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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Urology Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Medica Hospitalia
Vikawati, Nura Eky
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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PHENOTYPE-GENOTYPE AND PEDIGREE ANALYSIS OF ISOLATED HYPOSPADIAS PATIENTS Vikawati, Nura Eky; Santosa, Ardy; Juniarto, Achmad Zulfa; Faradz, Sultana MH
Indonesian Journal of Urology Vol 25 No 1 (2018)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v25i1.390

Abstract

Objective: Hypospadias is a malformation in urethra which has many range of severity. A patient with Isolated hypospadias (IH), a mild disorder of sex development (DSD) has a hypospadias phenotype only. Hypospadias is considered as multifactorial disease in which genetic factors contribute to its development. Chromosome analysis in DSD including hypospadias is conducted for gender assignment and other possible genetic contributions. This analysis solely could not elucidate all genetic causes of hypospadias. Polymorphism of V89L in SRD5A2 is suggested as one of genetic risk factors of hypospadias. To determine the genetic risk factor and pattern of inheritance, a good pedigree construction is required. Material & methods: 35 eligible subjects with IH admitted to Center for Biomedical Research (CEBIOR) during 2012-2015 were randomly selected. 35 normal male as control were included in this study. Data on three generation pedigrees were collected from medical records in 35 affected subjects. Chromosome analyses were done by using G-banding technique. Polymorphism analysis of V89L in SRD5A2 gene was done using PCR-RFLP technique in all samples. Results: From the 35 affected subjects, the most frequent phenotype was penile hypospadias (47%), a pair of twins were monozygotic and one had a cousin diagnosed with urogenital abnormalities (i.e micropenis and chordae). All subjects had 46,XY chromosome. No chromosomal aberration was found. No positive correlation between polymorphism of V89L in SRD5A2 and risk of hypospadias (PR of CC+CG vs GG=1.0, 95% CI: 0.342−2.921, p value=1.0). Conclusion: The pedigree data from our study implies tendency of genetic involvement in hypospadias cases. There were no chromosomal aberrations in hypospadias cases. The finding on polymorphism of V89L in SRD5A2 gene does not support that of previous studies.
Physical Activity Correlates to Body Mass Index among Medical Students Vikawati, Nura Eky; Sarosa, Hadi; Makarim, Fadli Rizal; Fasitasari, Minidian
Jurnal Kedokteran Brawijaya Vol 31, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2020.031.02.8

Abstract

Physical activity (PA) has a positive effect on preventing risk on cardiovascular and metabolic syndrome, including obesity. Learning behavior that tends to be sedentary causes medical students to tend to be physically inactive. This present study aimed to associate the physical activity (PA) level with blood pressure, body mass index, and non-fasting blood glucose level (NFBG) among medical students. This cross-sectional study was conducted from February to March in 2019 on the first-year medical students at Sultan Agung Islamic University (UNISSULA). A total of 167 medical students (64.7% female and 35.3% male) were enrolled in this study. The international physical activity questionnaire (IPAQ)-short form was used to measure the PA level. The activity level was classified into low, moderate, and high. Blood pressure and glucose level were measured using a digital sphygmomanometer and NFBG dipstick. The association between PA level and Body Mass Index (BMI), Blood Pressure (BP), and NFBG level were analyzed using Spearman's correlation test. Chi square test was done to analyse the difference of PA level between male and female groups. The majority of the respondents had a low PA level (64.7%). A positive association was shown between PA level and BMI (p<0.05, r=0.192). Female medical students tend to be physically inactive than males (OR 2.004, 95% CI (1.038-3.8690)). Female students need to be encouraged to do more physical activity. The university's policies that promote physical outdoor activity need to be suggested.  
TIDAK DIDAPATKAN KECEMASAN PADA PETUGAS KESEHATAN DALAM MENGHADAPI PANDEMI COVID-19 Vikawati, Nura Eky; Nurrahma, Herlin Ajeng; Hardini, Intan Tri; Hidajati, Elly Noer
Syifa'Medika Vol 11, No 2 (2021): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v11i2.2990

