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All Journal Jurnal Ilmu dan Teknologi Kesehatan Jurnal Pengabdian Kesehatan Jurnal Buana Farma Borneo Journal of Pharmacy Media of Health Research
Prajawanti, Kadeq Novita
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Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Perbedaan Nilai Tekanan Darah Antara Operator Produksi Dengan Petugas Laboratorium Pabrik Spunbond Di Balongbendo Negara, Yohanes Ardian Kapri; Anwari, Farida; Prajawanti, Kadeq Novita; Octifani, Amellya
Media of Health Research Vol. 1 No. 3 (2023): Media of Health Research, December 2023
Publisher : Lembaga Publikasi Ilmiah Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70716/mohr.v1i3.21

Abstract

Employees who work in their jobs must achieve work goals within a certain period of time. The purpose of the study was to determine the difference in blood pressure values and hemoglobin levels between Production Operators and Laboratory Officers of the Spunbond Factory in Balongbendo. Blood pressure measurement used ABN aneroid tensimeter, while hemoglobin level measurement used easy touch GCHB. The type of research used was quantitative observational analytic with a cross sectional approach. Data analysis using Statistical Package for Social Science (SPSS) includes chi square test, paired sample t-test, and independent sample t-test. Independent sample t-test statistical test obtained p-value> 0.05. Indicates that there is no significant difference between systolic and diastolic blood pressure values before and after working Production Operators with Laboratory Officers. The results of measuring the hemoglobin level of Production Operators, obtained an average hemoglobin level of 15.0 mmHg. While the results of measuring the hemoglobin level of Laboratory Officers obtained an average value of 15.4 mmHg. The results of the independent sample t-test statistical test obtained a p-value of 0.280 or p-value> 0.05. That there is no significant difference in hemoglobin levels between Production Operators and Laboratory Officers.
Effect Of Aegle marmelos on IgM And IgG Antibody Titers in Rattus norvegicus Prajawanti, Kadeq Novita; Nurdianto, Arif Rahman; Rahmawati, Novia; Negara, Yohanes Ardian Kapri
Jurnal Ilmu dan Teknologi Kesehatan Vol 11 No 1 (2023): September 2023
Publisher : Poltekkes Kemenkes Jakarta III

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32668/jitek.v11i1.1314

Abstract

Aegle marmelos is a traditional plant with many therapeutic benefits; for example, it is used as an immunomodulatory agent. Literature studies reveal many functional and bioactive compounds, such as alkaloids, phenolics, coumarins, flavonoids, terpenoids, and other antioxidants. Based on its chemical content, Aegle marmelos could be an immunomodulatory agent because it can stimulate the production of antibodies against foreign antigens, increasing IgM and IgG. This study aims to determine the effect of Aegle marmelos filtrate on IgM and IgG titers in Rattus norvergicus induced (sheep red blood cells) SRBC 2%. In this study, 30 rats were divided into five groups: negative control received standard diets, positive control received SRBC 2% injection, P1 received SRBC 2% + Aegle marmelos filtrate 25%, P2 received SRBC 2% + Aegle marmelos filtrate 50%, and P3 received SRBC 2% + Aegle marmelos filtrate 75%. The results showed that administration of Aegle marmelos filtrate could increase IgM titers at the highest dose of 75%, although it was not statistically significant. Meanwhile, Aegle marmelos filtrate does not affect IgG titers in SRBC 2% compared to treatment groups.
Antidiabetic and TNF-α Lowering Effect of Tagetes erecta Extract in Alloxan-Induced Diabetic Rats Prajawanti, Kadeq Novita; Negara, Yohanes Ardian Kapri; Arianing, Intan Febiola; Junitasari, Fitri
Borneo Journal of Pharmacy Vol. 8 No. 2 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i2.6871

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by impaired insulin production or action, often leading to pancreatic β-cell dysfunction and apoptosis. Pro-inflammatory cytokines, notably Tumor Necrosis Factor-alpha (TNF-α), play a critical role in the pathogenesis of type 2 diabetes (T2D). While Tagetes erecta (marigold) has demonstrated potential in lowering blood glucose in hyperglycemic conditions, its anti-inflammatory effects in diabetic models remain underexplored. This study aimed to evaluate the antidiabetic and TNF-α lowering effects of T. erecta extract in alloxan-induced diabetic rats. Twenty-five male Wistar rats were divided into a normal control group (n=5) and a diabetic group (n=20) induced by alloxan (blood glucose ≥126 mg/dL). Diabetic rats were then randomized into four treatment subgroups (n=5 each): untreated diabetic control, and diabetic groups treated with T. erecta extract at doses of 25 mg/kg BW, 50 mg/kg BW, or 75 mg/kg BW (administered intraperitoneally). Statistical analysis revealed that T. erecta extract significantly reduced blood glucose levels in alloxan-induced diabetic rats (p <0.05). Furthermore, the highest dose of T. erecta extract (75 mg/kg BW) effectively attenuated elevated TNF-α levels, demonstrating a significant anti-inflammatory effect. In conclusion, this study provides compelling evidence that T. erecta extract exhibits both antidiabetic and anti-inflammatory properties by significantly lowering blood glucose and TNF-α levels in alloxan-induced diabetic rats, particularly at the 75 mg/kg BW dose.
Gasik: Gerakan Edukasi Siswa Anti Narkoba Dalam Upaya Menciptakan Pengetahuan Generasi Muda Berbasis Teknologi Charisma, Acivrida Mega; Octifani, Amellya; Prajawanti, Kadeq Novita; Anwari, Farida; Negara, Yohanes Ardi Kapri
Jurnal Pengabdian Kesehatan Vol 8, No 2 (2025): Jurnal Pengabdian Kesehatan
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM) STIKES Cendekia Utama Kudus

