp 7.9, and Sp 8.5 for Bacillus subtilis (18 mm inhibition); Sp 8.10 for Escherichia coli (10 mm inhibition); Sp 8.9 and Sp 8.10 (10 mm inhibition) for Pseudomonas aeuriginosa. Based on these results marine bacteria strain Sp 7.9 and Sp 8.10 were selected to be used for further studies in the isolation of bioactive that has potential as antidiabetic and antibacterial. Results of molecular identification conducted by InaCC show that identity of both strains based on BLAST Homology using NCBI database were Bacillus thuringiensis.
Co-Authors Akhmad Darmawan ASEP SUPARMAN Dwi Puspita Sari, Dwi Puspita Lotulung, Puspa Dewi N. Lukitasari, Nurraya Maryani, Faiza Nina Artanti Rizna Triana Dewi Saraswati, Vienna Tutik Murniasih