Abstract

ABSTRAKPetugas kesehatan sebagai garda terdepan dalam pandemi COVID-19 dihadapkan pada dilema yang dapat menimbulkan gejala psikopatologis seperti kecemasan. Hal tersebut dikarenakan tidak sedikit jumlah petugas medis yang meninggal selama pandemi. Faktor ketersediaan APD, riwayat komorbid diri dan keluarga, latar belakang pekerjaan menjadi beberapa faktor yang mungkin menimbulkan gejala kecemasan. Penelitian bertujuan untuk mengukur tingkat kecemasan petugas kesehatan di kota Semarang dan beberapa daerah luar kota Semarang. Kuisioner Zung Self Anxiety Rating Scale (ZARS) digunakan untuk mengukur tingkat kecemasan. Data faktor risiko terkait kecemasan diukur dan disebar bersama dengan kuisionair ZARS melalui google-form. Data dianalisis secara deskriptif dan statistik dengan chi-square test. Terdapat 155 responden yang mengisi informed consent dan mengisi google-form dengan lengkap. Dari 155 responden, 151 diantaranya tidak mengalami gejala cemas dan 4 sisanya mengalami kecemasan ringan-sedang. Tidak didapatkan hubungan antara kecemasan dengan beberapa faktor risiko terkait cemas yang diukur (p>0,05). Tidak ditemukannya kecemasan pada penelitian ini bukan berarti tidak ditemukan gejala psikopatologis lain yang mungkin muncul selama pandemi COVID-19. Diperlukan penelitian lain dengan metode pengukuran lebih objektif dan mengukur faktor-faktor risiko cemas khususnya pada petugas kesehatan di Semarang dan sekitarnya.
PERBANDINGAN PROGRAM LATIHAN OTAGO MODIFIKASI DAN LATIHAN BERJALAN TERHADAP PHYSICAL PERFORMANCE PADA LANSIA PRE-FRAIL Vikawati, Nura Eky; Julianti, Hari Peni; Dewi, Novita Sari; Mariani, Endang Sri
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 2 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i2.874

Abstract

Background: Multicomponent training program like OTAGO is considered to improve the physical performance of pre-frail elderly, thereby reducing risk of fall. The Short Physical Performance Battery (SPPB) is a combination test that assesses physical performance and becomes a fall risk screening test for pre-frail elderly. This study aimed to compare the modified OTAGO to walking training on physical performance as measured by SPPB in the pre-frail elderly. Methods: This was an observational study with a cross-sectional design. The data were taken from the previous study including pre-frail subjects in Prolanis, Gunung Pati area, Semarang before and after giving intervention (modified OTAGO vs walking training) for 6 weeks. The SPPB score was measured from balance function test, chair stand test, and 4-meter walking test before and after the intervention. Data analysis was using SPSS ver 20.0. Paired sample T-test and Wilcoxon signed ranks test were used to analyze the SPPB score before and after interventions in the modified OTAGO and walking training group, respectively. Mann-Whitney U was used to analyze the difference in the average improvement of SPPB score. Results: There was a significant improvement in SPPB score before and after interventions either in modified OTAGO (p=0.013) or walking training (p=0.013). No significant difference was found in the average improvement of SPPB score in both groups (p=0.826). Conclusion: Both modified OTAGO and walking training intervention can improve the physical performance of pre-frail elderly. The modified OTAGO training is not superior in improving physical performance compared to walking training.
Co-Authors Achmad Zulfa Juniarto Ardy Santosa Dewi, Novita Sari Hadi Sarosa Hardini, Intan Tri Hari Peni Julianti Hidajati, Elly Noer Makarim, Fadli Rizal Mariani, Endang Sri Minidian Fasitasari Nurrahma, Herlin Ajeng Sultana MH Faradz