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31596/jpk.v8i2.458

Abstract

Narkotika, psikotropika, dan obat-obatan terlarang atau yang biasa disebut dengan narkoba di bidang kesehatan memberikan manfaat yang cukup besar bagi penyembuhan dan keselamatan manusia. Tujuan dilakukannya kegiatan gerakan edukasi siswa anti narkoba dalam upaya menciptakan pengetahuan generasi muda berbasis teknologi di SMAN 1 Kedamean agar peserta didik sebagai target kegiatan sosialisasi dapat memahami dampak yang ditimbulkan.  Metode yang digunakan adalah observasi langsung dan penyuluhan disekolah sasaran. Kegiatan penyuluhan untuk menciptakan Pengetahuan Generasi Muda Berbasis Teknologi di adakan di SMAN 1 Kedamean Kabupaten Gresik  pada Hari Rabu, 14 Agustus 2024 dengan peserta yaitu seluruh siswa SMAN 1 Kedamean dengan total peserta setidaknya 58 anak dari kelas XII. Jalanya kegiatan sosialisasi dilakukan melalui tiga tahap, yang pertama adalah pemutaran video mengenai video profil, pembagian kuisioner, sesi kedua sosialisasi materi, upaya pencegahan HIV, dan sesi yang terakhir sosialisasi gerakan edukasi siswa anti narkoba. Kemudian dilakukan sesi tanya jawab dan diskusi. Kegiatan pengabdian masyarakat ini meningkatkan pengetahuan siswa tentang pendidikan moral, narkoba, dan dampak penyalahgunaan narkoba dari sudut pandang kesehatan, sosial, dan hukum. Peningkatan pemahaman siswa-siswi akan bermuara pada terciptanya sikap dan perilaku bebas narkoba. Diharapkan kedepannya remaja terutama siswa-siswi SMA yang merupakan bagian dari generasi muda Indonesia menjadi generasi milenial yang bebas narkoba. Hasil dari kegiatan ini adalah tumbuhnya kesadaran bagi para peserta kegiatan mengenai bahaya penggunaan narkoba. Informasi yang disampaiakan melalui kegiatan ini menjadi wawasan yang membuat peserta semakin sadar dan waspada bahwa penggunaan narkoba dengan berbagai bentuknya sangat berbahaya dan merugikan.
ARTIKEL REVIEW : AKTIVITAS ANTIOKSIDAN BUNGA MAWAR MERAH (Rosa damascene Mill.) Oktavia, Dian Ayu; Aristia, Bella Fevi; Prajawanti, Kadeq Novita
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1403

Abstract

Red rose (Rosa damascena Mill.) is an ornamental plant that is rich in bioactive compounds such as flavonoids, anthocyanins, phenols, vitamin C, tannins, and saponins that function as natural antioxidants. The purpose of this article is to review research results related to the antioxidant activity of red rose flowers in various dosage forms and extraction methods. This review was conducted through a literature review of 10 selected scientific articles in the range of 2015-2025 using the exclusion and inclusion method. The results showed that most of the red rose flower extracts showed very strong antioxidant activity, characterized by IC₅₀ values < 50 ppm, even in some studies reaching < 20 µg/mL. Antioxidant activity is influenced by the type of solvent, temperature and processing time, as well as the combination of ingredients such as bengkoang or mint leaves. Polar extracts such as ethanol and methanol tend to give the best results, while high temperature treatment and long heating times tend to reduce the effectiveness of active compounds. Thus, rose red flowers have great potential as a source of natural antioxidants that can be utilized in functional food, cosmetic, and pharmaceutical products.
Co-Authors Anwari, Farida Arianing, Intan Febiola Aristia, Bella Fevi Charisma, Acivrida Mega Junitasari, Fitri Negara, Yohanes Ardi Kapri Negara, Yohanes Ardian Kapri Novia Rahmawati Nurdianto, Arif Rahman Octifani, Amellya Oktavia, Dian Ayu